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Maria Majellaro makes it clear that Celtarys isn’t just a ligand provider. Maria Majellaro Celtarys specializes in the custom development of fluorescent ligands  using a modular Their method allows researchers to explore different linker positions, tailor activity (agonist or antagonist Maria emphasizes the importance of genuinely listening to researchers: understanding the biological question discovery workflow on the company page . _______________ Keyword Cloud:   GPCR data platform , fluorescent ligands

re early in your career or pushing the edge of MoA design, weekly lesson help you apply key concepts like The Corner comes will live monthly AMA sessions with Dr. Kenakin. Binding Assays Across Platforms   Celtarys Research presents CELT-419, a nanomolar-affinity fluorescent ligand optimized for D3 receptor assays in both baculovirus and live-cell systems. GPCR mutations in cancer   show both driver-like patterns and high redundancy, prompting a call for multiomics

Watch Episode 168 Success in science is rarely linear. Maria Majellaro Now, she leads a team of talented chemists at Celtarys, developing fluorescent ligands company page . _______________ Keyword Cloud:   GPCR scientist network , career development , fluorescent ligands

eyJ1IjoiaHR0cHM6Ly9kb2kub3JnLzEwLjExMTEvYnBoLjcwMDcyIiwiciI6ImUyZGZlOTFjLTM5YzgtNDA5Yi04NTUyLWI5NjUwNGRlNzc4MyIsIm0iOiJtYWlsX2xwIiwiYyI6IjAwMDAwMDAwLTAwMDAtMDAwMC0wMDAwLTAwMDAwMDAwMDAwMCJ9 The B2D consortium revives biodiversity as a source for selective GPCR ligands

Maria worked with had developed a technology that allowed for flexible, fast synthesis of fluorescent ligands

Maria Majellaro, highlighting their fluorescent ligand tools for live-cell GPCR assays.   industry side, Novo Nordisk, Septerna, and Deep Apple advance billion-dollar GPCR programs, while Eli Lilly GLP-1R/GIPR biased agonism enhances metabolic outcomes Ghrelin receptor flips D2 signaling without a ligand It emphasizes scaffold selection, linker optimization, and assay compatibility to enhance target binding Constitutive ghrelin receptor activity, not dimerization or ligand binding —reverses dopamine D2 signaling

readouts: proximity, immuno assays, pulldowns Validated antibodies + digital search platform Entire library  (e.g., 14-3-3) Heterodimerization Endogenous vs. overexpressed systems Orphan GPCR deorphanization Ligand students and visiting scientists are already expanding this work, bringing in computational layers  like Listen to the complete episode to learn more. _________________ Keyword Cloud : GPCR scientist network

GPCRs in Disease Sakmar highlights how endothelial cells, which express a wide array of GPCRs, are likely The Tools to Detect Them Using the multiplexed GPCR library and Luminex assay , researchers can now: sees a future where this system is not just used for detection, but for functional screening : add ligands

This collaboration aims to amplify the visibility and adoption of Celtarys’ cutting-edge fluorescent ligand Celtarys Research develops high-quality, fluorescently labeled ligands and innovative chemical biology These tools enable high-resolution binding studies, kinetic analysis, and live-cell imaging, empowering “We’re thrilled to partner with Celtarys and introduce their high-performance fluorescent ligands to binding in live cells, and design better experiments, core to advancing GPCR-targeted discovery.”

In this case, we would like to focus on the synthesis of fluorescent probes. has several advantages: it is usually very robust, good yields, reagents are found in most chem labs (like Not only do they work in aqueous medium, but also in aprotic solvents like DMF, where you will need to Thanks to the unique linker structure we obtain, which can be divided into three differentiated parts It also poses some disadvantages – just like acid-amine amide coupling, some byproducts are obtained

trajectory in motion, culminating in a scalable, multiplexed platform to investigate GPCR-RAMP biology  like What emerged was a dual-tagged GPCR library  (DUET constructs), now publicly available via Addgene ,

arrestin engagement, a biased NTSR1 modulator targets pain without the need for opioids, and a real-time lipid Terry Kenakin, these five modules reveal how location bias, intracellular signaling, and ligand kinetics

Moments like these helped him own his identity as a scientist.

GPCR Store is live!   — A tale of detergent tails: GPCR activation beyond ligands .   A new commentary highlights how detergents and cholesterol shape mGluR2 activation—no ligand required

This week brings sharp new insights into how minor changes in ligand structure can flip GPCR function When someone signs up for a course, membership, or event through your referral link, you’ll receive a

Terry Kenakin, and catch up on cutting-edge insights through our full library of symposia recordings, Learn the fundamentals of ligand activity, mechanism of action, and GPCR discovery strategy—all at your Arrestin2 binds β₁AR without ligand-induced activation, reshaping our understanding of biased signaling A new cell-based tool detects receptor activity and reveals endogenous ligands.   Whether you're decoding a hidden receptor state or hunting for the next orphan GPCR ligand, we're here

