Search Results

While writing a literature review on opioid and alcohol addiction susceptibility, something shifted. drug combinations that mirror contamination patterns, and experimental designs that evolve with new adulterants She is especially interested in mu-opioid receptor signaling  and how xylazine, as an alpha-2 adrenergic

Breakthroughs this week: Decoding ADGRE5 signaling; Eli Lilly’s obesity pill vs Novo’s Wegovy; Certa Misinterpreting displacement curves in allosteric assays means discarding viable compounds—or worse, advancing GPCR Premium Membership Gives You an Edge The GPCR field is advancing at breakneck speed.

Terry Kenakin's insights on target residence time can reshape how you evaluate and advance lead compounds fentanyl slows inhalation via opioid receptors, while xylazine prolongs exhalation through alpha-2 adrenergic Competitive Edge:  Stay informed on emerging public health threats and the scientific research aimed at addressing Listen now to understand how two mechanisms intersect—and why pharmacologists are critical in addressing GPCR University Course Attendee Ready to gain a competitive advantage?

Adapted from: Zhang Y, Tang H, Chen W, Zhang J. Optimizing GPCR Drug Discovery with Fluorescence Polarization: Key Advantages and Future Perspectives Advancing Fluorescence Polarization Assays with Custom Fluorescent Ligands Looking ahead, fluorescence expected to expand its role in GPCR research through the development of novel fluorescent probes and advanced Contact us  to drive further advancements in GPCR drug discovery!  

, Catherine Demery’s research  is about receptors and signaling pathways—how mu-opioid  and alpha-2 adrenergic The combination is not merely additive; it’s synergistic, shrinking tidal volume even when breathing With street-level contamination rising faster than medicine can adapt, Catherine’s work shows why overdose But that mechanism has no impact on xylazine, which works through alpha-2 adrenergic receptors. And the illicit supply is moving faster than clinical medicine can adjust.

organized by both the EFMC and the ACSMEDI, in an effort to share the most novel medicinal chemistry advancements She has a lot of experience working for bigger businesses which she now shares as an advisor for startups table discussion with these excellent scientists felt like a dream come true, and Maria enjoyed giving advice

It is involved in several pathophysiological processes such as Parkinson’s disease, depression, addiction homogeneous conditions, using lanthanide (europium, terbium) as donors.[17] Lanthanides provide unique advantages Specific binding is shown, obtained from total binding and unspecific binding ( a ) CB1R expressing adherent measurement (specific binding measured using CP55490 at 10 μM concentration) ( b ) CB2R expressing adherent Chem.   2019 , 62  (1), 276–287. https://doi.org/10.1021/acs.jmedchem.8b00368 . (9)         Adams, A.

Radioligands have been used to study GPCRs for decades, but with the advances in the fluorescence field They have several advantages, such as the minimal chemical modifications in the original ligand, high Representative images of non-fixed HCTT116 colorectal tumor cells co-stained with hA2B-A3 adenosine receptor Images were taken 2 min after the addition of Celt-327 to the medium. -            Fluorescent probe

and commonly used method is the amide coupling  using acid and amine .[ 1 ] This method has several advantages only do they work in aqueous medium, but also in aprotic solvents like DMF, where you will need to add Its biggest advantage is the presence of Cys residues in proteins, although sometimes S-S bridge reduction

This iterative process of continuous, planned improvement ensures you're always addressing the next critical

space to revisit core pharmacology concepts, master new ones, and sharpen your thinking to directly advance

Add a data scientist. Surely more hands will move the needle. And when you chain your highest-paid scientists to repetitive admin work, you’re not solving problems Ambiguous Decision Gates: Molecules advance or stall based on vibes, not criteria.

Alessandro admits he struggled at first with handing over parts of his projects, fearing mistakes.

Elevate Your GPCR Science with Essential Frameworks for Precision Drug Discovery: An Insight into Advanced orforglipron, delivers weight loss of up to an average of 27.3 lbs in first of two pivotal Phase 3 trials in adults This event is a critical opportunity to stay informed, but the real advantage lies in applying these ” - DrGPCR University Course Attendee Get a competitive advantage—Join Dr.

matter—and when they don’t ✅ Guidance on extracting meaningful information from binding experiments that advance

GPCRs Aren’t Just Surface Receptors Anymore From β2-adrenoreceptors to CCRs and dopamine receptors, multiple

Kinetic measurements reveal hidden liabilities or advantages that static affinity numbers cannot. These aren’t theoretical questions—they directly impact your ability to advance the best candidates faster

Must-read publications:  A deep dive into proximity-dependent proteomics of adenylyl cyclase isoforms Bridge the gap between disciplines:  Get practical advice from a computational expert on how wet-lab To succeed, you need to move beyond standard approaches and adopt the frameworks that are driving real

Whether working on opioid withdrawal, addiction vulnerability, or chronic pain, GPCR-related signaling

Breakthroughs this week: Structure-based discovery of positive allosteric modulators of the A1 adenosine insights:  Structure-Based Drug Design Summit; AI-Powered GPCR Research; Lab-in-the-Loop Hit Discovery advances Terry Kenakin’s featured talk on “The Kinetics of Allostery” offers a rare live glimpse into advanced

He’s focused on RGS proteins , pain comorbidities  like addiction and depression, and pushing for more

Key Concepts in Binding Terry unpacks several key concepts related to orthosteric binding: Langmuir Adsorption Additionally, competitive inhibitors can interfere with this binding process, leading to reduced efficacy By considering factors like the Langmuir adsorption isotherm and binding curves, researchers can better

That’s Why I Built Yamina’s Consulting Corner This is not “advising.” Unlike traditional advisors, I'm not just observing; I'm part of your team . Corner helps teams move from data chaos to decisive action ✅ This is hands-on support —not passive advising

Advances in biased signaling, allosterism, and endosomal signaling have opened new therapeutic frontiers

UConn accepted the research done in the BMS lab as part of the dissertation Sokhom met weekly with advisors path is a model of possibility for professionals in the biotech industry who still dream of earning advanced

ligands differently activate class A GPCR NMBR, with allosteric communication hubs modulating signaling, advancing

core models—fundamentals that fuel confidence and fluency Move beyond theory to apply selectivity, ADME , and early safety in real development contexts Advance with nuanced lessons on allostery, residence

proximity, immuno assays, pulldowns Validated antibodies + digital search platform Entire library hosted on Addgene

Kotliar sees a future where this system is not just used for detection, but for functional screening : add

What emerged was a dual-tagged GPCR library  (DUET constructs), now publicly available via Addgene ,