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held a postdoctoral position at Forschungszentrum Jülich (Germany), where he worked on calculating ligand

research focuses on class B GPCRs and understanding how GPCR signaling and function is mediated by various ligands

Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors

regulating renal and cardiovascular function, and identifying renal/cardiovascular olfactory receptor ligands

University of Wisconsin-Madison in the lab of Sam Gellman on the study of analogs of the GPCR peptide ligand

used radioligand binding methods to dissect receptor function from the adenylyl cyclase activated by ligands

This project aims to characterise the molecular pharmacology of GPR146 and to validate the proposed ligands

Computational Biochemistry at Uppsala University , where his lab uses structure-based modeling to predict GPCR-ligand

He primarily studies the chemokine receptor CXCR3 as it has three naturally occurring ligands and thus

screening, and identification of small molecule regulators of these proteins, and progressing such ligands

. - Arthur will work on designing ligands for specific receptors, aiming to create biased agonists for Arthur explained the concept of endogenous allosteric ligands and the possibility of using a neutral allosteric ligand as a preferred therapeutic approach, emphasizing the importance of looking for low

In particular, FB contributed to the discovery that CXCL12 is the ligand for the CXCR4 receptor and can

Technology Evolution and Ligand Residence Time Prediction Yamina Berchiche and Aurelien Rizk discussed The conversation also revolved around the company's ability to predict the residence time of a ligand The discussion concluded with the idea that ligand residence time could be an important factor in effective

biased agonism, and also on allosteric interactions between GPCRs and other proteins and small molecule ligands

best leverage these exciting new techniques in areas such as protein structure prediction, bioactive ligand

He established the concept of ligand-independent functions of orphan receptors in heterodimers with other

determination of the β1-adrenoceptor and adenosine A2A receptor in multiple different conformations bound to ligands

These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling Critically, these ligands reduce addiction-associated behaviors in animal models without the side effects

Michelle Halls unpacks how GPCR signaling isn’t just about ligand–receptor interaction. For decades, molecular modeling focused on explaining — rationalizing why a ligand binds, why a mutation A good model doesn’t just match published structures; it forecasts new biology, new ligands, and new By integrating molecular docking, molecular dynamics, and machine learning, they design ligands with Unlike reversible ligands, their impact can persist long after the compound is gone — creating durable

Two-Pore-Potassium channels using electrophysiology, molecular and chemical biology techniques, and fluorescence

Mechanical dissociation of the two fragments aided by protein binding ligands and cell movement serves

Ligand binding and mechanical force applied on the ECR regulate receptor function. from a single-molecule perspective and investigating how the binding of extracellular transsynaptic ligands Ligand-induced GPR110 signaling stimulates neurogenesis and synaptogenesis during development, and the absence of the ligand-induced signaling causes object recognition and spatial memory deficits in adulthood

. 🗓️ Upcoming 4-Week Course: Development of GPCR Ligands as Therapeutic Drugs starting March 20 – April Highlights of the Week How Ligands Achieve Biased Signaling toward Arrestins Stéphanie Gaillard , Neha A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Adam Structural and Molecular Insights into GPCR Function A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Ligand-Independent Spontaneous Activation of Purinergic

< Back to Full Agenda Session II AGPCR signaling pathways and trafficking Localization of putative ligands ADGRG6 Drives Proteolytic Processing, Trafficking And Signalling Pal Kasturi Localization of putative ligands

protein engineering, receptor pharmacology, and structural biology to study how different types of ligands

techniques including various mass spectrometry approaches, single particle cryo-EM and single-molecule fluorescence

Terry Kenakin’s unique course, Development of GPCR Ligands as Therapeutic Drugs , and gain essential Trial and Plans to Advance Next-Generation Oral Small Molecule PTH1R Agonist Revolutionizing Protein-Ligand in Oncology and Immunology Spatial analysis of a complete DIPG-infiltrated brainstem reveals novel ligand-receptor prolactin-releasing peptide receptor signaling and G-protein coupling selectivity Decoding the structural basis of ligand

Collectively these proteins form a cell surface complex that acts as a recognition platform for Wnt ligands

Synaptamide, an endogenous ligand for GPR110, binds to the N-terminal G-protein autoproteolysis-inducing

Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors