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.; Drago, F. Current Drug Treatments Targeting Dopamine D3 Receptor. Nature Methods   2011 , 8  (12), 1027–1036. https://doi.org/10.1038/nmeth.1768 . (19)      Schueder, F. ; Stein, J.; Stehr, F.; Auer, A.; Sperl, B.; Strauss, M.

Degorce F, Card A, Soh S, Trinquet E, Knapik GP, Xie B.

B., Panova, O., Hilger, D., Casiraghi, M., He, F., Maul, L., Gmeiner, P., Kobilka, B.

Heydenreich, F. M., Marti-Solano, M., Sandhu, M., Kobilka, B. K., Bouvier, M., & Babu, M.

Ciruela F, Jacobson KA, Fernández-Dueñas V.

detecting endogenous GPCR activity in primary cell cultures using ONE-GO biosensors Quantitation of F-actin

M., Thian, F. S., Kobilka, T. S., Schnapp, A., Konetzki, I., Sunahara, R. K., Gellman, S.

H., Heydenreich, F. M., Kawakami, K., Masureel, M., Maeda, S., Garcia, K.

References Brogi, S., Corelli, F., Di Marzo, V., Ligresti, A., Mugnaini, C., Pasquini, S., & Tafi, A.

aGPCR family was performed highlighted a new hydrophobic conserved motif composed of phenylalanine (F)

C et al. 2013) for O-glycosylation and the sulfinator tool for tyrosine sulfation sites (Monigatti F

Despite major advances in the field of pharmacological CVD treatments, particularly in the field of heart failure

October 2022 "The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system is well understood in cardiomyocytes and vascular smooth muscle cells (VSMCs). In the former, stimulation of Gs-coupled receptors leads to increases in contractility, whereas stimulation of Gq-coupled receptors modulates cellular survival and hypertrophic responses. In VSMCs, stimulation of GPCRs also modulates contractile and cell growth phenotypes. Here, we will focus on the relatively less well-studied effects of GPCRs in cardiac fibroblasts, focusing on key signaling events involved in the activation and differentiation of these cells. We also review the hierarchy of signaling events driving the fibrotic response and the communications between fibroblasts and other cells in the heart. We discuss how such events may be distinct depending on where the GPCRs and their associated signaling machinery are localized in these cells with an emphasis on nuclear membrane-localized receptors. Finally, we explore what such connections between the cell surface and nuclear GPCR signaling might mean for cardiac fibrosis." Read more at the source #DrGPCR #GPCR #IndustryNews

model of neuroinflammation Feasibility validation of Orion analogs in clinical development Cerini, F.

Carl F. Cori and Mrs. Cori.

Bandekar with help from Nathan Zaidman and Abhishek K. Singh

But what looks solid internally often fails to signal true readiness from the FDA’s perspective . 👉

sense of fun, the kind of scientific joy that makes late-night imaging sessions feel lighter and big failures

Most biotech pitches don’t fail because the science is weak. They fail because the story is unclear. 👉 A confusing pitch doesn’t just slow down progress.

Some worked in one tissue but failed in another. Some detected off-targets.

Some of the most promising biotech teams aren’t failing; they’re just stuck.

Yet, any pharmacologist who’s pushed beyond textbook theory knows: biology rarely plays fair. These deviations aren’t failures—they’re clues. In Kenakin's words, “Every slope, every curvature, every failure to fit—those are the whispers of the

Michelle was part of a cohort that joined as postgrads in shared facilities, pooling reagents, ideas, and failures

When technology reduced the cost of failure, scientists could push boundaries faster.

The lab has witnessed both spectacular accuracy and puzzling failures.

A well-behaved molecule in a dish can fail spectacularly in vivo, leaving teams with years of sunk costs

cardiomyocyte-specific Adhesion G Protein Coupled Receptor G1 (ADGRG1/GPR56) promotes pressure overload-induced heart failure

Good molecules can fail quietly at this stage —not because they’re weak, but because they’re too strong When they’re ignored, they become sources of silent failure : under-penetration, persistent off-target

, he lays out the mindset that helped shape products used across biotech and academia—and why play, failure They think too narrowly, focus too early, and equate unexpected results with failure. “You can try, try, try—and fail, fail, fail,” Eric says. But those failures are where new paths emerge, often leading to transformative tools like the IP1 assay Eric Trinquet Built to Fail, Built to Win: Inside the IP1 Assay Origin Story The IP-One assay didn’t

From failing fast to embracing serendipity, Eric shares the mindset (and messy origin stories) that shaped