📰 GPCR Weekly News, December 11 to 17, 2023

Hi friends! The latest and greatest in GPCR research is here, this week we’ve curated 14 GPCR papers, 7 industry news, and 2 GPCR job offers!

This week's highlights:

• Kudos to our partner, GPCR Therapeutics, for partnering with Bridge Biotherapeutics to pioneer IPF treatment with CXCR4-LPA1 inhibitors!

• Dr. Ross Cheloha's research involves semi-synthetic nanobody-ligand conjugates with enhanced transcriptional outputs at neurokinin receptor-1

• Congratulations to Dr. Nicole Perry-Hauser, on her selection as a 2024 Discovery Science Emerging Scholar at Vanderbilt University! 

Save the date:

February 8 - 29: Join Dr. GPCR University's live Zoom sessions hosted by Dr. Terry Kenakin. The course covers basic pharmacology in four weekly segments. Only 14 out of 20 spots remain. Registrations are open to Dr. GPCR Ecosystem Premium Members and free site Members! The cost is $299 and includes:

• All 4 live Zoom sessions ( 4x 1 hour lecture + 30 mins Q&A)

• Complementary one-year Dr. GPCR Ecosystem Premium memberships

• 30-minute one-on-one meeting with Dr. Kenakin, according to his availability

• Access to the cohort’s Dr. GPCR Ecosystem group, where you can find Dr. Kenakin and your classmates

• Access to the course materials and recordings once the course is completed

• Course completion certificate signed by Dr. Kenakin and Dr. GPCR

• Access to Dr. GPCR Ecosystem contents and perks, including our forums, private groups, and all Ecosystem members

Go to Dr. GPCR University and save your spot today! 

The GPCR Weekly News will take a holiday break. We'll pause our regular updates during this time and will resume our newsletter in the upcoming year on Thursday, January 4, 2024. We appreciate your continued support and readership.

Wishing you all a joyful holiday season and a prosperous New Year!🎄✨

Let’s dive into the Classified GPCR News from December 11th to 17th, 2023.

GPCR Activation and Signaling

• GPCR screening reveals that the metabolite receptor HCAR3 regulates epithelial proliferation, migration, and cellular respiration

• Spatiotemporal Optical Control of Gαq-PLCβ Interactions

• Snapshot of the cannabinoid receptor 1-arrestin complex unravels the biased signaling mechanism

GPCR Binders, Drugs, and more

• Semi-synthetic nanobody-ligand conjugates exhibit tunable signaling properties and enhanced transcriptional outputs at neurokinin receptor-1

GPCRs in Cardiology, Endocrinology, and Taste

• Transcriptional profiling of Kiss1 neurons from arcuate and rostral periventricular hypothalamic regions in female mice

• Cardiac optogenetics: shining light on signaling pathways

GPCRs in Oncology and Immunology

• Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation

• From odor to oncology: non-canonical odorant receptors in cancer

Methods & Updates in GPCR Research

• Phosphorylation Sites of the Gastric Inhibitory Polypeptide Receptor (GIPR) Revealed by Trapped-Ion-Mobility Spectrometry Coupled to Time-of-Flight Mass Spectrometry (TIMS-TOF MS)

• A rapid, tag-free way to purify functional GPCRs

• tANCHOR fast and cost-effective cell-based immunization approach with focus on the receptor-binding domain of SARS-CoV-2

• Microscopy and spectroscopy approaches to study GPCR structure and function

Structural and Molecular Insights into GPCR Function

• Using AlphaFold and Experimental Structures for the Prediction of the Structure and Binding Affinities of GPCR Complexes via Induced Fit Docking and Free Energy Perturbation

• A computational insight on the aromatic amino acids conjugation with [Cp*Rh(H2O)3]2+ by using the meta-dynamics/FMO3 approach

Industry News

• GPCR Therapeutics Announces Out-Licensing Agreement with Bridge Biotherapeutics in Idiopathic Pulmonary Fibrosis

• Former execs from Pfizer obesity drug program have started a new biotech with $52M from VC fund ATP

• Structure Therapeutics - Providing the next generation of high-impact medicines 

• Structure Therapeutics Provides Comprehensive GSBR-1290 Program Update Including Clinically Meaningful Proof-of-Concept Data From Phase 2a Clinical Study 

• Neurocrine opening two Phase 1 trials in oral Parkinson’s therapies

• Bearing Fruit: Deep Apple Therapeutics Launches to Screen AI-Generated Virtual Libraries

• AbbVie to Acquire Cerevel Therapeutics in Transformative Transaction to Strengthen Neuroscience Pipeline 

GPCR Events, Meetings, and Webinars

• January 16 - 19, 2024 | 23rd Annual PEP Talk

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• February 11 - 14, 2024 | 2024 BPS Annual Meeting

• March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

•  October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Postdoctoral Scholar - O’Neill Lab

• NEW Junior Research Scientist

•  Postdoctoral Fellow

• Post-Doc Research Associate

• Assistant/Associate Professor 

• Principal scientist – oncology biomarker expert

• Postdoctoral Fellow

• Scientific Assistant  

Explore Dr. GPCR Ecosystem