He had to decide, week by week, what could pause and what couldn't, and whose careers would bear the infrastructure as a substitute for physical proximity Chance and opportunity as drivers of a scientific career Gutkind reflects that the most significant advances in his career didn't come from confirming a premise pandemic 09:20 "Physical distancing, not social distancing" 11:31 Chance versus scientific knowledge in a career A large component of his work is centered around dysregulated signaling in cancer and the development

I have 10 years of experience in the development and management of R&D projects and teams in the field I have developed my expertise in the field of pharmacology and biochemistry of GPCR and the crucial role I developed G.CLIPS biotech's innovative technology as a synthesis of the different knowledge, experiences , and know-how from the different stages of my career.

Together with Irina Kufareva , UCSD, her team developed a novel approach to identifying ligands for orphan GPCRs by developing a powerful new computational tool for identifying ‘surrogate’ ligands (borrowed Her career goal is to leverage this expertise to establish a research program that takes orphan GPCRs

. 💼 Job Board & Career Growth Helping researchers and biotech companies find the right opportunities Donate $25 $1,000 Catalyst Funds scholarships, retreats, and mentorship opportunities for early-career Help Us Close the Gap Between Academia and Biotech Together, we can accelerate GPCR discoveries and develop

At UCSF, he develops structural models of GPCRs using sparse experimental data - combining restraints to receptor pharmacology versus single-receptor studies Building scientific community at the early-career The failed experiment that built a career Bender's NPY2 labeling project - designed to generate DEER He articulates that the lateral connections formed at early-career conferences, between people who will 52:54 Bench fluency as a guard against over-interpreting computational models 58:16 Advice for early-career

Mid-career, he has worked in finance and developed high-frequency trading systems. early-stage medical device start-up and in 5 years was responsible for project R&D and managing a focused development

cell surface proteins that mediate Wnt signaling — one of the most fundamental pathways in vertebrate development He began his scientific career studying adenosine receptor signaling during a PhD with Bertil Fredholm compound became the first pharmacological handle on frizzled SAG1.3, a small molecule agonist originally developed The development of a HEK cell line with all class F receptors knocked out — generated by Benoît Vanhollebeke's changed everything 53:43 Conformational change as the strongest argument for GPCR identity 01:03:11 Career

That gap in care sparked a curiosity that became a career. He joined Mount Sinai through FlexMed — bypassing the MCAT — and was torn between a career in pharma Pivoting: Redefining the Pain Research Playbook Looking ahead, Serafini’s vision is bold: build a lab that develops He aspires to become a physician-scientist, with a focus on translational in vitro and in vivo model development Other academic interests of his include studying pharmaceutical finance & healthcare administration and developing

drug discovery moved from a stubborn crystallography problem to a generative platform — through the career 00 Welcome and guest introduction 02:32 How an undergraduate lecture on β-adrenergic signaling set a career One of her career path-defining moments came when she visited Dr. Chris Tate and Dr. co-founder of Heptares Therapeutics , now called Sosei Heptares , a GPCR-focused drug discovery and development Join me and learn more about her fascinating career trajectory. Dr.

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors

He currently leads Revvity's Research and Development activities, focusing on biochemical and cellular Before joining Revvity, Eric worked for Cisbio Bioassays first as Director of Technological Development screening to developing innovative solutions such as the IP-One kit for studying G Protein-Coupled Receptors department, leading her team on the development of innovative HTRF™ and AlphaLISA™ kits for pharma, Eric Trinquet, Director of Research and Development at Revvity.

and experimental systems (purified proteins, cultured cells, model organisms) in combination with the development Our ongoing efforts have direct implications in cancer, embryonic development defects, and neurological spans training in Spain, Belgium, and a postdoctoral fellowship at UC San Diego, where he navigated a career

The conversation also covers what happens when taste pharmacology intersects with drug development - ABOUT THE GUEST Masha Niv is associate professor and vice dean of research and development at the Hebrew Niv's lab developed a machine learning predictor trained on intensely bitter compounds that can flag bitterness risk from chemical structure alone, early in the development pipeline. Niv's lab is developing a recommendation system - trained on known receptor-ligand pairs and the structural

behind each transition: from chemistry to pharmacology, from membrane to endosome, from bench to product development The role is rarely discussed in academic career advising, yet it draws directly on GPCR pharmacology John Traynor , Kathryn worked to develop and understand first-in-class allosteric modulators of opioid There she researched the beta-2 adrenergic receptor and developed assays to investigate real-time activity Kathryn’s passion is developing solutions to problems in whatever form is most efficient: novel instrumentation

study by crystallography, and the question of how to solve that became the organizing problem of his career His work developed the thermostabilization platform - a systematic approach to engineering receptor stability slightly from the final edited audio. 01:35 Meet Tate - membrane protein biochemist, MRC LMB 02:12 Career In 2005 he started working on the development of conformational thermostabilization of GPCRs, which resulted In 2016 mini-G proteins were developed as a tool for the structure determination of GPCRs in the fully

