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In This Session, You’ll Gain: ✅ Modeling tools to understand how restricted diffusion  in tissues like

Pay attention to that. What began as a quiet obsession soon demanded a bigger stage. control localised signaling, how disease hijacks these systems, and how to target them for therapeutic gain

In This Session, You’ll Gain: ✅ A clear explanation of why allosteric modulators don’t displace ligands—they

Introduction Cannabinoid receptors are GPCRs, and two main types exist, CB1R and CB2R.

In this session, you’ll gain: ✅ A clear breakdown of how intracellular vs. extracellular receptor access

Gaining control over disease-related events in non-alcoholic steatohepatitis (NASH), an advanced form

In this session, you’ll gain: Clarity on high-impact early safety assays and their compelling rationale

While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point

Many early-stage biotechs show the same pattern: strong scientific progress paired with an operating discipline, the organization typically shifts from “busy but slightly lost” to “focused, aligned, and gaining

What You’ll Gain Spot false confidence early  → Sensitivity differences can turn full agonists into partials

the interactions of SMO with cholesterol and other lipid molecules in the ciliary membrane, and to gain

Monash team built rotational PhD cohorts  — students cycled through multiple groups in their first year, gaining

Gain career inspiration from Ajay’s bold questions and pivots.

receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent the main

Like many young scientists, she explored different paths and gained industry experience before realizing

What you gain: Detect scaffold liabilities early—hERG inhibition, mutagenicity, and mechanistic red flags

In This Session, You’ll Gain Clarity on how ADME governs translational success A deeper understanding

Deep mutational scanning, for instance, is gaining popularity as a strategy due to its ability to comprehensively

In This Session, You’ll Gain: ✅ The ability to calculate how many replicates you really  need for 95% By comparing two means (paired or unpaired) you’ll learn whether the divergence is genuine or whether

GPCR Premium Members this week gain curated, early access to: Industry insights : GPCRs and mRNA in drug At Alkermes, Sokhom Pin built an in vitro pharmacology group from scratch—not just a lab, but a culture

In this session, you’ll gain: A clear conceptual map of Schild analysis and its origins.

In this session, you’ll gain: ✅ Proven strategies  to balance in vitro vs. in vivo testing early — when

In this session, you’ll gain: ✅Clarity on Definitions:  What truly distinguishes orthosteric from allosteric

Mandibulofacial dysostosis with alopecia results from gain-of-ETAR function via allosteric effects on

In this session, you’ll gain: ✅ A mental model you can trust  for predicting how GPCR ligands behave

Mandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric

ERK activation pathways can be categorised into two main sub-pathways based on their subcellular localisation

remaining non-sensory receptors, with functions more readily linked to pathology, are currently the main cell surface, or because they have an enhanced capacity to elicit receptor internalization, thereby gaining 17706–17711. https://doi.org/10.1073/pnas.0805098105 · Development and use of new technology to gain

The G-protein-coupled receptors in the human genome form five main families.

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