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Home → Flash News → New insights into FPR2 signaling! β-arrestin plays a pivotal role in postendocytic trafficking, plasma membrane recycling, and regulating signal ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2 β-arrestin plays a pivotal role in postendocytic trafficking, plasma membrane recycling, and regulating signal ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2

Retreat Program < Back to schedule Interaction with the cell adhesion molecule NEGR1 affects mGluR5 cell signalling

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Inhibition of Relaxin Autocrine Signaling Rottapel’s research interests lies in the elucidation of signal transduction pathways in cancer, immune

Home → Flash News → Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization January 14, 2025 Category GPCR Weekly News Did you know that cell types can affect the GPCR-mediated signalling Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system

How Michelle Halls turned an unexpected summer project into a GPCR research career redefining spatial signaling Home → Flash News → How GPCR Spatial Signaling Sparked a Scientific Journey How GPCR Spatial Signaling fellowship at University of Cambridge, and eventually a leadership role at the forefront of GPCR spatial signaling From reluctant intern to scientific leader From local signaling to spatial pharmacology From spark to strategy Read the full story here🔗 https://www.ecosystem.drgpcr.com/post/how-gpcr-spatial-signaling-sparked-a-scientific-journey

Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights GPCR Podcast Strategic Partners Leadership, Impact, and GPCR Signaling with Dr. Michelle Halls In this episode Dr.Michelle Halls shares how dissecting the spatial organization of GPCR signaling From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar localized signaling events, how these mechanisms are hijacked in disease, and how they can be leveraged

This is your last chance to register for “The Practical Assessment of Signaling Bias” with Dr. https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias This is your last chance to register for “The Practical Assessment of Signaling Bias” with Dr. https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias

Home → Flash News → Interested in learning more about signaling bias? You’re in the right place! 👀 ✳️ Go to https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias GPCR Courses Interested in learning more about signaling bias? You’re in the right place! 👀 ✳️ Go to https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias

Home → Flash News → Deepen your understanding of signaling bias with Dr. ⬇️ ➡️https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias GPCR Courses Deepen your understanding of signaling bias with Dr. ⬇️ ➡️ https:// www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias

TAS2R14, the most promiscuous bitter taste receptor, bound to the drug flufenamic acid (FFA) and its signaling for site-targeted compound design. 🧪✨ Learn more about this exciting breakthrough in bitter taste signaling TAS2R14 , the most promiscuous bitter taste receptor, bound to the drug flufenamic acid (FFA) and its signaling for site-targeted compound design . 🧪✨ Learn more about this exciting breakthrough in bitter taste signaling . ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a-bitter-anti-inflammatory-drug-binds-at-two-distinct-sites-of-a-human-bitter-taste-gpcr

next Dr.GPCR University course is open for registrations 🙂 Learn about "The Practical Assessment of Signaling Membership https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias next Dr.GPCR University course is open for registrations 🙂 Learn about "The Practical Assessment of Signaling Membership https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias

🔬🧪 Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug inbox ➡️https://www.ecosystem.drgpcr.com/reviews/molecular-glues%3A-a-new-approach-to-modulating-gpcr-signaling-bias 🔬🧪 Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug inbox ➡️ https:// www.ecosystem.drgpcr.com/reviews/molecular-glues%3A-a-new-approach-to-modulating-gpcr-signaling-bias

Home → Flash News → The registration deadline for the 1-day workshop “The Practical Assessment of Signaling ✳️Click here https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias GPCR Courses The registration deadline for the 1-day workshop “The Practical Assessment of Signaling ✳️Click here https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias

high-resolution deep mutational scan of MC4R reveals how thousands of genetic variants impact obesity-linked signaling latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling high-resolution deep mutational scan of MC4R reveals how thousands of genetic variants impact obesity-linked signaling latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling

Home → Flash News → This study adds a key piece to the puzzle of adhesion GPCR signaling. ➡️https://www.ecosystem.drgpcr.com/adhesion-gpcrs/n-terminal-fragment-shedding-contributes-to-signaling-of-the-full-length-adhesion-receptor-adgrl3 January 28, 2025 Category GPCR Weekly News This study adds a key piece to the puzzle of adhesion GPCR signaling ➡️ https:// www.ecosystem.drgpcr.com/adhesion-gpcrs/n-terminal-fragment-shedding-contributes-to-signaling-of-the-full-length-adhesion-receptor-adgrl3

News → GPCRs regulate key biological processes, but how exactly do inhibitory Gαi proteins control signal Weekly News GPCRs regulate key biological processes, but how exactly do inhibitory Gαi proteins control signal ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/germline-mutations-in-a-g-protein-identify-signaling-cross-talk-in-t-cells

Discover how GPR65 reshapes our understanding of GPCR signaling and its role in cancer, with Dr. GPCR Podcast Strategic Partners Signals, pH, and Discovery : Cracking GPCR Mysteries with Dr. This dual functionality—environmental sensing and compartment-specific signaling—offers a new layer of reflects on the value of a supportive lab culture , the need for better experimental tools in GPCR signaling My research has looked at the trafficking and signaling of adrenergic and proton-sensing receptors, with

recent study explores how Gi, Gq, Gs proteins, and PKC contribute differently to intracellular Ca²⁺ signaling latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling recent study explores how Gi, Gq, Gs proteins, and PKC contribute differently to intracellular Ca²⁺ signaling latest GPCR News delivered to your inbox ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling

New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor how we target it in drug design. 🧠 Pain, inflammation, metabolism: the implications go far beyond signaling Biased Agonism Profile of βCGRP on CGRP Family Receptors #GPCR #CGRP #DrugDiscovery #Pharmacology #SignalTransduction New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor how we target it in drug design. 🧠 Pain, inflammation, metabolism: the implications go far beyond signaling

Terry Kenakin ’s hands-on workshop, The Practical Assessment of Signaling Bias . Didn’t sign up? Highlights of the Week How Ligands Achieve Biased Signaling toward Arrestins Stéphanie Gaillard , Neha obesity drug discovery: Cell-based assays for GLP-1 and the G-Suite March 17 - 21, 2025 | 2nd GPCR signaling Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing GPCR Activation and Signaling g , MC4R , docking , opioid , peptide ligand design , protein design , Ca2+ oscillation , GPCRs , basal

Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals

Tom Sakmar & Ilana Kotliar break down the link between GPCR autoantibodies, long COVID, and disease signaling Tom Sakmar & Ilana Kotliar break down the link between GPCR autoantibodies, long COVID, and disease signaling

journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor signaling journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor signaling

from learning the hard way about gel electrophoresis to discovering the hidden complexities of GPCR signaling from learning the hard way about gel electrophoresis to discovering the hidden complexities of GPCR signaling

Home → Flash News → How does nanoscale GPCR organization shape signaling? GPCR Podcast How does nanoscale GPCR organization shape signaling?

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13 ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13

GPCR Podcast Strategic Partners Developing new tools to uncover GPCR signaling patterns with Remi Janicot works on diverse models and diseases, and has developed a wide array of tools to dissect GPCR/G protein signaling Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling

Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights GPCR Podcast , we sit down with Michelle Halls , leader of the Spatial Organisation of Signalling lab Her team is redefining how we understand GPCR signaling — not just at the cell surface, but in space, In this episode, you’ll learn: How GPCR pre-assembly enables femto-level signal detection. How disease can hijack signaling organization — and what that means for drug discovery.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.