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Who I Work With ✅ Biotech Teams  – Especially those lacking in-house GPCR leads or overwhelmed by CRO Let’s talk through your program—no pitch, just clarity.

physiological and disease functions, yet knowledge of their role in colon cancer stem cell maintenance is still lacking

in endothelial cells, which was evidenced by the attenuation of organ fibrosis in mice specifically lacking

A panel discussion will tackle best practices for measuring GPCR signaling bias in vitro and what that

The panels are packed. Everyone’s rushing from one talk to the next. But the truth?

Currently-approved treatments have improved patient outcomes, but therapies to stop or reverse HF are lacking

They happen in the hallway between sessions, at the coffee station, or in the ten minutes after a talk It's the size where you can actually talk to everyone in the room. Where you walk away with a handful of connections that actually go somewhere, not a stack of business Their deorphanisation track record (17 identified natural receptor-ligand pairs) speaks to the depth

Procrastination may seem tempting, but tackling your work incrementally will save time and reduce stress

However, researchers faced a challenge with the target C5aR , as they lacked the appropriate tools to However, there is a notable lack of fluorescent probes available in the market for this receptor.

After a brief pause over the holidays and last month, we’re back in full force—designed to help you make

extracellular N-termini by 31 amino acids, but detailed insights into their functional differences are lacking

The Era of Cold Fingers and Patience Back then, GPCR signaling experiments weren’t elegant; they were

It was supposed to be just a summer project—routine pipetting, repetitive assays, a box to tick before Many GPCR scientists trace their origin story back to a single unexpected spark. Not a grand plan.

This technique can acquire three-dimensional image stacks, facilitating the reconstruction of GPCR distribution If the experiment is done on live cells , tracking real-time receptor internalization becomes possible

Welcome back GPCR Fans, Clean data can still mislead if the underlying assumptions aren’t tested.

With this high-resolution, dynamic view of GPCR activation, scientists can better tackle diseases by

We highlight this article by Tahk et al.  

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already

quantification of SST2/SST5 dimerization in rat GH3 as well as in human melanoma cells either expressing (A7) or lacking

stall not because the target is wrong—but because the chemical matter  interacting with that target lacks

To tackle these, the lab employs molecular docking, molecular dynamics simulations, and ligand-based

or pharmacological activation of endogenous Ca2+ signaling transducers; however, such approaches can lack

And once you see it, you’ll never go back.

And once you make that shift, you’ll never go back.

It was mostly just because, I need to be back in the lab.”

Using CRISPR-Cas9 knockout HEK cells lacking Gs proteins, a study by Stallaert et al. in 2017 showed

Upcoming events:  “Drug Discovery at Superluminal Speeds”; and Discovery on Target 2025—GPCR track you Expect practical guidance on TR-FRET compatibility, photobleaching resistance, and 3D stack acquisition druggability 🔹 The role of cryo-EM in capturing fully activated GPCR complexes 📅 Catch Aaron’s full talk at Discovery on Target, Sept 24–25 in Boston. 🎥 Plus, join us at the GPCR Track, GPCR Happy Hour, and

With over 21,000 views  and 7,785 downloads  from Volume I, the Signal Transduction  Research Topic is back

Jack Antel to its clinical advisory board Crinetics Pharmaceuticals First Quarter 2023 Earnings: Revenues

Premium members can always go back and watch the recorded talks at any time. A corazonin G protein-coupled receptor gene in the tick Ixodes scapularis yields two splice variants,