Search Results

Many G-protein-coupled receptors (GPCRs) including EP4 are localized in cilia for modulating cAMP signaling

The turning point came during her master’s program in pharmacogenomics. And GPCR pharmacology isn’t just an academic pursuit—it’s essential to understanding and responding to

Further difficulties arise from the existence of cross-reactivity with other GPCRs and differences in of chemokine receptors which are regulated by globular protein ligands, unlike most of the class A GPCRs

cryo-EM has enabled insights into important drug target families such as G protein-coupled receptors (GPCRs

Retrograde trans-synaptic rabies virus tracing revealed that postsynaptic cAMP signaling is required Given that postsynaptic latrophilin adhesion-GPCRs drive synapse formation and produce cAMP, we suggest

G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular

characterize ligand interactions with cell surface membrane proteins such as G-protein coupled receptors (GPCRs

"The effects of the neurohormone melatonin are mediated by the activation of the GPCRs MT1 and MT2 in

their functional activities are achieved by binding to the cell surface G protein-coupled receptors (GPCRs

is a key protein that mediates desensitization and internalization of G protein-coupled receptors (GPCRs

dependent kinase inhibitor 1B; CQ: chloroquine; E2F1: E2F transcription factor 1; FBS: fetal bovine serum; GPCRs

Opioid receptors belong to class A of G protein-coupled receptors or GPCRs and signaled mainly through Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain.

Exendin-4, and possibly through G protein-coupled receptors (GPCRs), increases levels of cAMP and upregulates

Think of it like catching a train: two passengers have tickets (affinity), but only the one who sprints Unlock “Kinetics: Advanced Applications” Only in Terry’s Corner Why Terry’s Corner Most pharmacology training

Each program appears to increase optionality and reduce risk. 👉 This is where strategic overload begins When multiple programs advance at the same time, trade-offs become implicit instead of explicit. The problem is not that there are multiple programs. If one program slows, another might accelerate. Letting go of a program can feel like abandoning potential value.

Scientific Thinking — and Why They Break Down in Biotech Operations Leadership   👉 Scientific thinking trains the window of opportunity has often closed.   3️⃣ “Deep analysis leads to better answers” Scientific training

They are not there to confirm what works; they are trained to identify what might break later . Because by the time they do, your timelines will stretch, your budgets will strain, and your confidence

It is that biotech founders are trained to trust scientific momentum , while financial risk builds silently

PK errors no longer dominate failure statistics, but fundamental blind spots still derail programs Kenakin shows that programs fail when these questions are skipped, deferred, or answered implicitly instead

In my case, I was fortunate to be part of a program that allowed for lab rotations.

Corner Your work demands clarity, speed, and confidence, especially when early decisions determine which programs

The Spark of Addiction Science After two years in industry, Catherine enrolled in a master’s program

Open source programming packages for cheminformatics and structural bioinformatics are powerful tools

Programs move forward because they sound fundable, not because the data justifies the timing.

company mantra Investor communication feels reactive and apologetic Key documents live in the CEO’s brain

Over time, this constant adjustment drains confidence and momentum, even when the science is strong.

Teams that skip this step carry an invisible scope that slowly drains focus. 4️⃣ How decisions will be