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vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies High-affinity

Binders, Drugs, and more Engineered Human Antibody with Improved Endothelin Receptor Type A Binding Affinity

BRL37344-like effects on mouse metabolism Mechanistic insights into sodium ion-mediated ligand binding affinity

Notably, GRKs phosphorylate active GPCRs, enabling high-affinity arrestin binding, which is crucial for

Lackman et al. 2023), which provide extra negative charges to the N-terminus thereby increasing binding affinity