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Home → Flash News → Seeking to gain more knowledge on signaling bias? 🚀 Registrations open until February 14th ⚠️ Last spots available for “The Practical Assessment of Signaling Register today at https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias GPCR Courses Seeking to gain more knowledge on signaling bias? 🚀 Registrations open until February 14th ⚠️ Last spots available for “The Practical Assessment of Signaling

Home → Flash News → New insights into FPR2 signaling! β-arrestin plays a pivotal role in postendocytic trafficking, plasma membrane recycling, and regulating signal ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2 β-arrestin plays a pivotal role in postendocytic trafficking, plasma membrane recycling, and regulating signal ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2

Home → Flash News → Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization January 14, 2025 Category GPCR Weekly News Did you know that cell types can affect the GPCR-mediated signalling Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system

Retreat Program < Back to schedule Interaction with the cell adhesion molecule NEGR1 affects mGluR5 cell signalling

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Inhibition of Relaxin Autocrine Signaling Rottapel’s research interests lies in the elucidation of signal transduction pathways in cancer, immune

This is your last chance to register for “The Practical Assessment of Signaling Bias” with Dr. https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias This is your last chance to register for “The Practical Assessment of Signaling Bias” with Dr. https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias

Home → Flash News → Deepen your understanding of signaling bias with Dr. ⬇️ ➡️https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias GPCR Courses Deepen your understanding of signaling bias with Dr. ⬇️ ➡️ https:// www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias

Home → Flash News → Interested in learning more about signaling bias? You’re in the right place! 👀 ✳️ Go to https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias GPCR Courses Interested in learning more about signaling bias? You’re in the right place! 👀 ✳️ Go to https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias

Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights . << Back to podcast list Strategic Partner(s) Leadership, Impact, and GPCR Signaling with Dr. Michelle Halls In this episode Dr.Michelle Halls shares how dissecting the spatial organization of GPCR signaling From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar localized signaling events, how these mechanisms are hijacked in disease, and how they can be leveraged

next Dr.GPCR University course is open for registrations 🙂 Learn about "The Practical Assessment of Signaling Membership https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias next Dr.GPCR University course is open for registrations 🙂 Learn about "The Practical Assessment of Signaling Membership https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias

🔬🧪 Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug inbox ➡️https://www.ecosystem.drgpcr.com/reviews/molecular-glues%3A-a-new-approach-to-modulating-gpcr-signaling-bias 🔬🧪 Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug inbox ➡️ https:// www.ecosystem.drgpcr.com/reviews/molecular-glues%3A-a-new-approach-to-modulating-gpcr-signaling-bias

Home → Flash News → The registration deadline for the 1-day workshop “The Practical Assessment of Signaling ✳️Click here https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias GPCR Courses The registration deadline for the 1-day workshop “The Practical Assessment of Signaling ✳️Click here https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias

Home → Flash News → This study adds a key piece to the puzzle of adhesion GPCR signaling. ➡️https://www.ecosystem.drgpcr.com/adhesion-gpcrs/n-terminal-fragment-shedding-contributes-to-signaling-of-the-full-length-adhesion-receptor-adgrl3 January 28, 2025 Category GPCR Weekly News This study adds a key piece to the puzzle of adhesion GPCR signaling ➡️ https:// www.ecosystem.drgpcr.com/adhesion-gpcrs/n-terminal-fragment-shedding-contributes-to-signaling-of-the-full-length-adhesion-receptor-adgrl3

Terry Kenakin for "The Practical Assessment of Signaling Bias" workshop! 🚀 Learn the practical issues with detecting, measuring, and quantifying GPCR ligand-biased signaling Terry Kenakin for "The Practical Assessment of Signaling Bias" workshop! 🚀 Learn the practical issues with detecting, measuring, and quantifying GPCR ligand-biased signaling Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal

How Michelle Halls turned an unexpected summer project into a GPCR research career redefining spatial signaling Home → Flash News → How GPCR Spatial Signaling Sparked a Scientific Journey How GPCR Spatial Signaling From reluctant intern to scientific leader From local signaling to spatial pharmacology From spark to Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal

recent study explores how Gi, Gq, Gs proteins, and PKC contribute differently to intracellular Ca²⁺ signaling latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling recent study explores how Gi, Gq, Gs proteins, and PKC contribute differently to intracellular Ca²⁺ signaling latest GPCR News delivered to your inbox ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling

New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor how we target it in drug design. 🧠 Pain, inflammation, metabolism: the implications go far beyond signaling Biased Agonism Profile of βCGRP on CGRP Family Receptors #GPCR #CGRP #DrugDiscovery #Pharmacology #SignalTransduction New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor how we target it in drug design. 🧠 Pain, inflammation, metabolism: the implications go far beyond signaling

TAS2R14, the most promiscuous bitter taste receptor, bound to the drug flufenamic acid (FFA) and its signaling for site-targeted compound design. 🧪✨ Learn more about this exciting breakthrough in bitter taste signaling TAS2R14 , the most promiscuous bitter taste receptor, bound to the drug flufenamic acid (FFA) and its signaling for site-targeted compound design . 🧪✨ Learn more about this exciting breakthrough in bitter taste signaling Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal

Discover how GPR65 reshapes our understanding of GPCR signaling and its role in cancer, with Dr. GPCR podcast. << Back to podcast list Strategic Partner(s) Signals, pH, and Discovery : Cracking GPCR This dual functionality—environmental sensing and compartment-specific signaling—offers a new layer of reflects on the value of a supportive lab culture , the need for better experimental tools in GPCR signaling My research has looked at the trafficking and signaling of adrenergic and proton-sensing receptors, with

high-resolution deep mutational scan of MC4R reveals how thousands of genetic variants impact obesity-linked signaling latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal

News → GPCRs regulate key biological processes, but how exactly do inhibitory Gαi proteins control signal Weekly News GPCRs regulate key biological processes, but how exactly do inhibitory Gαi proteins control signal ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/germline-mutations-in-a-g-protein-identify-signaling-cross-talk-in-t-cells Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal

Tom Sakmar & Ilana Kotliar break down the link between GPCR autoantibodies, long COVID, and disease signaling Tom Sakmar & Ilana Kotliar break down the link between GPCR autoantibodies, long COVID, and disease signaling

Home → Flash News → How does nanoscale GPCR organization shape signaling? GPCR Podcast How does nanoscale GPCR organization shape signaling?

from learning the hard way about gel electrophoresis to discovering the hidden complexities of GPCR signaling from learning the hard way about gel electrophoresis to discovering the hidden complexities of GPCR signaling

journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor signaling journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor signaling Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal

Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13 ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13

Michelle Halls unpacks how GPCR signaling isn’t just about ligand–receptor interaction. Michelle Halls unpacks how GPCR signaling isn’t just about ligand–receptor interaction. It’s about where and how signaling happens — spatially confined microdomains, scaffolding proteins, and This level of organization defines specificity in signaling, and understanding it changes how we think : 👉 https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/leadership-luck-and-gpcr-signaling #GPCR #DrGPCR

Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights GPCR Podcast , we sit down with Michelle Halls , leader of the Spatial Organisation of Signalling lab Her team is redefining how we understand GPCR signaling — not just at the cell surface, but in space, In this episode, you’ll learn: How GPCR pre-assembly enables femto-level signal detection. How disease can hijack signaling organization — and what that means for drug discovery.