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Before your GPCR ligand ever meets its receptor, it meets the enzymes that determine whether it survives Discovery Program So what does that mean for discovery scientists designing the next generation of GPCR Even the most elegant GPCR ligand can fail if it never reaches its receptor. This lecture challenges scientists to move beyond binary inhibition data and embrace a systems-level Kenakin with your own enzyme or GPCR interaction puzzles.

GPCR , the global nonprofit platform dedicated to advancing GPCR science through education, community , and platform visibility , is proud to spotlight pHSense™ , a new reagent family from Revvity , now GPCR. GPCR  is a global nonprofit platform advancing GPCR research  through education, community, and platform assay platforms. 🔍 Learn More → Listen to the Podcast with Revvity’s Eric Trinquet → Explore the pHSense

isn't just  about the latest and best assay; it's about the framework that ensures the right assay data GPCR, we recognized this core problem. We'll look at how overlooked operational details, such as misaligned data from diverse GPCR assay types Part 2: The Data Disconnect : Discover how fragmented, unmanaged GPCR data  cripples scientific progress Learn how to build an integrated data pipeline  that transforms this chaos into a strategic asset.

GPCR. Dear Dr. We’re redesigning the platform for smoother navigation  and preparing to relaunch Dr. GPCR isn’t just a digital platform — it’s a community. GPCR About Dr. GPCR Dr. GPCR is a global platform dedicated to connecting GPCR scientists, industry experts, and innovators through

How a Collaboration Led to a GPCR Imaging Breakthrough JB didn’t set out to contribute to a GPCR imaging When David later shared early data — including a moment where he realized he could image an entire islet It was the start of a scientific partnership with the potential to shift how GPCRs could be visualized Designing Reliable GPCR Imaging Tools for Real Biological Systems Success brought new challenges. What started as one molecule request is now a platform vision — a future where any GPCR could be illuminated

This was more than data. It was ignition. discovery — the instant where the experiment stops being data and starts being meaning. Feeling the urge to take phone pictures of super-resolution data and send them to collaborators because They exchanged instincts as much as data, and built a shared rhythm of problem-solving.  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization

August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve Classically, GPCR internalization has been considered to lead to receptor desensitization. Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in , which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets Read more at the source #DrGPCR #GPCR #IndustryNews

Why Speed Matters in GPCR Drug Discovery Nine out of ten GPCR programs stall  not because the target GPCR Kinetics: The Critical Data You Can’t Afford to Skip Equilibrium potency data only tells part of “GPCRs are nature’s prototype allosteric proteins. Everything they do is allosteric.” Kenakin with your own enzyme or GPCR interaction puzzles. This AMA helps you read that story faster, so you don’t just generate data—you generate direction. 🟢

Broichhagen aka JB, the goal was bold and elegant: Create a photo-switchable ligand to remotely control GPCR They had a tool that did bind the GPCR… but not in the light-controlled way they wanted. Most labs would have stopped there — archived the data, moved on, written it off as a failed bet. “Negative data” isn’t negative — it’s directional. What Changed After This Data This imaging tool is now being used to: Re-evaluate where GLP-1 and GIP

Hi GPCR Community, If you work on GPCR discovery, you already know: early signals can mislead, and timing This week, we focus on how to convert ambiguous data into confident, defensible Mechanism of Action calls—before Career opportunities:  Research Assistant; Postdoctoral Associate; Senior Scientist, Data Science—curated GPCR scientists, translational pharmacologists, biotech discovery teams, platform company leaders, and community platform to help train and inspire the next generation of scientists.

GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

Following the Data Into GPCR, Metabolic Disease and GLP-1 After his PhD, Hodson entered neuroendocrinology You always need a scientific anchor — but you also need the courage to follow data where it leads. GPCRs Re-Enter the Story — Not as Theory, but as Tools GPCRs have always been powerful drug targets — That partnership eventually produced fluorescent GPCR tools  that allow researchers to visualize GPCR  involved in metabolic signaling — explaining confusing data that had accumulated for years.

Exploring the Hidden Dynamics: How Kinetics Reveals What Equilibrium Conceals in GPCR Research. We’re zeroing in on kinetic tools that reveal what steady-state data can’t—so you can vet leads faster Breakthroughs this week:  Septerna begins first-in-human trial of SEP-631 for CSU; Maxion’s KnotBody® platform reduce background (far-red/near-IR), and match channels to your cytometer for clean, multiparametric data GPCR innovation is accelerating.

Carlsson’s philosophy is simple but radical: modeling should generate hypotheses, not just rationalize data GPCR Modeling in Context: Then and Now When Carlsson entered the GPCR field in the early 2000s, structural data was scarce. newest tools in the lab’s arsenal is AlphaFold , DeepMind’s AI-powered protein structure prediction platform Why Predictive GPCR Modeling Matters Now The convergence of machine learning, improved GPCR structures

Exploring the intracellular allosteric site GPCRs represent one of the largest and most vital families For this reason, GPCRs have been a focus of drug development for decades due to their role in regulating Conventional GPCR drug discovery has largely focused on orthosteric sites, but recent breakthroughs in GPCR activity, enabling greater specificity and fewer side effects. allosteric site common in class A and class B GPCRs, particularly in chemokine receptors.

Take a look at our GPCR coverage for this week. We've got 11 GPCR papers, seven industry news pieces, a new GPCR event, and even a job ad.   with real-time kinetics Discovering new ligands and GPCR behaviors for unique drug profiles   GPCR Event Let’s dive into the   Classified GPCR News  from July 29th to August 4th, 2024 GPCR Activation and Signaling GPCR Ecosystem

GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud GPCR. GPCR provides a unique platform to reach scientists at every stage of GPCR research,”  said Wilson Gomes GPCR Dr. Their proprietary chemistry platform enables rapid generation of conjugates, such as labeled ligands,

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already targeting platforms reshaping immunotherapy pipelines. Upcoming events:  GPCR-UK Network Meeting, neuroGPCR symposium, and Transatlantic ECI GPCR event—where GPCR Podcast Listener Why Dr. GPCR Premium 🔹 What’s included?

GPCR podcast is now available! Our guest is Mark Schmeizl! Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

GPCR Premium: Sneak Peek Want the full classified brief? GPCR , our mission is simple but urgent: Accelerate GPCR biology and drug discovery by connecting scientists GPCR Podcast, the Revvity team built pHSense™ from the ground up by listening to what GPCR scientists GPCR innovation is accelerating. GPCR and the offered resources in my work sphere." — DrGPCR University Attendee GPCR innovation doesn

GPCR Ecosystem paid membership with extra benefits? 🔬Join the #GPCR movement today! ➡️ https://www.ecosystem.drgpcr.com/plans-pricing #gpcr #drgpcr

Read more at the source #DrGPCR #GPCR #IndustryNews

In GPCR drug discovery, a single mistaken assumption can derail an entire program. Why Misreading Antagonism Delays GPCR Drug Discovery If a dose-response curve shifts to the right, you Why now:  GPCR research is accelerating—and the projects that succeed will be those built on clear, accurate

That gave them capabilities others couldn’t match — from receptor biosensor platforms to live-cell imaging The lab went from project-level thinking to platform-level strategy  — a critical shift for GPCR biology What Changed After This Data The pooled funding model turned the lab into a magnet: postdocs, visiting Evolved Year 0  — Shared lab space established; PI buy-in secured Year 2  — Core imaging and signaling platforms GPCR Premium  for deep dives, strategic tools, and behind-the-scenes conversations shaping the GPCR field

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface. During Drosophila embryonic salivary gland (SG) invagination, the GPCR ligand Folded gastrulation (Fog Here, we reveal that the Smog GPCR transduces Fog signal to regulate Rho kinase accumulation and myosin Our data support a model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 "GPCRs modulate a plethora of physiological processes and mediate the effects of one-third Read more at the source #DrGPCR #GPCR #IndustryNews

Drugs Change the Game For decades, drug design has treated GPCRs as surface targets. Kenakin walks you through the science, the data, and the practical methods for making it happen.   This isn’t just theoretical—Kenakin shows data from risperidone, comparing offset rates in open compartments Kenakin shows how this plays out in model systems and clinical data—and why residence time should be GPCRs now have validated intracellular  allosteric sites.

GPCR podcast is now available! Our guest is Dr. Adriano Marchese! Learn about his remarkable career and research in #GPCR signaling and trafficking. Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

Join us and learn how to quantify your kinetic GPCR signaling from the expert himself: Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface. During Drosophila embryonic salivary gland (SG) invagination, the GPCR ligand Folded gastrulation (Fog Here, we reveal that the Smog GPCR transduces Fog signal to regulate Rho kinase accumulation and myosin Our data support a model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent Read more at the source #DrGPCR #GPCR #IndustryNews