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October 2022 GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates epithelial apicobasal polarity "The adhesion family of G protein-coupled receptors (GPCRs GPR125 (ADGRA3), an orphan adhesion GPCR, has been shown to modulate planar cell polarity in gastrulating Thus, the basolateral protein GPR125, an autocleavable adhesion GPCR, appears to play a crucial role Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the newsletter HERE

Hello GPCR friends👋, Stay informed with the latest developments in GPCR research and industry news! GPCR Symposium is coming up on July 21st on Structural and Molecular Insights on GPCR Activation. Methods & Updates in GPCR Research Illuminating the brain-genetically encoded single wavelength fluorescent Gliovascular Unit of Glioblastoma Associate Director / Director, Clinical Operations Postdoctoral Research GPCR Ecosystem

one GPCR Event, and two GPCR job ads! Research G-Protein Coupled Receptor Gpr-1 Is Important for the Growth and Nutritional Metabolism of Jude Children’s Research Hospital adds $13 million project to Research Collaboratives Program AIRSUPRA World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Post-Doc position NEW Lead Researcher Senior Researcher in Structural Biology Post-Doctoral Fellow Postdoctoral Fellow Research Laboratory

and lipid second messenger signaling Methods & Updates in GPCR Research A bioluminescent and homogeneous Research Unit NEW Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder , pharmacology Research Fellow Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Director - Single-molecule Imaging Center Scientific Assistant Postdoctoral Fellowship- Mechanistic Biology Research GPCR Ecosystem

Greetings GPCR enthusiasts! Join us to explore the fascinating world of GPCRs. Showcase your research by contacting us at Hello@DrGPCR.com Stay informed with Dr. Methods & Updates in GPCR Research Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent on Gliovascular Unit of Glioblastoma Associate Director / Director, Clinical Operations Postdoctoral Research GPCR Ecosystem

October 2022 "The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system In VSMCs, stimulation of GPCRs also modulates contractile and cell growth phenotypes. Here, we will focus on the relatively less well-studied effects of GPCRs in cardiac fibroblasts, focusing We discuss how such events may be distinct depending on where the GPCRs and their associated signaling Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5 homo- and hetero-dimer formation "The process of GPCR dimerization can have profound effects on GPCR activation, signaling, and intracellular trafficking. Somatostatin receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent Read more at the source #DrGPCR #GPCR #IndustryNews

neurotransmitter responses by G-protein regulators András D Tóth, Gábor Turu, and László Hunyady for their research Research Design, Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes research position Senior or Lead Researcher Senior Scientist, Cryo-Electron Microscopy Postdoctoral Research Associate Senior Scientist - Discovery Biotherapeutics Join Dr. GPCR Ecosystem

GPCR Access to Dr. Research Direct Binding Methods to Measure Receptor-Ligand Interactions How accurately can one predict Investigator, In Vitro Biology NEW Associate Scientist Postdoctoral Scholar - O’Neill Lab Junior Research Scientist Postdoctoral Fellow Post-Doc Research Associate Assistant/Associate Professor Explore Dr. GPCR Ecosystem

October 2022 "Over three decades of research have provided thorough insights into G protein-coupled receptor (GPCR) regulation. Read more at the source #DrGPCR #GPCR #IndustryNews

Research GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer models and interface Derivatives: Natural Occurrence, Structural Diversity, and Biological Activity Advances in steroid research Jobs - Contact Mark Schmeizl NEW Scientist NEW Lead Researcher NEW Post-Doctoral Fellow Sr Scientist in Obesity, Muscle, and Metabolism Post-Doctoral Fellow Research Associate I, Tissue Culture Post-Doc Research Associate Postdoctoral Fellow Explore Dr.

October 2022 Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Negative Allosteric Modulator, ORG27569, and Analogs "A growing number of G-protein-coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

Adhesion GPCRs CryoEM structures of adhesion in GPCR CD97: Filling in some of the gaps GPCR Activation Research Optogenetic Microwell Array Screening System: A High-Throughput Engineering Platform for Genetically Announces Settlement of INGREZZA Abbreviated New Drug Application (ANDA) Litigation PostEra Announces a Research Jobs NEW Sr Scientist in Obesity, Muscle, and Metabolism NEW Post-Doctoral Fellow NEW Research Associate I, Tissue Culture Post-Doc Research Associate Postdoctoral Fellow Research Scientist/Postdoctoral Associate

August 2022 "Several G-protein coupled receptors (GPCR) are upregulated in Alzheimer's Disease (AD), This article focuses on the role of Aβ granules and their possible interaction with GPCRs that modulate Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Symposium on GPCR Activation and Signaling was a great success. Methods & Updates in GPCR Research Computational design of dynamic receptor-peptide signaling complexes Research Associate NEW Lab Manager Vice President, Medical Affairs Associate Scientist - Technology Senior Research Scientist/Principal Scientist- Technology Tissue Culture Scientist/Tissue Culture Manager Postdoctoral Researcher Director - Targeted Oncology Explore Dr.

Hébert and their colleagues research on 'G Protein-Biased Agonists for Intracellular Angiotensin Receptors Daly and their team research on 'β-arrestin-dependent and -independent endosomal GPCR activation by Jobs NEW Researcher / Senior Researcher in Structural Biology NEW Research Specialist NEW Science Research Writer Postdoctoral Fellow Research Laboratory Specialist Associate Postdoc Research Associate Director , Regulatory Affairs Research Scientist/Senior Scientist I - Molecular Pharmacology Explore Dr.

GPCR Symposium about 'GPCRs as Therapeutic Modalities' rocked it! Research Target immobilization on glass microfiber membranes as a label-free strategy for hit identification Jobs NEW Senior Vice President, Oncology Clinical Research NEW Scientist (level I or II) NEW Research Fellow Research Technician II - Surgery Post-Doc Research Associate Research Technician Senior Research GPCR Ecosystem

Graeme Milligan and their colleagues research on Pro-phagocytic function and structural basis of GPR84 and Signaling Protein Research Tools First-In-Class Drug Shows Potential for Treatment of Cannabis Use Jobs NEW Research Technician II - Surgery NEW Post-Doc Research Associate NEW Research Technician Senior Research Associate, In Vitro Pharmacology - Crinetics Pharmaceuticals Postdoc In Cell Biology Of Protein Trafficking Postdoctoral Fellow Researcher / Senior Researcher in Structural Biology Research Specialist

GPCR Symposium on 'GPCRs as Therapeutic Modalities'. Research Magnetic Liposomes Infused with GPCR-Expressing Cell Membrane for Targeted Extraction Using latest science paper was published by the American College of Clinical Pharmacology Sosei and Cancer Research Junior) Research Associate Protein Science Postdoctoral Fellow Research Laboratory Specialist Associate Postdoc Research Associate Director, Regulatory Affairs Research Scientist/Senior Scientist I - Molecular

Research Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications Immunotherapies at Sachs Associates' Biotech Forum Celtarys Research and G-CLIPS join forces to revolutionize Jobs NEW Senior Research Associate, In Vitro Pharmacology - Crinetics Pharmaceuticals NEW Postdoc In Cell Biology Of Protein Trafficking NEW Postdoctoral Fellow Researcher / Senior Researcher in Structural Biology Research Specialist Science Research Writer Postdoctoral Fellow Research Laboratory Specialist

Welcome, GPCR buffs! Join us for our weekly round-up of GPCR News. Congratulations to our Dr. GPCR Symposium on Structural and Molecular Insights on GPCR Activation. Methods & Updates in GPCR Research A coiled-coil-based design strategy for the thermostabilization of the Gliovascular Unit of Glioblastoma Associate Director / Director, Clinical Operations Postdoctoral Research GPCR Ecosystem

From Bench to Breakthrough: Why pHSense Matters Decades of GPCR research have relied heavily on engineered Just a plate reader, an agonist, and an endogenous GPCR. GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical tools to accelerate your research or career. 👥 Build connections. 🧪 Get insights. 🎧 Stay ahead.

Hello Sweet GPCR Enthusiasts, This week at Dr. GPCR: a new podcast episode with Dr. GPCR Store is live!   — A tale of detergent tails: GPCR activation beyond ligands .   Explore this week’s research, tools, and biotech insights in one place. GPCR Team

2022 Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR simulation was conducted to elucidate binding mechanisms of a middle-sized flexible molecule, bosentan, to a GPCR generalized ensemble method that produces a free-energy landscape of the ligand-receptor binding by searching Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 "Class A (rhodopsin-like) G protein-coupled receptors (GPCRs) are constitutive phospholipid scrambling is not detectable in the resting plasma membrane of mammalian cells that is replete with GPCRs considered whether cholesterol, a prominent component of the plasma membrane, limits the ability of GPCRs This mechanism may explain the inability of GPCRs to scramble lipids at the plasma membrane." Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 "Emerging evidence suggests that G protein-coupled receptor (GPCR) kinases (GRKs) are associated reveal an interaction between the βarr2 finger loop domain and ICL2 and ICL3 of APH1A, similar to a GPCR-β-arrestin Read more at the source #DrGPCR #GPCR #IndustryNews

Hi there GPCR enthusiasts! Join us this week for a deep dive into the world of GPCRs. Methods & Updates in GPCR Research A Peptidisc-based Survey of the Plasma Membrane Proteome of a Mammalian Confo Therapeutics Enters Into Research Collaboration For GPCR-Targeting Antibody Discovery With AbCellera on Gliovascular Unit of Glioblastoma Associate Director / Director, Clinical Operations Postdoctoral Research GPCR Ecosystem

hypercalcemia caused by biased allosteric CaSR autoantibodies "Biased agonism is a frontier field in GPCR research. insights into the phenotype and characteristics of AHH and the mechanisms by which the biased agonism of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews

This week, we've curated 12 GPCR papers. GPCR Symposium for the year, which will focus on GPCRs in Immunology and Oncology. and lipid second messenger signaling Methods & Updates in GPCR Research An image-based abplex method Jobs NEW Post-Doc Research Associate NEW Postdoctoral Fellow Research Scientist/Postdoctoral Associate GPCR Ecosystem

GPCR Symposium on GPCR Activation and Signaling. Methods & Updates in GPCR Research Multiplexed selectivity screening of anti-GPCR antibodies. , Medical Affairs Associate Scientist - Technology Senior Research Scientist/Principal Scientist- Technology Tissue Culture Scientist/Tissue Culture Manager Postdoctoral Researcher Director - Targeted Oncology Senior Scientist - Antibody Engineering Scientist—Immuno-Oncology Convergent Research - Senior Scientist