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Gq-bound conformations ♦️ Comparison with Gs-bound PTH1R ♦️ Strategic implications for biased agonist design

circuits — insights that inform next-generation functional assay development and translational therapeutic design changed our understanding of GPCR signaling in metabolic tissues What collaborative chemistry enabled in designing

The episode explores gpcr internalization , fluorescence-based probe design, and how functional assay academic tool development to real-world adoption Balancing innovation with validation in GPCR assay design By combining fluorophore design, ligand chemistry, and pharmacology, his work enables precise visualization

provide a molecular explanation of small molecules for their pre-clinical efficacy and to support the design

If you work with GPCRs, this perspective changes how you design experiments and interpret data. 🎧 Watch

It shaped how we design experiments, make decisions, and lead teams. In this week’s Dr.

Jens Carlsson on predictive modeling—where structure-based design and MD guide experiments (and where

We designed the Ecosystem to support your work —no matter where you are in your GPCR journey. contributing behind-the-scenes tools and insight What Makes the Ecosystem Different Built for Drug Discovery Designed by scientists in the GPCR space to accelerate your research goals Collaborative by Design Connects researchers

The kind of impact that shows up in how experiments are designed, which compounds get prioritized, and

Whether you’re running simulations, screening compounds, or designing next-gen molecules, this insight

pharmacologically relevant population Compatibility with live cells, tissue, and deep-imaging setups A design

I have extensive training in computer-aided drug design.

current interests include the development of HTS fluorescence-based kinetic binding assays specifically designed

He explains what chemical design can solve that antibodies can’t, how to validate functional assay systems Why this matters How a chemist with zero biology training became a leader in GPCR probe design.

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors

years of applied discovery experience from Terry Kenakin distilled into practical, modular lessons designed

Up Logo Contest Enter our logo contest for a chance to have your design represent the upcoming event.

Medicine for their discovery of G-proteins and their role in signal transduction in cells, Paul was designated

By integrating molecular docking, molecular dynamics, and machine learning, they design ligands with uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn’t consciously design

With a deep focus on structure-based drug design, Jens discusses how his lab bridges simulation and experiment—and Outside academia, he advises companies through a consulting arm focused on ligand design strategy.

understand the mechanism and structural bases for ligand binding and efficacy to help optimize the design The Sunahara lab has also been developing protein-based therapeutics using structure-guided design and

Discover our comprehensive Trademark Policy designed to protect the integrity and uniqueness of Dr. Buttons And Badges Guideline These guidelines provide you with the design specification for various Dr GPCR Logo in different marketing materials, such as a new T-shirt design, a toy, software packaging, These trademarks include the Logo, Buttons, Badges, Website Design, and other pictures and graphic designs

her team made considerable breakthroughs in the field of GPCR stabilization and structure-based drug design

Action-oriented : Conversations designed to spark collaborations, not just chatter. How It Works?

To this end, her lab uses several computational structural biology tools and rational drug design approaches

antibodies targeting GPCRs by incorporating these natural binding partners into Twist’s antibody library design

Access expert-led courses, 200+ talks, community tools, and curated insights designed to keep your team

About Joshua Gross "I am a neuropharmacologist interested in exploiting GPCR biased signaling to design

— submit topics you and your team want covered next Weekly new courses — stay ahead of the science Designed

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors