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His interests are in receptor pharmacology, allosteric protein function, and drug discovery. Dr.

Bender uses virtual docking to find chemical probes for orphan GPCRs - receptors biology can't study This gap is one of the defining bottlenecks in receptor pharmacology, and closing it one receptor at He trained as a structural biologist at Vanderbilt University, working with X-ray crystallography, protein pharmacology versus single-receptor studies Building scientific community at the early-career stage "I have to go into more receptors. I can't stay with just the one." About Dr. Brian Bender Dr.

Workshop 2024 Endocrine Metabolic GPCRs Meet Inoviem Team GPCR ECI Transatlantic 2022 Editorial: GPCR and G Protein-Mediated Signalling Events in the Nervous System Dr.

Beatriz Blanco-Redondo on characterizing unknown adhesion GPCRs in Drosophila - receptor discovery, nocifensive Remulate is the receptor she secured funding to study, the one her first PhD student built an entire She trained in protein biochemistry and neuroscience, completing her PhD in Germany and her postdoctoral Since returning to Europe, her research has centered on receptor biology at the intersection of basic Scientific Themes of the Conversation First-contact receptor characterization, what it means to study

the lab works on diverse models and diseases, and has developed a wide array of tools to dissect GPCR/G protein signaling which I would be happy to discuss.

Aurelien Rizk shared that he had always focused on GPCRs but had also worked on other types of receptors They validated their technology and made collaborations for expertise on chemokine receptors. Therapeutic Effect and Receptor Interactions Aurelien Rizk and Yamina had a detailed discussion about They emphasized the need to quantify the dynamics of the pathways and the residence time of the receptor They also shared their preference for small molecule therapies over protein therapeutics.

the team’s strategy from traditional calcium assays to IP1 accumulation—and why it mattered for Gq-coupled receptors.

Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of GPCRs and a small family of accessory proteins called RAMPs. Ilana’s research is multi-disciplinary and involves a close collaboration with proteomics experts at

The scientists who do this work accumulate expertise - in receptor signaling, cardiovascular physiology A paper confirming the receptor's mechanotransduction function in endothelial cells appeared roughly hypothesis generator: what comes before the data Selected Quotes "There was a paper that came out a couple

submissions in structural biology, biophysics and biochemistry, with a particular focus on membrane proteins and protein folding."

His thesis work led to the development and application of light energy transfer methodology to study protein-protein

Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially Switzerland, Department of Biochemistry (2005-2009), where I started working on membranes and membrane protein

AI is reshaping how we understand protein dynamics , but only when driven by deep biological questions behind founding Blue Therapeutics and targeting supraspinal pain pathway What it means to “teach AI protein

Brian Shoichet BSc in Chemistry from MIT, Ph.D. with Tack Kuntz at UCSF; Postdoc with Brian Matthews in protein

matchmaking - applying recommendation system logic to the bitter taste receptor family Sweet taste receptor The cost is that finding antagonists for these receptors has proven far more difficult than finding agonists receptor inhibitor suppresses the sweetness of heavy water. Taste receptor expression throughout the body reshapes the meaning of drug off-targets Bitter taste receptors - bitter taste receptors in the airways, gut, heart, and cancer tissues 19:37 - Sweet taste receptors

Pluznick explores what changes when olfactory receptors are treated not as smell receptors but as general-purpose Her lab studies the role of understudied GPCRs — olfactory receptors, taste receptors, and orphan GPRs Reframing olfactory receptors as chemosensors. The name "olfactory receptor" narrows the imagination. Dr. Mice have ~1,000 olfactory receptors; humans have ~350.

build Virtual Reality solutions for Scientists and Engineers working at the nanoscale, specifically protein

Trained as a biochemist, he completed a PhD in protein engineering (Cambridge, UK) with Sir Gregory Winter

How receptor residence time — not affinity — rescued a CRF drug discovery program, and why a career in When Sam Hoare and the CRF receptor team at Neurocrin Biosciences discovered that their lead compound sat on the receptor for seven hours while a failed backup fell off in fifteen minutes, it exposed a After a PhD on allosteric modulation of dopamine receptors in Philip Strange's UK lab and a postdoc at in vivo stayed on the receptor for seven hours at room temperature.

pharmacologist and biophysicist, systems and synthetic biologist, technologist, heavy CRISPR user, protein

Fung has spent significant time in the industry studying membrane proteins, antibodies, and HTS methods

David Hodson on visualizing GLP-1 and GIP receptors in pancreatic islets and brain circuits to advance therapies for diabetes and obesity. << Back to podcast list Strategic Partner(s) Visualizing GLP-1 & GIP Receptors in Islets and Brain In this episode, Professor David Hodson discusses how GLP-1 and GIP receptors regulate metabolism across the pancreas and brain, and why visualizing receptor localization and signaling in Why this matters How receptor distribution in islets and brain circuits shapes incretin hormone drug

His lab has worked on building large-scale ways of empirically exploring questions in protein biochemistry

Tore Bengtsson on β₂-adrenergic receptor signaling, muscle metabolism, and how GPCR pharmacology can Tore Bengtsson , professor of physiology at Stockholm University, explores how β-adrenergic receptor “People think a receptor produces one signal. In reality, a receptor produces many signals.” That’s what we’ve now achieved with new compounds that stimulate the receptor in a novel way. Traditionally people thought receptor activation leads to one downstream pathway.

GIPR Imaging: From Cell Assays to In Vivo Systems Fluorescent tools for imaging endogenous incretin receptors across biological systems Interrogating Incretin Receptor Biology Across Biological Complexity GLP-1 and GIP receptors have emerged as central targets in metabolic medicine, yet their precise localization and dynamics in native contexts — without relying on receptor overexpression or genetic modification Enable simultaneous visualization of endogenous receptor localization and nanodomain organization in

graduate school at the University of California at Irvine, studying the regulation of ionotropic glutamate receptors , Oregon, to do a post-doctoral fellowship in the laboratory of Thomas Soderling studying glutamate receptor continued his post-doctoral training at Duke University, where he studied the regulation of adrenergic receptors contributions to understanding the signaling, regulation and in vivo actions of the neuroprotective receptors Randy’s lab has a special interest in studying disease-associated mutations to human GPCRs that perturb receptor

Its discovery and characterization have led to the development of GLP-1 receptor agonists, a therapeutic This session provides a foundational overview of GLP-1 physiology and receptor pharmacology. The session also reviews currently approved GLP-1 receptor agonists, highlighting pharmacokinetic strategies In this Masterclass, she introduces the physiological and pharmacological foundations of GLP-1 receptor

In parallel, his earlier work on orphan receptor deorphanization used co-evolution analysis and machine Together, these projects represent a rare attempt to connect the molecular detail of receptor pharmacology with the population-scale reality of how those receptors behave in living patients. genetic variants across human populations Co-evolution and machine learning as a framework for orphan receptor Orphan receptors can be systematically approached through evolutionary logic Rather than screening compound

doctoral dissertation was the first large-scale study of structure-activity relationships for adenosine receptors postdoc with John W Daly at NIH and Solomon Snyder at Johns Hopkins, he developed the first adenosine receptor He then joined WL/PD, where his lab demonstrated the existence of two subtypes of the adenosine A2 receptor In 1988, he joined Lilly as a receptor biologist in charge of a high-throughput screening lab.

Duvall discusses her lab’s work dissecting how GPCRs—especially neuropeptide Y (NPY) receptors—regulate and functional behavioral assays, including high-throughput and video-based methods, to reveal these receptors Why the study of conserved receptor pathways enables the development of broadly effective, species-independent How dissecting receptor function in non-neuronal tissues uncovers new parallels to human gut-brain communication If you often translate receptor mechanism findings from model organisms to human systems.