Search Results

neurotransmitter responses by G-protein regulators András D Tóth, Gábor Turu, and László Hunyady for their research GPCRs in Oncology and Immunology Unveiling G-protein coupled receptors as potential targets for ovarian cancer promotes fibroblast-to-myofibroblast transition in organ fibrosis progression Methods & Updates in GPCR Research World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW Postdoctoral Position NEW Postdoctoral research position Senior or Lead Researcher Senior Scientist, Cryo-Electron Microscopy Postdoctoral Research

back again: the lysophosphatidic acid-CCN axis in signal transduction NPFF stimulates human ovarian cancer sensor and a sink for CCL19 to coordinate collective leukocyte migration Methods & Updates in GPCR Research 2024 | SLAS Europe 2024 Conference and Exhibition June 2 - 4, 2024 | Chemotactic Cytokines GPCR Jobs Researcher / Senior Researcher in Structural Biology Research Specialist Science Research Writer Postdoctoral Fellow Research Laboratory Specialist Associate Postdoc Research Associate Director, Regulatory Affairs Research

protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer Methods & Updates in GPCR Research Target immobilization on glass microfiber membranes as a label-free Exhibition June 2 - 4, 2024 | Chemotactic Cytokines GPCR Jobs NEW Senior Vice President, Oncology Clinical Research NEW Scientist (level I or II) NEW Research Fellow Research Technician II - Surgery Post-Doc Research Associate Research Technician Senior Research Associate, In Vitro Pharmacology - Crinetics Pharmaceuticals

Hello GPCR friends👋, Stay informed with the latest developments in GPCR research and industry news! GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer therapy Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration Methods & Updates in GPCR Research Illuminating the brain-genetically encoded single wavelength fluorescent on Gliovascular Unit of Glioblastoma Associate Director / Director, Clinical Operations Postdoctoral Research

Microbiota Effects on the Immune System, and Western Diseases Lactate receptor GPR81 drives breast cancer Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant Methods & Updates in GPCR Research Derivatives: Natural Occurrence, Structural Diversity, and Biological Activity Advances in steroid research NEW Post-Doctoral Fellow Sr Scientist in Obesity, Muscle, and Metabolism Post-Doctoral Fellow Research Associate I, Tissue Culture Post-Doc Research Associate Postdoctoral Fellow Explore Dr.

platform clinically validated to guide treatment selection in patients with advanced haematological cancers pharma and healthcare foundations, and the establishment of a global company with locations in the UK

expression data in healthy tissues from the Genotype-Tissue Expression (GTEx) database with data from cancer samples in The Cancer Genome Atlas (TCGA) through the Gene Expression Profiling Interactive Analysis (GEPIA) tool, it is evident that β-arrestin expression is dysregulated in many cancer types. In certain cancer types, only one β-arrestin isoform's expression may be altered, while the other remains dissociation of crucial effector proteins within distinct subcellular locations remains a fundamental research

Showcase your research by contacting us at Hello@DrGPCR.com Stay informed with Dr. GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer Methods & Updates in GPCR Research Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent on Gliovascular Unit of Glioblastoma Associate Director / Director, Clinical Operations Postdoctoral Research

modulated by this tight mechanism with transcriptomic analysis revealing that while the majority of cancer and OR51E2, initially assumed to be GPCRs only expressed in prostate tissue, play a role in prostate cancer epithelial cells proliferation via activation by β-ionone which initiates prostate cancer cell cycle In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and Future directions Important directions in ORs research to advance drug discovery include the deorphanization

Bianca Plouffe and their colleagues' research on 'β-arrestin-dependent and -independent endosomal GPCR signaling Ciliary localization of a light-activated neuronal GPCR shapes behavior Methods & Updates in GPCR Research reinforces consistent reduction in risk of recurrence across key subgroups of patients with early breast cancer Pharmaceuticals Senior Director, In vitro pharmacology - Crinetics Pharmaceuticals In vivo Antibody Discovery Research Scientist In Vitro Biologist/Molecular Pharmacologist Senior Vice President, Oncology Clinical Research

October 2022 "While the role of G-protein-coupled receptors (GPCR) in cancer is acknowledged, their underlying demonstrate identification of a pleckstrin-homology (PH)-binding motif within PAR4, critical for colon cancer EGFR/erbB is among the most prominent cancer targets. Overall, our studies are expected to allocate new targets for cancer therapy. Pc(4-4) may become a promising candidate for future therapeutic cancer treatment."

Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news GPCRs in Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer Methods & Updates in GPCR Research Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Twist Bioscience and Astellas Enter into Multitarget Antibody Discovery Research Collaboration Neurocrine

Methods & Updates in GPCR Research The Road to Quantitative Lipid Biochemistry in Living Cells. GPCR Events, Meetings, and Webinars NEW AACR 2023 - American Association for Cancer Research (April 14 (July 2 - 7, 2023). 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs Convergent Research - Senior Scientist, Cell-Based Assay Development Post Doctoral Fellow Research associate in protein production Vice President, Oncology Clinical Research PostDoctoral Associate PostDoctoral Position Team

Devki D Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic fibroblast heterogeneity in fibroblast-associated diseases Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model Methods & Updates in GPCR Research Current and emerging Channels, and Transport Proteins (March 24 - 29, 2024) GPCR Jobs NEW Director, Regulatory Affairs NEW Research Robert Lefkowitz Lab Senior Research Specialist - Natural Sciences - Surgery Senior Scientist- Membrane

pathway network and its dynamics in the mesenchymal transition of glioblastoma Methods & Updates in GPCR Research Announces Settlement of INGREZZA Abbreviated New Drug Application (ANDA) Litigation PostEra Announces a Research TRUQAP™ (capivasertib) plus fulvestrant approved in the US for patients with advanced HR-positive breast cancer Pharmacology 2026 GPCR Jobs NEW Sr Scientist in Obesity, Muscle, and Metabolism NEW Post-Doctoral Fellow NEW Research Associate I, Tissue Culture Post-Doc Research Associate Postdoctoral Fellow Research Scientist/Postdoctoral

Methods & Updates in GPCR Research Activity Map and Transition Pathways of G Protein-Coupled Receptor 4256, a Highly Potent and Selective Inhibitor of GPR65, in Presentation at American Association for Cancer Research (AACR) Annual Meeting 2023 Setting GPCRs free Dr. - Senior Scientist, Cell-Based Assay Development Post Doctoral Fellow Research associate in protein production Vice President, Oncology Clinical Research PostDoctoral Associate PostDoctoral Position Team

for the treatment of metabolic disease Milena Malcharek , Graham Ladds , et al. for their extensive research Biology - Tectonic Therapeutic PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research mouse neutrophils Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking The Effect of Cancer-Associated Mutations

macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer It has begun to play important roles in drug development for complex diseases such as cancer, including triple-negative breast cancer (TNBC). incorporated the dynamics of TAMs into our previously published QSP model to investigate their impact on cancer

The latest and greatest in GPCR research is here, this week we’ve curated 14 GPCR papers, 7 industry Ross Cheloha's research involves semi-synthetic nanobody-ligand conjugates with enhanced transcriptional macrophage migration during tissue inflammation From odor to oncology: non-canonical odorant receptors in cancer Methods & Updates in GPCR Research Phosphorylation Sites of the Gastric Inhibitory Polypeptide Receptor of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Scholar - O’Neill Lab NEW Junior Research

Matthew T Eddy and his team's research on A2A adenosine receptor activation by G protein and mutations Oncology and Immunology Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer proliferation of T-cell lymphoma cells through the enhancement of apoptosis Methods & Updates in GPCR Research Heptares to take back GPCR agonist after GSK changes course All-rounder among receptors inspires drug research scientist – oncology biomarker expert NEW Postdoctoral Fellow NEW Scientific Assistant Scientist Lead Researcher

Professor Deane is one of the UK’s most accomplished bioinformaticians. Prior to this, Professor Deane was Deputy Executive Chair of the Engineering and Physical Sciences Research Council at UK Research and Innovation (UKRI). She has played an active role during the COVID-19 pandemic as the UKRI’s COVID Response Director, and was a member of SAGE, the UK Government’s Scientific Advisory Group for Emergencies.

This week's highlight includes congrats to: David A Cooper, David Minh, et al., for their research on If you have any research you would like to showcase to our community, you can submit a poster presentation April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK Research Technologist I Senior Scientist- Internal Medicine Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research Fellow Postdoctoral Fellow

By systematically mutating every amino acid in the protein and assessing the resulting phenotype, researchers By examining how mutations in the target protein affect its interaction with the drug, researchers can significant challenge in drug development, particularly in the treatment of infectious diseases and cancer resources, including time, financial investment, and specialised expertise, limiting accessibility for some research

and Immunology Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer combination with decitabine in relapsed or refractory acute myeloid leukemia Methods & Updates in GPCR Research Treatment of Insomnia OMass Therapeutics Releases First Protein Structures in PDB, Advances Lupus Therapy Research Structure Therapeutics Receives R&D Achievement of the Year Award for GPCR Research Bryan Roth, Natural | SLAS Europe 2024 Conference and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines GPCR Jobs NEW Research

Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs HIGHLIGHT Research Scientist, Computational Chemistry Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research in a mouse model of sciatic nerve injury GPCRs in Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis Methods & Updates in GPCR Research

Get the latest updates on breakthroughs in GPCR research with our concise and comprehensive summaries Their research reveals how VU0486846 reduces neurogliosis in female Alzheimer's mice. Dr. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK Technologist I Senior Scientist- Internal Medicine Research Unit Postdoctoral Scholar – Synaptic physiology , optical imaging, substance use disorder, pharmacology Research Fellow Postdoctoral Fellow – Molecular

Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer Methods & Updates in GPCR Research Deep-Learning-Enhanced Diffusion Imaging Assay for Resolving Local-Density Bioinformatics/Data Science at Department of Drug Design and Pharmacology Scientist/Senior Scientist (Research Assistant Research Fellow - School of Physics and Astronomy Postdoctoral Research Associate (Fixed Term

Katharina Grotsch, Bryan L Roth, Valery V Fokin  et al. for their research on Virtual Screening of a If you have any research you would like to showcase to our community, you can submit a poster presentation April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK Research Technologist I Senior Scientist- Internal Medicine Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research Fellow Join Dr.

👋 Take a look at the latest and greatest in GPCR research. Methods & Updates in GPCR Research Solvent accessibility of a GPCR transmembrane domain probed by in-membrane Sosei Heptares presented novel Computational Chemistry and Cheminformatics approaches for GPCR SBDD at UK - Senior Scientist, Cell-Based Assay Development Post Doctoral Fellow Research associate in protein production Vice President, Oncology Clinical Research Explore Dr.

ahead without noise or delays: Industry insights:  Structure-Based Drug Design Summit; AI-Powered GPCR Research Upcoming events:  5th MMCS New Trends in Drug Discovery; GPCR-UK Network Meeting; neuroGPCR Symposium unconventional path—from patient to scientist—exemplifies why personal mission matters in translational research Redefine your playbook:  Why Serafini believes that pain research needs to start from clinical phenotype s Corner  digital pharmacology courses Priority access to insights from major conferences, emerging research