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That’s where computational chemistry steps in. This case study highlights why computational chemistry is no longer a side tool—it’s a driver of discovery

Explore Terry's Corner From Chemistry Lab to GPCR Partner – New Podcast with Celtarys Dr. Maria Majellaro of Celtarys shares how her team translates medicinal chemistry into practical GPCR assay

delivers this week: a deep dive into molecular creativity, rational design, and the overlooked role of chemistry Terry’s Corner: Why Chemistry Still Rules For decades, discovery focused on targets. Terry Kenakin reveals how drug chemistry defines function, not just fit.

He went on to study medicine at the Royal College of Surgeons in Ireland before receiving his Medical

Here’s the surprising truth: up to 80% of GPCR-targeted drugs fail—not because of poor chemistry, but

You’ll uncover: Why pharmacology is the glue between chemistry and biology How to interpret drug behavior

It started not with biology—but with chemistry. Revvity and academic collaborator Prof. Mini Timeline: The Road to pHSense → Initial lanthanide probe design with Durham University (chemistry Revnity’s partnership with Durham (chemistry) and the Institute of Functional Genomics in Montpellier

Receptors: A Century of Research and Discovery Challenges and opportunities in cancer immunotherapy: a Society assays in drug discovery October 2024 | Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

GPCR University Learner Celtarys Research Recap: Medicinal Chemistry Highlights You May Have Missed The pace of innovation in medicinal chemistry is accelerating—and if you missed this year’s ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025 , you’re already behind.

Years of chemistry, photophysics, and pharmacology condensed into one breakthrough: pHSense , a reagent Rare-earth europium complexes offered potential—but the chemistry was brutal. They translated a fundamental principle of chemistry into a usable platform for pharmacology—showing how persistence, precision, and the courage to take on “impossible” chemistry can shift the entire GPCR

GPCR-targeted drug development, incorporating machine learning, innovative biophysical methods, and medicinal chemistry Discovery on Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry function NEW Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry

XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic NEW Senior Principal Scientist, Medicinal Chemistry cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry

in GPCR-targeted drug design, including machine learning, new biophysical techniques, and medicinal chemistry implications for drug development DeepCure team is excited to welcome Justin Potnick, to our Medicinal Chemistry Discovery on Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry Postdoc in Molecular Pharmacology - The Hauser Group Senior Scientist/Staff Scientist, Computational Chemistry

His tools exist because he constantly asks: What limitation is chemistry solving here? Throughout his own journey—from organic chemistry to chemical biology to GPCR imaging—every pivotal step

First-Ever Structure of a Complex Between an Antibody-based Agonist and a Class A GPCR Regulating Hunger and Satiety Discovery on Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry

adrenocorticotropic hormone (ACTH), were selected for an oral presentation at ENDO 2022, the Endocrine Society

August 2022 "Background and purpose: Misuse of opioids has greatly affected our society.

Publishes Whitepaper Highlighting the Importance and Challenges in Unlocking “Undruggable” GPCRs Endocrine Society Applications (Protein Biochemistry) Speculative Applications (Mass Spectrometry) Speculative Applications (Chemistry

With collaborations across medicinal chemistry and neuropathic pain research, Ben is bridging molecule

the exciting world of incorporating machine learning, innovative biophysical methods, and medicinal chemistry Discovery on Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry

Ligand Recognition and Molecular Gating Conference NEW April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry Exhibition June 2 - 7, 2024 | Chemotactic Cytokines NEW October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry Research Associate NEW Postdoctoral Fellow Research Scientist/Postdoctoral Associate in Computational Chemistry

XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry

| Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry Post-Doc Research Associate Postdoctoral Fellow Research Scientist/Postdoctoral Associate in Computational Chemistry

Louis-Jeantet Prize for Medicine 2022 by the Louis-Jeantet Foundation and the 2022 Benjamin Franklin Medal in Chemistry Louis-Jeantet Prize for Medicine 2022 by the Louis-Jeantet Foundation and the 2022 Benjamin Franklin Medal in Chemistry

GPCR-targeted drugs, including the role of machine learning, new biophysical techniques, and medicinal chemistry Discovery on Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry Postdoc in Molecular Pharmacology - The Hauser Group NEW Senior Scientist/Staff Scientist, Computational Chemistry

| Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

ET (Presentation #OR18) at ENDO 2022, the Endocrine Society's 104th annual meeting in Atlanta from June

Their proprietary chemistry platform enables rapid generation of conjugates, such as labeled ligands,

Ranking Partial Agonists Without Losing Meaning Chemists want a single number. These GPCR pharmacology insights are essential for directing chemistry toward the property that actually

| Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry