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with Purpose Joe’s personal mission— to make a positive impact on people’s lives —drives their client selection

pitfalls and what assay system choice does to bias estimates Translating pathway-level data into lead selection

taste receptors far beyond the tongue - 29:54 Aha moments, mentorship, and advice for junior scientists Selected

Selected Quotes "If you had asked me in 2008 if I would be a recruiter slash career coach, I didn't even

career 12:20 Rotation students as the sorting hat 13:20 When the working hypothesis fails 14:30 Closing Selected

self-contained blocks 04:47 The Zoom effect — quieter voices speaking up 05:49 Closing reflections 06:01 Outro Selected

Selected Quotes "This mutant mosquito disrupting a single gene and changing this incredibly strong behavioral

collaboration with Patrick Sexton and Jim Burch, and the discovery of hybrid molecules with functional selectivity

infrastructure breaks down at national scale 10:16 Lessons for the next one, and the shape of the new normal Selected

“Let’s embrace the challenge to study all of them… they’re unique in how they bind ligands, how selective

:28 The hidden cost of being the only one in the room 57:05 What the pandemic did to a mouse colony Selected

connecting with the field 01:02:48 Eureka moment - patterns across the whole receptor family, read by eye SELECTED

Vaccine development speed and public trust 33:40 Staying sane — pickleball, walking, and community Selected

The aha moment: gut microbes, a GPCR, and blood pressure 39:58 Diversity as everyone's responsibility Selected

SELECTED QUOTES "Research is a privilege, it isn't a right."

Selected Quotes "The very simple concept is that GPCRs do not need to be mutated to be oncogenic."

:43 A weekly release cycle built around user feedback 24:13 Why vaccines still take eighteen months Selected

58:34 Three aha moments - a diffraction pattern, a thermostabilization screen, and a synchrotron SELECTED

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and knowing your worth 02:05:22 Top three aha moments from a career in pharmacological data analysis Selected

Selected Quotes "We tried to look for bias and classify our drugs, new and standard drugs, according

Selected Quotes "My computational team told me, 'this receptor is not using arrestin to internalize.

stay humble, give back 01:01:55 What pharmacologists bring to drug discovery that nobody else does SELECTED

compounds in Western diet 50:13 - Advice for junior scientists and resources for the GPCR community SELECTED

moments: the G-protein mini-gene origin and finding an inverse agonist where none had been reported SELECTED

Selected Quotes “Computational work allows you to look at data from a different perspective and identify

week Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity equilibrioception GPCR Activation and Signaling Extensive location bias of the GPCR-dependent translatome via site-selective Function Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity

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A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Adam GPCR Function A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity