the early days of ion channel chemistry to pioneering peptide–fluorophore conjugates for the GLP-1 receptor Why targeting the pharmacologically relevant surface-exposed receptor pool changes the way scientists The moment when super-resolution imaging revealed nanoscale receptor domains that conventional tools Berlin, focusing on developing fluorescent chemical tools to visualize GPCRs and other cell-surface proteins lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand receptor

.” — Alex Serafini Blind Spots: The Underestimated Role of RGS Proteins in Pain Although not a self-proclaimed specialist, Serafini found himself repeatedly drawn to them, or more precisely, to RGS (Regulators of G protein Signaling) proteins. and addiction/withdrawal on the mesocorticolimbic system, focusing on transcription factor and RGS protein maladaptations, behavioral RGS protein drug "screening", and the role of SARS-CoV-2 on CNS function

Research interests: Signaling mechanisms involving GPCRs and heterotrimeric G proteins" Dr.

designed to assess the kinetics of unlabelled compounds (and chemical fragments) and the use of purified receptor / effector proteins as tools for drug discovery. " Dr.

Bender uses virtual docking to find chemical probes for orphan GPCRs - receptors biology can't study This gap is one of the defining bottlenecks in receptor pharmacology, and closing it one receptor at He trained as a structural biologist at Vanderbilt University, working with X-ray crystallography, protein pharmacology versus single-receptor studies Building scientific community at the early-career stage "I have to go into more receptors. I can't stay with just the one." About Dr. Brian Bender Dr.

Beatriz Blanco-Redondo on characterizing unknown adhesion GPCRs in Drosophila - receptor discovery, nocifensive Remulate is the receptor she secured funding to study, the one her first PhD student built an entire She trained in protein biochemistry and neuroscience, completing her PhD in Germany and her postdoctoral Since returning to Europe, her research has centered on receptor biology at the intersection of basic Scientific Themes of the Conversation First-contact receptor characterization, what it means to study

Workshop 2024 Endocrine Metabolic GPCRs Meet Inoviem Team GPCR ECI Transatlantic 2022 Editorial: GPCR and G Protein-Mediated Signalling Events in the Nervous System Dr.

the lab works on diverse models and diseases, and has developed a wide array of tools to dissect GPCR/G protein signaling which I would be happy to discuss.

Aurelien Rizk shared that he had always focused on GPCRs but had also worked on other types of receptors They validated their technology and made collaborations for expertise on chemokine receptors. Therapeutic Effect and Receptor Interactions Aurelien Rizk and Yamina had a detailed discussion about They emphasized the need to quantify the dynamics of the pathways and the residence time of the receptor They also shared their preference for small molecule therapies over protein therapeutics.

Marro describes a Gq coupled receptor program in which four lead series with sub nanomolar calcium potency The discussion extends to biased GLP1 receptor agonists that favor membrane retention and faster recycling gastrointestinal and cardiovascular metabolic disease, including the discovery of small molecule GLP1 receptor Emax as a driver of in vivo efficacy - Setting a high bar for what counts as true biased agonism - Receptor Keeping GLP1 receptors at the membrane can shape the therapeutic profile Building on work from Stephen

the team’s strategy from traditional calcium assays to IP1 accumulation—and why it mattered for Gq-coupled receptors.

Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of GPCRs and a small family of accessory proteins called RAMPs. Ilana’s research is multi-disciplinary and involves a close collaboration with proteomics experts at

The scientists who do this work accumulate expertise - in receptor signaling, cardiovascular physiology A paper confirming the receptor's mechanotransduction function in endothelial cells appeared roughly hypothesis generator: what comes before the data Selected Quotes "There was a paper that came out a couple

submissions in structural biology, biophysics and biochemistry, with a particular focus on membrane proteins and protein folding."

Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially Switzerland, Department of Biochemistry (2005-2009), where I started working on membranes and membrane protein

His thesis work led to the development and application of light energy transfer methodology to study protein-protein

AI is reshaping how we understand protein dynamics , but only when driven by deep biological questions behind founding Blue Therapeutics and targeting supraspinal pain pathway What it means to “teach AI protein

matchmaking - applying recommendation system logic to the bitter taste receptor family Sweet taste receptor The cost is that finding antagonists for these receptors has proven far more difficult than finding agonists receptor inhibitor suppresses the sweetness of heavy water. Taste receptor expression throughout the body reshapes the meaning of drug off-targets Bitter taste receptors - bitter taste receptors in the airways, gut, heart, and cancer tissues 19:37 - Sweet taste receptors

Pluznick explores what changes when olfactory receptors are treated not as smell receptors but as general-purpose Her lab studies the role of understudied GPCRs — olfactory receptors, taste receptors, and orphan GPRs Reframing olfactory receptors as chemosensors. The name "olfactory receptor" narrows the imagination. Dr. Mice have ~1,000 olfactory receptors; humans have ~350.

Brian Shoichet BSc in Chemistry from MIT, Ph.D. with Tack Kuntz at UCSF; Postdoc with Brian Matthews in protein

How receptor residence time — not affinity — rescued a CRF drug discovery program, and why a career in When Sam Hoare and the CRF receptor team at Neurocrin Biosciences discovered that their lead compound sat on the receptor for seven hours while a failed backup fell off in fifteen minutes, it exposed a After a PhD on allosteric modulation of dopamine receptors in Philip Strange's UK lab and a postdoc at in vivo stayed on the receptor for seven hours at room temperature.

David Hodson on visualizing GLP-1 and GIP receptors in pancreatic islets and brain circuits to advance therapies for diabetes and obesity. << Back to podcast list Strategic Partner(s) Visualizing GLP-1 & GIP Receptors in Islets and Brain In this episode, Professor David Hodson discusses how GLP-1 and GIP receptors regulate metabolism across the pancreas and brain, and why visualizing receptor localization and signaling in Why this matters How receptor distribution in islets and brain circuits shapes incretin hormone drug

build Virtual Reality solutions for Scientists and Engineers working at the nanoscale, specifically protein

Trained as a biochemist, he completed a PhD in protein engineering (Cambridge, UK) with Sir Gregory Winter

pharmacologist and biophysicist, systems and synthetic biologist, technologist, heavy CRISPR user, protein

Fung has spent significant time in the industry studying membrane proteins, antibodies, and HTS methods

His lab has worked on building large-scale ways of empirically exploring questions in protein biochemistry

Laura Duvall's lab has traced this suppression to a specific neuropeptide Y family receptor, one she What pulls Duvall back to this receptor personally is its apparent conservation: the same NPY family receptor she found in mosquito gut tissue has a close relative in the human colon, doing a job no one A neuropeptide receptor turned up in a tissue no one expected. One receptor sits at the intersection of two very different behaviors.

Tore Bengtsson on β₂-adrenergic receptor signaling, muscle metabolism, and how GPCR pharmacology can Tore Bengtsson , professor of physiology at Stockholm University, explores how β-adrenergic receptor “People think a receptor produces one signal. In reality, a receptor produces many signals.” That’s what we’ve now achieved with new compounds that stimulate the receptor in a novel way. Traditionally people thought receptor activation leads to one downstream pathway.

GIPR Imaging: From Cell Assays to In Vivo Systems Fluorescent tools for imaging endogenous incretin receptors across biological systems Interrogating Incretin Receptor Biology Across Biological Complexity GLP-1 and GIP receptors have emerged as central targets in metabolic medicine, yet their precise localization and dynamics in native contexts — without relying on receptor overexpression or genetic modification Enable simultaneous visualization of endogenous receptor localization and nanodomain organization in