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are saying about this podcast "You made it a very comfortable and engaging experience, and it felt like I've listened to the episodes multiple times and it's just like being at a conference getting new ideas Am very grateful for Dr GPCR livening up the week in these difficult times! Sam @Pharmamechanic Listen and subscribe where you get your podcasts

for understudied receptors like the galanin receptor family. << Back to podcast list Strategic Partner I spent a lot of time exploring and going to the library. Or were the screening strategies themselves limited? Let’s shift gears a little bit. Yamina Berchiche: That sounds like an exciting direction.

<< Back to podcast list Strategic Partner(s) Dr. Yamina Berchiche on the web - Website - LinkedIn - PubMed - Twitter - Facebook - Dr. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Thanks for listening

. << Back to podcast list Strategic Partner(s) Brian Bender: Computational Probes for Orphan GPCR The Finding an endogenous agonist - when one is even known - is rarely sufficient: a large peptide or lipidated His research focuses on predicting GPCR structural ensembles from limited experimental data and using Even when an endogenous agonist is known, it may be a large peptide or lipidated compound that cannot Brian Bender on the web LinkedIn Twitter ResearchGate Dr.GPCR Member Google Scholar Dr.

. << Back to podcast list Strategic Partner(s) Gunnar Schulte: Frizzled Receptors and the GPCR Identity They carry the characteristic seven-transmembrane topology, but their ligands are large, lipid-modified problem — lipid modifications, carrier proteins, and what makes these ligands so difficult to work with The Wnt ligand problem may be the field's deepest bottleneck Wnt ligands are approximately 35–40 kDa, Gunnar Schulte on the web Schulte Lab LinkedIn Google Scholar Orcid YouTube Dr.

. << Back to podcast list Strategic Partner(s) Antony Boucard: Adhesion GPCRs and the Molecular Code 1,000 amino acids, autoproteolytic cleavage at the membrane, and a near-total absence of characterized ligands And whether you're there for a short time or for the rest of your life, you'll have the best time of your life during the time you're doing it." GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr.

. << Back to podcast list Strategic Partner(s) Sam Hoare: Receptor Residence Time and GPCR Data Analysis Which ligand binds tightest, ranks highest, earns the most attention in an SAR campaign. Samuel Hoare on the web Pharmechanics LLC LinkedIn Pubmed Google Scholar YouTube Dr. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

. << Back to podcast list Strategic Partner(s) Alexander Hauser: GPCR Pharmacogenomics and Precision for putative peptide-binding orphan GPCRs, producing a library of 218 synthetic peptides and yielding detail of receptor pharmacology with the population-scale reality of how those receptors behave in living blindly against orphan GPCRs, Hauser designed a ligand library by learning the structural and evolutionary Hauser on the web Twitter ResearchGate University of Copenhagen LinkedIn Google Scholar Dr.

. << Back to podcast list Strategic Partner(s) Michel Bouvier: BRET, Biased Agonism, and the Tools That From the development of BRET-based biosensors that revealed receptor behavior in living cells, to the SCIENTIFIC THEMES OF THE CONVERSATION The limits of the binary receptor model and what inverse agonism You're the first one understanding a little bit more how things work. And life is a lot about that."

. << Back to podcast list Strategic Partner(s) Brian Arey - Part 2: GPCR Drug Discovery and the Science a gut feeling than a literature review. I feel like as scientists, we should be who we are. Just because I don't act like somebody else doesn't mean I'm not a good scientist. Brian Arey on the web LinkedIn ResearchGate Pubmed Dr.

. << Back to podcast list Strategic Partner(s) Brian Arey: Discovering Signaling Bias at the FSH Receptor children - not because they are scientists, but because he wanted them to understand what he spent his life What had looked like biochemical noise in circulating hormone pools was, in this framework, a mechanism Brian Arey on the web LinkedIn ResearchGate Pubmed Dr. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr.

. << Back to podcast list Strategic Partner(s) David Gloriam: Orphan Receptors, GPCRDB, and the Data family of membrane receptors, yet a significant portion remain orphans - proteins whose endogenous ligands to move from a bare protein sequence to a pharmacologically characterized receptor with identified ligands to the de-orphanization of GPR139 and GPR55, including the identification of sub-nanomolar peptide ligand GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr.

. << Back to podcast list Strategic Partner(s) Chris Tate: Thermostabilizing GPCRs for Structural Biology a paper on thermostabilization of an unrelated membrane protein, read on a Friday afternoon in the library It came from Tate's habit of spending Friday afternoons in the library reading outside his immediate You have to be robust, you have to have a skin like a rhino sometimes." GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr.

Pfleger on NanoBRET live-cell assays, receptor complex pharmacology, and what it took to move GPCR biology from HEK cells to phase 2 clinical trials. << Back to podcast list Strategic Partner(s) Pfleger: NanoBRET But in living tissue, GPCRs do not operate alone - they form dynamic complexes with other receptors, scaffold proteins, and cytoskeletal components, and those interactions reshape conformation, ligand binding The development of NanoBRET - including live-cell ligand binding assays built on CRISPR-expressed receptors

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. << Back to podcast list Strategic Partner(s) Tore Bengtsson: Rethinking β₂-Adrenergic Signaling in When I was about ten years old, I lived on an island in the Stockholm archipelago. Yamina Berchiche: So your father pushed you into science quite literally. Dr. This has been observed in athletes and even in livestock production. Different ligands can bias signaling toward different pathways.

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. << Back to podcast list Strategic Partner(s) Masha Niv: Bitter Taste Receptors and the Drug Discovery She traces the receptor-ligand matchmaking problem at the heart of the field: 25 subtypes, thousands promiscuity, and the challenge of orphan receptors with no known ligand Extraoral expression of taste GPCRs - physiological roles in the airways, gut, heart, and cancer tissues Receptor-ligand matchmaking Masha Niv on the web Niv Lab LinkedIn Twitter Pubmed Google Scholar Dr.

. << Back to podcast list Strategic Partner(s) Elva Zhao: G Protein Regulation and Biased Signaling at transducer coupling events produce glucose-lowering efficacy and which drive the GI side effects that limit "I feel like I'm not finished yet with answering my own question. And also, I'm fresh out of PhD. So why not do a little bit more?" Elva Zhao on the web LinkedIn Monash University Pubmed Twitter Dr.

Cheloha builds nanobody-GPCR ligand conjugates that rescue weak peptides, engineer receptor selectivity , and probe endosomal signaling at NIH. << Back to podcast list Strategic Partner(s) Ross Cheloha: Nanobody-GPCR Why do some ligands continue activating from the endosome while others don't? And can selectivity for one receptor subtype be engineered without redesigning the ligand from scratch Ross Cheloha on the web NIDDK Cheloha Lab Google Scholar LinkedIn Twitter ResearchGate Dr.

. << Back to podcast list Strategic Partner(s) Debbie Hay: Class B GPCRs, RAMPs, and the Migraine Pharmacology three different functional units depending on which RAMP is present, and those distinctions determine ligand Hay examines the molecular pharmacology of the calcitonin receptor and calcitonin-like receptor - with on the molecular pharmacology of class B GPCRs - specifically the calcitonin receptor and calcitonin-like Because we don't have selective ligands."

. << Back to podcast list Strategic Partner(s) Annette Gilchrist: Native Cell Systems, Biased Agonism receptor FFA2 in type 2 diabetes, and muscarinic receptors, her lab screens in disease-relevant cell lines reveal instead The practical limits of biased agonism - cell-type context, effector availability, and Go or Gz that are critical in neuronal signaling, for example, and simply absent in standard lines. You do it because you can't imagine your life doing anything else.

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