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Results found for "Chris Evans"
- How a Failed Med School Dream Sparked a GPCR Biotech Revolution
It’s about how moments of redirection — even disappointment — can open new paths to impact.
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
Surprisingly, this interaction did not result in G12 activation, even in the presence of GTP, which is
- Your GPCR Program Decisions Depend on Good Data Interpretation
But Terry Kenakin’s new Emerging Drug Hunter lecture reveals why this assumption can mislead even experienced
- A Note from Yamina: Building the Next Chapter of Dr. GPCR
This year, we hosted in-person Happy Hours in Boston (one even sponsored!)
- Optimizing HTRF Assays with Fluorescent Ligands: Time-Resolved Fluorescence in GPCR Research
This means that even if one of the ligands they are bound to is promiscuous, it will not compromise assay
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
The gravity of this regulation becomes even more apparent when we consider the potential consequences
- Assay Sensitivity: The Hidden Lever Driving GPCR Drug Discovery
. ✅ Why adjusting system sensitivity can uncover hidden efficacy, silent antagonism, or even inverse
- Therapeutic validation of an orphan G protein‐coupled receptor
Some studies have also reported GPR84 involvement in pain, atherosclerosis, and even metabolic disorders
- Advantages of Fluorescent Probes in GPCR Assays
At Celtarys, we focus on developing fluorescent tools that keep minimal background signal even without
- Competitive vs Non-Competitive GPCR Antagonists: How to Interpret Pharmacology Data with Confidence
the wrong interpretation of antagonist behavior can derail your conclusions, your experiments, and even
- The Hidden Burn: How Internal Misalignment Drains Your Biotech’s Runway
They have strong early data and an even stronger burn rate. Everyone’s busy. No one’s clear.
- 📰 GPCR Weekly News, May 13 to 19, 2024
And here's something even better: the video versions of our podcast episodes are now available to the
- From Failed Experiments to Predictive GPCR Models
At one point, he even questioned whether research was the right career for him.
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
absence of G proteins (Gether 2000), with numerous intermediate sub-states in between (Vauquelin and Van and can differ in intrinsic efficacy; 2) partial agonists are incapable of inducing maximal activity even
- Glyco-sulfo hotspots in the chemokine receptor system
In addition, tyrosine sulfation is heterogenous between cell lines or even on the same cell (Scurci I
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
Baek et al., 2021) allow the prediction of the 3D structure of a protein from the amino acid sequence even
- Structural landscape of the Chemokine Receptor system
US28 evolved high constitutive activity to evade host immunity, whereas ACKR3 functions as a homeostatic
- A robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.
validation, a larger range of compounds will be tested, including screening chemical libraries with even 999. (12) Martín-Fontecha, M.; Angelina, A.; Rückert, B.; Rueda-Zubiaurre, A.; Martín-Cruz, L.; Van , S.; Beck, J.; Nettekoven, M.; Benito-Cuesta, I.; Grande, T.; Drawnel, F.; Widmer, G.; Holzer, D.; Van V.; Van Der Stelt, M.; Pacher, P.; Gertsch, J.; Ullmer, C.; McCormick, P. J.; Oddi, S.; Spaink, H.
