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Yet fentanyl is increasingly not alone. Rapids alone, the number of fentanyl samples containing xylazine has risen 30 to 60 percent in just a year

GPCRs pose a critical challenge in drug discovery: a vast therapeutic potential with many targets yet Contact us  if you have any questions about our fluorescent ligands. Our scientific team can guide you choose or design the right fluorescent ligand for your research.  

Here you can find the full program . Figure 1. UIC Student Center East. Sometimes when you’re in the field you forget the importance GPCRs holds in drug development as a whole Wendy Young’s talk, during session 3 on day 2, was also incredible. Wendy Young. Charles Yeung from Merck and Dr. Rico Gerup Petersen from Vipergen APS.

Fluorescent Probes and Radioligands: When should you use one or the other? If you are curious about fluorescent probes, fluorescent probe design or GPCR tools, feel free to contact

You can check what we do here on our website!   coupling  using acid and amine .[ 1 ] This method has several advantages: it is usually very robust, good yields Not only do they work in aqueous medium, but also in aprotic solvents like DMF, where you will need to

Why Half-Life Can Lie to You Most teams use systemic half-life as a proxy for action. Rebuild Your Metrics. Redefine Your Pipeline If your development program is built around potency alone, you may be leaving expertise meet the real questions you’re asking in the lab. Don’t just keep pace—outpace the field. 🟢 40 years of expertise at your fingertips: Explore the complete

Over the years you see the lab establishing, and for both of us, of course, growing.”   At the start it was difficult, because you see all these projects and you think, ah, I don’t know… but “You can guide them to learn the technique and go over it. But at the same time, you pass the same struggle before… you shape the new generation too.”  

conclusions, your experiments, and even your program’s credibility. Don't let misconceptions about receptor binding kinetics slow your progress—gain the clarity you need Sharpen your discovery decisions ➤ Yamina's Consulting Corner - Building Your GPCR Program for Breakthroughs your professional trajectory. Gain the insights, tools, and connections you need to excel in your field and make your mark.

Beyond the Curve: Questions This Lesson Helps You Answer This lesson pushes you to go deeper than surface-level Terry’s Corner  is built to help you avoid those traps. If you want to avoid costly misinterpretations and strengthen your pharmacology toolkit, Terry’s Corner is your edge. Keep yourself and your team updated on the newest releases.

Watch Episode 171 What happens when your protein has no known ligands, no structure, and very little “…now you have a plethora of 400 models that you can start with molecular dynamics, docking, virtual Want to level up your modeling skills?

Move Faster, Smarter, and with Confidence   When you understand what your assays are truly showing you Why the Myth of High and Low Affinity Binding Sites Could Be Slowing Your Pipeline   If you’re working Are You Using Models That Slow You Down?   Don’t let outdated interpretations slow your next program. pipeline moving forward, toward your next milestone.

If you’re still treating GPCRs as passive targets, your screening filters may be blind to key liabilities Your Strategy Should Be Too. Outdated models can mislead your team, waste your resources, and cost your pipeline months of progress If you’re ready to stop guessing and start optimizing, this lecture is your next step. Scientists acting on today’s insight will shape tomorrow’s breakthroughs. 40 years of expertise at your

In this session, you’ll gain: ✅ A clear breakdown of how intracellular vs. extracellular receptor access You get longer activity with shorter exposure—a dream scenario for drug designers. You’ll learn how to recognize and harness this in your own programs.   If your pipeline is built only around extracellular engagement, you might be leaving opportunities untapped Don’t just keep pace, stay ahead. 40 years of expertise at your fingertips: Explore the complete library

Every day spent misunderstanding what your assays are truly showing you can lead to costly missteps—wasted Kenakin’s kinetic insights help you translate assay readouts into actionable knowledge that keeps your you measuring equilibrium, or could early-time-point artifacts be skewing your interpretation? insight from your kinetic data. You’ll gain clarity that accelerates your path from discovery to clinic: Know when your assays truly

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already Lauren Slosky, Stuart Maudsley and Yamina Berchiche invite your insights for Volume II. Position your research for maximum visibility.   this is your decision advantage. FAQ: What You Get with Dr. GPCR Premium 🔹 What’s included?

“Doing every day the results, I was getting in love with the topic and decided—yeah, I want to do this —Alessandro Nicoli Want to explore computational GPCR science yourself?

Are you ready to truly understand how pharmacologists predict whole-body drug response from a single Probability Models   This is practical drug development expertise from Terry’s 40+ years of experience Beyond the lessons, Terry's Corner  is your exclusive gateway. Ecosystem Premium Members: Look for significant savings on this and other resources in your weekly Dr Elevate your pharmacology expertise. Unlock "Pharmacologic Models" now

I never was particularly explicitly interested in GPCR signaling... but the thing about GPCRs... is you these targets falling short clinically: “The downstream cascade is probably a little bit weaker than if you Takeaway Forget what you think you know about GPCR drug targets.

Welcome GPCR Fans,   Every discovery-phase decision you make shapes your entire pipeline trajectory—and your team doesn’t misinterpret key signals. If you’re not there, you’re missing an opportunity to benchmark your strategy against the best in the Secure your spot ➤ Why Dr. Don’t Fall Behind—Access the Edge You Need 👉 Ready to sharpen your discovery decisions?

Watch Episode 170 Why We’re Here What if your own body pushed you into science? For Dr. After years of living with unresolved pain following surgery for a pilonidal cyst, Alex was left without "When you talk to patients that have an unmet need, you learn things that no one is thinking about in

However, this doesn’t always mean what you think it means. . 📚 Whether you're new to pharmacology or brushing up on basics, this lesson will change how you think You'll gain valuable insights into the critical role binding plays in pharmacology. This understanding can enhance your appreciation for drug development and therapeutic action.

Why I Started GPCR Consulting You've got great data. You've got brilliant scientists. The assays are running, data is flowing in from your CROs or your internal labs , yet progress stalls You can't move fast without clarity, and you can't make confident decisions without robust structure. If you're navigating a stuck GPCR program, planning your next crucial milestone, or struggling to gain /drgpcr/yamina-corner

Is Your GPCR Program Slowing Down—Even With Good Data? You’re not alone. One without the other will quietly kill your momentum. you move faster—with fewer blind spots, tighter execution, and a clear line of sight to your next key decision. 🚀 Book your free 30-minute strategy call Let’s unlock the momentum your GPCR program needs . 👉 https://calendly.com/drgpcr/yamina-corner Or explore how we can work together: 👉 Yamina.org 🔑

Why Culture Matters in Drug Discovery You can’t innovate under pressure.

Watch Episode 169 What if you could earn a PhD while supporting a family and working full time in drug only pursued experiments that were scientifically sound and directly publishable, a skill honed from years Takeaway If you’re navigating work, life, and scientific ambition, Sokhom Pin proves it’s possible to have it all, if you design it yourself. _________________ Keyword Cloud: GPCR training program , GPCR

Terry Kenakin takes you on a captivating tour through the history of pharmacology : a journey that spans Fast-forward a few thousand years, and we’re talking beta receptors, receptor theory, and AI-generated And yes, you'll even meet the man who turned failed experiments into a Nobel Prize-winning discovery Whether you're stepping into pharmacology for the first time or rekindling your interest, this lesson Curious yet?

From assessing drug potency to predicting effects, these curves aren't just for data—they’re your entry In classic Terry style, the lecture walks you through: What dose-response curves are and why they’re deceive—and how to avoid being misled The statistical tricks that elevate a rough curve into a real insight You'll

It’s 40 years of hard-won insight distilled into accessible, high-impact content designed for learners This is your chance to get ahead of the curve. . 👉 Ready to understand what your molecules are really doing? Unlock "Why Terry's Corner" now

Terry’s Corner gives you timeless and timely tools to improve selectivity, model efficacy, and design Upgrade Your Screening Strategy Leadership in Ligand Design  – The Celtarys Origin Story   In  this founder

Terry Kenakin , a veteran pharmacologist with over 40 years of industry experience. You’ll explore: What makes a “discovery team” tick (and why teamwork is non-negotiable) The difference If you're just beginning your pharmacology journey… This is the lesson that will connect the dots. You’ll leave with the language, logic, and big-picture view that underpins all future learning in pharmacology Don’t miss your chance to learn from one of the best: Unlock “Introduction to Drug Discovery" now