Search Results

Research interests: Signaling mechanisms involving GPCRs and heterotrimeric G proteins" Dr.

His interests are in receptor pharmacology, allosteric protein function, and drug discovery. Dr.

In this episode, Silvio discusses G protein signaling in the context of cancer, immunotherapies, and

Workshop 2024 Endocrine Metabolic GPCRs Meet Inoviem Team GPCR ECI Transatlantic 2022 Editorial: GPCR and G Protein-Mediated Signalling Events in the Nervous System Dr.

Among other projects, I studied the role of β-arrestin in G protein trafficking, the impact of GPCR ubiquitination early tasks at Michelle’s lab, which involved creating stable cell lines and identifying potential protein the potential of multiplexing assays in expanding the scope of scientific exploration and finding new protein Yamina shared her experiences at Rockefeller, where she studied chemical receptors.

The adapter protein 3BP2 is mutated in Cherubism. that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell function and scavenger receptor

Blind Spots: The Underestimated Role of RGS Proteins in Pain Although not a self-proclaimed GPCR specialist , Serafini found himself repeatedly drawn to them, or more precisely, to RGS (Regulators of G protein Signaling) proteins. and addiction/withdrawal on the mesocorticolimbic system, focusing on transcription factor and RGS protein maladaptations, behavioral RGS protein drug "screening", and the role of SARS-CoV-2 on CNS function

the lab works on diverse models and diseases, and has developed a wide array of tools to dissect GPCR/G protein signaling which I would be happy to discuss.

Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of GPCRs and a small family of accessory proteins called RAMPs. Ilana’s research is multi-disciplinary and involves a close collaboration with proteomics experts at

submissions in structural biology, biophysics and biochemistry, with a particular focus on membrane proteins and protein folding."

Aurelien Rizk shared that he had always focused on GPCRs but had also worked on other types of receptors They validated their technology and made collaborations for expertise on chemokine receptors. Therapeutic Effect and Receptor Interactions Aurelien Rizk and Yamina had a detailed discussion about They emphasized the need to quantify the dynamics of the pathways and the residence time of the receptor They also shared their preference for small molecule therapies over protein therapeutics.

His thesis work led to the development and application of light energy transfer methodology to study protein-protein

Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially Switzerland, Department of Biochemistry (2005-2009), where I started working on membranes and membrane protein

Sponsors GPCR Retreat Program < Back to schedule Atypical Structure and Function of Typical Chemokine Receptors of the principal efforts of our laboratory is to understand the physiological consequences of NMDA receptor The NMDA receptor is a subtype of glutamate neurotransmitter receptor that regulates the formation and Our laboratory is interested in the role of NMDA receptors not only on neurons, but also on other cells Our laboratory has a long-standing interest in the way that NMDA receptors contribute to the symptoms

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type -1-receptor #gpcr #drgpcr Published on February 6, 2025 Category GPCR Weekly News Subscribe to the Dr ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type -1-receptor #gpcr #drgpcr Recent Articles Previous Next

Home → Flash News → How does a superagonist activate M2 muscarinic receptors? www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/visualizing-agonist-induced-m2-receptor-activation-regulated-by-aromatic-ring-dynamics Published on March 31, 2025 Category GPCR Weekly News How does a superagonist activate M2 muscarinic receptors www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/visualizing-agonist-induced-m2-receptor-activation-regulated-by-aromatic-ring-dynamics

Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling /high-resolution-deep-mutational-scanning-of-the-melanocortin-4-receptor-enables-target-characterization-for-drug-discovery Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling /high-resolution-deep-mutational-scanning-of-the-melanocortin-4-receptor-enables-target-characterization-for-drug-discovery

Home → Flash News → Adenosine A3 receptor has been proposed to have significant roles in metabolism and /buff.ly/42b6ra3 #gpcr #drgpcr Published on January 16, 2025 Category GPCR Weekly News Adenosine A3 receptor Understanding how persistent binding affects receptor turnover, tissue penetration, and PK/PD relationships Inhibition In GPCR Discovery Programs Every drug you design will meet an enzyme before it meets its receptor Pharmacology: The Hidden Gatekeepers of GPCR Drug Discovery Before your GPCR ligand ever meets its receptor

out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors methods-and-updates-in-gpcr-research/development-of-a-nanobret-assay-platform-to-detect-intracellular-ligands-for-the-chemokine-receptors-ccr6

Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Complex Allosteric Cannabinoid Receptor

Brian Shoichet BSc in Chemistry from MIT, Ph.D. with Tack Kuntz at UCSF; Postdoc with Brian Matthews in protein

the team’s strategy from traditional calcium assays to IP1 accumulation—and why it mattered for Gq-coupled receptors.

Home → Flash News → Forget one receptor at a time. GPCR Podcast Forget one receptor at a time.

shares his journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor shares his journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor

With tools like AlphaFold , his lab can now model receptor–peptide complexes in seconds — an achievement October 27, 2025 Terry's Corner Read full article Receptor pharmacology has evolved. Their lab doesn’t just simulate receptor-ligand interactions after the fact; they aim to forecast receptor conformations that favor Gq coupling. ♦️ Two distinct Gq-bound conformations ♦️ Comparison with Gs-bound The result: a framework for designing ligands with altered receptor preferences. ♦️ Defines “public”

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13 ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13

allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors

Gunnar Schulte Gunnar Schulte is a Professor in receptor pharmacology and research group leader for the section Receptor Biology and Signaling at the Department of Physiology and Pharmacology. University, Melbourne Australia, GPCR pharmacology; 2006) before starting his independent research team "Receptor Most importantly my research team tries to understand underlying mechanisms of WNT-receptor interaction , the relevance of receptor dynamics, and receptor complex composition for signal initiation and specification

regulation of axonal transport by tricyclic antidepressants (M.Sc.) and molecular pharmacology of opioid receptors Marc Caron, where I cloned the dopamine D5 receptor gene and investigated the regulation of dopaminergic and adrenergic receptors. pursues the study of the molecular, structural, pharmacological and signaling features of dopamine (DA) receptors druggability potential of new signaling partners we identified that drive the formation of different DA receptor

can overcome these obstacles by producing high-quality antibodies that more accurately mimic natural protein