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we explore how computational tools—especially AlphaFold —are helping crack the mystery of olfactory GPCRs The Problem: Hundreds of Receptors, Almost No Ligands Alessandro’s work focuses on olfactory GPCRs—nearly : Predicting the “Face” of a Receptor When Alessandro began his PhD, structural models of olfactory GPCRs —Alessandro Nicoli A New Era of GPCR Research AlphaFold didn’t just fill a gap—it shifted the focus of Start with our GPCR training program and get hands-on with virtual tools shaping the future of drug discovery

Highlights: Congratulations to our amazing Board Member JoAnn Trejo for being elected to the British Pharmacological Events, Meetings, and Webinars December 10 - 12, 2024 | Pharmacology 2024 January 13 - 16, 2025 | PepTalk | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs GPCR Molecular Pharmacologist Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic , GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology

Watch Episode 167 Some GPCR-targeting antibodies don’t inhibit receptors. They activate them. GPCRs, are likely targets for antibody-based immune responses. This is the future of GPCR immunology . ________________ Keyword Cloud : GPCR autoantibodies , GPCR immunology , GPCR diagnostics , Dr. GPCR ecosystem , multiplex assays

By combining fiber photometry with FRET-based biosensors, we were able to track GPCR-dependent signaling Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Summit 2022 held between Oct. 10 - 16, it's FREE! Join the #GPCR movement by signing up now! ➡️ https://bit.ly/3cKMXlw #gpcr #drgpcr

GPCR event of the year is the 3rd edition of the Summit. Come join us from October 10 to 16 to hear about exciting #GPCR research from amazing speakers. GPCR Ecosystem site member to attend the Summit, it’s free! ➡️ https://bit.ly/3SUkB8D #gpcr #drgpcr

October 2022 Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered activation mechanism "The mechanistic details of the tethered agonist mode of activation for the adhesion GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

But what are the conformation changes that drive GPCR dimerization? How dynamic are GPCRs dimer interfaces? GPCRs constantly bind to form dimers and dissociate to form monomers. But how can we target GPCR dimers? via%3Dihub #GPCR #DrGPCR#Ecosystem

GPCR Summit is totally FREE for our Ecosystem site members? ➡️ https://www.ecosystem.drgpcr.com/ #gpcr #drgpcr

We found that some agonist-induced GPCR/14-3-3 signal intensities can rapidly decrease. could also be paralleled with GPCR/β-arrestin-2 signals, indicating diminished levels of GPCR/signal Furthermore, we found that certain GPCR ligands can regulate GPCR/14-3-3 signals temporally, suggesting a new approach for GPCR drug development by modulating GPCR/14-3-3 signals temporally." Read more at the source #DrGPCR #GPCR #IndustryNews

Welcome to the 4th official Adhesion GPCR Consortium newsletter! de Investigación y de Estudios Avanzados del IPN (Cinvestav) How did you become involved in adhesion GPCR AB: I became aware of the existence of adhesion GPCRs while completing my graduate studies. The family of adhesion GPCRs called the Latrophilins or ADGRLs first captured my attention due to their to how pharmacological approaches will be developed, i.e., splice isoform-specific agonist/antagonist

DrGPCR Ecosystem membership or listen wherever you get your podcast for free ➡️https://bit.ly/3UdxgnR #gpcr

are involved in mGlu5a receptor internalization "The internalization of G protein-coupled receptors (GPCRs Additionally, using the Gαq/11 inhibitor YM-254890, GPCR kinase 2 and 3 (GRK2 and GRK3) KO cells, and Our PKC KO cell lines expand the repertoire of KO HEK293A cell lines available to research GPCR pharmacology Moreover, since pharmacological tools to study PKC isozymes generally lack specificity and/or potency Read more at the source #DrGPCR #GPCR #IndustryNews

GPCRs have also been identified within the mitochondria. Compartmentalized GPCR Signaling from Intracellular Membranes. Nuclear G-protein-coupled receptors as putative novel pharmacological targets. Functional selectivity of GPCR-directed drug action through location bias. Frontiers in pharmacology, 9, 431. https://doi.org/10.3389/fphar.2018.00431

