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Results found for "ASPET"
- Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C...
potency, we present the PKC KO cell lines as more specific research tools to investigate PKC-mediated aspects
- Targeting Intracellular Allosteric Sites in GPCRs
endogenous orthosteric activity, therefore having the potential to maintain the temporal and spatial aspects Advances in understanding the structural and mechanistic aspects of biased GPCR signaling are crucial
- Phenylalanine 193 in Extracellular Loop 2 of the β 2-Adrenergic Receptor Coordinates β-Arrestin ...
adrenergic receptor (β2AR) is a prototypical and extensively studied GPCR that can provide insight into this aspect
- Navigating the Signaling Network: RTK and GPCR Crosstalk Uncovered
One fascinating aspect of the cellular signaling network is the crosstalk between G protein-coupled receptors
- Is Your GPCR Drug Discovery Program Built for Breakthroughs or Breakdowns?
Learn how to build an integrated data pipeline that transforms this chaos into a strategic asset.
- G protein-coupled receptor kinase 2 is essential to enable vasoconstrictor-mediated arterial ...
As GRK2 is implicated in controlling various aspects of cellular growth, we examined whether GRK2 could
- 📰 GPCR Weekly News, June 3 to June 9, 2024
sponsorship opportunities for this exciting event, which brings together scientists worldwide to explore all aspects
- TM5-TM6: structural switches that modulate the coupling of serotonin receptors to Gs or Gi
of G proteins, so the comparison and structural analysis of these complexes revealed two important aspects
- Orthosteric vs. Allosteric Interactions: The Silent Decider of Safety and Success
The Mechanistic Edge Behind Smarter Drug Discovery One of the most powerful aspects of this session is
- Optimizing HTRF Assays with Fluorescent Ligands: Time-Resolved Fluorescence in GPCR Research
HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications
- 📰 GPCR Weekly News, May 20 to 26, 2024
also seeking sponsors to support this exciting event that unites scientists worldwide to explore all aspects
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
This technique has uncovered fundamental aspects of the G protein-coupled receptor (GPCR) function, including
- 📰 GPCR Weekly News, May 27 to June 2, 2024
sponsorship opportunities for this exciting event, which unites scientists worldwide to explore all aspects
- Competitive vs Non-Competitive GPCR Antagonists: How to Interpret Pharmacology Data with Confidence
Gain a competitive edge by transforming your GPCR data from chaos into a strategic asset, enabling faster
- Why Biotech Fundraising Fails Due to Intellectual Property Gaps
. 👉 An early red flag appears when intellectual property is treated as a static asset.
- The Hidden Burn: How Internal Misalignment Drains Your Biotech’s Runway
But if you catch it early and fix it decisively, alignment becomes one of your strongest strategic assets
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
endogenous orthosteric activity, therefore having the potential to maintain the temporal and spatial aspects
- A robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.
HTRF: A Technology Tailored for Drug Discovery - A Review of Theoretical Aspects and Recent Applications
- Fluorescence based HTS compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells
Altogether, these aspects hint that the linker design and strategy can provide options for the tuning
