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- GPCRs regulate key biological processes, but how exactly do inhibitory Gαi proteins control signal transduction beyond adenylyl cyclase suppression? New research sheds light on these pathways! ⨠Want to learn more? Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! | Dr. GPCR Ecosystem
New research sheds light on these pathways! ⨠Want to learn more? New research sheds light on these pathways! ⨠Want to learn more?
- Class B GPCR drugs are reshaping treatment for migraine, diabetes, and obesity- but did you know ligand bias plays a key role in their success? This new review explores how tweaking peptide drugs can boost efficacy, reduce side effects, and unlock next-gen therapies. Subscribe to the Dr. GPCR Newsletter š° and get the latest GPCR News delivered to your inbox ā”ļøhttps://www.ecosystem.drgpcr.com/reviews/where-are-we-now%3F-biased-signalling-of-class-b-g-protein-coupled-receptor-targeted-therapeutics #gpcr#drgpcr | Dr. GPCR Ecosystem
ā Class B GPCR drugs are reshaping treatment for migraine, diabetes, and obesity- but did you know ligand News Class B GPCR drugs are reshaping treatment for migraine, diabetes, and obesity- but did you know ligand
- Did you know? š Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! š§¬š” These innovative compounds, āPhoto-BQCisAā and āPhoto-BQCtrAns,ā offer subtype-selective precision by combining allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors (M1-M5). š¬āØ Learn more about this breakthrough in the Ecosystem! | Dr. GPCR Ecosystem
Photo-BQCisAā and āPhoto-BQCtrAns,ā offer subtype-selective precision by combining allosteric modulation with light āPhoto-BQCtrAns,ā offer subtype-selective precision by combining allosteric modulation with light control
- šØ Exciting Opportunity for Professionals in Drug Development! šØ Register today for a one-of-a-kind online course at Dr. GPCR University: "Development of GPCR Ligands as Therapeutic Drugs." š Dates: March 20 - April 10, 2025 ā° Time: Thursdays, 10:00 AM - 11:30 AM (EST) This advanced course is essential for anyone working in drug development and focuses on: The essentials of new drug development Key pharmacokinetic elements (absorption, distribution, clearance) Hepatic metabolism and the Cytochrome P450 system Drug safety and toxicology (including drug-drug interactions) And much more! Gain deep insights into GPCR drug candidates and learn the critical assays and techniques required to bring therapeutic molecules to life. šØ Only 25 spots available ā register now! š” This is a great opportunity for both academia and industry professionals. Sessions will be live, and youāll also have 1:1 discussion time with the instructor. Full PDFs of the slides will be available! š https://buff.ly/lVEcRUc #GPCR #DrugDevelopment #Pharmacokinetics #TherapeuticDrugs #OnlineCourse #DrGPCRUniversity #PharmaceuticalIndustry | Dr. GPCR Ecosystem
GPCR University: "Development of GPCR Ligands as Therapeutic Drugs." š Dates: March 20 - April 10, 2025 candidates and learn the critical assays and techniques required to bring therapeutic molecules to life Sessions will be live, and youāll also have 1:1 discussion time with the instructor. GPCR University: "Development of GPCR Ligands as Therapeutic Drugs." š Dates: March 20 - April 10, 2025 Sessions will be live, and youāll also have 1:1 discussion time with the instructor.
- How does a superagonist activate M2 muscarinic receptors? New simulations reveal the conformational changes from inactive to active states to highlighting how ligand dynamics drive GPCR activation! Catch the full story in the Ecosystem! https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/visualizing-agonist-induced-m2-receptor-activation-regulated-by-aromatic-ring-dynamics #GPCR #drGPCR #M2R #drugdiscovery #moleculardynamics | Dr. GPCR Ecosystem
New simulations reveal the conformational changes from inactive to active states to highlighting how ligand New simulations reveal the conformational changes from inactive to active states to highlighting how ligand
- A high-resolution deep mutational scan of MC4R reveals how thousands of genetic variants impact obesity-linked signaling pathways and highlights new opportunities for precision drug discovery Subscribe to the Dr. GPCR Newsletter š° and get the latest GPCR News delivered to your inbox ā”ļø https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/high-resolution-deep-mutational-scanning-of-the-melanocortin-4-receptor-enables-target-characterization-for-drug-discoveryĀ #gpcr#drgpcr | Dr. GPCR Ecosystem
high-resolution deep mutational scan of MC4R reveals how thousands of genetic variants impact obesity-linked high-resolution deep mutational scan of MC4R reveals how thousands of genetic variants impact obesity-linked
- Check out our #SpotifyWrapped š! In 2024, Dr. GPCR reached listeners worldwide, sparking conversations about GPCRs with top experts. Thank you for tuning in! ššļø ā³ļøCheck out our top episode: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-148-with-dr-arthur-christopoulos #gpcr #drgpcr | Dr. GPCR Ecosystem
GPCR reached listeners worldwide, sparking conversations about GPCRs with top experts. GPCR reached listeners worldwide, sparking conversations about GPCRs with top experts.
- š Running a GPCR lab? Applying for grants? Launching a nonprofit? Ep.165 of the Dr.GPCR Podcast is your finance + operations crash courseādelivered by two experts who support early-stage mission-driven teams like Dr. GPCR. š§ Smart, practical, and full of real talk: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup | Dr. GPCR Ecosystem
finance + operations crash courseādelivered by two experts who support early-stage mission-driven teams like finance + operations crash courseādelivered by two experts who support early-stage mission-driven teams like
- Dr. Kathryn E Livingston | Dr. GPCR Ecosystem
<< Back to podcast list Dr. GPCR Podcast Strategic Partners Dr. Kathryn E Livingston About Dr. Kathryn E Livingston Dr. Kathryn E Livingston is currently a Product Manager at Gator Bio , a biotechnology company providing Kathryn E Livingston on the web LinkedIn ResearchGate Pubmed Google Scholar Dr. : The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening
- Custom Molecules, Fluorescent Probes: When Chemists Think Like Biologists with Dr. Maria Majellaro from Celtarys | Dr. GPCR Ecosystem
Discover how Celtarys Research is transforming GPCR assay development with fluorescent ligands in this GPCR means for the global research community. << Back to podcast list Dr. GPCR Podcast Strategic Partners Custom Molecules, Fluorescent Probes: When Chemists Think Like Biologists Their approach is highly consultativeāthey donāt just sell ligands, they co-develop solutions. GPCR ecosystem , GPCR drug discovery , fluorescent ligands , GPCR scientist network , custom ligand development
- Coffee Break with lights snacks | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Coffee Break with lights
- Did you know that GPR180 helps regulate lipid metabolism and may play a role in preventing obesity? recent study shows that overexpression of GPR180 in adipose tissue improves lipid metabolism and protects against HFD-induced obesity, while its knockout worsens lipid accumulation. This finding highlights GPR180 as a potential therapeutic target for metabolic disorders! Catch up on this exciting research in the Ecosystem today! šš Youāll need to register, but donāt worryāitās free! ā”ļøhttps://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/gpr180-reduces-adiposity-by-inhibiting-lipogenesis-and-fatty-acid-uptake-in-adipocytes #gpcr #drgpcr #metabolism #obesity | Dr. GPCR Ecosystem
Home ā Flash News ā Did you know that GPR180 helps regulate lipid metabolism and may play a role in preventing recent study shows that overexpression of GPR180 in adipose tissue improves lipid metabolism and protects against HFD-induced obesity, while its knockout worsens lipid accumulation. obesity Published on March 3, 2025 Category GPCR Weekly News Did you know that GPR180 helps regulate lipid against HFD-induced obesity , while its knockout worsens lipid accumulation .
- Dr. Simone Prƶmel & Dr. Ines Liebscher | Dr. GPCR Ecosystem
<< Back to podcast list Dr. GPCR Podcast Strategic Partners Dr. Simone Prƶmel & Dr. Ines Liebscher About Dr. Ines Liebscher Dr. With the little knowledge on these receptors available, there were multiple questions to tackle. Ines Liebscher on the web Website LinkedIn Researchgate Dr. GPCR Ecosystem Enjoying the Dr.
