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β-strand folding of phosphorylation clusters guides GPCR binding to arrestin Dietary dibutyryl cAMP supplementation transcription factor 21 GPCRs in Neuroscience Pregabalin inhibits purinergic P2Y2 receptor and TRPV4 to suppress Heptares Will Receive US$3.75 Million Payment in Multi-Target Partnership Sosei Heptares Announces Submission Amgen noncommittal on oral obesity med until phase 1 data arrive Form and Function - Consequences of subcellular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

If you're attending the GPCR Retreat, be sure to swing by our booth and snap a photo at our banner! Get the inside scoop by subscribing to our monthly Dr. Signaling The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

the intracellular allosteric site GPCRs represent one of the largest and most vital families of cell surface While this has the potential to enhance GPCR subtype-selectivity, it also presents a significant challenge target selectivity, which can arise from greater sequence variation in allosteric sites among receptor subtypes when compared to the conserved orthosteric region, or from selective cooperativity with a particular subtype This is particularly important when dealing with receptor subtypes that exhibit significant similarity

Sakmar and his team used 'bioluminescence resonance energy transfer to measure cell-surface expression Submit your logo design by Nov 1st on the Logo Contest page. Subscribe to Dr. GPCR Newsletter for more insights! for novel drug discovery Application of bioluminescence resonance energy transfer to quantitate cell-surface Data for AI-designed LSD1 and MALT1 Inhibitors at ESMO 2023 Restoring the function of a human cell surface

Submit a logo design by Nov 1st on the Logo Contest page. No registration is needed to submit your logo design. Subscribe to Dr. activates two G protein-coupled receptors with differential second messengers for diuresis in Drosophila suzukii Beyond the G protein α subunit: investigating the functional impact of other components of the Gαi3 Celebrating Lefkowitz’s 50 Years at Duke Novo Nordisk stops Ozempic kidney trial after early signs of success

Submit a logo design by Nov 1st on the Logo Contest page. No registration is needed to submit your logo design. Subscribe now to Dr. G-protein-coupled receptor Target for Therapeutic Development DKK 25 million to development of databases supporting medical research ‘Define your own success’: Duke leaders talk success, failure at symposium honoring Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

You can submit your logo design by November 1st, and registration is unnecessary to participate. Also, If you attended any of the talks, we'd truly value your feedback through our survey. Subscribe now to gain access to exclusive insights from Dr. GPCR Newsletter! GPCR Activation and Signaling The non-nutritive sweetener sucralose increases β-arrestin signaling at Research Polyphosphate uses mTOR, pyrophosphate, and Rho GTPase components to potentiate bacterial survival

For attendees, kindly spare a moment to complete our survey. If you're already registered, kindly use the provided form to submit your poster abstracts. Abstract submissions close on October 2nd. Submit your logo design by November 1st. You don't need to be registered to participate. Access exclusive insights by subscribing to the Dr. GPCR Newsletter!

conformational selection: Nanobodies have a unique shape that allows them to bind to cavities or clefts on the surfaces Nbs can stabilize specific conformations of proteins, including unstable structural intermediates and substates This Nbs binds to the extracellular surface of the Rhodopsin receptor and stabilizes the photo-activated S., Schnapp, A., Konetzki, I., Sunahara, R. K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W.

If you have registered, please submit poster abstracts through this form and the short talk selections Abstract submissions close on October 2nd. Subscribe to the Dr. S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning Prediction of survival Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit Conference and Exhibition June 2 - 4, 2024 | Chemotactic Cytokines GPCR Jobs NEW Research Technician II - Surgery

GPCR, was featured as Superluminal Medicines Launches to Drug Protein Conformations in a Flash. Christopher Langmead and colleagues' work on the 5-HT2C receptor as a therapeutic target for substance Submit poster abstracts here; short talks will be selected from Abstracts. Abstract submissions close on October 2, and final registration ends on September 21. Subscribe to the Dr. GPCR Newsletter for more insights!

You can submit your poster abstracts using this form and short talks will be selected from abstracts. Please remember that the early-bird registration deadline ends tomorrow, the abstract submissions deadline Subscribe to Dr. GPCR Newsletter to gain access to further insights! Bacillus thuringiensis Cry4B toxin involves Na+/K+ ATPase GPCR Promiscuity Reshapes Islet Physiology TGR5 supresses Morgan Stanley 21st Annual Global Healthcare Conference CEO Raymond Stevens to Speak at STAT Future Summit

Sudarshan Rajagopal and their lab team study on 'Location bias: A "Hidden Variable" in GPCR pharmacology Submit poster abstracts via this form; short talks will be selected. Early-bird registration deadline is September 8, abstract submissions close on October 2, and final registration Subscribe to Dr. GPCR Newsletter to receive more insights! Conference NEW April 5 - 10, 2024 | AACR Annual Meeting NEW May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

Abstract submission for oral presentations closes at 11:30 pm EST today! Abstract submission for poster presentations closes at 11:30 pm EST on August 30, 2023. Submit poster abstracts using this form; short talks will be selected from submissions. Early-bird registration and abstract submissions close on September 8, and final registration ends on

The diversity in GPCR signaling regulation suggests an individualized control mechanism. The hypothesis arises that GPCR and β-arrestin-centered effector complexes vary based on subcellular Knockout studies in mice suggest that β-arrestin isoforms possess some level of functional redundancy , and their imbalance is linked to pathological conditions, including cancer (Gros, R. et al. 2000, Sun However, β-arrestins do not consistently act as oncogenes or tumor suppressors.

