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David Hodson walks through how his team uses fluorescence tools and chemically engineered ligands to listen Researchers navigating complex datasets, balancing innovation with assay rigor, or working across chemistry–pharmacology–physiology

Here are three questions to help you check in with yourself: 1️⃣ Do you delay or dilute decisions while

GPCRs demanded something different: the integration of modeling, medicinal chemistry, and pharmacology Predictions from modeling inform chemistry. Chemistry fuels assays. Chemists understand why certain molecules are worth the effort to synthesize. Medicinal chemists can synthesize molecules, but must choose carefully from infinite possibilities. in mind, chemistry connected to assays, and assay data cycling back to refine predictions.

Modern real-time assays can deliver these insights earlier, faster, and cheaper than most teams assume Programs aren’t killed because of bad ideas—they’re paused when the chemical matter isn’t compelling

assays in drug discovery October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

Collaborating with chemists, biologists, and pharmacologists not only made his predictions more useful Today, his group includes around ten computational chemists and one in-house medicinal chemist. This is when the synthetic expertise of the chemist becomes essential. Carlsson notes that it’s easier to find pharmacologists to run assays than it is to persuade chemists

It was the result of chemistry, collaboration, and relentless effort until the signal finally confirmed The Chemistry That Almost Didn’t Work Designing pH-sensitive rare-earth complexes was not an obvious The chemistry involved is notoriously complex. Solubility poses significant challenges. The chemistry originated from Parker’s lab. What started as a chemistry problem has evolved into a discovery platform.

cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry

GPCR-targeted drug development, incorporating machine learning, innovative biophysical methods, and medicinal chemistry The full agenda is now available; check it here ! Discovery on Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry function NEW Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry (5-HT2A) GPCRs in Oncology and Immunology The power of many: Multilevel targeting of representative chemokine

This partnership aims to bring advanced chemical probe strategies to the forefront.

Explore Terry's Corner From Chemistry Lab to GPCR Partner – New Podcast with Celtarys Dr. Maria Majellaro of Celtarys shares how her team translates medicinal chemistry into practical GPCR assay

of Discovery pHSense wasn’t built in a vacuum—it was born from decades of groundwork in rare earth chemistry It’s the product of layered collaborations—with Durham University chemist David Parker on the probe chemistry

year of expert training Unlock On-Demand Yearly Access Now — Premium Members Get Over 50% Discount at Checkout

Seemed Like Magic Before modern pharmacology, enzymes were mysterious catalysts that seemed to defy chemical In this lecture, you’ll revisit the early days of discovery: when scientists thought cellular chemistry isn’t a checkbox; it’s a survival test. Yet many discovery teams still relegate them to the “ADME” checklist, rather than the strategic design

months of expert training Unlock On-Demand Yearly Access Now — Premium Members Get Over 50% Discount at Checkout updates, priority event alerts, vetted jobs, and commentary that connects dots across pharmacology, chemistry

It started not with biology—but with chemistry. Revvity and academic collaborator Prof. Mini Timeline: The Road to pHSense → Initial lanthanide probe design with Durham University (chemistry Revnity’s partnership with Durham (chemistry) and the Institute of Functional Genomics in Montpellier

Adjusting assay sensitivity—whether through expression systems, chemical modulation, or engineered desensitization—provides

GPCR members save  50%+  (check your Weekly News code). Years of chemistry, photophysics, and pharmacology condensed into one breakthrough: pHSense , a reagent Rare-earth europium complexes offered potential—but the chemistry was brutal. They translated a fundamental principle of chemistry into a usable platform for pharmacology—showing how persistence, precision, and the courage to take on “impossible” chemistry can shift the entire GPCR

GPCR members save  50%+  (check your Weekly News code).

By combining deep expertise in GPCR biology with advanced fluorescence chemistry, Celtarys custom-developed Curr Chem Genomics. 2009 May 28;3:22-32. doi: 10.2174/1875397300903010022.

Chem Rev. 2017 Jan 11;117(1):139-155. Chem Rev. 2017 Jan 11;117(1):139-155. doi: 10.1021/acs.chemrev.6b00177 Alavi MS, Shamsizadeh A, Azhdari-Zarmehri

Unlock On-Demand Yearly Access Now — Premium Members Get Over 50% Discount at Checkout ➤ Revvity x Dr scientists actually need—and validating it where it counts. 🎧 Go behind the scenes with Revvity —from the chemistry

Here’s who we've talked to so far: 🎥 Check out the interview with Dr. from UNC and Terry's Corner We'll continue to update this section as new videos are released — so check

Unlock real SAR:  Deconvolute potency into affinity vs. efficacy to make medicinal chemistry cycles more

Internal checks (like requiring a Schild regression slope of unity for competitive antagonism) add further Chemists suddenly have meaningful levers to pull. The lesson: models don’t just need data. shifted curves left Sometimes it raised baseline activity Sometimes it boosted the maximum response Chemists

Must-read publications:  A structural modeling study revealing non-canonical mechanisms of chemokine-driven

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Axxam’s capabilities span the full spectrum of GPCR families, including aminergic, peptide, lipid, and chemosensory

Adapted from: Zhang Y, Tang H, Chen W, Zhang J. ACS Med Chem Lett. 2022 Jan 10;13(2):243-249. doi: 10.1021/acsmedchemlett.1c00598.

ACS Chem Biol. 2014 Sep 19;9(9):1918-28. doi: 10.1021/cb5004042.