- Toronto, Ontario (2015) - Bromont, Québec (2014) - Cleveland, Ohio (2013) London, Ontario (2012) Fairmont

Not failure.

That argument is not abstract: it is the conclusion of someone who has watched large programs fail to

The compound, aplaviroc, lowered viral load and reached humans before failing in phase three on liver Twenty some receptors and roughly fifty chemokines were long read as a fail safe arrangement. That gap, he argues, is where drugs fail, and closing it is the work that actually matters for making

Yamina and Arthur from Monash University discussed Arthur's career journey, the importance of hard work, failure They discussed the value of hard work, failure, and the significance of differentiation in their personal

emphasizes the importance of research environments that allow curiosity, experimentation, and even failure

Silvio Gutkind on G protein hotspot mutations, why the canonical GαQ pathway fails in uveal melanoma, The canonical assumption that targeting PLC would be therapeutic has failed in the clinic, and patients 16:45 Why CXCR3 may decide who responds to checkpoint inhibitors 20:28 GαQ, uveal melanoma, and the failure

Streicher trained in signal transduction during his PhD on heart failure and p38 MAP kinase, and moved Attempts to replicate the arrestin-knockout phenotypes on clean mouse backgrounds have failed. Dr. John Streicher 01:49 From heart failure to opioids — a path through signaling 07:49 Why the mu receptor turns out that it was signal transduction, and he worked on the signaling cascades involved in heart failure

.” — Alex Serafini Failure & Frustration: From Pipettes to Pandemic Disruption The road hasn’t been smooth He's equally focused on sex differences in pain processing and the failure of "one-size-fits-all" models

fluorescence chemistry, functional assays, and product development, Eric takes us through the highs, failures A mix of scientific curiosity, a tolerance for failure, and a commitment to delivering real-world impact—one

Failure is documented, not buried.

not, and that assumption has downstream consequences for how drugs are characterized and how trial failures junior scientists distills to a single criterion: if the curiosity isn't deep enough to outlast the failures those setbacks, but the ones for whom the pull toward the question is stronger than the push of the failure It's just not fair on the junior scientists who then follow up on that work to find it can't be repeated "If you've got that deep, deep drive still to get over those failures and pick yourself up, and that's

In this wide-ranging conversation, he reflects on the mentors, failures, and bold questions that shaped What You’ll Learn in This Episode How Ajay’s failed MD/PhD application rerouted his path toward a breakthrough using it to predict signaling bias The entrepreneurial lessons no one tells postdocs: how to pitch, fail That “failure” became a launchpad: Ajay later joined the lab of Dr.

Neurocrin Biosciences discovered that their lead compound sat on the receptor for seven hours while a failed The failed backup fell off in fifteen minutes.

Fiona Marshall walks through the decade when membrane proteins kept failing to crystallize in detergent non-orthosteric binding sites on GPCRs Biased agonism, target validation, and animal-to-human translation failure Marshall's caution is hard-won: many animal-model-validated GPCR drugs have failed in the clinic precisely

why rotation students act like a sorting hat, and why breakthroughs come from working hypotheses that fail a lab is its physical walls, and how much is the community, the plan, and the willingness to let a failed students as cross-pollinators between labs Why breakthroughs tend to come from working hypotheses that fail Breakthroughs come from working hypotheses that fail. Dr. knowledge in a career 12:20 Rotation students as the sorting hat 13:20 When the working hypothesis fails

Good Faith We introduce programs such as the Dr. GPCR Ambassador, in good faith and expect the same good faith in return. Please note that we may withhold awards where we believe customers are acting in bad faith or otherwise We cannot cover every nefarious scenario, nor will we attempt to, but we do promise to be fair and reasonable

Small missteps can derail entire programs: underperforming assays, off-track CROs, and data that fails

Hauser's research program asks a pointed question: if a patient fails to respond to a psychiatric drug

The trafficking failure itself may encode something about how tightly ORs are regulated in olfactory orthology calls are often ambiguous, and in the Pluznick lab's hands, putative orthologs frequently fail

architecture - what a dimer with no prior blueprint looks like What remains unsolved: why drug discovery still fails harder problem is understanding the human body well enough to predict why a compound that works in vitro fails Science is brutal, things fail for months, and the only way through is genuine passion for being in the

Eric Trinquet, creator of HTRF and IP-One assays, turned failure into breakthrough tools for GPCR science About GPCR Product Launches: Years in the Making What it really takes to launch a GPCR product—years of failure

beta-arrestin simultaneously — far exceeding the simple binary framework that guided a biased agonist into a failed Dichotomy — The AT1 receptor couples to Gq, Gi, G12, and beta-arrestin simultaneously, and the clinical failure A Clinical Trial Failure That Pointed Forward The Trevena biased agonist for the AT1 receptor failed Hebert argues this was not a failure of the concept but of incomplete pharmacological characterization

Industry News Pain targets in ion channel pathways: an Innovation Distillery spotlight ‘It’s not for the faint

Replays Weekly GPCR Insights (papers, jobs, events) Networking with a global scientist community One failed Think of Premium as insurance against wasted experiments and failed drug leads.