Submit a 1-minute abstract video using this form! Submit your abstracts for poster presentation using this form - short talks will be selected from these submissions. Remember, the early-bird registration and Abstract submission deadline is September 8, and the final Make sure to stay in the loop with the Dr. GPCR Newsletter!

Devki D Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic Submit a 1-minute abstract video using this form. Chemokine Receptor 4 Antagonist and Mobilizer of Hematopoietic Stem/Progenitor Cells, in Mice and Healthy Subjects Positive Allosteric Modulator Program To Receive Additional Chf 2.7 Million From Indivior In Extended Substance Robert Lefkowitz Lab Senior Research Specialist - Natural Sciences - Surgery Senior Scientist- Membrane

This week's highlights: Driving Pharma Innovation in Oncology: Domain Therapeutics' Success Proven by Submit a 1-minute abstract video and tell us more about your project using this form. Stay tuned by subscribing to the Dr. GPCR Newsletter! Way To Develop Drugs Without Side Effects Driving Pharma Innovation in Oncology: Domain Therapeutics' Success Robert Lefkowitz Lab Senior Research Specialist - Natural Sciences - Surgery Senior Scientist- Membrane

GPCR Symposium on Structural and Molecular Insights on GPCR Activation was a success! Submit a 1-minute abstract video and tell us more about your project in this form. Stay updated by subscribing to Dr. GPCR Newsletter! Addex Mglu2pam Demonstrates Potential In Substance Use Disorder. GPCR Events, Meetings, and Webinars NEW Summer GPCR Zoominar session (July 27, 2023).

Remember to subscribe to Dr. GPCR Newsletter for updates! Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase. Transport Proteins (March 24 - 29, 2024) GPCR Jobs NEW Senior Research Specialist - Natural Sciences - Surgery

If you're interested in presenting a poster, simply fill out the submission form and submit a 1-minute Be sure to subscribe to Dr. GPCR Newsletter for updates!

If you want to present a poster, all you have to do is fill out the submission form and submit a 1-minute And don't forget to subscribe to Dr. GPCR Newsletter for updates! Neuroscience Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits Sosei Heptares Doses First Subject in Phase I Trial with HTL0048149, a First-in-Class GPR52 Agonist for

We are looking for poster presenters; please fill out the poster submission form. Please note that you will have to submit a 1-minute abstract video. Stay up-to-date as the program develops by subscribing to our monthly Dr. GPCR Newsletter. Activation and Signaling Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses in people with overweight or obesity in Boehringer Ingelheim and Zealand Pharma Phase II trial with survodutide

Chemokine receptors (CKRs) belong to a subfamily of G-protein-coupled receptors (GPCRs) and play a crucial to CRS3 Chemokines possess a conserved tertiary structure known as the interleukin 8-like chemokine superfamily The subfamily-defining CC/CXC/CX3C/XC motif is located in the N-loop and forms two conserved disulfide The spacing between the cysteine residues in the N-loop determines the subfamily-specific arrangement Common to all four chemokines, the distal N-termini interact with a hydrophobic surface at the bottom

GPCR News by subscribing to our monthly newsletter. Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production Industry News Coherus to Acquire Surface Oncology Confo Therapeutics and AbCellera partner on GPCR-targeting

GPCR News by subscribing to our monthly newsletter. Our founder Dr. Yamina A. Methods & Updates in GPCR Research A Peptidisc-based Survey of the Plasma Membrane Proteome of a Mammalian

GPCR News by subscribing to our monthly newsletter. Activation and Signaling Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation. Transcriptomic analysis of human cytomegalovirus to survey the indirect effects on renal transplant recipients GPCR Events, Meetings, and Webinars FREE Symposium - IPI Surfacing (June 15, 2023) GPCRs in drug discovery

GPCR News, please subscribe to our monthly newsletter. Multiple Subthreshold GPCR Signals Combined by the G-Proteins Gαq and Gαs Activate the Caenorhabditis Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief. FREE Symposium - IPI Surfacing (June 15, 2023) NEW GPCRs in drug discovery: challenges & solutions (June

At the cellular level, the plasmatic membrane is a thin layer of lipids that surrounds the entire cell Whit this scope, the authors challenged the current model, wich suggest that β-arrestin translocates This pre-association enables β-arrestin to explore its surroundings through lateral diffusion and engage

GPCR Symposium on GPCR Activation and Signaling was a great success. interested in giving a talk, contact us at Hello@DrGPCR.com, and if you would like to present a poster, submit GPCR News, please subscribe to your monthly newsletter. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion