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- Targeted Activation of G-Protein Coupled Receptor-Mediated Ca 2+ Signaling Drives Enhanced Cartilage
or pharmacological activation of endogenous Ca2+ signaling transducers; however, such approaches can lack
- Fluorescence Polarization in GPCR Research
We highlight this article by Tahk et al.
- GPCR Allostery: Unlock Hidden Mechanisms and Make Smarter Drug Decisions
Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already
- The Five Traps of Ignoring Kinetics
And once you see it, you’ll never go back.
- Curve Shifts Don’t Lie, But Your Eyes Might
And once you make that shift, you’ll never go back.
- Understanding the Journey: Catherine Demery's Path to Addiction Science
It was mostly just because, I need to be back in the lab.”
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
Using CRISPR-Cas9 knockout HEK cells lacking Gs proteins, a study by Stallaert et al. in 2017 showed
- 📰 GPCR Weekly News, May 1 to 7, 2023
Jack Antel to its clinical advisory board Crinetics Pharmaceuticals First Quarter 2023 Earnings: Revenues
- 📰 GPCR Weekly News, July 17 to July 23, 2023
Premium members can always go back and watch the recorded talks at any time. A corazonin G protein-coupled receptor gene in the tick Ixodes scapularis yields two splice variants,
- Mechanism vs. Assumption: A Model-First Path to Getting GPCR MoA Right
Upcoming events: “Drug Discovery at Superluminal Speeds”; and Discovery on Target 2025—GPCR track you Expect practical guidance on TR-FRET compatibility, photobleaching resistance, and 3D stack acquisition druggability 🔹 The role of cryo-EM in capturing fully activated GPCR complexes 📅 Catch Aaron’s full talk at Discovery on Target, Sept 24–25 in Boston. 🎥 Plus, join us at the GPCR Track, GPCR Happy Hour, and
- The Hidden Driver of GPCR Drug Success: Why Target Residence Time Matters More Than You Think
With over 21,000 views and 7,785 downloads from Volume I, the Signal Transduction Research Topic is back
- 📰 GPCR Weekly News, June 5 to 11, 2023
Our website is updated as we confirm speakers so please check back often.
- 📰 GPCR Weekly News, February 13 to 19, 2023
From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction.
- 📰 GPCR Weekly News, September 18 to 24, 2023
If you couldn't make it, no sweat – our premium members can always go back and watch the recorded talks Short talk selections will be announced soon. Abstract submissions close on October 2nd.
- 📰 GPCR Weekly News, August 28 to September 3, 2023
You can submit your poster abstracts using this form and short talks will be selected from abstracts. pathophysiology and treatment of CNS disorders GPCRs in Oncology and Immunology From outside to inside and back
- 📰 GPCR Weekly News, February 26 to March 3, 2024
a resounding success; we have a waitlist for those eager to attend this course, which wil be coming back
- How Understanding Intracellular Drug Access Can Transform Your GPCR Drug Discovery Program
Welcome back GPCR fans, The pace of GPCR innovation is accelerating at a rate that can be difficult to
- 📰 Breaking Down the Latest GPCR Discoveries: a Weekly Update (Nov 27-Dec 3, 2023)
Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors Industry News Sosei Heptares to take back In Parkinson’s Treatment GPCR Events, Meetings, and Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk
- 📰 GPCR Weekly News, November 20 to 26, 2023
with Multispan Cell Engineering and Assay Services $3bn sales potential for drug Sosei Heptares wants back Discovery and Development GPCR Events, Meetings, and Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk
- 🤯Mind-blowing GPCR Scoops! Discover the Latest Breakthroughs! ⦿ Nov 18 - 24, 2024
platform to connect from anywhere in the world And if you go for a Premium Membership , you'll not only back
- Harnessing Deep Mutational Scanning for Enhanced Drug Discovery
Additionally, DMS is not universally applicable to all proteins; it struggles with proteins that lack
- Structural landscape of the Chemokine Receptor system
CKRs can be classified into typical CKRs, atypical CKRs (ACKRs) which lack G-protein signaling, and viral variants of CCL15, namely CCL15L (residues 26-92) and CCL15M (residues 27-92), while the third structure lacks
- ⛵Sailing the GPCR Seas: Your Weekly Research Voyage! ⦿ Nov 11 - 17, 2024
GPCR University 🎥 Access to the recorded classes of GPCR Courses and talks from Symposia 💲 Discounted with AEF0217 in young adults with Down syndrome Novartis pays Schrödinger $150M, bets billions on the back
- From Failed Experiments to Predictive GPCR Models
His lab has already begun using AlphaFold models to identify ligands for targets that lack experimental
- Enzyme Inhibition Pharmacology: The Hidden Gatekeepers of GPCR Drug Discovery
In every lab, candidates fail not because they lack potency at a receptor, but because they stumble at
- Hop in the Time Machine with GPCR: Unraveling the Future of Research! ⦿ Nov 24 - Dec 1, 2024
We're zooming back to the future of GPCR discoveries. We're about to reveal our University CheatSheet —a sneaky peek at all our talks, presentations, and courses
- 📰 GPCR Weekly News
We're excited to be back and share our weekly newsletter! Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
models, such as deep learning neural networks, are often referred to as "black boxes" because they lack databases from experimental labs and new AI techniques will allow more associations and will promote multi-task
- Decoding β-Arrestins: from Structure to function
Despite their contributions, these methods often lack cellular auxiliary structures and proteins.














