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The results show that the combination of pGRP with PTK2 inhibition or of pGRP with pCIB > pCIBm in additive

Depolarization alone, without a muscarinic agonist, results in a nicotinic ionotropic receptor potentiation

The results were striking: AlphaFold2 outperformed homology models, achieving a 60% hit rate for compounds

As a result, cryo-EM has begun to make major impacts in bringing critical therapeutics to market.

Further studies showed that ADGRA1 deficiency resulted in higher dendritic branching complexity and spine

Together, these results suggest strain-dependent and sex-related differences in the behavioral and pharmacokinetic

Our results suggest that GPR15/GPR15L have a pathogenic role in RA and their antagonizing could be a

The presence of PAR2 and PAR4 in biopsies of aggressive breast and colon cancer tissue specimens is demonstrated

Taken together, our results provide new insight into host processes that affect Hc-macrophage interactions

These results suggest that GPR3 expression in RGCs helps maintain neuronal survival and accelerates axonal

Knockdown of GPR125 as well as that of Dlg1 results in formation of aberrant cysts with multiple lumens

Our results reveal that the extended N-terminus of the long isoform limits G protein activation yet elevates

The deepest basin in the resultant free-energy landscape was assigned to native-like complex conformation

Taken together, our results contribute to a better understanding of the biased signaling process of a

Our site-directed mutagenesis results show that mutations of this interface impact the function of the

display one or more of the following pharmacological characteristics: 1) affinity modulation where the resulting could be achieved by merging both orthosteric and allosteric pharmacophores within a single compound, resulting

Key results: Eight additional MQs were identified with nanomolar affinities for the V2R, all antagonists

In this study, these results may provide a better understanding on the evolution of GPCRs, and expand

Our results showed that the inhibition of cellular respiration hindered the internalization of F-Hst1

Effects of NBI-1117567 in Healthy Adults Crinetics Pharmaceuticals Reports First Quarter 2024 Financial Results and Provides Business Update Nxera Pharma Operational Highlights and Consolidated Results for the First

Taken together, our results indicate that the astrocytic Gi pathway plays an inhibitory role in neuroinflammation

Taken together, these results will benefit further investigations to determine physiological functions

Every step felt like it could make or break the result, The pace and precision of GPCR research today

Results: On day 7 post-infraction, MI rats showed LV dysfunction with higher serum levels of cardiac Both can result in a positive inotropic effect.

We found that 7α,25-OHC-induced allodynia is dependent on MAPK and NF-κB signaling pathways and results

Probe Selection for GPCR Imaging Probe selection is a key step to obtaining good and significative results

Results and Discussion The TR-FRET assay performed in living HEK-293 T cells expressing CB1R using CELT

The resulting NETs presumably activate platelets and coagulation factors, further contributing to the

Here, we report on a new WHIM syndrome mutation that results in a frame shift within the codon for Ser339

Results: The complementary DNA (cDNA) sequence and deduced amino acids of HLGR2 were obtained and analyzed