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Initially applied to biomarkers in blood, its no-wash, miniaturized design caught the attention of high-throughput Classic pH probes failed in plate readers—too noisy, too dim. pHSense rewrote that rule, enabling high-throughput

receptor axes play a pivotal role in the recruitment and oriented trafficking of immune cells both towards

The interpretation of high and low affinity binding sites on GPCRs. Under certain experimental conditions, what appears to be a second high-affinity site may simply reflect

Celtarys Research's first article provides a detailed examination of conjugation strategies to develop high-performance

functional selectivity  has transformed GPCR drug discovery, showing how to bias receptor signaling toward

since they have extended fluorescence duration, enable delayed emission readings, have narrow bands and high report the first example of a Tag-lite® binding assay for both CBs using CELT-335, which exhibits a high The high affinity of CELT-335 for CB1R was maintained in the Tag-lite® assay (Ki=44.8nM in radioligand High specific binding was observed by measuring 10uM concentrations of the appropriate competitors ( Schematic representation of the high correlation between reference compounds affinity data obtained through

That alignment between curiosity and urgency set her on the path toward doctoral research.

produce robust effects on behavior across species, and recent research has benefited from advances in high-resolution

These studies also show that disrupting the dimerization of GLP-1R results in decreased high-affinity extracellular domain (ECD), facilitating the partial disengagement of the peptide while maintaining high-potency

Steyaert bridged fundamental high-impact research in biomedical sciences with the mechanistic understanding

Interestingly, there were also significant differences in receptor degradation, with S339fs5 having a very high promotes enhanced signaling, reduced phosphorylation, β-arrestin binding and endocytosis, and a very high

HLGR2 is a typical GPCR and shows high structural and sequence similarity with other insect LGR2 proteins rate (45.00%), body malformation, abnormal wing expansion, failed cuticle melanization (63.33%), and high

At high cholesterol concentrations, LYCHOS bound to the GATOR1 complex, a guanosine triphosphatase (GTPase

New high-resolution structures of CB1 receptor in different functional states have significantly improved

neuropeptide receptor npr-38 regulates avoidance and stress-induced sleep in Caenorhabditis elegans Towards

To exert their functions requiring high sensibility and specificity, T cells need to integrate different

structure models in the functional study and structure-based drug design of GPCRs, which required reliable high-resolution

She found herself drawn toward the science behind the drugs, rather than their clinical application.

ligand, enabling cell-free as well as cellular NanoBRET-based binding studies in a non-isotopic and high-throughput

GPCR mutations in cancer   show both driver-like patterns and high redundancy, prompting a call for multiomics

protein complexes and solute carriers, are relevant to immunology indications and rare diseases with high

Thus, we need to know much more about the structures of receptor-ligand complexes at high resolution.

meningitidis is a Gram-negative opportunistic pathogen that is responsible for causing human diseases with high

state; three-dimensional (3D) cell models, or organoid models, that assist with target identification, high-throughput

Despite its high mechanistic complexity, the modularized QSP platform can be readily reproduced, expanded

Despite this high number of GPCR targeted drugs, only a small portion (∼110) of the human GPCRome (consisting

Propranolol, initially prescribed for high blood pressure, irregular heart rate, essential tremor, and

Hence, the H3R conformational biosensor in membranes might be a ready-to-use, high-throughput alternative

Louis-Jeantet Foundation and the 2022 Benjamin Franklin Medal in Chemistry from The Franklin Institute "Huge

effective at monitoring real-time A2BAR receptor labeling using live-imaging modalities, and displayed high