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Samuel Hoare Sam completed his Ph.D. in biochemistry, studying allosteric modulation of dopamine receptors life science, and academic scientists in the development of new therapeutics and the understanding of receptor about his love for GPCRs, kinetics, and decorticate the complexities of GPCR function to better target receptors

Professor Pfleger has developed extensive expertise in profiling receptor binding and function at the globally-recognized expertise in bioluminescence resonance energy transfer (BRET) technology, including his patented Receptor-Heteromer Investigation Technology (Receptor-HIT) for studying heteromers.

student visa was in the work, during which time I thoroughly reviewed the literature on the melanocortin receptor first project where I demonstrated that MRAP2 regulates the signaling of multiple G protein-coupled receptors contributed to an In-vivo project that showed that MRAP2 regulates the growth hormone secretagogue receptor necessary modification leading to a structural change granting the arrestins access to the core of the receptor Cone was the first to clone the melanocortin receptors (the GPCRs that led to the discovery of MRAP2)

Summary Arthur's Career Journey and Allosteric Receptors Yamina and Arthur discussed Arthur's career journey and his contributions to the field of pharmacology, with a focus on allosteric receptors and also discussed the re-emergence of interest in certain programs, the importance of connections across receptor They also discussed their own research on chemokine receptors and the importance of understanding the They also delved into the different signaling of Class B receptors and the potential for modulation at

10 2022 19:00:00 GMT+0000 (Coordinated Universal Time) Details Regulation of Metabotropic Glutamate Receptor Fung Mon Oct 10 2022 21:00:00 GMT+0000 (Coordinated Universal Time) Details Environment Matters: One Receptor Dawaliby Tue Oct 11 2022 12:00:00 GMT+0000 (Coordinated Universal Time) Details Fine-tuning glutamate receptor (Coordinated Universal Time) Details Isolating ligand binding kinetics of mini G protein bound GPCR receptor Wed Oct 12 2022 18:50:00 GMT+0000 (Coordinated Universal Time) Details Oxytocin-Vasopressin Ligand-Receptor

👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14, the most promiscuous bitter taste receptor 👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14 , the most promiscuous bitter taste receptor more about this exciting breakthrough in bitter taste signaling. ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling

, study multiple targets and signaling pathways, investigate target species variations, deorphanize receptors , and more Comprehensive Coverage >1500 Human GPCRs products, including: 90% Target coverage Orphan receptors cell line backgrounds Multiple Mechanisms of Actions (MOA) cAMP accumulation β-Arrestin recruitment Receptor validated portfolio for obesity and diabetes GPCR targets, including GLP-1, GIP, GCG, MC4, PYY, AMY receptors AMYs) Apelin (APJ/AGTRL1) Representative Data: GLP-1R Multi-MOA Profiling Eurofins DiscoverX's GLP-1 receptor

As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

Research (IMSR) of the University of Birmingham and Co-Director of the Centre of Membrane Proteins and Receptors physicists, engineers and computer scientists focusing on the basic mechanisms of G protein-coupled receptor that GPCRs are not only active at the plasma membrane but also at intracellular sites and that these receptors

Mark von Zastrow where she identified novel core cellular machinery critical for G protein-coupled receptor cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling and receptor postdoctoral research in Oxford, investigating the signalling and trafficking of the G protein-coupled receptor (GPCR), calcium-sensing receptor, and its role in calcium homeostasis.

degree in biochemistry from Leipzig University (Germany) being already fascinated by G protein-coupled receptors They also discussed the challenges of studying metabolites and their receptors, the relationship between Challenges in Studying Metabolites and Receptors Claudia and Yamina discussed the challenges of studying metabolites and their receptors, particularly in relation to fermented foods. They also explored the potential for better tools to understand and discover new metabolites or receptors

those early papers on lipid-rich domains and GPCR–G protein compartmentalization reframed her view of receptor those early papers on lipid-rich domains and GPCR–G protein compartmentalization reframed her view of receptor

GPCR Retreat Program < Back to schedule Structure-based discovery of functionally selective 5-HT1A receptor

endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor research interests involve resolving signaling pathways downstream of aGPCRs and establishing how/if these receptors

Jens Carlsson challenges scientists to go beyond explaining data — and start predicting the future of receptor With tools like AlphaFold , his lab can now model receptor–peptide complexes in seconds — an achievement

explore the development of powerful multiplex tools designed to map GPCR-RAMP interactions across the receptor That curiosity laid the foundation for a broader investigation into receptor activity-modifying proteins The lab’s early partnership with students like Emily Lorenzen catalyzed a transition from single-receptor From Many to One: De-Orphanization and Precision Focus “You can use this system to de-orphanize receptors Instead of focusing on a single receptor, students now gravitate toward platforms , biosensors , and

and worked closely with Dr Birgitte Holst studying structural and mechanistic properties of ghrelin receptor associated with obesity and other metabolic diseases, including GPR10, Melanocortin 4, Serotonin 2C and TRH receptors cell-based in vitro technologies to study mechanistic properties of GPCRs and understanding the dynamics of receptor Jacek shared his fascination with the growth hormone secretion receptor and the melanocortin 4 receptor Yamina, in turn, talked about her work on melanocortin receptors and an upcoming collaboration with a

Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis Adhesion G protein-coupled receptor localized in the developing and adult synapses and interact with synaptic scaffold proteins and glutamate receptors Several adhesion G protein-coupled receptors (aGPCRs) have recently been shown to play critical roles Dimitris Placantonakis on the web Placantonakis Lab Google Scholar LinkedIn Adhesion G protein-coupled receptor endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor

the early days of ion channel chemistry to pioneering peptide–fluorophore conjugates for the GLP-1 receptor Why targeting the pharmacologically relevant surface-exposed receptor pool changes the way scientists The moment when super-resolution imaging revealed nanoscale receptor domains that conventional tools lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand receptor

peptide agonist mechanism that differed from the common example known at the time, protease activated receptors Adhesion GPCRs pre-cleave themselves and the two resultant fragments of the receptor remain together adhesion GPCRs in complex physiological contexts…one being our discovery that GPR56 is the platelet receptor

pharmacology, and pharmacoepidemiology with innovative computational methods to gain novel insights into receptor identify human signaling systems and thereby discovered endogenous peptides activating several orphan receptors

assistant at the Victor Chang Cardiac Research Institute where he investigated the orphan G protein-coupled receptor Brendan is now a final year PhD candidate in the Orphan Receptor Laboratory headed by Associate Professor

Shenoy’s postdoctoral research discovered that ubiquitination of mammalian G protein-coupled receptors for lysosomal degradation, whereas ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels GPCRs in regulating renal and cardiovascular function, and identifying renal/cardiovascular olfactory receptor

Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors Sachdev pursued Ph.D. in the same lab where she investigated the molecular pharmacology of cannabinoid receptors

Blanco Redondo Abstract "The Drosophila genome contains five loci encoding adhesion G-protein coupled receptors remoulade (remo) gene is a homologue of the vertebrate aGPCR ADGRA family, sharing the same overall receptor We found that the receptor is cleaved despite the lack of a consensus GPS sequence. Langenhan where I am studying and characterizing newly generated adhesion GPCR receptors in Drosophila

If your team relies on receptor visualization — discovery, screening, translational work — this story Michelle Halls unpacks how GPCR signaling isn’t just about ligand–receptor interaction. Why receptor location matters as much as receptor type. October 27, 2025 Terry's Corner Read full article Receptor pharmacology has evolved. Their lab doesn’t just simulate receptor-ligand interactions after the fact; they aim to forecast receptor

Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Biased agonism at the GLP-1 receptor

focuses on the mechanisms underlying biased signaling at GPCRs, specifically, the role of differential receptor He primarily studies the chemokine receptor CXCR3 as it has three naturally occurring ligands and thus