- š§ "You will always feel like you know nothingā and thatās completely fine." In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren shares: š¬ How GPCR spatial organization shapes signaling and drug responses š His interdisciplinary journey from physics to pharmacology š” Why embracing the unknown is key to scientific breakthroughs A must-listen for biophysicists, pharmacologists, and drug hunters pushing the boundaries of discovery! šļø Tune in now:Ep 162 with Dr. Gabriele Kockelkoren #DrGPCR #GPCR #Biophysics #Pharmacology #DrugDiscovery #SciencePodcast | Dr. GPCR Ecosystem
Home ā Flash News ā š§ "You will always feel like you know nothingā and thatās completely fine." from physics to pharmacology š” Why embracing the unknown is key to scientific breakthroughs A must-listen GPCR Podcast š§ "You will always feel like you know nothingā and thatās completely fine." from physics to pharmacologyš” Why embracing the unknown is key to scientific breakthroughs A must-listen
- Smells Like GPCR Spirit: Cracking Olfactory Codes with Alessandro Nicoli | Dr. GPCR Ecosystem
. << Back to podcast list Dr. Like many, his path to GPCR research wasnāt linearāit evolved through academic exploration and mentorship Build predictive models to discover new ligands . 8. Explore online resources like āTalktorials.ā Despite their relevance, they remain understudied due to the limited knowledge of their ligands and the
- Dr. Maria Majellaro perfected her focaccia recipe. Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry. Itās not just culinary precision, itās a metaphor for drug discovery done right. In Ep. 168, she shares how Celtarys went from a thesis idea to a biotech reality. Meet Dr.GPCRās new partner: Celtarys š š See what theyāre cooking up now: Ep 168 with Dr. Maria Majellaro from Celtarys #GPCRresearchCommunity #DrGPCR #StartupScience #BiotechFounders #GPCRscientistNetwork | Dr. GPCR Ecosystem
Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry. Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry.
- What if you could map GPCR-RAMP interactions across the entire superfamily in a single experiment? Thatās precisely what Dr. Kotliar from the Sakmar lab made possible! In Ep.167 of the Dr. GPCR Podcast, we chat with Drs. Tom Sakmar and Ilana Kotliar about how their lab developed: A multiplexed Luminex assay to screen hundreds of interactions at once A 220-clone DUET-tagged GPCR library, available on Addgene An online interface to search GPCR-RAMP data and antibody validations This is open-access science at its best, built for the GPCR research community. ā³ļø Listen to the episode: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRresearch #DrGPCRecosystem #GPCRdrugdiscovery #GPCRtrainingprogram #GPCRpodcast | Dr. GPCR Ecosystem
A multiplexed Luminex assay to screen hundreds of interactions at once A 220-clone DUET-tagged GPCR library antibody validations This is open-access science at its best, built for the GPCR research community. ā³ļø Listen A multiplexed Luminex assay to screen hundreds of interactions at once A 220-clone DUET-tagged GPCR library antibody validations This is open-access science at its best, built for the GPCR research community. ā³ļø Listen
- Check out the latest GPCR news in the Ecosystem today! Youāll need to register but donāt worry, itās Free! Cutting-edge cryo-EM reveals how LYCHOS, a lysosomal protein, senses cholesterol to regulate metabolism and cell growth ā”ļøhttps://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/cryo-em-reveals-cholesterol-binding-in-the-lysosomal-gpcr-like-protein-lychos #gpcr #drgpcr | Dr. GPCR Ecosystem
structural-and-molecular-insights-into-gpcr-function/cryo-em-reveals-cholesterol-binding-in-the-lysosomal-gpcr-like-protein-lychos structural-and-molecular-insights-into-gpcr-function/cryo-em-reveals-cholesterol-binding-in-the-lysosomal-gpcr-like-protein-lychos
