. << Back to podcast list Strategic Partner(s) Elva Zhao: G Protein Regulation and Biased Signaling at Receptor The GLP-1 receptor is among the most clinically validated targets in metabolic disease - yet the signaling asks how the regulatory proteins that most GPCR pharmacologists have not yet addressed actually shape signaling Nigel Bennett on biased signaling at the PAR2 receptor, then with Profs. Why GLP-1 Drugs Still Produce Nausea - and What Biased Signaling Might Fix The GI side effects of GLP

GPCR Identity Question Frizzled receptors are a family of 10 cell surface proteins that mediate Wnt signaling He began his scientific career studying adenosine receptor signaling during a PhD with Bertil Fredholm This would mean the receptor itself determines whether a signal flows through disheveled or through a Several were — the signal Schulte had mapped was an off-target receptor effect, not the kinase pathway to understand the role of WNT/Frizzled signaling in biology, physiology, and disease.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

nanobody-GPCR ligand conjugates that rescue weak peptides, engineer receptor selectivity, and probe endosomal signaling How does receptor conformation shape the duration of downstream signaling? Conformation selectivity changes the duration of the signal PTH receptor exists in G-protein coupled and duration of signaling 40:25 Are GPCRs still a good drug target? "I don't think tight binding equals longer signaling is necessarily the whole story.

in Jeff Benovic’s laboratory studying the regulation of G protein-coupled receptor trafficking and signaling Adriano’s research has contributed to our understanding of the role that ubiquitin plays in GPCR signaling His lab has shown a role for -arrestins and PTMs in GPCR trafficking and signaling and has leveraged this knowledge to reveal the spatial and temporal requirements for GPCR activation of signaling pathways The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic

Angers is an expert in the field of signal transduction. Moon , where he identified and characterized novel components of the Wnt signaling pathway and a new He is the recipient of the Canada Research Chair in Functional Architecture of Signal Transduction. His research program is developed to understand the signaling mechanisms underlying the Wnt and Hedgehog families of growth factors and their signaling mechanisms in development, adult tissue homeostasis,

Terry Hebert on why challenge trials weren't ready, what it takes to hold a GPCR signaling lab together The discussion moves across three scientific registers: the practical mechanics of holding a GPCR signaling His work is grounded in careful assay development and a conviction that the signaling space around a BRET platforms for GPCR signaling — The role of resonance-energy-transfer-based assays in capturing signaling Much of his work is based on GPCR signaling in the context to cardiovascular diseases.

Background and Localization Influence GPCR Function Scientific Abstract Most of what we know about GPCR signaling Hebert's research focuses on the angiotensin AT1 receptor, a signaling hub coupled to Gq, Gi, G12, and His research centers on GPCR signaling networks, biosensor development, and the role of cellular context His contributions span GPCR dimerization, nuclear receptor signaling, and the emerging role of G-proteins cells may not reflect what happens in native tissues, and how biosensors reveal cell-type-dependent signaling

His research spans four decades of GPCR signaling, from cyclic AMP and adrenergic receptor biology to The tumor signals fibroblasts to raise GPR68 expression, and the low pH of the tumor microenvironment then activates that receptor, which signals back to promote cancer survival. Biased signaling is real but harder to exploit than expected GPR68 couples to both Gq and Gs, and the That accidental assignment launched a career in GPCR signaling that has now spanned over four decades

January 2021 and has contributed to multiple projects exploring the underlying mechanisms of biased signaling These previous endeavors involved exploring the effect of subcellular location on the signaling profile biased ligands, elucidating the role of site-specific receptor phosphorylation in the differential signaling She is currently working on her senior thesis which involves identifying the non-canonical signaling

research program is to gain a thorough and mechanistic understanding of processes that control cell signaling The precise control of PAR signaling is critical for proper temporal and spatial dynamics of signaling Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR She has made numerous important discoveries related to the mechanisms that control PAR1 signaling and

InterAx Biotech, where he specializes in the development of a technology platform deciphering cell signaling pathways combined with AI-based approaches to elucidate structure to signaling relationship. Gebhard Schertler, he developed methods for kinetic mathematical analysis of GPCR signaling. Biotech, shared about the company's development of a discovery platform for GPCRs and their focus on signaling about the intricacies of cell signaling and chemokine receptors.