It's starting to look a lot like Christmas at Dr. GPCR! Listen up, folks! VI drives arrestin-independent internalization and signaling of GPCRs Corticotropin-releasing factor-like learning GPCRs in Oncology and Immunology Short-chain fatty acids and cancer The path of GPR87: from a P2Y-like Insights into GPCR Function AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound

’s Highlights: G protein-coupled receptor (GPCR) pharmacogenomics Miles D Thompson , David Reiner-Link Recorded GPCR Courses and Symposia / Summit 💲 Special Pricing on GPCR courses GPCR Forum Start a lively Direct line to the Dr. GPCR community members Join the GPCR fan club and geek out with fellows! It's like having a treasure map to academic success! receptors Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1

High-affinity agonists reveal recognition motifs for the MRGPRD GPCR Chunyu Wang ,  Yongfeng Liu ,  Marion 2025: adding odorant receptors, data mapper, structure similarity search and models of physiological ligand A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR Lior Peri ,   if you go for a Premium Membership , you'll not only back our mission but also snag fantastic perks like Direct line to the Dr.

It challenges you to push your limits, adapt to unforeseen challenges, and develop habits that will serve

angiotensin II-induced calcium signaling in striatal neurons Rafael Rivas-Santisteban , Ana Muñoz , Jaume Lillo community and delivering exceptional services to achieve our goal of leading a vibrant and healthy life Direct line to the Dr. We're working hard to keep the lights on and the coffee brewing by sprinkling a bit of magic on our revenue (MC4R-like) mutations in goldfish (Carassius auratus) Identification of a vital transcription factor

a collection of titratable residues spans from the extracellular surface to the transmembrane area, linking strategies, where drugs are designed to target multiple sites or pathways simultaneously, reducing the likelihood Limitations Deep mutational scanning encounters several constraints that affect its broad applicability DMS requires considerable resources, including time, financial investment, and specialised expertise, limiting Future directions As deep mutational scanning continues to evolve, its future directions will likely

De Graaf   for their excellent work on Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Targeting G Protein-Coupled Receptors Olfactive Biosolutions Establishes Scientific Advisory Board GLP-1s like signaling-competent receptors GPCRs in Neuroscience Astrocyte Gi-GPCR signaling corrects compulsive-like intestinal dendritic cells Methods & Updates in GPCR Research Generation of CRISPR/Cas9 modified human iPSC line Molecular Insights into GPCR Function Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability

While GPCRs can exist as monomers, some types, like class C GPCRs, are obligate dimers, either as homodimers For example, dimerization has been shown to affect signaling pathways in class A dopamine receptors like both homodimers and heterodimers, which may play a crucial role in modulating receptor function and ligand These dimeric interactions may contribute to the phenomenon of biased agonism, where ligands produce Harikumar, K.G., et al., Impact of secretin receptor homo-dimerization on natural ligand binding.  

New ligands and new GPCR behaviors that produce unique drug profiles (i.e. intracellular ligands and November 14th: The Application of GPCR Ligand Kinetics to Candidate Design. November 21st: Unconventional GPCR Ligands as Drugs. December 5th: Unique Exploitable GPCR-Ligand Behaviors for Therapeutic Benefit. miss out on the opportunity to get your questions answered by our knowledgeable teacher or initiate a lively

Apply unique pharmacologic assays and unconventional ligands to unveil GPCR activities. Adjust ligand kinetics and tissue disposition for optimal therapeutic activity. Environment Tailored to Your Needs Maximize your learning experience by accessing our comprehensive library Get ready to be blown away by our fantastic lineup of speakers HERE ! Let's make your brand shine like never before!

,  Andrea Vernall , et al. for their fantastic paper on Development of Putative Bivalent Dicovalent Ligands New ligands and new GPCR behaviors that produce unique drug profiles (i.e. intracellular ligands and November 14th : The Application of GPCR Ligand Kinetics to Candidate Design. November 21st : Unconventional GPCR Ligands as Drugs. December 5th : Unique Exploitable GPCR-Ligand Behaviors for Therapeutic Benefit.

New ligands and new GPCR behaviors that produce unique drug profiles (i.e. intracellular ligands and November 14th : The Application of GPCR Ligand Kinetics to Candidate Design. November 21st : Unconventional GPCR Ligands as Drugs. December 5th : Unique Exploitable GPCR-Ligand Behaviors for Therapeutic Benefit. 🌟 Get pumped up - the complete agenda is live; don't miss out HERE !

for predicting G protein-coupled receptor (GPCR) structures, especially when experimental data were limited However, this method has limitations: its accuracy is heavily dependent on the availability and quality In a recent study on TAAR1, a GPCR linked to central nervous system disorders, researchers compared the synthetic compounds, limiting its utility in drug discovery involving novel drug-like molecules. Ligand discovery from a dopamine D3 receptor homology model and crystal structure.

Exclusive Deal for Scientists Residing and Working in Developing Nations If you live and work  in a developing 🌟 Exciting news - the complete agenda is live; check it out HERE ! GPCRs in Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis Methods & Updates in GPCR Research GPCRSPACE: A New GPCR Real Expanded Library Study Conformational Dynamics and Signaling in Drug Discovery Flavors of GPCR signaling bias Glucagon-like