Search Results
Results found for "GPCR research community"
- Beyond Clearance: The Strategic Power of Irreversible Drug Binding
GPCR members save 50%+ with your Weekly News code. 👉 Join Terry’s Corner & Secure Your Spot for the Kenakin with your own enzyme or GPCR interaction puzzles.
- Targeted Activation of G-Protein Coupled Receptor-Mediated Ca 2+ Signaling Drives Enhanced Cartilage
This study demonstrated Gαq-G-protein coupled receptor (GPCR)-mediated [Ca2+]i signaling involvement cartilage-like matrix production, and it established hM3Dq as a powerful tool for elucidating the role of GPCR-mediated
- Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa
These disorders are mainly related to the abnormalities in the rod G protein-coupled receptor (GPCR),
- Prostaglandin signaling in ciliogenesis and development
Many G-protein-coupled receptors (GPCRs) including EP4 are localized in cilia for modulating cAMP signaling
- Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas ...
and review Odorant receptors (ORs) account for about 60% of all human G protein-coupled receptors (GPCRs Glioma is the most common adult malignant brain tumor and requires novel therapeutic strategies to improve
- Applications of Cryo-EM in small molecule and biologics drug design
cryo-EM has enabled insights into important drug target families such as G protein-coupled receptors (GPCRs
- Engineered synaptic tools reveal localized cAMP signaling in synapse assembly
Given that postsynaptic latrophilin adhesion-GPCRs drive synapse formation and produce cAMP, we suggest
- Disentangling bias between G q, GRK2, and arrestin3 recruitment to the M 3 muscarinic acetylcholine
G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular
- On-cell nuclear magnetic resonance spectroscopy to probe cell surface interactions
characterize ligand interactions with cell surface membrane proteins such as G-protein coupled receptors (GPCRs
- Target Residence Time: The Hidden Driver of In Vivo Efficacy
And when receptors are dense (like GPCRs on membranes), this rebinding hits the collisional limit , where
- Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors
"The effects of the neurohormone melatonin are mediated by the activation of the GPCRs MT1 and MT2 in
- Reflections on My PhD Journey: Lessons Learned
environment, paired with a supportive supervisor, laid the foundation for a fulfilling and productive research Supervisors not only guide your research but also shape your academic and professional growth. These mini "journal clubs" kept me informed about the latest research and sharpened my critical thinking choose a lab and mentor that align with your values and goals, embrace the discipline of structured research challenges will test your resolve, but every small victory along the way shapes you into a stronger researcher
- New role of β-arrestins in MOR signaling
in the U.S., combatting the opioid overdose epidemic has become a mean challenge for the scientific community Opioid receptors belong to class A of G protein-coupled receptors or GPCRs and signaled mainly through Biochem Biophys Res Commun. 2023 Jan 15;640:64-72. doi: 10.1016/j.bbrc.2022.11.098.
- Synaptic integration of subquantal neurotransmission by co-localized G protein coupled receptors in
Colocalization of different actions of GPCRs provide synaptic integration within presynaptic terminals
- HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G 1/S cycle
dependent kinase inhibitor 1B; CQ: chloroquine; E2F1: E2F transcription factor 1; FBS: fetal bovine serum; GPCRs
- Understanding Orthosteric Binding: The Key to Drug Action
This foundational knowledge guides researchers in the development of new therapeutics. By considering factors like the Langmuir adsorption isotherm and binding curves, researchers can better
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial ...
Exendin-4, and possibly through G protein-coupled receptors (GPCRs), increases levels of cAMP and upregulates
- SLAS2022 International Conference and Exhibition
any changes made that will impact our ability to hold the event in-person, we will notify the SLAS community Don't miss the chance to present your innovative research at this year's conference.
- TeachOpenCADD - A teaching platform for computer-aided drug design
both the theoretical as well as practical aspect of these topics, the platform addresses students and researchers Topics are continuously expanded and open for contributions from the community.
- From Ox Liver to AI: How the History of Pharmacology Shapes Its Future
What do roasted ox liver and AI-powered virtual screening have in common?