Introduction Desensitization limits the duration and magnitude of GPCR signaling, and the machinery that Instructor Adriano Marchese's research examines how GPCR signaling is regulated by β-arrestin-dependent and β-arrestin-independent pathways, with the goal of identifying and targeting novel aspects of GPCR signaling brings this mechanistic view of receptor regulation to the question of how desensitization shapes GPCR signaling

proteins, and cytoskeletal components, and those interactions reshape conformation, ligand binding, and signaling developed BRET and NanoBRET-based live-cell platforms that capture protein-protein interactions and signaling His research centers on GPCR functional interactions, with a focus on arrestin signaling, receptor complex Bias Signaling Is a Kinetic Problem, Not Just a Pathway Problem Spider plots comparing signaling bias For Pfleger, the reach of the technology is not a source of pride as much as a signal that the field

computational protein design, hybrid GPCR constructs, and how computational pipelines can accelerate GPCR signaling These hybrid receptors enable researchers to probe receptor signaling, investigate G protein coupling Listeners gain insight into how computational protein design can accelerate receptor signaling research This strategy can reveal signaling pathways or structural features of orphan GPCRs that cannot easily Yamina Berchiche: So you can essentially probe the signaling pathways of receptors that are otherwise

Industrial GPCR Pharmacology Scientific Abstract This conversation traces how GPCR pharmacology, receptor signaling , the identification of receptor activity-modifying proteins (RAMPs), and the realization that CGRP signaling The discovery of RAMPs was only possible because the assay tied receptor signaling to a highly amplified Apart from APOE4 in Alzheimer’s disease, most signals failed to reach robustness with available cohort at GSK, expectations for GPCR target discovery from association studies, and reflections on why many signals

She identified the structural determinant controlling biased signaling of melatonin type 2 receptors which led to the finding that both β-arrestin and G protein can simultaneously bind to some GPCRs when signaling Funded by a Wellcome Trust Seed Award, she investigated biased and compartmentalized G protein signaling Her subsequent work has focused on understanding the role of compartmentalized Gq signaling by the cytomegalovirus-encoded

My long-term research interests involve resolving signaling pathways downstream of aGPCRs and establishing how/if these receptors’ adhesive properties influence signaling events, and in turn, whether signaling

I then undertook my first project where I demonstrated that MRAP2 regulates the signaling of multiple Concurrently, I described the mechanisms by which MRAP2 regulates GHSR1a signaling; this project brought Using this novel technique, I showed that MRAP2 biased GHSR1a signaling and shut down its constitutive activity; this work resulted in a first author publication in Science Signaling. to create a scientific session at the American Physiology Summit (APS) 2024 dedicated to GPCR biased signaling

His group studies the unusual signaling mechanisms employed by these atypical 7-transmembrane receptors More recently, Ben’s lab has begun studying GPCR signaling pathways that operate within the primary cilium Ben studied developmental and cancer signaling as a postdoctoral fellow with Philip Beachy at Stanford

Gasser " I received my BS and MS in Zoology & Physiology at the University of Wyoming, where I studied signaling Lowry's lab, examined the role of organic cation transporter 3 (OCT3) in the regulation of monoamine signaling Research in my lab is currently focused on understanding the signal transduction pathways activated by

spanned chemokine receptor conformational dynamics at the Université de Montréal, CXCR3 splice-variant signaling Tom Sakmar's lab, where she characterized the signaling diversity of three alternative splice variants Splice variants aren't just structural — they signal differently. question from Tom Sakmar, demonstrated that variants encoded by the same gene can recruit different signaling The implication: transcript-level diversity is itself a signaling mechanism, not a cloning artifact to

His current work extends that logic into signaling kinetics: the time dimension in GPCR signaling that independent research focuses on developing accessible mathematical tools for kinetic analysis of GPCR signaling Receptor residence time as a determinant of in vivo drug efficacy — and why affinity alone is insufficient Signaling Yet that is precisely how most labs treat time-course signaling data — collecting it, plotting it, and To me, that's what we've been doing with time-course signaling data."

live online scientific sessions focused on G protein-coupled receptor (GPCR) biology, pharmacology, signaling entering drug discovery If you work directly with receptor systems, ligand design, efficacy modeling, or signaling These webinars are designed for scientists with foundational knowledge in receptor pharmacology, signaling operational models Allosteric modulators (PAMs and NAMs) Biased agonism Dose–response modeling Calcium and signaling

NIDDK) - NIH, USA as a postdoctoral fellow and trained on understanding the physiological role of GPCR signaling GPCR-based drugs for the treatment of obesity and Type 2 Diabetes (T2D) by exploring metabolically important signaling Sai Prasad Pydi on the web Molecular Metabolism & Cell Signaling Laboratory Website Twitter.com Research

Silvio Gutkind, who has spent more than three decades pushing GPCRs as oncogenic signaling systems, the continued at the NIH across neurobiology and oncogenes, and grew into a multi-decade program on GPCR signaling GαS, Gα13) GαQ-driven uveal melanoma and the limits of the canonical PLC pathway Non-canonical GαQ signaling Non-canonical signaling opened a new drug target. In this episode, Silvio discusses G protein signaling in the context of cancer, immunotherapies, and

engineers and computer scientists focusing on the basic mechanisms of G protein-coupled receptor (GPCR) signalling To study GPCR signalling, they develop and use innovative optical methods based on FRET and single-molecule microscopy, which allow them to directly observe signalling events in living cells and tissues with