- A new study from the Hudson Lab at the University of Glasgow shows that the FFA receptor antagonist AH7614 is actually an inverse agonist - suppressing fat cell formation, boosting lipolysis and reducing glucose uptake. Explore how targeting FFA4 could help fight metabolic disorders. Catch up with the latest research conducted in the Hudson lab in Ep. 161 of the Dr. GPCR Podcast. Subscribe to the Dr. GPCR Newsletter š° and get the latest GPCR News delivered to your inbox ā”ļøhttps://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/inverse-agonism-of-the-ffa4-free-fatty-acid-receptor-controls-both-adipogenesis-and-mature-adipocyte-function #GPCR #drGPCR #FFA4 #metabolism #adipocytesā | Dr. GPCR Ecosystem
receptor antagonist AH7614 is actually an inverse agonist - suppressing fat cell formation, boosting lipolysis receptor antagonist AH7614 is actually an inverse agonist - suppressing fat cell formation, boosting lipolysis
- Unlock the full potential of the Dr. GPCR platform by updating your profile 𧬠Find like-minded scientists, and colleagues who work on the same topic as you š ā³ļøGo to https://www.ecosystem.drgpcr.com/account/my-account and update your profile #gpcr #drgpcr | Dr. GPCR Ecosystem
GPCR platform by updating your profile 𧬠Find like-minded scientists, and colleagues who work on the GPCR platform by updating your profile 𧬠Find like-minded scientists, and colleagues who work on the
- Session IX / Technology capsule: Light on aGPCR signaling and function | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Session IX / Technology capsule: Light This approach contrasts with other antigen forms like peptides or DNA, which face limitations in structural developing highly specific antibodies for complex targets, with implications for overcoming challenges like Gavin Zhang on the web LinkedIn < Previous Session Next Session >
- An opportunity you wonāt want to miss! ā ļø The next 4-week course with Dr. Terry Kenakin, āDevelopment of GPCR Ligands as Therapeutic Drugsā is coming up š§ Be the first to register, save your spot, and spread the word. This event will only happen once this year! ā³ļøGo to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs for more information! #gpcr #drgpcr | Dr. GPCR Ecosystem
Terry Kenakin, āDevelopment of GPCR Ligands as Therapeutic Drugsā is coming up š§ Be the first to register ā³ļøGo to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs Terry Kenakin, āDevelopment of GPCR Ligands as Therapeutic Drugsā is coming up š§ Be the first to register ā³ļøGo to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs
- In case you havenāt heard, registrations are open for the next 4-week course āDevelopment of GPCR Ligands as Therapeutic Drugs,ā with Dr. Terry Kenakin š Spots are filling up fast, run and save yours, and enjoy a 25% discount with your Premium Membership š ā³ļøGo to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr | Dr. GPCR Ecosystem
ā In case you havenāt heard, registrations are open for the next 4-week course āDevelopment of GPCR Ligands Membership š ā³ļøGo to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs Courses In case you havenāt heard, registrations are open for the next 4-week course āDevelopment of GPCR Ligands Membership š ā³ļøGo to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs
- Behind every great discovery is a great question š Dr. Dmitry Veprintsev shares how asking the right GPCR questions and dreaming big have shaped his work, in the latest Dr. GPCR podcast episode. If youāre passionate about GPCRs and drug discovery, this episode is a must-listen! ā³ļøListen at Ep 163 with Dr. Dmitry Veprintsev #DrGPCR #GPCRPodcast #Biotech #Pharmacology #GPCRScience | Dr. GPCR Ecosystem
If youāre passionate about GPCRs and drug discovery, this episode is a must-listen! ā³ļøListen at Ep 163 with Dr. If youāre passionate about GPCRs and drug discovery, this episode is a must-listen! ā³ļøListen at Ep 163 with Dr.
