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Research interests: Signaling mechanisms involving GPCRs and heterotrimeric G proteins" Dr.

From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar ligand concentrations, her work highlights why receptor localization and protein complex assembly matter high-throughput GPCR screens. ⸻ Inside This Episode How ultrasensitive GPCR signaling emerges from pre-assembled receptor–effector Why receptor localization and scaffolding dramatically shift functional readouts in disease models. The moment when femtomolar ligand concentrations uncovered unexpected receptor sensitivity.

and received my Ph.D. in Molecular Medicine in 2010 after studying the orphan atypical cannabinoid receptor I was fascinated by the multitude of processes that are regulated/dysregulated by GPCRs and RGS proteins A fungal serine protease allergen with GPCR-modulating features was discovered as a new biomarker and I studied the function of RGS5, calcium-sensing receptor, and an orphan adhesion GPCR, GPR64/ADGRG2 in

designed to assess the kinetics of unlabelled compounds (and chemical fragments) and the use of purified receptor / effector proteins as tools for drug discovery. " Dr.

John and his team focus on understanding how signal transduction cascades downstream of the opioid receptors work, including the unique organization of chaperone protein Hsp90 modulation of opioid signaling in

His interests are in receptor pharmacology, allosteric protein function, and drug discovery. Dr.

In this episode, Silvio discusses G protein signaling in the context of cancer, immunotherapies, and

GPCR Podcast Strategic Partner(s) Scaling GLP 1 Receptor Tools Through Academia Industry Collaboration access aren’t planned from the start Why fluorescence-based assays outperform antibodies for studying receptor focuses on bottom-up chemical tool development for imaging and interrogating GPCRs and other cell-surface proteins His research focuses on class B GPCRs, including the GLP-1 and GIP receptors, with an emphasis on understanding how these receptors operate within complex tissues such as the pancreas and brain.

Workshop 2024 Endocrine Metabolic GPCRs Meet Inoviem Team GPCR ECI Transatlantic 2022 Editorial: GPCR and G Protein-Mediated Signalling Events in the Nervous System Dr.

the early days of ion channel chemistry to pioneering peptide–fluorophore conjugates for the GLP-1 receptor Why targeting the pharmacologically relevant surface-exposed receptor pool changes the way scientists The moment when super-resolution imaging revealed nanoscale receptor domains that conventional tools Berlin, focusing on developing fluorescent chemical tools to visualize GPCRs and other cell-surface proteins lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand receptor

Among other projects, I studied the role of β-arrestin in G protein trafficking, the impact of GPCR ubiquitination early tasks at Michelle’s lab, which involved creating stable cell lines and identifying potential protein the potential of multiplexing assays in expanding the scope of scientific exploration and finding new protein Yamina shared her experiences at Rockefeller, where she studied chemical receptors.

the lab works on diverse models and diseases, and has developed a wide array of tools to dissect GPCR/G protein signaling which I would be happy to discuss.

Blind Spots: The Underestimated Role of RGS Proteins in Pain Although not a self-proclaimed GPCR specialist , Serafini found himself repeatedly drawn to them, or more precisely, to RGS (Regulators of G protein Signaling) proteins. and addiction/withdrawal on the mesocorticolimbic system, focusing on transcription factor and RGS protein maladaptations, behavioral RGS protein drug "screening", and the role of SARS-CoV-2 on CNS function

The adapter protein 3BP2 is mutated in Cherubism. that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell function and scavenger receptor

Michelle describes how reading those early papers on lipid-rich domains and GPCR–G protein compartmentalization reframed her view of receptor pharmacology. Why receptor location matters as much as receptor type. October 27, 2025 Terry's Corner Read full article Receptor pharmacology has evolved. Their lab doesn’t just simulate receptor-ligand interactions after the fact; they aim to forecast receptor

Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of GPCRs and a small family of accessory proteins called RAMPs. Ilana’s research is multi-disciplinary and involves a close collaboration with proteomics experts at

submissions in structural biology, biophysics and biochemistry, with a particular focus on membrane proteins and protein folding."

