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Finding Science Through Serendipity Carlsson didn’t grow up with a vision of becoming a scientist. It wasn’t until his postdoctoral years at UCSF—under Brian Shoichet—that GPCRs entered his scientific Career Lessons for Young Scientists Carlsson’s journey holds several lessons for early-career researchers Finally, he advises young scientists to celebrate small wins. content you won’t find anywhere else. 🔬 Fuel your science. 🤝 Grow your network. 🚀 Lead the future

From Patient to Researcher Alex wasn’t always planning to be a scientist. There, he learned how to frame pain not just as a symptom, but as a signal — and a scientific challenge Building a Career from the Inside Out Now back in med school, Serafini aims to follow the physician-scientist researchers needs to start from lived experience, not just literature. _________________ Keyword Cloud: GPCR research community , chronic pain , GPCR drug discovery , GPCR scientist network , pain neuroscience

What began as a small, volunteer-driven initiative has grown into a vibrant global network — thousands of scientists, founders, students, and partners who now learn, collaborate, and move the field forward GPCR resources, connect new scientists, and earn rewards  for helping expand access to GPCR knowledge GPCR Retreat  — our largest in-person event yet, designed to bring together scientists, industry leaders GPCR is a global platform dedicated to connecting GPCR scientists, industry experts, and innovators through

Listen to the episode ➤ Quick Links Assess GPCR Biased Signaling of Agonist How GPCR Collaboration Built GPCR education and community infrastructure accessible to scientists worldwide. GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need GPCR innovation is accelerating. GPCR Team

With pHSense™, scientists can finally track GPCR internalization  in real time—even at physiological assays  and the scientific “aha” moments that drove its development. GPCR. GPCR Dr. Through our podcast, training programs, and partner content, we help scientists connect, collaborate,

May 2022 "Seoul, South Korea, 28 April 2022 – GPCR therapeutics, Inc., a venture-backed clinical stage company with an innovative approach to drug discovery based on targeting G Protein Coupled Receptors (GPCR ) pairs, today announced four appointments to its Scientific Advisory Board (SAB). GPCR just had a very successful first meeting including all the Scientific Advisory Board." Read more at the source #DrGPCR #GPCR #IndustryNews

Why Speed Matters in GPCR Drug Discovery Nine out of ten GPCR programs stall  not because the target Scientists get frameworks, not guesswork. “Scientists love to control experiments. CROs have standard ways of doing them. “In industry, scientists bring targets forward. There’s no central committee handing down orders. For scientists in discovery, this means two things: Technical clarity drives survival.

GPCR imaging? The Human Reaction Behind a GPCR Imaging Milestone Scientists rarely talk about the emotional side of GPCR imaging doesn’t just visualize receptors. It gives scientists a way to feel the biology. Multi-receptor visualization in complex tissue The dream is ambitious and increasingly feasible: A catalog where scientists  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization

Hi GPCR Community, If you work on GPCR discovery, you already know: early signals can mislead, and timing Career opportunities:  Research Assistant; Postdoctoral Associate; Senior Scientist, Data Science—curated It’s built for scientists and leaders who want the signal, not the scroll: frameworks that clarify mechanism GPCR scientists, translational pharmacologists, biotech discovery teams, platform company leaders, and community platform to help train and inspire the next generation of scientists.

“These tools can dramatically improve how scientists measure ligand-receptor interactions, visualize GPCR provides a unique platform to reach scientists at every stage of GPCR research,”  said Wilson Gomes GPCR’s global network, educational content, and discovery tools, visit  ecosystem.drgpcr.com . ______ expert-led courses, and networking. GPCR empowers scientists and companies advancing receptor biology and drug discovery.

Broichhagen aka JB, the goal was bold and elegant: Create a photo-switchable ligand to remotely control GPCR They had a tool that did bind the GPCR… but not in the light-controlled way they wanted. This solved a long-standing problem in GPCR biology: You can't understand signaling if you can’t see  The Larger Lesson for Scientists and Innovators This story isn’t just about a GPCR imaging tool. For Early-Career Scientists Don’t optimize your trajectory for papers.

opportunities:  A curated list of new positions, including a Research Associate, a Senior Research Scientist Without a solid grasp of these concepts, scientists risk misinterpreting critical data, leading to flawed GPCR-Based Drug Discovery conference is where the future of GPCR therapies will be defined. GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who The pace of GPCR innovation is accelerating.

As scientists, we know curves don’t equal clarity. previews; positive ACCESS data for Structure Therapeutics’ oral GLP-1 agonist aleniglipron, Principal Scientist—In saturation curves, displacement assays, stoichiometry pitfalls, and kinetic traps, the lesson equips scientists A quick rating on Spotify or Apple Podcasts — and a YouTube subscribe — helps us reach more scientists GPCR Premium Membership Gives You an Edge Premium Membership is designed for scientists and teams who

partnership built on trust and curiosity — reshaped both careers and helped unlock a new generation of GPCR How a Collaboration Led to a GPCR Imaging Breakthrough JB didn’t set out to contribute to a GPCR imaging It was the start of a scientific partnership with the potential to shift how GPCRs could be visualized How Chemical Probes Transformed GPCR Imaging and Outperformed Antibodies As JB continued exploring the Designing Reliable GPCR Imaging Tools for Real Biological Systems Success brought new challenges.

August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve Classically, GPCR internalization has been considered to lead to receptor desensitization. Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in , which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets Read more at the source #DrGPCR #GPCR #IndustryNews

roles spanning PhD entry points to senior translational pharmacology—Protein Expression, Drug Discovery Scientist , and Staff Scientist in Molecular Pharmacology—curated with notes on fit, skill spikes, and timelines GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need GPCR innovation is accelerating. & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the

GPCR, we recognized this core problem. the entire GPCR program as a single, interconnected entity. Part 2: The Data Disconnect : Discover how fragmented, unmanaged GPCR data  cripples scientific progress Part 3: The Financial Friction : Explore how a lack of precise alignment between GPCR scientific milestones The GPCR Precision Blueprint is more than a concept.

We've got 11 GPCR papers, seven industry news pieces, a new GPCR event, and even a job ad.   to connect with fellow scientists and explore the latest in adhesion GPCR biology. Contest before August 15, 2024 Sponsorship Opportunities :   Elevate your brand's presence at this scientific   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Senior Scientist, GPCR Ecosystem

for pharmacologists and biotech scientists who need to translate mechanistic nuance into better decision-making Upcoming events:  GPCR-UK Network Meeting, neuroGPCR symposium, and Transatlantic ECI GPCR event—where This is the lens that lets scientists anticipate drug effects, decode kinetic behavior, and optimize This is a chance to shape the next scientific consensus on how GPCRs work, signal, and fail. GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who

Career opportunities:  Senior Scientist, Phage Display | Manager, CMC Management | Translational R&D GPCR , our mission is simple but urgent: Accelerate GPCR biology and drug discovery by connecting scientists GPCR Podcast, the Revvity team built pHSense™ from the ground up by listening to what GPCR scientists GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need + expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking

#177 The Career That Was Never Planned To Focus on GLP-1 Hodson didn’t begin with the identity of “scientist GPCRs Re-Enter the Story — Not as Theory, but as Tools GPCRs have always been powerful drug targets — That partnership eventually produced fluorescent GPCR tools  that allow researchers to visualize GPCR Emerging direction: Multi-target GPCR + myostatin-pathway combinations. Can GPCRs act as “delivery ZIP codes” for targeted therapies?

GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

GPCR Modeling in Context: Then and Now When Carlsson entered the GPCR field in the early 2000s, structural Why Predictive GPCR Modeling Matters Now The convergence of machine learning, improved GPCR structures For scientists, this is an intellectual challenge: demand more from your models.  Want to go deeper into GPCR modeling? Dr. collaboration. 🧠 Learn from the field’s top innovators. 📈 Sharpen your translational impact. 🔗 Connect with scientists

2026 GPCR Pharmacology AMA: Receptor Theory, Biased Signaling & Assay Interpretation The first GPCR Pharmacology as new videos are released: ▶️ https://www.youtube.com/@TerryPharmacologyCorner New White Paper on GPCR School of Medicine, has authored a new white paper in collaboration with Eurofins DiscoverX: Assess GPCR τ/KA) or log(max/EC50)) Systematic comparison of biased agonists using modern functional assays For scientists Forty years of pharmacological expertise — organized into a year-round framework for serious GPCR scientists

explicitly interested in GPCR signaling... but the thing about GPCRs... is you always kind of end up landing at a GPCR as a major target." GPCRs in the Background, But Always Present Even though his primary focus wasn’t GPCRs themselves, Serafini Takeaway Forget what you think you know about GPCR drug targets. data platform , GPCR training program , pain research , opioid signaling .

Exploring the intracellular allosteric site GPCRs represent one of the largest and most vital families For this reason, GPCRs have been a focus of drug development for decades due to their role in regulating Conventional GPCR drug discovery has largely focused on orthosteric sites, but recent breakthroughs in GPCR activity, enabling greater specificity and fewer side effects. allosteric site common in class A and class B GPCRs, particularly in chemokine receptors.

— a transformation that reshaped how scientists design experiments and interpret signaling. When technology reduced the cost of failure, scientists could push boundaries faster. networks, biased signaling, and functional selectivity. For Early-Career Scientists: Don’t over-invest in proving your pipetting skills. Research Every generation of GPCR scientists inherits the tools of the last and builds the next.

In GPCR drug discovery, a single mistaken assumption can derail an entire program. Why Misreading Antagonism Delays GPCR Drug Discovery If a dose-response curve shifts to the right, you when irreversible binding, receptor reserve, or allosteric effects mimic classical patterns —leading scientists over upcoming topics Who it’s for:  drug discovery teams, pharmacologists refining their toolkit, and scientists Why now:  GPCR research is accelerating—and the projects that succeed will be those built on clear, accurate

One fascinating aspect of the cellular signaling network is the crosstalk between G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). GPCRs, known for their involvement in a myriad of physiological processes, mediate mostly signaling through The cross-talk between growth factor receptors and GPCRs is an intriguing area of study. , leading to segregation of RTK-to-Gαi pathways from canonical GPCR-to-Gαi pathways.

facilities for receptor assays PhD students trained across multiple techniques, not just one pipeline Senior scientists For Early-Career Scientists Don’t just pick a project — choose an ecosystem. What Changed After This Data The pooled funding model turned the lab into a magnet: postdocs, visiting scientists Timing, leadership alignment, and a critical mass of motivated scientists converged. GPCR Premium  for deep dives, strategic tools, and behind-the-scenes conversations shaping the GPCR field