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Careers built on prestige, titles, or external pressure can burn out quickly. how opioids impair breathing, why xylazine complicates interventions, and how receptor-level insights can

These data indicate that sea bass GnIHR signals can be transduced through the PKA and PKC pathways, and GnIH can interfere with kisspeptin actions by reducing its signaling.

They can also function independently of GPCR activation upon acquiring mutations that prevent GTPase YM-254890 (YM) can inhibit signaling by both GPCR-activated wild type αq and GPCR-independent αqQ209L

When these factors aren’t understood, binding data can appear precise while quietly misleading decision-making Broichhagen, and David Hodson discuss GLP-1 receptor probes, fluorescence-based assays, and why availability can

With this high-resolution, dynamic view of GPCR activation, scientists can better tackle diseases by Beyond GPCRs, the methods and insights from this study can be applied to other fast, transient biological

These challenges can obscure real biological signals and complicate the identification of robust hits Probe panels—such as lysosomal dyes or cytoskeletal markers—can be integrated to support multiplexed When combined with a competitor such as the CB2-selective partial agonist GW40583, displacement curves can

Does it interact with the receptor in a way that biology can use? Members can also propose new topics, ensuring relevance to real-world discovery problems.

Alex Serafini’s journey proves how personal pain can lead to professional purpose — and why the next

There is no limit to the number of posters we can accommodate, so hurry and submit your poster so that we can add it to the list of posters and increase the number of people who can ''stop by'' it on March

Premium: Sneak Peek A fast editorial preview of what Premium Members get in full this week — so you can It’s built to compress your time to clarity—so you can pick better targets, stress-test hypotheses earlier

That’s your signal: kinetics are moving faster than your tools can measure. lectures  that sharpen the tools you actually use in discovery A growing on-demand library  of lessons you can

Whether it's chronic pain, addiction, or another unmet need, keeping the real-world impact in focus can It’s about how moments of redirection — even disappointment — can open new paths to impact.

challenge dogma and deepen our view of receptor dynamics, from the surprising discovery that β-arrestin can

Studies have indicated that transmembrane helix 7 (TMH7) and the highly conserved NPXXY motif can be

"I'm particularly interested in model development... seeing if we can bring preclinical models much closer

orphan GPCR (Sharman et al., 2011), although it is widely accepted that medium‐chain fatty acids (MCFAs) can and 2. which ligands can be used as tool compounds to study the function and biology of this receptor distinct functional outcomes of agonist ligands (Pillaiyar et al., 2018) with biased properties which can

We determined whether SVEP1 and integrin α9β1 can regulate VSMC contraction."

Here, we ask the question whether agonists with very slow off-rates can cause the formation of particularly

and Heterodimer Information flow from a source to a receiver becomes informative when the recipient can that GPCRs may physically interact with each other has led to the hypothesis that their dimeric state can

You can already explore the platform and subscribe to The Kenakin Brief—our new newsletter packed with

In particular, platelets can activate neutrophils to form neutrophil extracellular traps (NETs). Furthermore, NETs can be found in the lung and other tissues and are associated with an increased mortality

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GPCR Ecosystem group, where you can find Dr. GPCR Symposia With a premium membership, you can watch on-demand the Dr. If you want to showcase your research, you can submit a poster presentation to our community, take advantage

What seems definitive during early screening can shift as assay systems, receptor expression levels,

Since studies have indicated that flavonoids can target brain GPCRs and provide neuroprotection via inhibition appreciable D2LR and D4R agonism and D1R antagonism, kurarinone might be a potential compound that can

GPCR Symposia With a premium membership, you can watch on-demand the Dr. If you want to showcase your research, you can submit a poster presentation to our community, take advantage

knowledge regarding the molecular details of psychedelic drug actions and suggest that these discoveries can

Terry Kenakin's insights on target residence time can reshape how you evaluate and advance lead compounds Discover how factors like restricted tissue diffusion and receptor density can dramatically alter drug

“Choosing one specific receptor is difficult… they’re unique because they can bind many different molecules

Schjoldager KT et al. 2020), and usually capped by a single sialic acid, although, in rare cases glycans can This effect could be driven by a specific carrier or it can potentially be related with the increase sulfation are important PTMs in chemokine receptor biology and pharmacology however the reported effects can Moreover, sulfated mCCR2 peptides can outcompete available chemokines, decreasing retinal degradation