- Started in medicinal chemistry. Got hooked on ligand design. Dr. Maria Majellaro didnāt plan to run a biotech company. A thesis project, a mentorās advice, and a leap during the pandemic changed everything. Now sheās leading Celtarys, building custom fluorescent probes, and partnering with Dr. GPCR to support assay development worldwide. Meet Celtarys and learn more about its leading work on ligand-linker-fluorophore chemistry š ā³ļø Listen now: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarys #GPCRcommunity #DrGPCR #FluorescentLigands #GPCRdrugDiscovery #ScientificLeadership #BiotechInnovation | Dr. GPCR Ecosystem
Got hooked on ligand design. Dr. Maria Majellaro didnāt plan to run a biotech company. Meet Celtarys and learn more about its leading work on ligand-linker-fluorophore chemistry š ā³ļø Listen Got hooked on ligand design. Dr. Maria Majellaro didnāt plan to run a biotech company. Meet Celtarys and learn more about its leading work on ligand-linker-fluorophore chemistry š ā³ļø Listen
- šÆ Crack the code of GPCR ligand development! In case you havenāt heard, Dr. Terry Kenakin is hosting a 4-week course on GPCR drug developmentāand registration closes in 3 days! ā ļø What youāll learn: ā Drug absorption, metabolism & clearance ā PK-PD modeling & therapeutic profiles ā Early safety assessments & toxicity risks š Limited spotsāsign up before March 18th! š Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharma #Biotech #Research | Dr. GPCR Ecosystem
Home ā Flash News ā šÆ Crack the code of GPCR ligand development! In case you havenāt heard, Dr. & clearance ā PK-PD modeling & therapeutic profiles ā Early safety assessments & toxicity risks š Limited š Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Courses šÆ Crack the code of GPCR ligand development! In case you havenāt heard, Dr. š Development of GPCR Ligands as Therapeutic Drugs | Dr.
- 220 GPCRs. One platform. Endless questions. In Ep.167 of the Dr. GPCR Podcast, Tom Sakmar and Ilana Kotliar reveal a full GPCR-RAMP interaction mapāpowered by Luminex, dual-tagged constructs, and open science. Big win for the GPCR community. ā³ļø Listen now: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRresearch #DrGPCR #GPCRpodcast #GPCRtools #OpenScience | Dr. GPCR Ecosystem
. ā³ļø Listen now: Ep 167 with Drs. Big win for the GPCR community. ā³ļø Listen now: Ep 167 with Drs.
- ā³ In case you havenāt heardāregistration for āDevelopment of GPCR Ligands as Therapeutic Drugsā closes March 18th! If youāre working on GPCR drug discovery, you know that finding a promising candidate is just the start. A drug must also: ā Be absorbed into the body ā Reach the right target ā Stay long enough to be effective ā Cause no harm š¢ Spots are limitedāregister by March 18th! š Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery | Dr. GPCR Ecosystem
Home ā Flash News ā ā³ In case you havenāt heardāregistration for āDevelopment of GPCR Ligands as Therapeutic into the body ā Reach the right target ā Stay long enough to be effective ā Cause no harm š¢ Spots are limitedāregister š Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Courses ā³ In case you havenāt heardāregistration for āDevelopment of GPCR Ligands as Therapeutic š Development of GPCR Ligands as Therapeutic Drugs | Dr.
- Do you know we can discover allosteric modulators that bind to the intracellular allosteric binding site to better fine-tune the GPCRsā activity? Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors CCR6 and CXCR1. Check out the latest GPCR news in the Ecosystem today! Youāll need to register but donāt worry, itās Free!Ā | Dr. GPCR Ecosystem
Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine methods-and-updates-in-gpcr-research/development-of-a-nanobret-assay-platform-to-detect-intracellular-ligands-for-the-chemokine-receptors-ccr6
- Weāre proud to welcome Celtarys as our media partner! Known for their fluorescent ligand innovation, Celtarys is helping researchers make biology visible, faster, smarter, and with more precision. Their chemistry speaks the language of biology, and now, theyāre speaking to the global GPCR community through this powerful collaboration. š Explore Celtarys on the Dr. GPCR Ecosystem: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem #DrGPCR #GPCRtools #FluorescentLigands #BiotechInnovation | Dr. GPCR Ecosystem
Known for their fluorescent ligand innovation, Celtarys is helping researchers make biology visible, Known for their fluorescent ligand innovation, Celtarys is helping researchers make biology visible,




