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- 🎯 Crack the code of GPCR ligand development! In case you haven’t heard, Dr. Terry Kenakin is hosting a 4-week course on GPCR drug development—and registration closes in 3 days! ⚠️ What you’ll learn: ✅ Drug absorption, metabolism & clearance ✅ PK-PD modeling & therapeutic profiles ✅ Early safety assessments & toxicity risks 📌 Limited spots—sign up before March 18th! 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharma #Biotech #Research | Dr. GPCR Ecosystem
GPCR Ecosystem #GPCR #DrGPCR #Pharma #Biotech #Research Published on March 15, 2025 Category Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharma #Biotech #Research Previous Next Recent Articles
- Lighting up a native pancreatic islet isn’t just a technical win it’s a shift in what GPCR imaging can reveal | Dr. GPCR Ecosystem
#drugdiscovery Previous Next Recent Articles Why Biotech Fundraising Fails Due to Intellectual Property Biotech fundraising has undergone a subtle yet significant shift. or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Started in medicinal chemistry. Got hooked on ligand design. Dr. Maria Majellaro didn’t plan to run a biotech company. A thesis project, a mentor’s advice, and a leap during the pandemic changed everything. Now she’s leading Celtarys, building custom fluorescent probes, and partnering with Dr. GPCR to support assay development worldwide. Meet Celtarys and learn more about its leading work on ligand-linker-fluorophore chemistry 🚀 ✳️ Listen now: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarys #GPCRcommunity #DrGPCR #FluorescentLigands #GPCRdrugDiscovery #ScientificLeadership #BiotechInnovation | Dr. GPCR Ecosystem
Maria Majellaro didn’t plan to run a biotech company. maria-majellaro-from-celtarys #GPCRcommunity #DrGPCR #FluorescentLigands #GPCRdrugDiscovery #ScientificLeadership #BiotechInnovation Maria Majellaro didn’t plan to run a biotech company. maria-majellaro-from-celtarys #GPCRcommunity #DrGPCR #FluorescentLigands #GPCRdrugDiscovery #ScientificLeadership #BiotechInnovation
- Did you know registrations are already open for all our 2025 Dr.GPCR University Courses? Check out what you can learn this year from the master, Dr. Terry Kenakin 😉and save your spot soon! Remember Premium Members get a 25% discount 🙌 ✳️Click here and start your next learning experience https://www.ecosystem.drgpcr.com/gpcr-courses #gpcr #drgpcr | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Can we preserve opioid pain relief without the side effects? 🔬 On Ep.166 of the Dr.GPCR Podcast, Ben Clements shares how positive allosteric modulators (PAMs) at the mu-opioid receptor could revolutionize treatment —with a 10x boost in methadone efficacy. Tune in for a masterclass on translational pharmacology, curiosity-driven science, and meaningful mentorship. 🎧 Full episode: Ep 166 with Dr. Ben Clements #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology #DrugDiscovery | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- A large-scale analysis of GPCR molecular dynamics reveals hidden allosteric sites and lateral gateways, unlocking new possibilities for drug discovery. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/large-scale-investigation-of-gpcr-molecular-dynamics-data-uncovers-allosteric-sites-and-lateral-gateways #gpcr#drgpcr | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Scientific careers are not just built on brilliance | Dr. GPCR Ecosystem
/dr-gpcr-podcast/leadership-luck-and-gpcr-signaling #GPCR #DrGPCR Previous Next Recent Articles Why Biotech Biotech fundraising has undergone a subtle yet significant shift. or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- "Solving financial puzzles feels just like solving scientific ones," says Joe St. Germain from Company Launch Partners. Behind every successful research organization, there is a rock-solid operations team. Don’t miss this rare conversation bridging science, structure, and strategy with Chuck DeWeese & Joe St. Germain. ✳️ Tune in now: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup | Dr. GPCR Ecosystem
Germain #gpcr #DrGPCR #ScienceStartup Previous Next Recent Articles Why Biotech Fundraising Fails Due Biotech fundraising has undergone a subtle yet significant shift. or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- An opportunity you won’t want to miss! ⚠️ The next 4-week course with Dr. Terry Kenakin, “Development of GPCR Ligands as Therapeutic Drugs” is coming up 🧐 Be the first to register, save your spot, and spread the word. This event will only happen once this year! ✳️Go to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs for more information! #gpcr #drgpcr | Dr. GPCR Ecosystem
#gpcr #drgpcr Previous Next Recent Articles Why Biotech Fundraising Fails Due to Intellectual Property Biotech fundraising has undergone a subtle yet significant shift. or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- A high-resolution deep mutational scan of MC4R reveals how thousands of genetic variants impact obesity-linked signaling pathways and highlights new opportunities for precision drug discovery Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/high-resolution-deep-mutational-scanning-of-the-melanocortin-4-receptor-enables-target-characterization-for-drug-discovery #gpcr#drgpcr | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Generic tools won’t solve tomorrow’s drug discovery challenges. That’s why Celtarys designs custom fluorescent probes for every target, built for real pharmacology, not just convenience. With Dr. GPCR and Celtarys joining forces, expect more visibility, more precision, and more scientific impact. 🚀 Get to know our media partner: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem #GPCRdrugDiscovery #GPCRecosystem #CustomLigands | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- New cryo-EM insights reveal how extracellular domains communicate with transmembrane regions in holo-adhesion GPCRs, uncovering mechanisms behind receptor activation. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/adhesion-gpcrs/conformational-coupling-between-extracellular-and-transmembrane-domains-modulates-holo-adhesion-gpcr-function #gpcr #drgpcr | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- GPCRs regulate key biological processes, but how exactly do inhibitory Gαi proteins control signal transduction beyond adenylyl cyclase suppression? New research sheds light on these pathways! ✨ Want to learn more? Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Dr. GPCR University is officially back! 🎆 Join Dr. Terry Kenakin for "The Practical Assessment of Signaling Bias" workshop! 🚀 Learn the practical issues with detecting, measuring, and quantifying GPCR ligand-biased signaling. ✳️Early Bird discounts for Premium Members! ➡️Register today at https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- A GPCR imaging breakthrough that didn’t start in a grant proposal | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Weekly News October 16 | Dr. GPCR Ecosystem
#DrGPCR #GPCR Previous Next Recent Articles Why Biotech Fundraising Fails Due to Intellectual Property Biotech fundraising has undergone a subtle yet significant shift. or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- 🔥 New Course Alert! “Development of GPCR Ligands as Therapeutic Drugs” with Dr. Terry Kenakin is here! Spots are filling up fast—Premium Members get 25% off! This advanced course is exclusively available in the Ecosystem, so don’t miss your chance to learn from the best. 🔹 Secure your spot now! 👉 https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr #pharmacolgy #drugdiscovery #research | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- In case you haven’t heard, registrations are open for the next 4-week course “Development of GPCR Ligands as Therapeutic Drugs,” with Dr. Terry Kenakin 👏 Spots are filling up fast, run and save yours, and enjoy a 25% discount with your Premium Membership 🚀 ✳️Go to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Did you know? 🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! 🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision by combining allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors (M1-M5). 🔬✨ Learn more about this breakthrough in the Ecosystem! | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- New biosensor technologies are shedding light on GPCR dynamics directly in cells, offering exciting possibilities for multiplexing and miniaturization! Curious about how these advances could impact drug discovery? Check out the latest review on GPCR biosensors. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- ama session sept 18 post 1 | Dr. GPCR Ecosystem
#GPCR #DrGPCR #Pharmacology #DrugDiscovery #Biotech #AllostericModulation #Kinetics #AssayDevelopment #EarlyDiscovery #PharmaR&D #BiotechInnovation Previous Next Recent Articles Why Biotech Fundraising Biotech fundraising has undergone a subtle yet significant shift. But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Did you know that GPR20, a potential therapeutic target to treat gastrointestinal stromal tumours, performs high constitutive activity when coupling with Gi? Check out this paper to see how molecular dynamics simulation can be used to explore its constitutive activation mechanism. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/exploring-the-constitutive-activation-mechanism-of-the-class-a-orphan-gpr20 #gpcr #drgpcr | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Ever wondered how we perceive bitterness? 👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14, the most promiscuous bitter taste receptor, bound to the drug flufenamic acid (FFA) and its signaling partner gustducin! 🌟 This discovery reveals an unusual dual binding mode of FFA and offers tools for site-targeted compound design. 🧪✨ Learn more about this exciting breakthrough in bitter taste signaling. | Dr. GPCR Ecosystem
cid=79a6b35e-7ba6-44a0-863b-0842f5a5cfd3 #gpcr #drgpcr #bittertaste Previous Next Recent Articles Why Biotech Biotech fundraising has undergone a subtle yet significant shift. or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Visualizing GPCRs in their native environment changes everything | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- irreversible drugs post 1 | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
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GPCR Ecosystem: uniting scientists, biotech, and innovators to advance GPCR research worldwide. Who We Are We are a global network of scientists, biotech innovators, pharma professionals, CRO leaders & Get Our Weekly News See Why it Matters 6,600+ followers 200+ Research Labs 1,500+ Scientists 50+ Biotech Now, it's a global ecosystem of scientists, biotech teams, CRO leaders, and trainees working to move Premium Members Include: ✔ Drug hunters at early-stage biotechs ✔ CRO leaders building assays and tools
- irreversible drugs post 3 | Dr. GPCR Ecosystem
#ReceptorPharmacology #MedicinalChemistry #PKPD #DrugDevelopment Previous Next Recent Articles Why Biotech Biotech fundraising has undergone a subtle yet significant shift. or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Did you know that GPR180 helps regulate lipid metabolism and may play a role in preventing obesity? recent study shows that overexpression of GPR180 in adipose tissue improves lipid metabolism and protects against HFD-induced obesity, while its knockout worsens lipid accumulation. This finding highlights GPR180 as a potential therapeutic target for metabolic disorders! Catch up on this exciting research in the Ecosystem today! 🏆📖 You’ll need to register, but don’t worry—it’s free! ➡️https://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/gpr180-reduces-adiposity-by-inhibiting-lipogenesis-and-fatty-acid-uptake-in-adipocytes #gpcr #drgpcr #metabolism #obesity | Dr. GPCR Ecosystem
Biotech fundraising has undergone a subtle yet significant shift. no longer something that comes up late in the process. 👉 It has become an early signal of whether a biotech or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs? New cryo-EM structures from Chen et al. (Nature, 2025) reveal that β-arrestin1 and β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping arrestin conformation, complex stability, and engagement mode. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Also, β-arrestin2 lacks a membrane anchor, making it more dynamic — a potential clue to its functional specialization. These findings underscore how barcode location + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias #Phosphorylation #DrGPCR | Dr. GPCR Ecosystem
CryoEM #StructuralBiology #SignalingBias #Phosphorylation #DrGPCR Previous Next Recent Articles Why Biotech Biotech fundraising has undergone a subtle yet significant shift. or heavier legal Attila Foris 5 days ago The Hidden Operating Cadence That’s Actually Driving Your Biotech But here’s the uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
