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“It was not just a molecule—it was a partner interacting with a protein or DNA… that opened a new world

Orion Biotechnology Completes Discovery of First-in-Class Molecule Against Undrugged GPCR Target in Four MPGPCR Conference (November 15 -17, 2023) Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels

in different functional states have significantly improved our molecular understanding of CB1 ligand interactions

By examining how mutations in the target protein affect its interaction with the drug, researchers can Trends in Biotechnology , 29 (9), 435–442. https://doi.org/10.1016/j.tibtech.2011.04.003 Fowler, D.

GPR39 is a GPCR which can interact with Zn and modulate the colonocytes' survival.

It is expressed in the paraventricular nucleus of the hypothalamus, where it interacts with various G

A Gαs preferentially interacts with dimeric β2-AR, but not monomeric β2-AR, in a resting state, resulting

Conformational Rearrangements of a G Protein-Coupled Receptor Influence of the Water Model on the Structure and Interactions Membrane and the Solvent: Rigid versus Flexible Water Models Probing the energy landscape of the lipid interactions

Matthew Eddy, et al. for their investigation on Interaction Networks within Disease-Associated GαS Variants SUCNR1 G protein-coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling Interaction

These models provide insights into the interface, important side-chain interactions, and activation mechanism The interface indicates a strong involvement of the connecting loop.

analysis (WGCNA) were performed using R software, and functional enrichment analysis and protein–protein interaction

In cellular-adhesion assays, LK30 specifically broke the trans-cellular interaction of ADGRL3 with teneurin

A comparison of the PTH-bound and PTHrP-bound structures reveals distinct ligand-receptor interactions

Modulating GPCR and 14-3-3 protein interactions: prospects for CNS drug discovery. GPCRs in Neuroscience PACAP key interactions with PAC1, VPAC1, and VPAC2 identified by molecular dynamics

These probes facilitate localization of receptors, tracking of their internalization and are also safer as they can be used to determine receptor activation dynamics, ligand binding geometry and receptor interactions Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors.

, we discover specific residues within TM5 and TM6 that function as micro-switches to form specific interactions

We find that the inactive GP first interacts with TM3, which further leads to the TMD rearrangement and

the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which interacts

A comparison of the PTH-bound and PTHrP-bound structures reveals distinct ligand-receptor interactions

observed differences in the binding affinity and cooperativity arise from the functional groups that interact

mouse versus human GPR116 and recapitulate these findings in a model supporting tethered agonist:ECL2 interactions

Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome Antagonistic interactions I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) NEW Structure, Mechanism, and Drug Interactions

In contrast to A2AAR agonists, which simultaneously interact with both Ser2777.42 and His2787.43, 2 only

metastasis "β-Arrestins are ubiquitously expressed intracellular proteins with many functions which interact

David Eliezer, et al. for their research on Control of G protein-coupled receptor function via membrane-interacting activation of bombesin receptor subtype-3 Control of G protein-coupled receptor function via membrane-interacting

perspective of the usefulness of computational studies to evaluate protonation-coupled opioid-receptor interactions

Erica K Sloan ,   Kevin Pfleger ,  Peter J McCormick , Cristina Salmerón ,   Paul A Insel PGxDB: an interactive Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International β-blockers and antihistamines: A clinical trial is needed Methods & Updates in GPCR Research PGxDB: an interactive

Receptor Landscape Tampering in Lung Fibroblasts GPCRs in Neuroscience System-wide mapping of peptide-GPCR interactions in C. elegans GPCR interactions involving metabotropic glutamate receptors and their relevance to the Conference November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting February 3 - 7, 2024 | SLAS2024 International

ligands binding at the same location generally show little or no similarity, and the amino acid residues interacting

metastasis "β-Arrestins are ubiquitously expressed intracellular proteins with many functions which interact