July 2022 Confo Therapeutics receives €1.7 million VLAIO grant for further research on GPCR modulators The grant should help expand Confo Therapeutic’s research on G protein-coupled receptor (GPCR) drug candidates . " Read more at the source #DrGPCR #GPCR #IndustryNews

The GPCR Opportunity GPCRs are the largest and most diverse group of membrane receptors. A New Wave of GPCR Drug Discovery GPCRs are considered highly druggable, with GPCR-targeting therapeutics chemical synthesis using Orion’s proprietary multiplex synthesis technology, and then screened for pharmacological in industry, and one that is uniquely capable of generating drug candidates with optimal molecular pharmacological Orion has world-renowned expertise in GPCR pharmacology and protein engineering, and its proprietary

Reviews, GPCRs, and more Species dependence of A3 adenosine receptor pharmacology and function. Deadline February 12, 2023 Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology June 4-8,2023. 2023 Molecular Pharmacology (GRS) Seminar GRC. June 10 - 11. June 11-16, 2023. 19th World Congress of Basic & Clinical Pharmacology 2023. July 2 - 7. GPCR Ecosystem

Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Newsletter HERE

#biotech #lifesciences #appointment #GPCR #Oncology" Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Activation and Signaling Molecular Mechanisms of PTH/PTHrP class B GPCR Signaling and Pharmacological Deadline February 12, 2023 Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology June 4-8,2023. 2023 Molecular Pharmacology (GRS) Seminar GRC. June 10 - 11. June 11-16, 2023. 19th World Congress of Basic & Clinical Pharmacology 2023. July 2 - 7. GPCR Ecosystem

Papers GPCRs: Signal Transduction. Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology. June 4-8,2023. 2023 Molecular Pharmacology (GRS) Seminar GRC. June 10 - 11. June 11-16, 2023. 19th World Congress of Basic & Clinical Pharmacology 2023. July 2 - 7. GPCR Ecosystem

cooperative interaction between G βγ subunits and GIRK channels determines both the amplitude and kinetics of GPCR-dependent Read more at the source #DrGPCR #GPCR #IndustryNews

GPCRs in Neuroscience CGRP physiology, pharmacology, and therapeutic targets: Migraine and beyond. Exploring pharmacological inhibition of Gq/11 as an analgesic strategy. Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology. June 4-8,2023. 2023 Molecular Pharmacology (GRS) Seminar GRC. June 10 - 11. June 11-16, 2023. 19th World Congress of Basic & Clinical Pharmacology 2023. July 2 - 7.

G protein-coupled receptors (GPCRs) are a vast family of membrane-bound proteins crucial for transmitting 'unproductive coupling'[1] and a fascinating phenomenon known as GPCR priming [2]. The enhanced signalling observed in GPCR priming is attributed to the formation of temporal non-cognate-GPCR GPCR priming opens new avenues for understanding the nuanced regulatory mechanisms governing GPCR signalling Mol Pharmacol, 2017. 91(5): p. 533-544.

What if the way we've been studying GPCRs—arguably the most important drug targets in pharmacology—has Here’s the surprising truth: up to 80% of GPCR-targeted drugs fail—not because of poor chemistry, but Join Terry’s Corner and stay updated on the latest in GPCR research—delivered in a format that’s as approachable

Hi GPCR Enthusiasts (and Arrestin Aficionados!)   This week at Dr. GPCR, we’re decoding arrestin-driven signaling and spotlighting the tools to match.   Check out our new on-demand course on non-canonical GPCR behaviors and a podcast episode tracing 30 years of GPCR-RAMP discovery. GPCR Updates   Advanced Methods for the Optimization of Candidate Selection  – Master GPCR behavior beyond

2022 "The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the adhesion GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative understanding on how endogenous PTHrP transduces signals through its cognate G-protein coupled receptor (GPCR understanding of the biased signaling process of a native protein hormone acting in conjunction with a GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor (GPCR

GPCR Virtual Cafe is back! Our first guest speaker is none other than Dr. Ben Myers! Learn about communication between GPCRs and PKA, Class F GPCR Smoothened & the Hedgehog signaling pathway https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe