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with a higher specific activity, but a shorter half-life (60 days), which complicates storage, besides changing

In all cases, the receptor interaction changes downstream signalling and the responses to receptor agonists

Structural analysis of SMO domains shows significant changes in the CRD and ICD, during the course of

Anyone who joins before the change is fully grandfathered  — your rate stays locked, and your whole team

Target Engagement—Don’t Chase It with Irreversible Drugs When binding outlives exposure, everything changes

. 🎧 Go behind the scenes with Revvity —from the chemistry to the critical moments that changed everything

Adapted from: Zhang Y, Tang H, Chen W, Zhang J. is most effective at studying interactions between large proteins and small ligands thanks to this change

Every time a problem arises, we trace it back to its root cause, implementing changes that prevent its

Here, we investigate the conformational changes induced by the binding of a nanobody (Nb80) on the active-like

Crucially, altering one does not inherently change the others—a principle often overlooked in early discovery

This paper thoroughly investigated the role of single amino acid changes to clarify the molecular mechanisms

Seeing that probe expose receptor distribution across an entire native islet changed what they believed

clarity—so you can pick better targets, stress-test hypotheses earlier, and focus on experiments that change

That’s where Terry’s Corner changes the game.

Farma Reports Its 2023 Annual Financial Resultsand Confirms Its 2024 Outlook Sosei Heptares officially changed

Guo, W., et al., Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface

That changed when JB’s team walked in with a different lens.

And that difference changes everything. 👉 Scientific thinking values thoroughness, error reduction,

Anyone who joins Premium before these changes go live will be grandfathered at their current rate , as

from March 4th to 10th, 2024 GPCR Activation and Signaling Glu1022.53-Mediated Early Conformational Changes

Why micro-domains change what “global” signaling can and can’t explain.

This makes it an ideal candidate for GPCR research, where accuracy in detecting subtle signaling changes

GPCRs has well‑known limitations—fixation artifacts, epitope masking, low expression, conformation changes

What Changes When Your Pitch Works When your biotech pitch lands, the difference is immediate and powerful

Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

announced the winners of its Transforming Cancer Therapeutics grant, which focuses on developing life-changing

Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

de l'Innovation Technologique (Technological Innovation Award) Sosei Heptares Receives Approval for Change

Drug Targets: Allosteric Function and Biased Signaling" at the DOT NEW October 3, 2023 | FREE Seminar: Changing