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Marc Caron Tribute Episodes ( #100 , #101 & #102 ), featuring over 30 expert guests , including Dr.

For Schulte, the scarcity of pharmacological tools is not just a technical inconvenience — it is the His lab investigates the molecular mechanisms of frizzled receptor activation, including G-protein coupling old adenosine receptor times, that we have the small molecule available and get crystal clear tenfold increase

His group contributed to the de-orphanization of GPR139 and GPR55, including the identification of sub-nanomolar

GPCR-relevant society memberships cost $200–$600+ per year and offer a fraction of what University includes

His numerous awards include: 2008 Sato Award; 2009 Medicinal Chemistry Hall of Fame (American Chemical

Kim describes a personal inclination toward challenging research areas. GPCR Drug Discovery Is Increasingly Structural Modern GPCR drug discovery increasingly integrates structural Showing those structures to my colleagues—and realizing that the experiment actually worked—was incredibly

remotely; the continuity of receptor pharmacology work already in the pipeline before the shutdown, including

Randy has received a number of research prizes, including the PhRMA New Investigator Award, the Distinguished

The discussion also explores GPCRs beyond the cell surface — including caged ligands designed to drug Hebert argues this was not a failure of the concept but of incomplete pharmacological characterization Hebert's lab is transitioning to iPSC-derived cardiomyocytes and fibroblasts, including cells from patients

) and arrestins as GPCR regulators and as mediators of distinct signaling pathways through partners including In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

novel paradigms of drug action at GPCRs, particularly allosteric modulation and biased agonism, and incorporates Professor Christopoulos has over 360 publications, including in leading international journals such as He has also been the recipient of multiple awards, including the John J. GPCR AI Summary Quick recap Yamina and Arthur discussed Arthur's career journey in pharmacology, including Arthur shared his career journey, including his collaboration with Patrick Sexton and Jim Burch, and

calcium-sensing receptor, the molecular mechanisms governing their activation and regulation remain incompletely with their respective subunits, leading Fan to propose they are necessary structural components - not incidental spasticity in multiple sclerosis and spinal cord injury, but it carries significant side effects - including aha" moments that shaped a career - from MHC antigen presentation to the cryo-EM revolution 29:55 - Increasing

Successful GPCR research increasingly depends on close collaboration between these two domains. If the experimental data is poorly annotated or incomplete, the computational predictions will not be The terminology used in the literature is inconsistent.

conditioning around deference, the general insecurity of early-stage training, and the fear of appearing incompetent

Current focuses include GαQ-driven uveal melanoma, GαS mutations across pancreatic, colon, and appendix Most large cancer sequencing panels now include these genes — though most oncologists are still unsure That insight is now powering focal adhesion kinase–directed clinical trials, including one Dr.

distinction opened space for a more nuanced view of bitter compounds in nutrition and pharmacology - including screen extensively for efficacy, safety, and pharmacokinetics - but bitterness prediction was rarely incorporated

novel paradigms of drug action at GPCRs, particularly allosteric modulation and biased agonism, and incorporates Professor Christopoulos has over 360 publications, including in leading international journals such as He has also been the recipient of multiple awards, including the John J. They shared their unconventional approaches to research, including the creation of a critical mass of The conversation highlighted ongoing challenges within universities, including resistance to change and

early cloning of GPCRs in the mid-1980s and has since pushed the boundaries of GPCR biochemistry — including Most pharmacology datasets aren't useless for ML; they're incomplete. Buffers, incubation temperatures, time points, co-expression conditions, the specific Emax reference

His experience also includes translating knowledge generated into the selection of targets, screening co-founder of both Caldan Therapeutics (2015) which discovers novel therapeutics for metabolic diseases including Type 2 Diabetes and other indications including non-alcoholic steatohepatitis (NASH) and inflammatory

communicating across technical audiences — and introduces concrete tools for self-assessment and exploration, including Function over title Job titles in biotech are often creative and inconsistent — a medical science liaison

research focuses on understanding the fundamental cell biological mechanisms regulating GPCR activity, including

My postdoc work has made use of several techniques including various mass spectrometry approaches, single Besides research, I am passionate about teaching, science communication and making research more inclusive He participated in various academic competitions, including math, physics, and chemistry contests. He also discussed the challenges of choosing between job offers, including considering his wife's career

Badr worked in various science labs, including Dr. Christian Badr’s and Dr.

His postdoctoral training included research at the École Polytechnique Fédérale de Lausanne (2015–2016

and activation mechanism of this family of G protein-coupled receptors using innovative approaches, including

In my role at Orion Biotechnology, I work at the intersection of science and business, which includes Caron has received numerous awards including a Burroughs Wellcome Fund Career Award in the Biomedical Slosky’s work has been recognized through several travel and research awards, including the William James Slosky is passionate about training the next generation of scientists and increasing diversity, equity , and inclusion in science.

Majellaro Her decisions, often made intuitively rather than analytically, have led to key inflection points—including The company works with clients from pharma, CROs, and academia, including MD Anderson and several leading

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GPCR Podcast; her earlier episode covers her scientific profile in depth, including her research trajectory whole conversation: the structural shifts forced by the shutdown — planned reflection, remote meeting inclusion

academic group in Graz, she spent six and a half years at Novo Nordisk in early drug discovery, focused on incretin With comorbidities and aging populations driving drug discovery, the one-receptor-one-drug frame is increasingly eyeing industry or biotech 42:35 — On starting a GPCR company: why not too early 57:30 — Aha moments, including