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modulation and biased agonism, and incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour radioligand binding assays to cell-based functional assays, and the influence of Terry Kenakin and chemical They also discussed their own research on chemokine receptors and the importance of understanding the

The conversation traces the scientific and personal logic behind each transition: from chemistry to pharmacology Use as a navigational guide. 00:00 Introduction and ecosystem announcements 02:15 From inorganic chemistry Kathryn obtained her BS in Chemistry from Carnegie Mellon University and went on to receive a Ph.D. in

Vaidehi received her Ph.D. in quantum chemistry from the Indian Institute of Technology in India, where

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985,

Award (Australian Neuroscience Society), Vane Medal (BPS), Gordon Hammes Lectureship Award (American Chemical

Kenakin trained in chemistry and pharmacology at the University of Alberta and completed postdoctoral

Panelists from InterAx Biotech, Rockefeller University, and the University of New Mexico — computational chemists homology modeling, coarse-grained molecular dynamics, and genetic code expansion for site-specific chemistry in ligand design The true-negatives problem and how it distorts biological models The hybrid future: chemical Chemical intuition has no AI equivalent yet — and won't soon. The experience of a seasoned medicinal chemist mentally docking a molecule from a 2D structure is not

Trieste, then joined GSK in Stevenage as a Marie Curie Industrial Fellow working on aptamers against chemokine in Boston - 02:35 A fellowship discovered the day before the deadline - 07:26 Aptamers, SELEX, and chemokine

He leads a multidisciplinary research team comprising biologists, chemists, physicists, engineers and

he completed a PhD in protein engineering (Cambridge, UK) with Sir Gregory Winter (Nobel Prize for Chemistry

ABOUT RANDY Randy Hall is Professor of Pharmacology and Chemical Biology at Emory University School of agonist model - 39:38 Are adhesion GPCRs druggable, and what GPR97 changed - 46:46 In silico screening, chess

As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

While a chemistry undergraduate student at the University of Chicago, he attended a NATO Advanced Study Gobind Khorana at the Department of Chemistry at M.I.T. for postdoctoral training, where he learned gene including Richard Mathies and Fritz Siebert , and contributed substantially to elucidating the physical chemistry Recently, Tom’s lab discovered, along with Yu Chen and Ping Chi , that a mutant of CYSLTR2 is a driver

choice 31:33 The underground restaurant in San Francisco, born out of an immigration emergency — and Chef's

explores what changes when olfactory receptors are treated not as smell receptors but as general-purpose chemosensors Scientific Themes of the Conversation Olfactory receptors as general-purpose chemosensors outside the Reframing olfactory receptors as chemosensors. Pluznick argues they are better understood as chemical sensors that happen to dominate the nose. Her research is focused on the role of chemosensory GPCRs in regulating renal and cardiovascular function

Duke University in North Carolina, working with Marc Caron and Robert Lefkowitz (2012 Nobel Prize in Chemistry

By working with distinct chemical scaffolds like thiazolidines and xanthinediones, Ben is helping define Vision Ben’s work seeks to merge in vitro mechanistic data with in vivo efficacy , guiding medicinal chemists

Caron and his family moved to Durham, NC in 1977, following receipt of his BSc in Chemistry from Laval

Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

By the end of 2021, I moved back to Germany and joined the pharmaceutical chemistry group of Peter Kolb

at the University of Michigan, shares how personal loss and an unconventional career path—industry chemist Instead, she went hands-on—working as an analytical chemist in a GLP/GMP-regulated CRO, where precision

focused on understanding the role of compartmentalized Gq signaling by the cytomegalovirus-encoded chemokine

Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of Ilana graduated Summa cum laude from Cornell University, where she studied Chemistry and Chemical Biology

Nivedha Bioinformatics training, computational chemistry, and early research in carbohydrate–protein Before we dive into this episode, I invite you to check out the relevant links in the show notes.

proteins, cultured cells, model organisms) in combination with the development of novel tools (biosensors, chemogenetics

He received his B.S. in Chemistry from Duke University in 2016 where he worked in the lab of Dr. Stephen Craig and studied polymer chemistry and material science. He primarily studies the chemokine receptor CXCR3 as it has three naturally occurring ligands and thus

Always check for accuracy. Demet, who had studied various subjects including chemistry, physics, biology, and math, shared his interest

Kenakin trained in chemistry and pharmacology at the University of Alberta and completed postdoctoral

He works in a multidisciplinary Chemical Biology team based at the recently established US R&D hub in Always check for accuracy. passion for advancing science and improving patient outcomes, and their early interests in science and chemistry