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Join us in strengthening the global GPCR community. Your tax-deductible donation supports education, collaboration, and innovation. Dr GPCR is a 501(c)(3) non-profit. Support the GPCR Community — Empower the Next Generation of Discovery Your donation helps us serve the global GPCR community better — by upgrading the Dr GPCR University, creating more learning opportunities, and connecting scientists, students, and biotech innovators. - Secure donation through Wix - Dr. GPCR is a registered 501(c)(3) non-profit organization. 👉 Donate Now Why Donate? Every contribution helps us bridge the gap between academia and biotech — transforming knowledge into real-world impact more quickly. Your donation directly supports: Dr GPCR University : expanding and modernizing our educational programs to make cutting-edge GPCR knowledge accessible to everyone Dr GPCR Retreat: offering free or affordable gatherings that foster collaboration and mentorship across disciplines Happy Hours: informal, community-driven networking events that connect scientists, founders, and innovators in a relaxed setting Job Board: helping researchers and biotech companies find the right opportunities to grow together Community Infrastructure: maintaining the tools and platforms that keep the Dr GPCR Ecosystem open and thriving *Together , we’re creating a global home for everyone passionate about GPCR research, collaboration, and discovery. How Your Gift Helps? Every donation fuels the mission to make GPCR education and collaboration more accessible to everyone in the community. - $25+ 👉 Keeps Dr GPCR Happy Hours and community events free or affordable for participants around the world - $250+ 👉 Expands Dr GPCR University with new lessons, updated materials, and interactive learning modules - $5,000+ 👉 Powers new GPCR educational initiatives — including scholarships, retreats, and mentorship opportunities - $20,000+ 👉 Become a Strategic Partner — recognized across Dr GPCR channels for enabling global collaboration and impact Every contribution, big or small, helps the GPCR community learn, connect, and innovate together. 🎓 Elevate the University — Donate Today ❤️ Donor Recognition We believe generosity deserves visibility. Every donor receives a personal thank-you email and receipt Selected donors are thanked publicly in podcast intros, videos, or events Donations above $20 K are acknowledged as Strategic Partners , featured on our website and community pages Donate Frequency One time One time Monthly Monthly Yearly Yearly Amount $25 $25 $250 $250 $1,000 $1,000 $5,000 $5,000 Other Other 0/300 Comment (optional) Donate $25 FAQ Is my donation tax-deductible? Yes. Dr GPCR is a registered 501(c)(3) non-profit organization. Contributions are tax-deductible to the extent permitted by law. Can I make a donation on behalf of a company? Yes — Use the “Comment” section to add the company name in the donation form, and we’ll provide an invoice/receipt. Can I become a monthly supporter? Absolutely. Monthly donations sustain long-term programs and can be changed at any time. Can I be recognized publicly? Yes — we love thanking our donors through the Podcast, YouTube, and Summit platforms. Help us close the gap between academia and biotech. Together, we can accelerate GPCR discoveries and develop more effective drugs for everyone. 👉 Donate Now to Support the Dr GPCR Ecosystem

Founded in 2020, Dr. GPCR unites researchers, industry, and partners to accelerate GPCR science and drug discovery—through connection, education, and real‑world collaboration. About Dr. GPCR Ecosystem We unite the GPCR community to advance drug discovery. We bring the GPCR community together to fuel GPCR drug discovery—one receptor at a time. Our goal is to deepen our understanding of GPCR function and accelerate the development of better therapies together. Founded in 2020, Dr. GPCR was created to break down barriers across academia, biotech, pharma, and CROs—so knowledge, tools, and talent can flow where they’re needed most. Contact Us Our Mission Advance GPCR science and drug discovery by connecting people, data, and opportunities across the global GPCR ecosystem. Our Vision A world where GPCR insights translate quickly into real‑world therapies through an open, trusted, and collaborative community. What We Do (in Three Verbs) Connect — Researchers, founders, students, and industry partners meet, learn, and collaborate. Educate — Courses, talks, and curated content that turn expertise into execution. Accelerate — Intros, resources, and visibility that move projects and careers forward. Who Should Join To join the community, you should be actively related to the GPCR field , including: Academic researchers (PI, postdoc, student) Industry scientists and R&D leaders Biotech and pharma founders/operators CRO/technology providers serving GPCR programs Clinicians and translational teams Investors and BD professionals focused on GPCRs Eligibility: We verify GPCR relevance during onboarding to preserve focus and quality. Partner With Us Build visibility, trust, and feedback directly from your target audience. Partner perks: Direct interaction with researchers, founders, and decision‑makers Access to all member perks for your entire team Product & service listings in ecosystem directories Speaking, demo, and content opportunities Input into community programming and field priorities CTA: Contact us to partner Our Values Scientific Rigor — Evidence first; hype last Openness with Intent — Share to accelerate; respect boundaries Diversity & Inclusion — More perspectives → better science Member‑First — We build what the community needs Execution — Ideas become results through consistent cadence Meet The Team Founder & Director Yamina Berchiche Get in touch Co-Founder Attila Foris Get in touch Board Member Anne M. Quinn Get in touch Board Member JoAnn Trejo Get in touch Board Member Maria Waldhoer Get in touch Chief Matchmaker Mark Schmeizl Get in touch

Share your thoughts and help shape the future of the Dr. GPCR Ecosystem. Your feedback guides improvements, new features, and community resources. Dr. GPCR Community Survey Help us build the next evolution of the GPCR Ecosystem — together. Every opinion counts. Whether you’ve joined our University sessions, explored our Job Board, or attended a Happy Hour, your feedback shapes what comes next. Let’s make Dr. GPCR more useful, connected, and inspiring for everyone in the field. 👉 Take the Survey Now Why Your Feedback Matters? We’re growing — and your input helps us grow in the right direction. By sharing your thoughts, you directly influence how we design new features, events, and educational programs. Your responses help us: Improve the Dr. GPCR University curriculum and resources. Make Retreats and Happy Hours more valuable and accessible. Build stronger connections between academia and industry. Develop new tools, training programs, and mentorship programs tailored to your specific needs. Your Voice Shapes Our Future Dr. GPCR was founded to bring the GPCR community together — and every survey response helps us strengthen that mission. This isn’t just a form — it’s how you influence the next generation of education, collaboration, and discovery. 💡 Start the Survey What We’d Love to Learn? We’ve grouped the questions into three sections so your feedback can make a real impact: 1. Your Experience How often do you use the Dr. GPCR platform? Which programs do you engage with most? (University, Retreat, Job Board, Newsletter, etc.) What has been your favorite experience so far? 2. Your Needs What topics or training modules would you like us to add next? What challenges do you face most in your research or biotech journey? How can we facilitate easier collaboration within the community? 3. Your Feedback How likely are you to recommend Dr. GPCR to a colleague? (1–10) What would make your experience even better? Any ideas, suggestions, or features you’d love to see in 2026? Survey 🙏 Thank You for Being Part of the Ecosystem Your feedback helps us: Keep events free or affordable Expand our shared knowledge base Support students and researchers entering the field Together, we’re building a home for everyone passionate about GPCR research and innovation.

Discover the incredible benefits of the Dr. GPCR University. ​All these benefits are designed to enhance your research experience and keep you informed about the latest developments in GPCR science.​ Accelerate Your GPCR Research Join a global community of scientists transforming how GPCR discoveries happen — through shared learning, collaboration, and expert insight. Access the tools, knowledge, and network that empower you to go further, faster. 🔥 Unlock Premium Now! Premium Membership Benefits Everything you need to stay at the forefront of GPCR research and advance your career. Expert-Led GPCR Courses 200+ Expert Talks Events & Jobs Board Complete GPCR Coverage Community Tools Career Matchmaker Why is it Worth It? Common concerns and why Premium delivers exceptional value "It's too expensive." At less than $1 a day, Premium gives you access to 20+ on-demand GPCR courses, 200+ expert talks, and global networking tools. One insight, one connection, one ‘aha’ moment — can save months of research time. "I already get what I need from papers." Papers inform. DrGPCR helps you understand and apply that knowledge — through structured training, expert context, and real interaction with peers from academia and industry. "I'm not sure I'll use it often." Even one course or one new collaboration can make a difference. Members often find value in ways they didn’t expect — from expert feedback to career-changing introductions. "Will this really help my career?" Yes. Members grow visibility, confidence, and connections that open doors. It’s not just about learning — it’s about being seen, supported, and part of something bigger . Choose a package that works for you $0 Free Stay in the loop! But know you’re only scratching the surface. 📩 Weekly GPCR Brief (basic) 🎙️ Full access to the podcast 📤 Submit jobs & events to the community 📰 Science, tools & trends — no paywall 💸 Share the mission. Earn as you go Join for Free! 🔥 Upgrade to Premium Premium Yearly $499 $ 499 Every year 🚀 Everything you need to master GPCR science — in one membership. Valid until canceled Join Premium Today! 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way. 🔒 Grandfather Guarantee, your rate never increases Premium Yearly for Teams $374.25 • per year • per person • 25% discount • minimum 5 seats How does it work? 1️⃣ Gather Your Team 2️⃣ Submit Your Team Details 3️⃣ Complete the Payment 4️⃣ Activate Memberships Get Your Team Discount Developing Countries $24.99 • per year • per person • 90% discount *subject to verification Eligibility Criteria ✔ Live and work in a developing country. ✔ Be employed by an institution, university, or company based in a developing country. ✔ Provide verifiable information for eligibility review. Check Eligibility Premium Yearly for Academic Teams $0.00 • per year • per person • 100% discount • subject to availability What You’ll Need? 🧩 Step 1: Fill Out the Instructor Form 🧱 Step 2: Plan Your Course Structure 📝 Step 3: Prepare Your Content 🎥 Step 4: Record a Short Video Chat 💬 Step 5: Join Your Private Course Group 💫 Step 6: Teach & Inspire Get Your Team Discount Frequently Asked Questions Premium Pricing University What is Dr. GPCR Premium? Dr. GPCR Premium is a membership program that gives scientists, students, and industry professionals access to expert GPCR courses, 200+ research talks, career resources, and a global network of GPCR specialists. Who should join Dr. GPCR Premium? Researchers, biotech professionals, CRO teams, students, and anyone seeking deeper insights, networking opportunities, and tools to accelerate GPCR-related research and career growth. What’s included in the Premium membership? • 20+ expert courses • Complete GPCR coverage • 200+ research talks • Virtual Café Access • Job board access and career tools • Networking through the Dr. GPCR community • Exclusive partner discounts and events How does Premium differ from the free membership? Free members get limited access to talks and resources, while Premium members enjoy full GPCR content, unlimited event replay access, and advanced networking and career tools. How much does Premium cost? Choose a package that works for you here.(https://www.ecosystem.drgpcr.com/gpcr-university-pricing) Is there a monthly payment option? Currently, the membership is billed annually for maximum savings and uninterrupted access. Choose a package that works for you here.(https://www.ecosystem.drgpcr.com/gpcr-university-pricing) Are the courses self-paced? Yes. All courses and talks are available on-demand so you can learn anytime. Can I register my entire team for Premium? Yes. The Team plan (https://www.ecosystem.drgpcr.com/gpcr-university-group-package-discount)offers discounted rates for groups of 5 or more. Do you offer discounts for students or developing countries? Yes. Members from developing countries can join for $24.99/year. Students please reach out to hello@drgpcr.org What happens after I join? You’ll receive instant access to all Premium resources, your member dashboard, and exclusive community tools to start networking and learning right away. Ready to Advance Your GPCR Research? Join thousands of researchers who trust DrGPCR for cutting-edge insights and resources. Start Your Premium Journey Try Free First

Browse past events hosted by the Dr. GPCR Ecosystem, featuring scientific meetings, workshops, and collaborations that brought the GPCR community together. Past Events - Where the Dr. GPCR community comes alive Welcome to the page where the heart of the Dr. GPCR community comes alive! Here, we celebrate the incredible moments that brought scientists, researchers, and GPCR enthusiasts together to share groundbreaking discoveries, spark new ideas, and forge lasting connections. From immersive workshops and high-energy summits to intimate retreats and virtual conferences, each event represents a milestone in our shared mission to advance GPCR science and collaboration worldwide. 👉 Dive into our event archive below to relive the energy, inspiration, and community spirit that make Dr. GPCR truly special. Be part of our journey — stay inspired by our collective passion for science, learning, and discovery. Filter Adhesion GPCR Workshop 2024 Endocrine Metabolic GPCRs Meet Inoviem Team GPCR ECI Transatlantic 2022 Editorial: GPCR and G Protein-Mediated Signalling Events in the Nervous System Dr. GPCR Ecosystem 2.0: Collaborating better Dr. GPCR: Advancing GPCR Drug Discovery Through Collaboration Discovery On Target 2024 GPCR targeted drug discovery Summit 2024 GPCR targeted drug discovery Summit 2023 The Dr. GPCR Podcast GPCR targeted drug discovery Summit 2022 Dr. GPCR: Where all GPCRs are created equal Dr. GPCR: Beyond the lab GRS and GRC Switzerland GPCR Retreat 2023 Leadership is a learned skill - PhageMed Unige GPCR Retreat 2022 Dr. GPCR: Beyond the lab Dr. GPCR: From idea to Ecosystem Dr. GPCR: Beyond the lab

Get in touch with Dr. GPCR Ecosystem today! Find our contact information and reach out to us for any inquiries or collaborations. Let's connect! Contact Do you need help with the Dr. GPCR Ecosystem or want to collaborate? Let's Connect! Address 14 Summer St. Malden, MA 02148 Email Hello@DrGPCR.com Phone 646-508-3568 Social Media First Name Last Name Email Message Send Thanks for submitting!

Discover CRO Bank Packages with Dr. GPCR Ecosystem. List your services and your brand on the world's first GPCR CRO Bank. Reach a targeted scientific audience and showcase your organization in the GPCR community. Be Discoverable When GPCR Teams Are Actively Evaluating Services and Tools Reach 1400+ GPCR researchers and company representatives. The GPCR CRO Bank is a marketing-first offering designed to help service providers and tool companies get found, evaluated, and contacted — not just recognized. Partner with us Today! Connect With The GPCR Community You've built incredible CRO services. But are the right scientists discovering them? Dr. GPCR is the world's largest nonprofit community focused on GPCRs. We are building the world's first CRO Service-focused GPCR bank. As a CRO partner, you'll gain trusted access to an engaged audience of biotech teams and drug discovery innovators—without having to fight for attention. Ready to share your CRO company with the GPCR world? Who the GPCR CRO Bank is For The GPCR CRO Bank is a strong fit for companies that want to: Make their services or products easily discoverable within the GPCR ecosystem Support inbound inquiries from teams actively evaluating CROs, platforms, or tools Present clear, structured product and service offerings in one trusted location Use ecosystem visibility to support commercial conversations and decision-making If your primary goal is brand credibility and long-term recognition across high-traffic ecosystem pages, a Strategic Media Partnership may be a better fit. Why Partner with Dr. GPCR? As a CRO partner, you'll be featured across our nonprofit platform, trusted by thousands of GPCR scientists and biotech professionals. 🎯 Reach Qualified Researchers Connect with scientists who are actively looking for tools like yours, without the noise of general platforms. 🤝 Build Trust Develop content that speaks their language and establishes your credibility in the GPCR research community. 🌐 Join a Curated Ecosystem Become part of a collaborative, curated ecosystem—not just another name on a crowded vendor list. We're focused on quality over quantity - and on partnerships that deliver long-term value to the field. What You Get as a CRO Partner? These channels are used to support discovery and evaluation — helping teams understand what you offer and how to engage with you. 📬 Newsletter Visibility ✓ Featured in our highly read weekly newsletter ✓ Tell your story with context, clarity, and purpose ✓ Bonus: Mentioned in podcast intros/outros 📄 Custom Company Page ✓ Permanent company profile on the Dr. GPCR Ecosystem ✓ Logo, branding, and description of your mission ✓ Contact links and key highlights 📝 Blog Contributions ✓ Contribute to blog posts on the Dr. GPCR platform as a valued partner ✓ Share insights on product launches, scientific discoveries, or customer stories ✓ Reach a targeted scientific audience with your contributions. 🎙️ Featured Podcast Episode ✓ Be the guest on a dedicated episode of the Dr. GPCR Podcast ✓ Feature up to 3 team members to share your story ✓ Distributed across podcast platforms and social media 📣 Social Media Promotion ✓ Engaging posts about your organization ✓ Targeted to GPCR researchers and biotech professionals ✓ Shared on LinkedIn and X (Twitter) 👩🔬 Premium Licenses ✓ 10 Scientists Premium Accounts ✓ 3 Non-Scientists Premium Accounts 🎤 Co-Branded Events & Training ✓ Collaborate on webinars and virtual training sessions to showcase your expertise ✓ Host educational events that focus on GPCR research ✓ Engage directly with the GPCR research community through these initiatives 🧰 Product or Service Pages ✓ Individual pages for each product or service ✓ Educate researchers and showcase technical value ✓ Provide downloadable resources or use cases Book Be part of the CRO Bank and showcase your GPCR Services Book a 30-minute Strategy Call with Yamina

Explore the milestones of Dr. GPCR, from its founding to today’s global community, and discover the journey that’s shaping the future of GPCR science. From Vision to Global Impact What began as a simple idea — to connect GPCR scientists and share knowledge freely — has grown into a global ecosystem driving collaboration, innovation, and discovery. Since 2020, Dr. GPCR has united researchers across disciplines and continents through conversations, summits, and shared milestones. 2020 🌱 The Beginning of a Community Vision & Launch Driven by a simple but powerful idea — to bring GPCR scientists together — Dr. Yamina Berchiche launched the Dr. GPCR Ecosystem , a space designed to break silos, spark collaboration, and open real dialogue across disciplines. Early Initiatives Feb 18, 2020 — The very first podcast episode was recorded. Jun 2020 — The first newsletter went out — to just three people . A small start, but the spark had been lit. Podcast Debut Jul 7, 2020 — The first Dr. GPCR Podcast episode premiered, featuring Dr. Paul Insel from UC San Diego — marking the beginning of hundreds of scientist-to-scientist conversations that would follow. First Summit Sep 14–18, 2020 — The inaugural Dr. GPCR Summit brought together researchers from five continents , with 5 live sessions , 26 pre-recorded talks , and five industry sponsors . A milestone moment that proved the power of community — even in a virtual world. Featured Appearances Aug 2020 — Featured on 17 Minutes of Science with Advancing GPCR Drug Discovery Through Collaboration . Oct 2020 — Presented at ERNEST with Beyond the Lab . Nov 2020 — Invited to the 9th GDR Meeting with Beyond the Lab . 2021 Expanding the Conversation Podcast Milestones Jan 2021 — Episode #26 released featuring Dr. Debbie Hay , University of Otago. Feb 2021 — Episode #27 released featuring Dr. Robert J. Lefkowitz , 2012 Nobel Laureate in Chemistry. 2nd Annual Summit Sep 13–19, 2021 — The 2nd Dr. GPCR Summit expanded the community’s reach and impact, featuring 27 live talks , 10 pre-recorded sessions , and five sponsors . Featured Appearances Jul 2021 — Featured at ECR Transatlantic with From Idea to Ecosystem . Oct 2021 — Featured at ERNEST with Where All GPCRs Are Created Equal . 2022 Building Momentum Podcast Growth May 2022 — Episode #37 released featuring Dr. Sam Hoare , Pharmechanics. May 2022 — Episode #42 released featuring Dr. Randy Hall , Emory University. New Programs Aug 11, 2022 — Virtual Café Series launched, featuring 16 episodes . Sep 20, 2022 — First contributor article published: Therapeutic validation of an orphan G protein‐coupled receptor by Inês Pinheiro . Oct 10–16, 2022 — Hosted the 3rd Annual Dr. GPCR Summit , featuring 34 live talks , 12 poster presentations , one pre-recorded session , and four partners . Dec 9, 2022 — GPCR Weekly News launched — now over 120 editions published . Community Engagement Mar 2022 — Featured at ERNEST with Dr. GPCR Ecosystem 2.0: Collaborating Better . Mar 2022 — Featured at ERNEST with Beyond the Lab . Mar 2022 — Media Partner at GPCR Targeted Drug Discovery Summit . May 2022 — Media Partner at GPCR Retreat . Jul 2022 — Media Partner at GPCR ECI Transatlantic . Nov 2022 — Featured at PhageMed Unige with Leadership Is a Learned Skill . 2023 A Year of Reflection and Growth Podcast Milestones Jan 2023 — Released the Dr. Marc Caron Tribute Episodes ( #100 , #101 & #102 ), featuring over 30 expert guests , including Dr. Kathleen Caron and Dr. Brian Kobilka , 2012 Nobel Laureate in Chemistry. First Symposium May 19, 2023 — Hosted the inaugural Dr. GPCR Symposium , bringing together over 100 attendees and featuring 11 live talks Community Engagement Feb 2023 — Media Partner at GPCR Targeted Drug Discovery Summit . Jun 2023 — Featured Talk Molecular Pharmacology GRC and GRS in Switzerland. Jun 2023 — Hosted Meet the Inoviem Team session. Nov 2023 — Co-organized the 22nd Great Lakes GPCR Retreat 2024 Strengthening Foundations and Expanding Horizons Educational Initiatives Feb 8, 2024 — Launched Dr. GPCR University with the first GPCR Course led by Dr. Terry Kenakin , enrolling 30+ students . Podcast Milestones May 9, 2024 — Episode #150 introduced the Dr. GPCR Team . May 16, 2024 — Episode #151 featured the Dr. GPCR Board . Community Engagement Mar 2024 — Media Partner at 3rd GPCR Targeted Drug Discovery Summit . Apr 2024 — Media Partner at Endocrine and Metabolic GPCRs meeting. Oct 2024 — Co-organized the Adhesion GPCR Workshop in Mexico City, with by 65+ participants . Oct 2024 — Media Partner at Discovery on Target . Non Profit Status Apr 2024 — Officially obtained non-profit organization status . Jul 12, 2024 — Hosted the first Board Meeting . Community Impact & Reach Podcast 180+ episodes 200+ guests 4,500+ hours of interviews 49,000+ plays Community 1,300+ ecosystem members 4 team members 6+ symposiums 15+ virtual café episodes Content 4,500+ GPCR papers categorized 200+ weekly news editions 100+ contributor articles 6 university courses Reach 3,800+ Twitter followers 3,000+ LinkedIn followers 100,000+ site sessions 400+ job listings shared

Advance your GPCR research career with Dr. GPCR University. Access 20+ on-demand GPCR courses, 200+ expert talks, weekly news, and a global scientist network. Join Premium today. Dr. GPCR University A nonprofit created by scientists, for scientists—bringing the global GPCR community together to advance biology and therapeutics. 📚 Learn faster. 🤝 Connect deeper. 🔬 Drive discoveries. Join the trusted home for GPCR scientists worldwide, where collaboration fuels innovation and every voice helps shape the future of discovery. Become a Premium Member Strategic Partner(s) Why Join? Learn from leading GPCR experts — anytime, anywhere Access trusted, on-demand courses designed to help you grow your knowledge and confidence. Stay ahead with complete GPCR coverage News, papers, jobs, and industry insights — all curated for scientists who care about what’s next. Get the latest GPCR news delivered to your inbox every week Stay informed and inspired — without the noise. Explore 200+ expert talks that bring GPCR discoveries to life From structural biology to therapeutics — hear directly from the scientists shaping the field. Connect with peers who speak your scientific language Build meaningful collaborations and friendships within a global community of GPCR experts. Find your perfect fit Through personalized matchmaking, discover new roles, partners, or team members who align with your goals. Explore the Masterclass Pharmacology Foundations Build the essential lens every scientist needs to see pharmacology clearly, from core principles to the hidden variables of drug disposition. Advanced Quantitative Approaches Sharpen your toolkit with rigorous quantitative methods that bring clarity to bias, binding, and response analysis. Agonists, Antagonists & Core Mechanisms Master the classic players in GPCR pharmacology and learn how agonists and antagonists shape efficacy, signaling, and therapeutic potential. Innovation & Strategic Application Translate science into impact by exploring unconventional ligands, unique GPCR behaviors, and the strategies to drive successful drug discovery projects. Allosteric Modulation & Kinetics Step beyond orthosteric drugs and uncover the power of allosteric modulators and kinetic insights to unlock new therapeutic dimensions. Explore Premium Package 🔥 Upgrade to Premium Premium Yearly $499 $ 499 Every year 🚀 Everything you need to master GPCR science — in one membership. Valid until canceled Join Premium Today! 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way. 🔒 Grandfather Guarantee, your rate never increases See all Discount Options Why is it Worth It? Common concerns and why Premium delivers exceptional value "It's too expensive." At less than $1 a day, Premium gives you access to 20+ on-demand GPCR courses, 200+ expert talks, and global networking tools. One insight, one connection, one ‘aha’ moment — can save months of research time. "I'm not sure I'll use it often." Even one course or one new collaboration can make a difference. Members often find value in ways they didn’t expect — from expert feedback to career-changing introductions. "I already get what I need from papers." Papers inform. DrGPCR helps you understand and apply that knowledge — through structured training, expert context, and real interaction with peers from academia and industry. "Will this really help my career?" Yes. Members grow visibility, confidence, and connections that open doors. It’s not just about learning — it’s about being seen, supported, and part of something bigger . Frequently asked questions What is Dr. GPCR University? Dr. GPCR University (https://www.ecosystem.drgpcr.com/gpcr-university)is an educational platform that provides in-depth learning and training resources on G protein-coupled receptors (GPCRs). At Dr.GPCR University, you’ll find: • Courses: Dive deep into curated educational content designed by experts in GPCR research. Our courses provide comprehensive, on-demand learning to help you expand your knowledge and stay current in the field. • Symposia Engage with leading scientists through our symposia, featuring in-depth discussions on cutting-edge research and breakthroughs in GPCR science. Each session brings together a community of experts to share insights and advancements. • Summit A global gathering of researchers and professionals showcasing the latest developments in GPCR research. Participate in presentations, networking opportunities, and collaborative sessions. • Virtual Café Listen to casual, interactive discussions with experts in the field. How do I register for Dr. GPCR University Masterclasses? To register for any course, you must have a FREE Ecosystem member account.(https://www.ecosystem.drgpcr.com/) We carefully screen anyone signing up to ensure they are real humans working on GPCRs, so you might not receive confirmation immediately. When signing up for the first time, try to complete as much information as possible about yourself. Who are the Dr. GPCR University Masterclasses designed for? The classes are designed for researchers, students, and professionals in biology, pharmacology, and biochemistry, but anyone interested in GPCR research is welcome to join. What topics are covered in the masterclasses? Masterclasses cover a variety of track including but not limited to pharmacology foundations, agonists, antagonists & core mechanisms , allosteric modulation & kinetics, advanced quantitative approaches and innovation & strategic application Can I register my team for a Dr. GPCR University Masterclasses? To register as a team, one of you must be a Premium Member.(https://www.ecosystem.drgpcr.com/plans-pricing) This person must email hello@drgpcr.or(mailto:hello@drgpcr.com)g indicating how many people will register for the course, the names of the participants, and their emails. We will contact each person individually to help them set up a FREE Ecosystem Membership.(https://www.ecosystem.drgpcr.com/) They will be asked to join a private group to keep updated with the latest announcements about the course. Are the masterclasses on-demand or live? Dr. GPCR University offers both on-demand and live classes led by experts in the field. On-demand classes are only available for Premium Members.(https://www.ecosystem.drgpcr.com/plans-pricing) Do I need prior knowledge of GPCRs to join the masterclasses? Some classes may require basic knowledge of GPCRs, but many are designed to accommodate beginners as well as advanced learners. What kind of certification will I receive upon completing a masterclass? Participants will receive a certificate of completion from Dr. GPCR University, which can be used to showcase your expertise and enhance your professional credentials. Can I access the course material after completing the course? Yes, if you are a premium member. What would you like to learn today? Too many choices? Use our CheatSheet ! Take the Next Step You're building the future of GPCR therapeutics. Now get the courses, insights, and network to accelerate it. Join Premium Membership

Join the Dr. GPCR Affiliate Program and earn commissions by helping connect the global GPCR community. Share our ecosystem, courses, and events to advance drug discovery together. Dr. GPCR Affiliate Program Earn by Empowering the GPCR Ecosystem Help us connect scientists, founders, and innovators while earning commissions for every member, partner, or course you bring into the Dr. GPCR community. Become our Brand Ambassador Our vision is to build the best platform for the GPCR community and help you the scientists and business owners to share their experiences with others, get help, and find the perfect tools, colleagues, build their strategy and advance our field. As an ambassador, with the Affiliate Program, you'll earn a commission whenever your referral link is used and a qualified purchase has been made by your friends, colleagues, or followers who are also part of the GPCR field. Become our Brand Ambassador About Dr. GPCR Ecosystem We aspire to provide opportunities to connect, grow, and thrive together as a dynamic group. The goal is to better understand and exploit the druggability of GPCRs, together. The Dr. GPCR Ecosystem members have the opportunity to solve problems, find answers to their questions, identify the perfect service provider, and, most importantly, boost their GPCR project with just a few clicks. The Ecosystem is designed for all GPCR professionals to have an affordable and highly effective way to showcase their knowledge, connect, and advance the field, together. About the Dr. GPCR brand ambassador affiliate program Who can be a Dr. GPCR ambassador? Scientists and trainees with a strong GPCR background who like and want to create content by writing articles about their favorite GPCR topics and sharing these on social media platforms such as LinkedIn and other options listed at the end of this page. Who is eligible for the Dr. GPCR affiliate program? A GPCR background is mandatory independent of your current position and industry. You also must be an individual Dr. GPCR Ecosystem membership holder. For full details on eligibility, please read our Affiliate Policy . How do I apply for the affiliate program? To become an affiliate, you must create an account here . How does the Dr. GPCR affiliate program work? After becoming a member of the affiliate program, you'll get your personalized link where you can send your potential clients. After every qualified sale, you will earn a commission of $50. How does the commission work? Each qualifying sale earns a commission (excluding sale cancellations). Does it cost me anything to become an affiliate? The program is free to join; there are no monthly charges and no minimum sales requirements. However, the number of ambassador members is limited. Dr. GPCR reserves the right to remove the least active members from the program. Can I invite someone to participate? Yes! You can invite anyone to participate, and we welcome anyone if they are qualified. Do I need to sign a contract? There's no contract to sign when joining our program. You will be required to agree to our Terms and Conditions and our Affiliates Policy when you sign up on Ecosystem.DrGPCR.com. You can leave the program at any time by contacting us. Dr. GPCR may also remove affiliates from the program at any time. Is there an exclusivity agreement when joining? There's no exclusivity agreement. You can take part in other affiliate programs as well as be part of ours. Are affiliates outside of the U.S. eligible for the Affiliate Program? Yes, you may join the affiliate program as long as you have a verified PayPal account. What type of channels, tools, and techniques can I use to promote Dr. GPCR Ecosystem? OK to use: - Writing, blogging, guest blogging, - Podcast, video, vlog - Social media sharing, - YouTube & TikTok channels, - Business Page and website, - Informational and fan sharing, - Presentations and meetups. Not OK to use: Advertising Spam Anything misleading or annoying Social media bios Paying or offering intensives for the use of your link How do I track my earning? We use a third-party provider, GoAffPro.com , where you'll create your own account and through your dashboard, you can track all your activities. When will I receive my affiliate commissions? Affiliate payments are processed and sent directly to your PayPal in 7 to 30 days. We could hold payments up to 30 days to allow for processing, chargebacks, etc. Good Faith We introduce programs such as the Dr. GPCR Ambassador, in good faith and expect the same good faith in return. Please note that we may withhold awards where we believe customers are acting in bad faith or otherwise acting contrary to the intent of this program. To be clear, commercializing, advertising, publishing, mass distributing, selling, or paying for the use of referral links is not appropriate, and we will not honor such links. We cannot cover every nefarious scenario, nor will we attempt to, but we do promise to be fair and reasonable. Closure We are so excited about the Dr. GPCR Ambassador program. It will be a remarkable journey and fun to build together the "next-generation" platform for the B2B industry. With your help, we can create a world where the living experience is joyful and worry-free. Are you ready? Sign up , explore, and connect with us. Become our Brand Ambassador

