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proteins expressed as various alternatively spliced isoforms thus potentially resulting in differential modulation

engineering, receptor pharmacology, and structural biology to study how different types of ligands modulate

strategies to express, reconstitute and assay engineered GPCRs using the visual pigment rhodopsin as a model that stemmed from this work, such as the concept of “functional micro-domains” and the “helix movement model Tom’s lab also pioneered the early use of computational homology modeling, molecular dynamics simulations

A GPCR background is mandatory independent of your current position and industry.

In the following years, he held several marketing and strategic positions in France and the US, primarily All four formats are validated in well-established models like GLP1R and Mu opioid receptor (MOR), and

From her early doubts to designing preclinical models of fentanyl and xylazine overdose, she reflects The methods used to measure respiratory depression in live models. shut down breathing through different mechanisms—work that blends receptor pharmacology, preclinical models

unstructured regions ♦️ Includes a web tool + viral chemokine engineering demo This is a must-read for GPCR modelers

the molecular mechanisms of adhesion GPCRs (aGPCRs) in lymphatic endothelial cells (LECs), a cellular model

The model behind the data 💡 Terry Kenakin shows how experimental snapshots can reveal much more—and drug discovery. 🟢 Built for pharmacologists building stronger pipelines and those rethinking legacy models

The Joy of Building with Purpose Joe’s personal mission— to make a positive impact on people’s lives

Why receptor localization and scaffolding dramatically shift functional readouts in disease models. validation under real experimental constraints, Tried to map signaling heterogeneity in disease-relevant models

The lab works with multiple models, including Caenorhabditis elegans, in vitro tissue culture, and mice

science is an intense and interactive experience, and a great training environment for our students and post-doctoral University in Australia, one of the pioneers in the medicinal chemistry, computational and mathematical modelling scientists working in the arenas of structure and signaling, neuroscience, cancer, translational and model organized two trainee symposiums to acknowledge formally the participation of our graduate students and post-doctoral

🚀 Whether you're diving into GPCR drug discovery, pharmacology, or advanced modeling, there's a course 🚀 Whether you're diving into GPCR drug discovery, pharmacology, or advanced modeling, there's a course

gain domain of adhesion GPCRs started during his postdoctoral studies and continued into his faculty position

My initial focus was on creating an automated chimeric homology modeling pipeline for GPCRs and since

studied receptor function in human physiology, receptor molecular pharmacology in cells, and animal models

My initial focus was on creating an automated chimeric homology modeling pipeline for GPCRs and since

California in San Francisco to continue his training as a postdoctoral researcher where he used structural models

Signaling Trafficking Metabolism Structure and Bioinformatics Health and Disease Immunology Nervous system Model

PK principles ✅ Clearance & Distribution – Renal & hepatic clearance, key pharmacokinetics ✅ PK-PD Modeling metabolism, PK principles✅ Clearance & Distribution – Renal & hepatic clearance, key pharmacokinetics✅ PK-PD Modeling

He continued to work at Warwick as a post-doc studying pro-hormone convertases before securing a 5-year His research group uses a combination of pharmacological investigations and mathematical modeling to

transmembrane receptors, combining biochemical and structural approaches with cell biology and in vivo models

He adapts interdisciplinary approaches (synthesis, modeling, pharmacology) to study G protein-coupled

Overall, the lab works on diverse models and diseases, and has developed a wide array of tools to dissect

computational structural biology tools and rational drug design approaches, ranging from molecular modeling

His laboratory uses knock-out and transgenic mouse models, along with different cell culture systems,

the understanding of how an orphan GPCR exerts its effects both in vitro (cell culture and ex vivo models

laboratory is to understand the physiological consequences of NMDA receptor deficiency using genetic mouse models

Ribeiro has supervised eleven M.Sc. and six Ph.D. students, as well as five post-doctorate fellows. her research group comprises four undergraduates, two M.Sc., and six Ph.D. students, as well as five post-doctorate These drugs were shown to be very effective to rescue the cell death observed in a mouse model of Huntington