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the lab works on diverse models and diseases, and has developed a wide array of tools to dissect GPCR/G protein signaling which I would be happy to discuss.

.” — Alex Serafini Blind Spots: The Underestimated Role of RGS Proteins in Pain Although not a self-proclaimed specialist, Serafini found himself repeatedly drawn to them, or more precisely, to RGS (Regulators of G protein Signaling) proteins. and addiction/withdrawal on the mesocorticolimbic system, focusing on transcription factor and RGS protein maladaptations, behavioral RGS protein drug "screening", and the role of SARS-CoV-2 on CNS function

The adapter protein 3BP2 is mutated in Cherubism. that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell function and scavenger receptor

Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of GPCRs and a small family of accessory proteins called RAMPs. Ilana’s research is multi-disciplinary and involves a close collaboration with proteomics experts at

submissions in structural biology, biophysics and biochemistry, with a particular focus on membrane proteins and protein folding."

Aurelien Rizk shared that he had always focused on GPCRs but had also worked on other types of receptors They validated their technology and made collaborations for expertise on chemokine receptors. Therapeutic Effect and Receptor Interactions Aurelien Rizk and Yamina had a detailed discussion about They emphasized the need to quantify the dynamics of the pathways and the residence time of the receptor They also shared their preference for small molecule therapies over protein therapeutics.

Sponsors GPCR Retreat Program < Back to schedule Atypical Structure and Function of Typical Chemokine Receptors of the principal efforts of our laboratory is to understand the physiological consequences of NMDA receptor The NMDA receptor is a subtype of glutamate neurotransmitter receptor that regulates the formation and Our laboratory is interested in the role of NMDA receptors not only on neurons, but also on other cells Our laboratory has a long-standing interest in the way that NMDA receptors contribute to the symptoms

Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Complex Allosteric Cannabinoid Receptor

David Hodson on visualizing GLP-1 and GIP receptors in pancreatic islets and brain circuits to advance therapies for diabetes and obesity. << Back to podcast list Strategic Partner(s) Visualizing GLP-1 & GIP Receptors in Islets and Brain In this episode, Professor David Hodson discusses how GLP-1 and GIP receptors regulate metabolism across the pancreas and brain, and why visualizing receptor localization and signaling in Why this matters How receptor distribution in islets and brain circuits shapes incretin hormone drug

His thesis work led to the development and application of light energy transfer methodology to study protein-protein

Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially Switzerland, Department of Biochemistry (2005-2009), where I started working on membranes and membrane protein

Gunnar Schulte Gunnar Schulte is a Professor in receptor pharmacology and research group leader for the section Receptor Biology and Signaling at the Department of Physiology and Pharmacology. University, Melbourne Australia, GPCR pharmacology; 2006) before starting his independent research team "Receptor Most importantly my research team tries to understand underlying mechanisms of WNT-receptor interaction , the relevance of receptor dynamics, and receptor complex composition for signal initiation and specification

🚀 This workshop will explore how different ligands (compounds) can stabilize unique receptor conformations , leading to distinct signaling outcomes—even when binding to the same receptor. 🧬 Receptor Flexibility : Ligands stabilize different receptor states, creating unique signaling pathways are Dynamic Players 🔹 Different ligands trigger unique receptor states, meaning the same receptor can This allows for a side-by-side comparison of how different compounds influence receptor signaling. 📌

regulation of axonal transport by tricyclic antidepressants (M.Sc.) and molecular pharmacology of opioid receptors Marc Caron, where I cloned the dopamine D5 receptor gene and investigated the regulation of dopaminergic and adrenergic receptors. pursues the study of the molecular, structural, pharmacological and signaling features of dopamine (DA) receptors druggability potential of new signaling partners we identified that drive the formation of different DA receptor

Brian Shoichet BSc in Chemistry from MIT, Ph.D. with Tack Kuntz at UCSF; Postdoc with Brian Matthews in protein

Paul Clarck , where she studied opioid receptors. AstraZeneca as a postdoctoral trainee, where she studied animal models of pain and sensory neuron sensitive-receptor Brigitte Kieffer , where she studied ligand-directed signaling at the delta-opioid receptor. Amynah studied how arrestins regulate ligand-directed signaling at delta-opioid receptors, and it is Andrew Charles that who specialized in animal models of migraine and delta-opioid receptors as a therapeutic

GIPR Imaging: From Cell Assays to In Vivo Systems Fluorescent tools for imaging endogenous incretin receptors Interrogating Incretin Receptor Biology Across Biological Complexity GLP-1 and GIP receptors have emerged Fluorescent chemical probes offer one of the most direct approaches for investigating receptor distribution and dynamics in native contexts — without relying on receptor overexpression or genetic modification Enable simultaneous visualization of endogenous receptor localization and nanodomain organization in

the team’s strategy from traditional calcium assays to IP1 accumulation—and why it mattered for Gq-coupled receptors.

graduate school at the University of California at Irvine, studying the regulation of ionotropic glutamate receptors , Oregon, to do a post-doctoral fellowship in the laboratory of Thomas Soderling studying glutamate receptor continued his post-doctoral training at Duke University, where he studied the regulation of adrenergic receptors contributions to understanding the signaling, regulation and in vivo actions of the neuroprotective receptors Randy’s lab has a special interest in studying disease-associated mutations to human GPCRs that perturb receptor

doctoral dissertation was the first large-scale study of structure-activity relationships for adenosine receptors postdoc with John W Daly at NIH and Solomon Snyder at Johns Hopkins, he developed the first adenosine receptor He then joined WL/PD, where his lab demonstrated the existence of two subtypes of the adenosine A2 receptor In 1988, he joined Lilly as a receptor biologist in charge of a high-throughput screening lab.

Trained as a biochemist, he completed a PhD in protein engineering (Cambridge, UK) with Sir Gregory Winter

can overcome these obstacles by producing high-quality antibodies that more accurately mimic natural protein

build Virtual Reality solutions for Scientists and Engineers working at the nanoscale, specifically protein

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

Fung has spent significant time in the industry studying membrane proteins, antibodies, and HTS methods

in his independent laboratory is focused on developing new pharmacological tools via chemistry and protein

AI is reshaping how we understand protein dynamics , but only when driven by deep biological questions behind founding Blue Therapeutics and targeting supraspinal pain pathway What it means to “teach AI protein

GPCR Retreat Program < Back to schedule Structure-based discovery of functionally selective 5-HT1A receptor