Turn GPCR discovery chaos into clarity—Yamina’s Corner offers expert GPCR strategy, CRO guidance, and tailored scientific support to accelerate your pipeline. Home About News Get in Touch Welcome Turn GPCR Chaos Into Insights Expert strategic and scientific consultancy to accelerate your pipeline Book My Consultation Critical Bottlenecks in Your GPCR Pipeline ❌ Overwhelming pharmacology Data ❌ Suboptimal CRO Partnerships ❌ Stalled Pipeline Progression ❌ Uncertainty in GPCR Investments Advisory Focus Areas Expert support for Biotech innovators, VC investors and CRO partners Biotech Pipeline Acceleration For Biotech Leaders & Scientists Actionable Data Insights: Translate complex GPCR pharmacology into clear decisions for lead optimization and candidate selection. Accelerated Program Progression: Design robust assay cascades and establish key go/no-go points to speed up your pipeline. Optimized CRO Collaboration: Streamline internal R&D and external CRO workflows to prevent delays and ensure preclinical success. Fuel Discovery VC Due Diligence & De-risking For Venture Capital Firms De-risk GPCR Investments: Identify critical scientific red flags and technical gaps in GPCR assets before committing capital. Actionable Scientific Validation: Ensure target companies execute the right GPCR pharmacology experiments to generate robust, decision-making data. Clear Platform Assessment: Gain rapid, independent insight into GPCR platform risks and true therapeutic potential to inform investment strategy. Fast-Track Discovery CRO Partnership & Optimization For Contract Research Organizations Elevate Scientific Offerings: Refine and optimize your GPCR assay platforms and in vitro models to deliver superior data quality and results. Enhance Client Project Delivery: Streamline workflows and improve scientific execution to increase client satisfaction and secure repeat business. Differentiate Your Market Position: Showcase your specialized GPCR expertise to stand out from competitors and attract high-value biotech and pharma partners. Power Discovery How We Work: Your Path to GPCR Success 1 Initial Strategic Alignment We begin with a focused discussion of your current GPCR program and critical challenges, identifying precise areas for collaboration. 2 Define Actionable Objectives Together, we clarify specific, measurable goals, from target validation and assay development to CRO selection or portfolio strategy, ensuring a tailored approach. 3 Collaborative Execution & Impact I integrate directly into your discovery process to remove roadblocks, enhance execution, and generate actionable scientific data, driving confident decisions and sustained preclinical progress. Advance My Discovery My Approach: Precision Guidance for GPCR Programs I provide the focused, scientific expertise that accelerates complex GPCR discovery programs, ensuring clarity and de-risking your path from target to candidate. I integrate seamlessly with biotech, VC, and CRO teams as a trusted, objective partner. Integrated Strategic Partnership We collaborate directly with your scientific and leadership teams. This partnership prevents bottlenecks and optimizes resource allocation, ensuring every strategic decision efficiently propels your program forward and aligns with critical business objectives. Biology-First, Data-Driven Solutions Every recommendation is rooted in GPCR biology, pharmacology experience. This provides evidence-based strategies leveraging deep GPCR expertise to overcome specific scientific challenges and maximize your program's potential. Accelerated Preclinical Progression I streamline critical operational processes, from advanced assay design and CRO management to rapid go/no-go decision-making. This focused execution accelerates preclinical milestones and maximizes the efficiency and return on your R&D investment. Core Values: The Foundation of Every Successful Partnership My advisory is built on principles that ensure clarity, minimize risk, and drive enduring results in GPCR drug discovery. Scientific Integrity Every recommendation is rigorously evidence-based, not reliant on assumptions. This ensures robust, defensible decisions that de-risk your program from early discovery to regulatory milestones. Operational Discipline I instill structure and consistency across every phase of your discovery process. This approach eliminates inefficiencies and standardizes workflows, accelerating your path to a preclinical candidate. Collaborative Partnership I operate as an embedded, invested partner with your team. Your program's success is my priority, fostering a transparent, results-driven environment that maximizes collective expertise and accelerates progress. About Yamina A. Berchiche I'm Yamina A. Berchiche, and I understand the intricate challenges of GPCR drug discovery. Small missteps can derail entire programs: underperforming assays, off-track CROs, and data that fails to drive decisions. That's precisely where my expertise becomes your strategic advantage. With over two decades dedicated to GPCR pharmacology across biotech, academia, and the non-profit sector, I bring unparalleled scientific depth and operational precision to every project. My work focuses on integrating directly with your team as a strategic partner. Whether it's optimizing CRO selection, building robust internal capabilities, or translating complex data into decisive program advancements, I help you eliminate friction, align efforts, and accelerate your path to success. As the founder of Dr. GPCR, I also offer a unique, broad perspective and trusted relationships within the field. This allows me to connect you with critical insights and key collaborators, further accelerating your progress in GPCR drug discovery. Let's Talk Discovery What Partners Say Here’s what it’s like to work together — from people I’ve supported on both sides of the bench. Anne Marie Quinn, CEO Montana Molecular As a CRO, we were delivering high-quality data across complex biotech programs, but translating that data into aligned, timely decisions across stakeholders wasn’t always straightforward. After partnering with her, communication became clearer, deliverables were better defined, and collaboration across teams ran more smoothly. She helped streamline complex projects and made the CRO–client relationship more effective and productive. Terry Kenakin, PhD UNC Chappel Hill In complex pharmacological discovery programs, scientific ambiguity and fragmented execution can quietly erode progress. Yamina brings the clarity, rigor, and structured decision-making that keeps programs on track. Across multiple discovery efforts, she established clear decision gates and alignment across teams, materially strengthening candidate progression and prioritization. Her involvement consistently elevates both the scientific discipline and the quality of portfolio-level decisions. Murat Tunaboylu, CEO Antiverse Before engaging Yamina, our team faced hurdles navigating complex early discovery decisions. We had critical program choices ahead and needed clearer direction. Bringing her in marked a meaningful shift. We made confident progress on a pivotal program and gained clarity on our next strategic focus. Yamina was instrumental in unifying our scientific and operational teams, strengthening alignment and driving momentum across execution. Abishek Iyer, CEO Ashta Therapeutics Before working with Yamina, we had solid internal momentum but needed to better align our biology, assay priorities, and compound strategy into a cohesive, decision-driven plan. Her input helped us structure the screening funnel, define clear go/no-go criteria, and integrate ADME and mechanistic assays in a way that reflected both biological rationale and operational realities. She has been a true thought partner — not only on tactical execution, but on pressure-testing hypotheses, challenging assumptions, and maintaining disciplined forward progress. Book Book My 30 Minutes Strategy Call Menu Home Services About News Ready to collaborate? Let’s talk about how I support GPCR discovery, pharmacology strategy, and cross-functional execution across biotech, VC, and CRO teams. Get in touch Connect LinkedIn Podcast Dr. GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr. GPCR Corp Proudly created with Wix.com

Discover special university group pricing for Dr. GPCR courses. Save with discounted packages and provide your students or faculty access to premium GPCR learning resources. Empower Your Team with Dr. GPCR Premium Give your team the tools to grow together and stay at the forefront of GPCR science. Save 25% on annual Premium Memberships when you enroll five or more members. Access expert-led courses, 200+ talks, community tools, and curated insights designed to keep your team connected, informed, and inspired. Important Information To qualify for the team discount, your group must include at least five members. If fewer than five members are submitted: • Memberships won’t be activated. • You’ll receive a 50% refund to cover processing costs. 👉 Please double-check your team list before submitting to avoid delays. Questions? We’re here to help: Hello@DrGPCR.org . How It Works? 1️⃣ Prepare Your Team Gather at least 5 team members . Each person must have or create a Dr. GPCR Ecosystem account. 3️⃣ Confirm and Pay Securely Review your submission and complete payment. You’ll receive a confirmation email immediately. 2️⃣ Submit the Team Form Provide names, emails, and organization details. This ensures proper access and personalized onboarding. 4️⃣ Membership Activation Our team manually reviews and activates all seats. Activation takes 3–10 business days . You’ll be notified once access is live. 💡 Need to add members later? We’ll help you update your team anytime. Apply for Your Team Discount 👇 📢 Limited-time offer – don’t miss out! First name* Last name* Email* Company name* Company Website* Names & Emails of Each Team Member (minimum 5)* Team Size* Annual Premium Team access. Minimum five seats. Priced per person per year. $374.25 Order Now 💡 Have questions? Contact us at Hello@DGPCR.org Book Plan Your Next Move in GPCR Discovery Meet directly with Dr. Yamina Berchiche for a focused strategy conversation to align your goals, uncover opportunities, and map your next steps.

Find answers to all your questions about the Dr. GPCR Ecosystem: courses, podcasts, memberships, events, and more. Frequently asked questions University Vault Premium Pricing GPCR Masterclass YC-Biotech YC-VC YC-CRO Terrys Corner Media Partner General University Dr.GPCR Podcast What is the University Vault? An exclusive, members-only archive of expert talks from past DrGPCR events, plus comprehensive courses and career resources. Who is it for? Researchers, scientists, postdocs, graduate students, and professionals in GPCR-related fields looking to advance their careers. Is the content still relevant? Absolutely. These presentations provide foundational and advanced insights that continue to inform current research, plus we continuously add new content. How often is new content added? New sessions are uploaded after each DrGPCR Summit or Symposia, plus we regularly add new courses, news, and update career resources.

Stay current in drug discovery with the University Vault. Quickly get up to speed on new GPCR targets and mechanisms, and gain a competitive edge with our extensive academic archive. University Vault: The Ultimate On-Demand GPCR Learning Library Every talk inside the University Vault represents years of research, collaboration, and innovation that continue to shape the GPCR field. Scientific breakthroughs don't expire! 200+ Expert Presentations 24/7 Access ∞ Rewatches Unlock the Vault Today! Filter & Explore Refine your experience with just three easy filters Select Category Select Event Select Format Activation Mechanism of Metabotropic Glutamate Receptor 5 Dr. Kaavya Krishna Kumar Location bias of GRKs and Arrestins Dr. Sudarshan Rajagopal Ligand-biased signalling and location bias; two faces of functional selectivity Dr. Michel Bouvier Structural basis of the regulation of human chemokine receptor and HIV-1 co-receptor CCR5 Dr. Polina Isaikina Gz-Enhanced Signal Transduction assaY (GzESTY) for GPCR deorphanization Dr. Cesare Orlandi Accurate Mechanistic Calculation of μ Opioid Receptor Signaling Efficacy - Poster Presentation Dr. David Minh 1 2 1 ... 1 2 ... 2 Become a Premium Member 🔥 Upgrade to Premium Premium Yearly $499 $ 499 Every year 🚀 Everything you need to master GPCR science — in one membership. Valid until canceled Join Premium Now 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way. 🔒 Grandfather Guarantee, your rate never increases What Scientists Appreciate The most comprehensive library of GPCR knowledge online. Period. Anonymous This looks super useful for drug discovery! The University Vault is a great way to keep up with academic progress and find new GPCR therapies. You can quickly learn about new targets and mechanisms, and it's an amazing competitive intelligence tool. Anonymous As a postdoc, my travel budget is limited. The University Vault gives me on-demand access to the talks I would have missed, keeping me at the cutting edge of the field. Being able to pause and re-watch complex presentations on signaling pathways has been crucial for advancing my own research. It’s the best professional development investment I’ve made. Anonymous Frequently Asked Questions University Vault Premium Pricing What is the University Vault? An exclusive, members-only archive of expert talks from past DrGPCR events, plus comprehensive courses and career resources. Who is it for? Researchers, scientists, postdocs, graduate students, and professionals in GPCR-related fields looking to advance their careers. Is the content still relevant? Absolutely. These presentations provide foundational and advanced insights that continue to inform current research, plus we continuously add new content. How often is new content added? New sessions are uploaded after each DrGPCR Summit or Symposia, plus we regularly add new courses, news, and update career resources. The Field is Evolving—Don't Fall Behind You don't need to attend every event to stay at the forefront of GPCR research. With the Vault, the knowledge comes to you—on demand, on your terms. Get Access Today!

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Using food perception and bioamine signaling networks to slow aging Date & Time Saturday, November 4th / 10:10 AM Abstract Coming Soon Authors and Affiliations Hillary A. Miller 1, Shijiao Huang 1, Elizabeth S. Dean 1, and Scott F. Leiser 1 1. University of Michigan About Scott Leiser "Scott Leiser is an Assistant Professor in the Research in the Molecular & Integrative Physiology Department at the University of Michigan. The Leiser laboratory is focused on the molecular mechanisms of aging, with an emphasis on stress response and metabolism. The lab works with multiple models, including Caenorhabditis elegans, in vitro tissue culture, and mice, to better understand the conserved mechanisms of aging. Recent research in his laboratory focuses on how organisms perceive and respond to environmental stress though cell non autonomous signaling mechanisms, and how these signals affect the health and longevity of the animal." Scott Leiser on the web University of Michigan Pubmed ResearchGate LinkedIn Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

<< Back to podcast list Strategic Partner(s) Dr. Mark Connor About Dr. Mark Connor Undergraduate BSc with Honours in Pharmacology from University of Sydney (1987, snake neurotoxins), Ph.D. from Department of Pharmacology, University of Washington (1992, mentor Charley Chavkin , sigma receptors). Postdoc with Graeme Henderson (Bristol, opioids and Ca signaling) and Mac Christie (Sydney, opioids in neurons, novel spider toxins). Grant-funded independent research positions from 2001 at University of Sydney (opioids and sensory neurons), Vollum Institute Portland (visiting scientist with Ed McCleskey, sensory neuron properties); Pain Management Research Institute (more opioids, cannabinoids and T-type Ca channels) and Brain and Mind Research Institute (Sydney). 2009, appointed Professor of Pharmacology at Macquarie University. Focus on study of drugs and toxins on GPCR (opioid, cannabinoid receptor) and ion channel (K, Ca, TRP channel) function; mostly electrophysiology and fluorescence-based reporters, but can grind and bind. Currently pursuing molecular pharmacology of phytocannabinoids and novel synthetic cannabinoids, with a focus on efficacy and novel targets. Interested in orthosteric and allosteric interactions, and still looking for some bias ... anywhere ... these days human only. Dr. Mark Connor on the web Researchers Twitter Google Scholar Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Strategic Partner(s) Dr. Stephane Angers About Dr. Stephane Angers Dr. Angers is an expert in the field of signal transduction. He obtained his Ph.D. from the Université de Montréal in 2002 under the guidance of Dr. Michel Bouvier . His thesis work led to the development and application of light energy transfer methodology to study protein-protein interaction and signal transduction. From 2002-2006 he was a Howard Hughes Post-Doctoral Fellow at the University of Washington in Seattle under Dr. Randall T. Moon , where he identified and characterized novel components of the Wnt signaling pathway and a new class of E3 ubiquitin ligases . In October 2006, Dr. Angers established his independent research program in the Department of Pharmaceutical Sciences at the Faculty of Pharmacy and the Department of Biochemistry at the University of Toronto. He is the recipient of the Canada Research Chair in Functional Architecture of Signal Transduction. His research program is developed to understand the signaling mechanisms underlying the Wnt and Hedgehog families of growth factors and their signaling mechanisms in development, adult tissue homeostasis, and human diseases. His pioneer work led to the development of novel antibody molecules blocking and activating the Wnt pathway for the treatment of cancers and regenerative medicine applications. He is the scientific founder of two biotech companies, ModMab Therapeutics , and AntlerA Therapeutics , which are pursuing the clinical development of these molecules. In September 2021, Dr. Angers was named Director of the Donnelly Centre of Cellular and Biomolecular Research at the University of Toronto, an internationally recognized Research Institute bringing together multidisciplinary teams of scientists. Dr. Stephane Angers on the web Angers Lab The Donnelly Centre Twitter Dr. GPCR Ecosystem LinkedIn Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer Date & Time Friday, November 3rd / 3:55 PM Abstract Coming Soon About Robert Rottapel "Dr. Rottapel is a Senior Scientist at the Princess Margaret Cancer Centre where he holds the Amgen Chair for Cancer Research. He is a Professor in the Departments of Medicine, Immunology and Medical Biophysics at the University of Toronto. After completing his medical studies at George Washington University, the NIH and UCLA, he pursued his postdoctoral studies with Allan Bernstein at the Lunenfeld Research Institute in Toronto and with Patrice Dubreuil at INSERM, France. Dr. Rottapel is a clinical rheumatologist at St. Michael's Hospital, University of Toronto. His clinical expertise is in monogenic autoinflammatory disorders and the autoimmune adverse effect resulting from checkpoint inhibitors in cancer patients. Dr. Rottapel’s research interests lies in the elucidation of signal transduction pathways in cancer, immune and bone cells. He has focussed on developing a comprehensive map of ovarian cancer essential genes using whole genome RNAi and CRISPR technology. This approach has provided insight into novel drivers resulting from the widespread gene copy number aberrations observed in ovarian cancer and the identification of emergent vulnerabilities associated with adaptation pathways required to buffer cancer associated stress states. Several of these targets are being developed for potential new therapeutic strategies in ovarian and pancreatic cancer. A second area of interest has been the elucidation of the molecular basis for a rare autosomal human disease called Cherubism. The adapter protein 3BP2 is mutated in Cherubism. The Rottapel lab has shown that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell function and scavenger receptor activation." Robert Rottapel on the web The Rottapel Lab Ontario Institute for Cancer Research University of Toronto Pubmed Google Scholar LinkedIn Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Unveiling Non-Canonical Functions for Gαq Signaling Pathways Date & Time Friday, November 3rd / 11:55 AM About Catalina Ribas " Dr. Catalina Ribas, is currently an Associate Professor at the University Autonomous of Madrid (UAM) and she has been Academic Secretary of Molecular Biology Department for several years. The research group led by Dr. Catalina Ribas, located in the Centro de Biología Molecular “Severo Ochoa” (UAM/CSIC) and belongs also to the Health Research Institute La Princesa, has extensive experience in the field of GPCR. Dr. Catalina Ribas made a postdoctoral stay in the laboratory of Dr. SM. Lanier in the MUSC (USA). During this period and her doctoral thesis, she has deepened the regulatory mechanisms of GPCR signaling. In her postdoctoral period, she has participated in the identification and characterization of proteins that act at the level of G proteins and which are part of a multimolecular signaling complex (AGS, de “Activators of G-protein signaling). In Spain, Dr. Ribas continued working on the regulation of GPCR. The group of Dr. Ribas has characterized the existence of a new signaling pathway with a relevant role in cardiac hypertrophy led by a new Gαq interactome. Recently, Dr. Ribas' group has described a new interaction region in a cellular protein that has turned out to be very relevant in the control of the cellular process known as autophagy. These results have been published in the journal Nature Communications (12 (1):4540, 2021) with the title "Gαq controls autophagy via modulation of the mTORC1 signaling hub". Furthermore, Dr. Ribas has also described a new protective role of G protein-coupled receptor kinase 2 (GRK2), a known regulator of Gq-GPCR signaling in HNSCC tumor progression (International Journal of Cancer, 2020). " Catalina Ribas on the web Severo Ochoa Molecular Biology Center X (Twitter) Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Breakfast 1 Date & Time Friday, November 3rd / 7:30 AM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

GPCR scientist Ben Clements shares how positive allosteric modulators could transform opioid therapy by boosting efficacy and reducing side effects. << Back to podcast list Strategic Partner(s) When to Walk, When to Run: Lessons from the GPCR Trenches with Dr. Ben Clements The Power of Inclusion in the GPCR Field This episode kicks off with a celebration of early-career scientists. Host Dr. Yamina Berchiche emphasizes the importance of diverse voices in the GPCR community: “It’s been a very difficult path to get more early-career scientists on the podcast. But it’s important to make your voice heard.” Benjamin Clements , a postdoctoral fellow at the University of Michigan, joins the conversation as a rising voice in GPCR pharmacology. His journey highlights the transition from general drug development to a deep dive into G protein-coupled receptors. From Aspirations to Application: Ben’s Path into Science Ben shares his winding yet deliberate entry into science. Initially driven by a general passion for biology and a childhood dream of being an astronaut, he began with intestinal choline transport research at UNC. The realization that basic science could impact real patients was transformative. “It’s not just raw science — this can help someone at the end of the day.” – Ben Clements His pivot into neuroscience and pharmacology during grad school at the University of Minnesota laid the groundwork for his current work in GPCR pharmacology. GPCRs and the Opioid Crisis: A New Pharmacological Frontier Now at the University of Michigan, Ben focuses on positive allosteric modulators (PAMs) targeting opioid receptors. The goal: maximize analgesia while minimizing side effects . “We’re enhancing the powerful pain-relieving effects of opioids while limiting respiratory depression, constipation, and abuse liability.” He is particularly excited by the novel application of PAMs in chronic and neuropathic pain models , including the neuroma model , which is typically opioid-insensitive. Allosteric Modulation: The New Frontier of GPCR Drug Discovery Ben reflects on the emerging potential of allosteric modulation in GPCRs — a field that has lagged behind ion channels in clinical applications. “Allosteric modulation in GPCRs is so novel and so exciting. There’s so much availability, so much we don’t know yet.” By working with distinct chemical scaffolds like thiazolidines and xanthinediones, Ben is helping define how structurally different PAMs may act on similar receptor sites. Scientific Rigor: The Value of ‘Old School’ Pharmacology Despite the availability of modern tools, Ben stresses the enduring value of classical methods like GTPγS assays , radioligand binding , and basic PK/PD models . “It doesn’t matter how many cool, fun tools you have. If you don’t understand the math that underlies an allosteric modulator, you won’t understand what’s happening.” This mindset keeps his science grounded, reproducible, and rooted in fundamentals. Mentorship, Team Culture, and the Joy of Science Science is serious work, but Ben believes fun and collaboration fuel great outcomes. At Michigan, his lab balances rigor with light-hearted engagement — like daily squirrel trivia on their whiteboard. “Science is fun. We produce great data, but we also joke around. That’s how we work best.” Strong mentorship, open communication, and peer learning — especially from undergraduate trainees — shape his development as both a scientist and future educator. Translating Discovery into Therapy: Bench to Bedside Vision Ben’s work seeks to merge in vitro mechanistic data with in vivo efficacy , guiding medicinal chemists toward creating druggable PAMs . “The goal is to smash all the amazing biology together and make a drug.” Using site-directed mutagenesis and pharmacological synergy assays , his team aims to understand how and where these compounds interact with the receptor, paving the way for structure-based drug design . Structural Biology Roadblocks: The Cryo-EM Challenge One bottleneck in Ben’s work is visualizing binding sites of PAMs via cryo-EM , due to low compound potency and membrane-embedded binding pockets. “Our compounds don’t bind well enough to be seen clearly. That’s a real challenge with allosterics.” Still, by collaborating with structural biology teams and combining cryo-EM with NMR , his lab is narrowing down potential binding regions. Lessons in Confidence, Collaboration, and Aha Moments From asserting himself as an undergrad to mastering unique techniques in grad school, Ben has accumulated key “aha” moments that shaped his confidence: Standing up to big names when safety was compromised. Realizing his technical skills were indispensable to the team. Discovering breakthrough results in neuroma pain models via a spontaneous collaboration. “We found something incredible — a tenfold shift in the methadone dose-response with our PAM.” Advice for Junior Scientists: Read, Rest, Run Ben closes with wisdom for early-career researchers: “Academia is about knowing when to walk and when to run.” – Advice from Kelsey Flepsen He advocates: Reading one paper a day. Taking care of yourself when possible. Pushing hard when deadlines or breakthroughs demand it. “Your brain’s not a machine. Let it rest. That’s when the best ideas come — in the shower or on a walk.” Key Takeaway This Episode with Ben Clements is a deep dive into the pharmacological potential of GPCRs , the power of mentorship, and the mindset required to thrive in science. With clarity, curiosity, and a collaborative spirit, Ben reminds us that impactful science isn’t just about technology — it’s about people, persistence, and timing. “Science is all about knowing when to walk and knowing when to run.” About Ben Clements Dr. Ben M Clements is a behavioral pharmacologist who uses in vitro and in vivo models to discover and characterize novel treatments for chronic pain and opioid use disorder. He received his Ph.D. in Pharmaceutics from the University of Minnesota in 2022, studying the pharmacokinetics and pharmacodynamics of NMDA receptor antagonists. At the University of Michigan, Ben focuses on determining the mechanisms of action of a series of positive allosteric modulators of the mu-opioid receptor. This project involves molecular pharmacology in cell models to determine binding sites and mechanisms of allostery, as well as efficacy studies in mouse and rat models of acute and chronic pain. Dr. Clements' work is primarily focused on translational developments of small molecule therapeutics, and intends to apply these ideas to an independent academic laboratory. In addition, he plans to continue studying how neuromodulators, both exogenous and endogenous, can influence cellular activity, physiological behaviors, and human health. Ben Clements on the web University of Michigan X Google Scholar LinkedIn Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Welcome Remarks Date & Time Thursday, November 2nd / 1:30 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Trainee Symposium II Date & Time Thursday, November 2nd / 3:00 PM - 4:00 PM Title: Linking Proteinase Activated Receptor (PAR) Cleavage to Osteoarthritis (OA) Severity About Amr Mousa "I am currently a Ph.D. student at the Schulich School of Medicine and Dentistry, Western University, researching the molecular mechanisms of Proteinase-Activated Receptors (PARs) in osteoarthritis. I got my Bachelor's in Pharmacy from Minia University in 2011 and began my career as a teaching and research assistant in Pharmacology and Toxicology. Later, I completed my Master's degree in Pharmacology at Minia University, focusing on hydrogen sulfide's role in hypertension-induced endothelial dysfunction. In November 2021, I joined Dr. Ramachandran's lab as a visiting graduate student, and in September 2022, I enrolled in the direct-entry Physiology and Pharmacology Ph.D. program with a specialization in musculoskeletal health research (CMHR). During my short academic journey, I was awarded the Young Investigator Transdisciplinary Research Award (2022-2023 and 2023-2024) from the bone and joint institute, Western University and the New Student Poster Award (2022). I also received the Scientific Excellence and Publication Award from Minia University for the years 2022 and 2023." Amr Mousa on the web Google Scholar Dr. GPCR Title: Balancing G Protein Selectivity and Efficacy in the Adenosine A2A Receptor About Louis-Philippe Picard "I earned my Ph.D. in Biochemistry, working under the guidance of Dr. Michel Bouvier, at the University of Montreal from 2015 to 2019. Currently, I am engaged in postdoctoral research in the laboratory of Dr. Scott Prosser. My primary research focus lies in gaining deeper insights into the structural mechanisms governing G protein-coupled receptors (GPCRs) and G protein activation. I employ a multidisciplinary approach that combines molecular pharmacology, biochemical assays, and biophysical techniques to unravel the intricacies of these processes." Louis-Philippe Picard on the web Google Scholar Dr. GPCR Title: Development of a Transgenic Mouse Platform for the Detection of Endogenous G protein Activity About Remi Janicot "After graduating as an undergrad from Ursinus College, I joined the Johns Hopkins School of Medicine to work as a lab tech in a neurophysiology lab investigating mechanisms behind pediatric epilepsy disorders. I then joined Boston University to pursue my scientific career as PhD student and joined the lab of Dr. Mikel Garcia-Marcos which investigates GPCR and G protein signaling" Remi Janicot on the web Boston University Dr. GPCR Title: Antibodies Expand the Scope of Angiotensin Receptor Pharmacology About Meredith Skiba "Meredith completed her PhD in Biological Chemistry with Janet Smith at the University of Michigan studying the biosynthesis of polyketide natural products using x-ray crystallography. She then joined Andrew Kruse’s lab for her postdoc in 2018 where she has employed protein engineering, receptor pharmacology, and structural biology to study how different types of ligands modulate angiotensin receptor signaling." Meredith Skiba on the web Harvard University University of Michigan Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

<< Back to podcast list Strategic Partner(s) Dr. Claudia Stäubert About Dr. Claudia Stäubert "I received my degree in biochemistry from Leipzig University (Germany) being already fascinated by G protein-coupled receptors (GPCRs) due to a stay as a scholarship student in the lab of Thue Schwartz (Copenhagen, Denmark). This fascination accompanied me and repeatedly challenged me ever since. During my Ph.D. at the International Max Planck Research School “The Leipzig School of Human Origins”, I focused on the evolutionary aspects of GPCRs. As a postdoc in the lab of Anders Nordström (Umeå, Sweden), I broadened my methodical and scientific horizon and focused on cellular metabolism and drug resistance phenomenon applying metabolomics analyses. Since 2014, I have led a research group at the Rudolf Schönheimer Institute of Biochemistry in Leipzig (Germany). We focus on several aspects of metabolite-sensing GPCRs including signal transduction, intracellular trafficking, and evolution. Our ultimate goal is to understand their role in immune cell function and cancer cell metabolism. " Dr. Claudia Stäubert on the web Stäubert Lab, Rudolf Schönheimer Institute of Biochemistry Leipzig LinkedIn ResearchGate ORCID ResearcherID Scopus Author ID Google Scholar PubMed Twitter Dr. GPCR AI Summary AI-generated content may be inaccurate or misleading. Always check for accuracy. Quick recap Yamina and Claudia had a wide-ranging discussion about Claudia's work on metabolites and their effects on the system. They also discussed the challenges of studying metabolites and their receptors, the relationship between metabolites, gut health, and disease progression, and Claudia's career journey in academia. They also explored the possibility of developing an ecosystem for the GPCR University. Summary Interview and Social Media Planning Yamina, from Dr. GPCR, discussed with Claudia, a guest from the Schiller Institute at Campstream, about Claudia's work and future plans. Yamina mentioned that they would use their discussion as a basis for crafting social media posts. Claudia, who has an interest in metabolites and their effects on the system, agreed. Yamina also pointed out that Claudia was their first guest of the year, indicating the start of a new series of interviews. Affordable Childcare and GPCR Research Discussion Yamina and Claudia discussed the importance of affordable childcare and the experiences of PhD students in the US and Europe. Claudia shared her experiences working in Sweden and Germany, and how she secured funding for her research on the effects of metabolites on GPCRs. Yamina expressed interest in attending a meeting about GPCRs and metabolism in the UK, but was unsure if she could make it due to travel constraints. Metabolite Activation of GPCRs: A Fascinating Discovery Claudia and Yamina discussed the role of metabolites in activating GPCRs, a process that they found fascinating. Yamina expressed interest in learning more about this topic as she realized her lack of knowledge on metabolite recognition or binding to GPCRs. Claudia suggested possible next steps, including researching review articles or articles to gain a higher understanding of what is known about this process. Challenges in Studying Metabolites and Receptors Claudia and Yamina discussed the challenges of studying metabolites and their receptors, particularly in relation to fermented foods. They acknowledged the difficulty of distinguishing between different compounds and the effect of media on the cellular system. They also explored the potential for better tools to understand and discover new metabolites or receptors. Yamina suggested the possibility of using native cells with optimized media, but Claudia highlighted the complexity of the system. They briefly touched upon the link between GPCRs and diseases, such as diabetes, but did not delve into detail. Metabolites, Gut Health, and Disease Progression Yamina and Claudia had a discussion about the relationship between metabolites, gut health, and disease progression. Yamina proposed that the metabolites in the gut of a non-healthy person might be different from those of a healthy person, which could affect receptor activity. Claudia agreed, suggesting that the complexity of the gut microbiome is akin to a "complicated city vicus". Yamina shared an example she heard in a podcast about fecal transplants and the relationship between the gut, brain, and metabolism. Both agreed on the complexity of the topic, with Claudia concluding that diseases might first affect the metabolites and not necessarily lack inherited genes. Academia, Career Journeys, and Advice Yamina and Claudia discussed Claudia's career journey in academia. Claudia shared her experiences and her love for her work, emphasizing the importance of research and learning in academia. Yamina highlighted the challenges of career choices, especially when family situations are involved. Claudia also mentioned the significant experiences that shaped her career trajectory, such as her time in an assurance lab and her trip to Sweden. Towards the end, Claudia offered advice to junior scientists, suggesting that they explore different fields and meet a variety of people to find their interests. She also mentioned her team's job openings and where people could find more information. Developing a Research Ecosystem at GPCR University Yamina and Claudia discussed developing an ecosystem for the GPCR University, with the goal of providing a central hub for researchers in the field. Yamina emphasized its vision for the platform to be a place where researchers can find content, ask questions, and collaborate, thereby avoiding the repetition of unsuccessful studies. They also touched on the potential for funding from external sources. Claudia briefly mentioned a recommendation from the Committee on Petitions. Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Strategic Partner(s) Dr. Arthur Christopoulos About Dr. Arthur Christopoulos " Arthur Christopoulos is the Professor of Analytical Pharmacology and the Dean of the Faculty of Pharmacy & Pharmaceutical Sciences, Monash University, Australia. His research focuses on novel paradigms of drug action at GPCRs, particularly allosteric modulation and biased agonism, and incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease. His work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular disease, obesity, diabetes, chronic pain and addiction. He has received substantial, long-term support from international and national competitive, charitable and commercial sources, as well as being academic co-founder of three GPCR-focussed biotechnology companies. Professor Christopoulos has over 360 publications, including in leading international journals such as Nature,Science and Cell, and has delivered over 180 invited presentations. He has served on the Editorial Board of 8 international journals and was a Councillor of the International Union of Basic and Clinical Pharmacology (IUPHAR). He has also been the recipient of multiple awards, including the John J. Abel Award and the Goodman and Gilman Award from the American Society for Pharmacology and Experimental Therapeutics; the Rand Medal from the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists; the British Pharmacological Society’s Gaddum Memorial Award; the IUPHAR Sir James Black Analytical Pharmacology Lecturer; the GSK Award for Research Excellence and a Doctor of Laws (Honoris Causa) from the University of Athens. Since 2014, Clarivate Analytics have annually named him a Highly Cited Researcher in ‘Pharmacology & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology & Biochemistry’. In 2017, he was elected a Fellow of the Australian Academy of Health and Medical Sciences, in 2018 as a Fellow of the British Pharmacological Society, and in 2021 he was elected a Fellow of the Australian Academy of Science for his seminal contributions to drug discovery. In 2023, he was elected a Fellow of the Pharmaceutical Society of Australia. " Dr. Arthur Christopoulos on the web Monash University Wikipedia Google Scholar LinkedIn Dr. GPCR AI Summary AI-generated content may be inaccurate or misleading. Always check for accuracy. Quick recap Yamina and Arthur from Monash University discussed Arthur's career journey, the importance of hard work, failure, and differentiation in academic and personal lives, and the value of international conferences. They also explored the significance of translating fundamental discoveries into clinical applications, the potential of new drugs, and the unique challenges within universities. Additionally, they discussed the importance of hiring based on differentiation, impact, and interest, the need for workforce development, and the potential of involving junior scientists and postdocs in their podcast. Lastly, they touched upon the global challenges of healthcare workforce growth, climate change, and emerging psychiatric disorders, as well as the importance of recording lectures and making pre-lesson materials available to students. Next steps - Yamina will share notes about PRISM and presentability with Arthur. - Arthur will share the story of PRISM's development and its impact on the field with Yamina. - Yamina will send an invite for a follow-up meeting with Arthur next Saturday at 9 PM. - Arthur and Yamina will prepare for the next meeting, focusing on the concept of biased agonism and discussing Dr. GPCR and the charity status. - Yamina will attempt to book Denise for a future podcast episode. Summary Arthur's Career Journey and Transition to Dean Yamina introduced Arthur to her team and discussed the use of a particular tool for meeting summaries. Arthur shared his career journey from pharmacy to becoming a professor, highlighting the influence of his mentors and the importance of his postdoctoral experience. They discussed the value of hard work, failure, and the significance of differentiation in their personal and academic lives. Towards the end, they focused on Arthur's transition to become Dean and his decision to move from Australia to the United States for a postdoctoral position. Postdoctoral Position, Scientific Dynamics, and New Drug Targets Arthur shared his decision to undertake a postdoctoral position with Nigel Bird's lab in the UK and his experiences of meeting influential figures during his time in the US. He and Yamina discussed the importance of preserving original work, the value of international conferences, and the dynamics between junior and senior scientists in a research environment. They also shared their admiration for the work of a mutual friend and discussed the history of muscarinic receptors, specifically focusing on the role of a compound that Arthur received from Fred. Lastly, they discussed the progress of new drugs targeting specific receptors for various diseases, with Arthur sharing insights on Eli Lilly's compound, Xanomeline, and the potential of M4 PAM for psychosis. Collaborative Research and Translational Approach Arthur and Yamina from Monash University discussed their collaborative approach to scientific research, emphasizing the benefits of combining their complementary skills and interests. They shared their unconventional approaches to research, including the creation of a critical mass of GPCR researchers in Australia and the initiation of a successful series of conferences. They also discussed the relocation of some university labs to facilitate collaboration and overcome the siloed department structure. Additionally, they explored the unique culture and structure of their Institute, highlighting its translational approach to research and its capacity to translate research into therapeutic commercialization. Lastly, Arthur shared three significant moments that shaped his career, including the evolution and impact of analytical pharmacology, particularly highlighting the role of Prism, a data analysis tool. Podcast Format, Team Culture, and Science Yamina and Arthur concluded their discussion and decided to take a short break. They talked about the format and length of their podcast, their professional interests, and their recent successful bid to bring Moderna to their university. They also explored the idea of starting a similar talk show format to 'Between Two Ferns', the importance of maintaining team culture, and the potential health issues among well-known scientists. Lastly, they discussed the growth and development of the Monash Institute of Pharmaceutical Sciences, the importance of knowing when to let go in scientific experiments, and the idea of a panel for building and incubating companies. Arthur's Pandemic Journey and Global Challenges Yamina and Arthur discussed Arthur's experiences during the Covid-19 pandemic, his journey as a research fellow in Australia, and his transition to the role of Dean. Arthur shared his insights into the unique grant funding system in Australia, the importance of impact in research, and the challenges of balancing administrative responsibilities with scientific pursuits. He also reflected on his personal health struggles, the growth of his university, and the faculty's successful response to the Covid crisis. The conversation also touched upon Arthur's career decisions, his scientific achievements, and the importance of learning from mistakes and self-confidence. Lastly, they discussed the global challenges of healthcare workforce growth, climate change, and emerging psychiatric disorders, as well as the importance of recording lectures and having pre-lesson materials available to students. Translating Discovery Into Clinical Application Arthur and Yamina discussed the importance of translating fundamental discoveries into clinical applications in their research, highlighting the unique opportunities presented by their location and partnerships with other institutions. They stressed the necessity of making their research goals clearer, avoiding replication, and adopting a more assertive approach in grant applications. They also emphasized the significance of fundamental discoveries, the role of biotech, and the need for efficiency and process development in university systems. The conversation highlighted ongoing challenges within universities, including resistance to change and the need to communicate expectations and protect established cultures. Hiring Process, Collaboration, and Education-Focused Initiatives Arthur emphasized the importance of differentiation, impact, and interest in their hiring process and fostering a culture of collaboration. He shared his vision of breaking down barriers and promoting education-focused initiatives, encouraging his team to be innovative and apply their skills to education. Yamina expressed a desire to learn from successful leaders and the importance of recognizing talent and matching it with the needs of a particular project. They also discussed the disruption within the pharmaceutical sector, the importance of workforce development, and the need for maintaining a healthy work-life balance. Lastly, they deliberated on involving junior scientists and postdocs in their podcast and the possibility of writing a book about their experiences in academia. Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Strategic Partner(s) Dr. Tobi Langenhan About Dr. Tobi Langenhan "I studied medicine at the University of Würzburg, where I obtained my license to practice and my Dr. med. degree in neuroanatomy. Then I moved to the University of Oxford on a 4-year Wellcome Trust Scholarship in Neuroscience, through which I gained an M.Sc. from Somerville College and a D.Phil. from Magdalen College Oxford, both in Neuroscience. For my doctoral studies, I joined the lab of Dr Andreas Russ at the Department of Biochemistry and first came across GPCRs, particularly the receptor family I have been investigating ever since: adhesion GPCRs. After returning to Germany I set up my own lab at the Institute of Physiology at Würzburg, where I later became Heisenberg Professor for 'Physiology and pathophysiology of mechanoceptive signalling pathways'. Shortly after was recruited to the Medical Faculty of Leipzig University, where I now head the Department of General Biochemistry at the Rudolf Schönheimer Institute. I work with invertebrate animal models (mainly D. melanogaster) and in vitro techniques to pick apart the physiological and pharmacological principles that underlie the workings of adhesion GPCRs in health and disease. This entails the deciphering of cellular and organ functions, which require individual adhesion GPCRs, and extends to the development of novel screening approaches to identify pharmacological modulators of human adhesion GPCRs." Dr. Tobi Langenhan on the web Langenhan Lab ORCID LinkedIn University of Leipzig Dr. GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Strategic Partner(s) Dr. Christel Menet About Dr. Christel Menet "I did my Ph.D. in Manchester UK with Prof Jonathan Clayden in organic chemistry. I then started my career at Evotec before moving to Domain Therapeutics (called Faust pharmaceutical at the time). After 2 years, I joined Galapagos where I spent almost 11 years and became head of medicinal chemistry. 6 years ago I decided to take on a new challenge by taking the position of CSO at Confo Therapeutics . I was the 6th employee and today we are more than 60 :) I have fun every day, and I love working with GPCRs. they are such great targets." Dr. Christel Menet on the web Hyphen Projects GPCRS Drug Discovery Confo Therapeutics LinkedIn Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Strategic Partner(s) Dr. Aurélien Rizk About Dr. Aurélien Rizk "Dr. Aurélien Rizk is a scientist and entrepreneur in drug discovery. He is Chief Scientific Officer and co-founder of InterAx Biotech, where he specializes in the development of a technology platform deciphering cell signaling pathways combined with AI-based approaches to elucidate structure to signaling relationship. During four years of postdoctoral research at ETH Zurich and the Paul Scherrer Institute in Switzerland, under the guidance of Prof. Gebhard Schertler, he developed methods for kinetic mathematical analysis of GPCR signaling. He also worked on creating novel methods for systems biology using temporal logic specifications while pursuing his Ph.D. at INRIA Paris-Rocquencourt, France. Before focusing on the development of innovative mathematical modeling and simulation methods for drug discovery, Dr. Aurélien Rizk co-founded Algorizk, a company that created real-time physics simulations for education, serving over 1 million users. His academic background includes studies in mathematics, physics, and computer science at the French Grande École, École Normale Supérieure de Cachan." Dr. Aurélien Rizk on the web InterAx Biotech Paul Scherrer Institut The Org LinkedIn Google Scholar Dr. GPCR AI Summary AI-generated content may be inaccurate or misleading. Always check for accuracy. Quick recap Yamina Berchiche and Aurelien Rizk engaged in a conversation about their professional backgrounds and current projects. They explored the potential of merging mathematical models with biology, the complexities of GPCRs within cells, and the applicability of technology to other fields. They also discussed the founding of a company focused on GPCRs, the transition from academia to the biotech sector, the evolution of a company that started with the development of technologies combining mathematical methods and a wet lab, and the importance of interdisciplinary teamwork in drug and technology development. They emphasized the significance of mathematical models in systems biology and pharmacology and the challenges of transferring information between different families of GPCRs. They wrapped up the conversation by discussing job opportunities at Interax Biotech and their anticipation for future interactions. Summary Professional Backgrounds and Projects Discussed Yamina Berchiche and Aurelien Rizk had a conversation about their professional backgrounds and current projects. Aurelien Rizk, a co-founder and CEO of Interax Biotech, shared about the company's development of a discovery platform for GPCRs and their focus on signaling pathways. He also talked about his past experiences in mathematics, physics, and computer sciences, and his involvement in developing mathematical models for various systems. The discussion concluded without any clear decisions, action items, or open questions. Integrating Mathematical Models and Biology: A Fascinating Discussion Yamina and Aurelien Rizk had a conversation about the importance of merging mathematical models and biology. They highlighted that while there was a time when biology lagged due to the lack of appropriate tools, it is now progressing faster. They found it fascinating to integrate both fields and the potential it holds. Aurelien Rizk mentioned the importance of being able to test and adjust predictions in real-life scenarios. They also touched upon the transferability of this approach across different systems, which Yamina found attractive. GPCRs, Software, and Fluid Dynamics Yamina Berchiche and Aurelien Rizk discussed the complexities of GPCRs within cells and the potential for applying models from one system to another. Yamina also questioned Aurelien Rizk about his interest in software, computer science, and mathematics. Aurelien Rizk shared his journey of using these disciplines in biology and how his company, Interax, came to be. The discussion ended with Aurelien Rizk sharing his current work on numerical simulations of fluid dynamics. GPCRs: A Focus for New Company Aurelien Rizk and Yamina Berchiche discussed the founding of a company focused on GPCRs and the potential applicability of the technology to other fields. Aurelien Rizk shared that he had always focused on GPCRs but had also worked on other types of receptors, indicating that the technology could be applied broadly. Yamina asked if there was ever a consideration to work on targets other than GPCRs, to which Aurelien Rizk explained that they chose GPCRs due to their wide application and potential impact. The conversation concluded with Yamina asking if Aurelien Rizk had a favorite GPCR to work on, though his response was not included in the transcript. Cell Signaling and Cancer Metastasis Discussion Aurelien Rizk and Yamina Berchiche had a detailed conversation about the intricacies of cell signaling and chemokine receptors. Yamina shared her research experience, emphasizing the fascination of understanding how cells respond to gradients and signals, particularly in relation to cancer metastasis. Aurelien Rizk also contributed to the conversation, highlighting the complexity of the process. However, the transcript is somewhat unclear and disjointed, making it difficult to summarize the specific points discussed. Academia to Biotech: Strategic Planning and Interdisciplinary Approach Yamina Berchiche and Aurelien Rizk discussed the differences between academia and the biotech industry, with Aurelien Rizk sharing his experiences transitioning from academia into the biotech sector. They highlighted the strategic importance of planning in the biotech sector due to limited funds and the need to show positive results when securing new investments. Aurelien Rizk also mentioned the interdisciplinary nature of his company, which includes mathematics, signaling pathways, a wet lab for data generation, and AI and computational chemistry. The discussion also touched on recent changes in leadership at Aurelien Rizk's company, with the introduction of a new CEO a year ago and the valuable contributions of Mark Levick, a former reviewer for the European Medicines Agency and CEO of a biotech company. Technology Evolution and Ligand Residence Time Prediction Yamina Berchiche and Aurelien Rizk discussed the evolution of the company, which started with the development of technologies combining mathematical methods and a wet lab to ensure the technology functioned. They validated their technology and made collaborations for expertise on chemokine receptors. The conversation also revolved around the company's ability to predict the residence time of a ligand and its potential correlation with a therapeutic effect or activation of a specific signaling pathway. The discussion concluded with the idea that ligand residence time could be an important factor in effective therapy. Therapeutic Effect and Receptor Interactions Aurelien Rizk and Yamina had a detailed discussion about the importance of gaining more information about the therapeutic effect in patients or animals and the dynamics of receptor interactions. They emphasized the need to quantify the dynamics of the pathways and the residence time of the receptor. Yamina raised a question about the transferability of information between different families of GPCRs and the possibility of generating a mathematical model for potential patterns. They also discussed the challenges of system dependency in data and the need to express data in a uniform way to apply models. Mathematical Models in Systems Biology and Pharmacology Aurelien Rizk and Yamina discussed the importance and relevance of mathematical models in systems biology and pharmacology. They reminisced about previous meetings and events, including a GPCR retreat where Terry presented his work. Yamina mentioned her struggle with the mathematical aspects of Terry's papers but acknowledged their importance in quantifying and removing system biases. They also discussed plans to offer a course with Terry, due to high interest. Towards the end, Aurelien Rizk shared his top three 'aha' moments as a scientist, emphasizing the importance of learning and controlling systems. Interdisciplinary Teamwork and Drug Development Yamina Berchiche and Aurelien Rizk emphasized the significance of interdisciplinary teamwork in drug and technology development, noting the challenges of communication and collaboration across different fields. They also shared their preference for small molecule therapies over protein therapeutics. Aurelien Rizk confirmed his attendance at the upcoming GPCR-Targeted Drug Discovery Summit in Boston. The discussion concluded with a brief overview of job opportunities at Interax Biotech, with Aurelien Rizk and Yamina clarifying that job openings are communicated via email and through their job board. They expressed their anticipation for future interactions. Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Strategic Partner(s) Dr. Adriano Marchese About Dr. Adriano Marchese Adriano Marchese is a Professor of Biochemistry at the Medical College of Wisconsin. Adriano received his Bachelor of Science degree in Pharmacology in 1991 from the University of Toronto. He continued his graduate studies at the University of Toronto where he earned his MSc (1994) and Ph.D. (1998) in Pharmacology. He then moved to Thomas Jefferson University in Philadelphia, PA, for his postdoctoral training in Jeff Benovic’s laboratory studying the regulation of G protein-coupled receptor trafficking and signaling. In 2004 Adriano joined the faculty of the Department of Pharmacology at Loyola University Chicago. In 2016 he decided to move his lab to the Medical College of Wisconsin in Milwaukee, WI. Adriano’s research has contributed to our understanding of the role that ubiquitin plays in GPCR signaling and trafficking. His laboratory is interested in understanding the mechanisms that govern spatial and temporal regulation of GPCR signaling by -arrestins and post-translational modifications (PTMs), such as phosphorylation, ubiquitination, and SUMOylation. His lab has shown a role for -arrestins and PTMs in GPCR trafficking and signaling and has leveraged this knowledge to reveal the spatial and temporal requirements for GPCR activation of signaling pathways related to cell survival, proliferation, and migration. The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic development. Dr. Adriano Marchese on the web Twitter LinkedIn Google Scholar Website Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Strategic Partner(s) Inês Pinheiro, Monserrat Avila Zozaya & Yamina Berchiche About Inês Pinheiro PharmD by training and Ph.D. candidate in Hartley's lab at the University of Geneva. As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and immuno-oncology. Inês Pinheiro on the web LinkedIn University of Geneva Twitter Dr. GPCR Ecosystem About Monserrat Avila Zozaya I am a cell biologist interested in studying GPCRs, especially adhesion GPCRs. Motivated by my scientific passion, I recently started a postdoctoral fellowship to study the role of GPCRs in the mechanisms of pain and its comorbidities. Monserrat Avila Zozaya on the web Antony Boucard Lab Dr. GPCR Ecosystem About Yamina Berchiche Dr. Yamina A. Berchiche is the founder of Dr. GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors (GPCRs), that control virtually everything in the body, as drug targets. The mission of Dr. GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the field and providing exposure to scientists through the Dr. GPCR podcast. Dr. Berchiche obtained her Master’s and Ph.D. in Biochemistry at the University of Montreal in Canada before training at The Rockefeller University in New York and the National Institutes of Health in Bethesda, Maryland. She developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell bioluminescence resonance energy transfer (BRET). Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the body. Yamina Berchiche on the web Website LinkedIn Facebook Twitter ResearchGate PubMed Google Scholar Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>