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We have explored hydrophobic groups of different sizes on both sides of the five-membered ring scaffold

Infiltrating GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients

Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in

Although the high-resolution crystal structures of the DOR with both agonist and antagonist have recently

As the mechanisms underlying spatial bias in GPCR signaling involve both temporal and spatial components Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular

sites of N-acetyl galactosamine (GalNAc)-type O-glycosylation in their N-termini as well as sulfation, both Both PTMs were shown to contribute to the binding of CCL5 and CCL8 and to a minor extend CCL3. The combined effects of both PTMs as well as the relevance of specific acceptor sites and glycan composition

This is also where Gq/Gs bind the receptor through both hydrophobic and polar interaction, while Gi/G12

In the experiment, similar sets of residues were found to be in significant contact with both ligands

domain 1 (FnIII.1) suggest the cysteine-rich (CR) and the FnIII.1 domains could assist the WAP domain both

discussed that one should consider when attempting to compare functional outcomes from different studies, both

Meanwhile, the antagonist ligands made interactions with W2866.48×48 and Y3167.43×42, both residues considered

Both PAR4 and PAR2 are able to drive the association of methyltransferase EZH2 with β-catenin, culminating

Since we cover both the theoretical as well as practical aspect of these topics, the platform addresses

Chronic human HF is characterized by several important neurohormonal perturbations, emanating from both

Pharmacological targeting of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717,

interactome includes numerous proteins which interact with differential domains of GRK2 to modulate both

the N-loop determines the subfamily-specific arrangement of the distal N-terminus and the 30s-loop, both By examining both the active and inactive states of CCR5, it becomes evident that there are four distinct Constitutive Activity of the viral CKR US28 and “Chemokine Scavenger” ACKR3 Both US28 and ACKR3 are constitutively Experimental 3D structures of both receptors reveal that they employ distinct mechanisms for constitutive

Most labs would have stopped there — archived the data, moved on, written it off as a failed bet. It enabled: Live-tissue visualization Cell-type-specific receptor mapping Validation in both the periphery

This dataset highlights how HCS can be used both to triage compound series and to extract quantitative signaling, tools that preserve cellular context will be increasingly important for designing ligands with both

evident increase in SRE-luc activity was noticed when COS-7 cells expressing GnIHR were challenged with both

In CRPC xenografts, antagonizing AVPR2, AVPR1A, or both significantly reduced CRPC tumor growth as well

Here, we report that the Ovarian Cancer G-Protein Coupled Receptor1 (OGR1 or GPR68) has dual roles in both

In vivo, suppression of postsynaptic cAMP signaling in CA1 neurons prevented formation of both Schaffer-collateral

Our earlier reports suggested that GPR3 enhances both neurite outgrowth and neuronal survival.

reports demonstrated that Fgr exhibits high constitutive activity, but can be further activated by both

The data support the inference that they act at the active interface between both transmembrane domains

influence the orthosteric binding pocket, potentially altering the rate of association, dissociation, or both On the other hand, selectivity could be achieved by merging both orthosteric and allosteric pharmacophores

In this review, we outline some key NMR techniques applied for on-cell NMR studies through both solution

however, attention has focused upon how stable multiprotein GPCR superstructures, termed receptorsomes, both

simulations which revealed different trajectories passing through the gap between TM helices IV and V for both