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Premium Membership pricing increases in 2026, and the 67% Terry’s Corner discount is going away. This year brought 20+ podcast episodes, 40% audience growth, and an 811% increase in new listeners. contributors Launch of The Foundry , supporting strategy and CRO alignment In-person community moments, including

You may see: Early stopping → potency distortions Different stopping times → incomparable datasets Curve

In this episode, JB pulls the curtain back on the mindset and tactics he’s used for years—including the

AI-assisted probe design Multi-receptor visualization in complex tissue The dream is ambitious and increasingly

They are signs of strategic incompleteness .

Live-cell high-content screening (HCS) offers an increasingly valuable alternative. , 16 synthetic cannabinoid receptor agonists (SCRAs) were evaluated using a CB2 live-cell HCS assay incorporating Because imaging is captured across thousands of intact cells, each measurement incorporates receptor Moderate displacement (50–70%) :  AV18A (68.83%), AV11 (60.78%) Low displacement (<50%) :  Compounds including Representative HCS images illustrating CELT331 binding (red) and Hoechst-stained nuclei (blue) across increasing

When David later shared early data — including a moment where he realized he could image an entire islet Antibodies As JB continued exploring the biology, a major obstacle emerged: validated antibodies for GPCRs, including GLP-1R, were inconsistent and incompatible with high-resolution imaging. David picked up unexpected chemistry insights — including a well-loved lesson involving acetonitrile They’re also performing increasingly complex imaging experiments that capture receptor dynamics in intact

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Orthosteric dose increases drive continuously stronger responses; NAMs and PAMs have structural ceilings A partial agonist appears neutral until expression or coupling is increased. Dr. NAMs, PAMs, and Subtle Mechanistic Traps Modulators are frequently labeled correctly but characterized incompletely These nonlinearities matter: Competitive inhibition decreases as substrate increases. Uncompetitive inhibition strengthens as substrate increases—opposite of intuition.

In research, including the GPCR world collaboration isn’t a luxury. It’s survival. To understand how incretin receptors behave in intact tissue, Hodson needed people who saw problems differently Hodson’s group felt the impact directly: imaging incretin receptors in intact islets and brain slices And interactions with GLP-1 pathways were inconsistent.

several performance-limiting factors: variable cell behavior, imaging artifacts, batch effects, and incomplete In this blog, you’ll learn:  How HCS works and why it is increasingly central to GPCR-based drug discovery However, their limitations become increasingly important as drug discovery moves toward high-information Key limitations of radioligand assays include:  • No spatial information  — signals are measured in bulk Incorporating internal controls, including known agonists or antagonists, allows normalization and facilitates

Here, the Schild plot becomes a diagnostic tool  rather than a checkbox test: Slopes >1  often mean incomplete Common revelations include: Mixtures of receptor subtypes  producing hybrid response patterns. Incomplete equilibration , where kinetics distort linearity.

In research, acting on incomplete or shaky data can destroy your credibility. Startups demand something different: ✅ Clarity of direction even when the picture is incomplete.

scientists embedded as “connectors” between programs This design had a strategic effect : talent density increased notes that the absence of individual ownership over physical space or specialized equipment removed the incentives Biotech teams, CRO alliances, and academic consortia face the same challenge: how to align incentives

These weren’t quaint inconveniences. They shaped how questions were asked.

. • Inclusive Growth : More access for developing nations, new instructors welcome, and global partnerships FAQ 🔹 What’s included?

drug matter beyond the familiar and encourages deliberate exploration of chemical novelty, rather than incremental They offer high specificity , favorable safety , and unique mechanisms , including GPCR modulation through

partners, and GPCR experts to help teams move faster — from idea to discovery — while reducing risk and increasing The Foundry will also include Yamina’s Consulting Corner — a place for teams to get tailored scientific For the first time, University courses will be included in Premium Membership , giving members full access GPCR is evolving — thoughtfully, inclusively, and sustainably.

Over time, that transparency has built enduring partnerships , including one of Carlsson’s earliest with explain why collaborators return, why projects move forward, and why his model of collaboration is increasingly

Common questions in the group include: Can we forecast ligand efficacy or selectivity?

Allosteric modulators and biased ligands aren’t exotic outliers—they’re increasingly common outcomes

This week's highlight includes congrats to: Miles Thompson , Alexander Hauser , Caroline Gorvin ,   et

Today, his group includes around ten computational chemists and one in-house medicinal chemist. Unlike protein sequences, small molecule data are often fragmented, inconsistent, or unavailable, making For early-career researchers, the takeaway is direct: GPCR drug discovery will increasingly depend on

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These include overexpression, tags, and fluorescent imaging.

Join leading scientists to investigate the most recent advancements in GPCR-targeted drug development, incorporating

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Your Membership Includes: Frameworks proven in real discovery programs On-demand lessons  designed for

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Why This Matters: The GPCR toolkit scientists use today—cAMP, IP-One, and now pHSense—didn’t evolve incrementally