Later in his career, Dr. Scientific Careers Depend on Teams, Mentors, and Community . 00 — Discovery of the prostaglandin EP4 receptor while searching for angiotensin-related sequences, development target discovery from association studies, and reflections on why many signals remained elusive. 52:00 — Career

Our goal is to deepen our understanding of GPCR function and accelerate the development of better therapies Accelerate — Intros, resources, and visibility that move projects and careers forward.

to elucidate the role of steroidogenesis in regulating sexual determination and adrenal and gonadal development Caron has received numerous awards including a Burroughs Wellcome Fund Career Award in the Biomedical

Aaron Sato, CSO of Twist Biopharma, describes the motif-directed library his team developed by collecting For Aaron, this work is personal: he has built his career hunting greenfield targets where others had His career has traced the evolution of antibody engineering, with leadership roles at DIAX, Oncomed, Aaron has a proven track record as a biologics leader as he led teams to discover and develop novel first-in-class

Professor Sunahara started his independent research career in the Department of Pharmacology at the University One example of our recent work surrounds a structure-based effort to develop ligands that specifically Our goal is to develop safer beta2AR-selective ligands for the treatment of asthma and acute rescue therapy The Sunahara lab has also been developing protein-based therapeutics using structure-guided design and Through structural and computational approaches the Sunahara lab and collaborators developed a thermostable

academia, she co-founded two GPCR-focused biotechs with Heidi Hamm - CUE Biotech and Caden Biosciences - developing as a discipline shaped how she has thought about the relationship between target validation and drug development The peptides she developed - 11 amino acids rather than 55, which created their own detection challenges argument Biologics have a substantially higher success rate than small molecules moving through the drug development therapeutics an underexplored area - particularly for orphan GPCRs, where compounds are already being developed

She developed expertise over the past two decades studying structure/function relationships of GPCRs Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors Driven by a passion for advancing drug development, John is committed to leveraging his expertise to Further down the track, he aims to apply this knowledge to develop novel chemical treatments for neuronal

The question has been central to Johnson's career since long before the tools to answer it properly existed She trained in high-throughput drug discovery at Vanderbilt - contributing to early functional assay development transcript and may require manual verification after video editing. 00:00 Introduction 01:27 Johnson's career All through her career, the recurring theme in Kari’s work has been GPCRs and more specifically Metabotropic

insightful experiences in academic, hospital, and industry labs, I decided to pursue a role in business development intersection of science and business, which includes target selection, preclinical strategy and business development to elucidate the role of steroidogenesis in regulating sexual determination and adrenal and gonadal development Caron has received numerous awards including a Burroughs Wellcome Fund Career Award in the Biomedical understand how the principles of receptor allosterism and functional selectivity can be leveraged in the development

In this conversation, Charlotte Crauwels discusses her work developing computational strategies to support Her research centers on developing computational pipelines that guide the design of hybrid or chimeric At that time, I wasn’t sure what career direction I wanted, so I started contacting computational research Eventually, I connected with my current supervisor and began developing GPCR-related research projects Charlotte Crauwels: The goal of my PhD was to develop a computational pipeline that supports the design

His research career has centered on GPCR signaling — with particularly deep work on beta-adrenergic receptors — a lens that has quietly shaped how he reads both disease mechanism and drug targets across a long career a pandemic 25:00 Genetic determinants of severity — ACE1 isoforms and population data 28:40 Vaccine development

His work focuses on developing novel β₂-adrenergic ligands that selectively engage signaling pathways Bengtsson began his research career studying brown adipose tissue under the mentorship of Dr. entrepreneur and founder of biotechnology companies translating GPCR pharmacology into therapeutic development therapeutics Key Insights from the Conversation A Childhood Physiological Experiment Sparked a Scientific Career Another company, Atrogi, is based on our research on β₂-adrenergic receptors and the development of new

GPCR during COVID — the career arc behind the ecosystem built for the field's unreached receptors. << Her career has moved through academic pharmacology, a research fellowship in B-cell molecular immunology problem in GPCR drug discovery — why ~250 non-olfactory receptors remain outside clinical attention Career "Brian throughout his career was told so many times that he should quit science. About this episode GPCRs have played a central role in my scientific career ever since I took Dr.

receptors recycle from the lysosome, and the quantitative pharmacology that turned an early artifact into a career Follow the questions, not the career. Asked what advice she gives young scientists, Dr. Piñeyro's answer is blunt: she does not think of herself as having built a career. "I do not think I have a career. I was not building a career. I was simply following my interests." About this episode Dr.

with receptors such as the μ-opioid and κ-opioid receptors, and how structural insights can guide the development interface of structural biology and drug discovery, where molecular structures inform the design and development One direction is to develop new tools using well-characterized receptors—the ones we understand well I can imagine myself in a biotech or pharmaceutical environment where I’m helping guide drug development Essentially serving as a bridge between the science and the development process. Dr.