Aurelien Rizk shared that he had always focused on GPCRs but had also worked on other types of receptors They validated their technology and made collaborations for expertise on chemokine receptors. Therapeutic Effect and Receptor Interactions Aurelien Rizk and Yamina had a detailed discussion about They emphasized the need to quantify the dynamics of the pathways and the residence time of the receptor They also shared their preference for small molecule therapies over protein therapeutics.

Sponsors GPCR Retreat Program < Back to schedule Atypical Structure and Function of Typical Chemokine Receptors of the principal efforts of our laboratory is to understand the physiological consequences of NMDA receptor The NMDA receptor is a subtype of glutamate neurotransmitter receptor that regulates the formation and Our laboratory is interested in the role of NMDA receptors not only on neurons, but also on other cells Our laboratory has a long-standing interest in the way that NMDA receptors contribute to the symptoms

Did you know that certain ergot derivatives can produce wash-resistant signalling through the 5-HT2B receptor et al. suggested that this phenomenon results from persistently/irreversibly internalised signalling receptor ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/mechanisms-of-constitutive-and-agonist-induced Did you know that certain ergot derivatives can produce wash-resistant signalling through the 5-HT2B receptor et al. suggested that this phenomenon results from persistently/irreversibly internalised signalling receptor

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type -1-receptor #gpcr #drgpcr Published on February 6, 2025 Category GPCR Weekly News Subscribe to the Dr ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type -1-receptor #gpcr #drgpcr Previous Next Recent Articles

His thesis work led to the development and application of light energy transfer methodology to study protein-protein

Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially Switzerland, Department of Biochemistry (2005-2009), where I started working on membranes and membrane protein

Home → Flash News → How does a superagonist activate M2 muscarinic receptors? www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/visualizing-agonist-induced-m2-receptor-activation-regulated-by-aromatic-ring-dynamics Published on March 31, 2025 Category GPCR Weekly News How does a superagonist activate M2 muscarinic receptors www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/visualizing-agonist-induced-m2-receptor-activation-regulated-by-aromatic-ring-dynamics

Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Complex Allosteric Cannabinoid Receptor

David Hodson on visualizing GLP-1 and GIP receptors in pancreatic islets and brain circuits to advance GPCR Podcast Strategic Partners Visualizing GLP-1 & GIP Receptors in Islets and Brain In this episode , Professor David Hodson discusses how GLP-1 and GIP receptors regulate metabolism across the pancreas and brain, and why visualizing receptor localization and signaling in real tissues is essential for Why this matters How receptor distribution in islets and brain circuits shapes incretin hormone drug

Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling /high-resolution-deep-mutational-scanning-of-the-melanocortin-4-receptor-enables-target-characterization-for-drug-discovery Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling /high-resolution-deep-mutational-scanning-of-the-melanocortin-4-receptor-enables-target-characterization-for-drug-discovery

Understanding receptor-specific nuances, like the role of NTF cleavage, is crucial for decoding their www.ecosystem.drgpcr.com/adhesion-gpcrs/n-terminal-fragment-shedding-contributes-to-signaling-of-the-full-length-adhesion-receptor-adgrl3 Understanding receptor-specific nuances, like the role of NTF cleavage, is crucial for decoding their www.ecosystem.drgpcr.com/adhesion-gpcrs/n-terminal-fragment-shedding-contributes-to-signaling-of-the-full-length-adhesion-receptor-adgrl3

Home → Flash News → A new study from the Hudson Lab at the University of Glasgow shows that the FFA receptor www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/inverse-agonism-of-the-ffa4-free-fatty-acid-receptor-controls-both-adipogenesis-and-mature-adipocyte-function Category GPCR Weekly News A new study from the Hudson Lab at the University of Glasgow shows that the FFA receptor www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/inverse-agonism-of-the-ffa4-free-fatty-acid-receptor-controls-both-adipogenesis-and-mature-adipocyte-function

Home → Flash News → Adenosine A3 receptor has been proposed to have significant roles in metabolism and /buff.ly/42b6ra3 #gpcr #drgpcr Published on January 16, 2025 Category GPCR Weekly News Adenosine A3 receptor Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling