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It was supposed to be just a summer project—routine pipetting, repetitive assays, a box to tick before Many GPCR scientists trace their origin story back to a single unexpected spark. Not a grand plan.

This technique can acquire three-dimensional image stacks, facilitating the reconstruction of GPCR distribution If the experiment is done on live cells , tracking real-time receptor internalization becomes possible

With this high-resolution, dynamic view of GPCR activation, scientists can better tackle diseases by

Welcome back GPCR Fans, Clean data can still mislead if the underlying assumptions aren’t tested.

quantification of SST2/SST5 dimerization in rat GH3 as well as in human melanoma cells either expressing (A7) or lacking

or pharmacological activation of endogenous Ca2+ signaling transducers; however, such approaches can lack

We highlight this article by Tahk et al.  

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already

stall not because the target is wrong—but because the chemical matter  interacting with that target lacks

To tackle these, the lab employs molecular docking, molecular dynamics simulations, and ligand-based

And once you see it, you’ll never go back.

And once you make that shift, you’ll never go back.

It was mostly just because, I need to be back in the lab.”

Using CRISPR-Cas9 knockout HEK cells lacking Gs proteins, a study by Stallaert et al. in 2017 showed

Jack Antel to its clinical advisory board Crinetics Pharmaceuticals First Quarter 2023 Earnings: Revenues

Premium members can always go back and watch the recorded talks at any time. A corazonin G protein-coupled receptor gene in the tick Ixodes scapularis yields two splice variants,

Upcoming events:  “Drug Discovery at Superluminal Speeds”; and Discovery on Target 2025—GPCR track you Expect practical guidance on TR-FRET compatibility, photobleaching resistance, and 3D stack acquisition druggability 🔹 The role of cryo-EM in capturing fully activated GPCR complexes 📅 Catch Aaron’s full talk at Discovery on Target, Sept 24–25 in Boston. 🎥 Plus, join us at the GPCR Track, GPCR Happy Hour, and

With over 21,000 views  and 7,785 downloads  from Volume I, the Signal Transduction  Research Topic is back

Our website is updated as we confirm speakers so please check back often.

From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction.

If you couldn't make it, no sweat – our premium members can always go back and watch the recorded talks Short talk selections will be announced soon. Abstract submissions close on October 2nd.

You can submit your poster abstracts using this form and short talks will be selected from abstracts. pathophysiology and treatment of CNS disorders GPCRs in Oncology and Immunology From outside to inside and back

a resounding success; we have a waitlist for those eager to attend this course, which wil be coming back

Welcome back GPCR fans, The pace of GPCR innovation is accelerating at a rate that can be difficult to

Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors Industry News Sosei Heptares to take back In Parkinson’s Treatment GPCR Events, Meetings, and Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk

with Multispan Cell Engineering and Assay Services $3bn sales potential for drug Sosei Heptares wants back Discovery and Development GPCR Events, Meetings, and Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk

a cold email from a biologist he’d never met, asking if he could synthesize a molecule “when you’re back

platform to connect from anywhere in the world  And if you go for a Premium Membership , you'll not only back

Additionally, DMS is not universally applicable to all proteins; it struggles with proteins that lack

You track the burn rate. You watch the runway shrink. You delay hires. We’re not talking about personality clashes or investor drama. 👉 We’re talking about the type of quiet This breeds passive execution, second-guessing, and a lack of ownership .