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In this regard, luminescence-based biosensors have revolutionized our ability to monitor GPCR signaling

Our results provide additional evidence for the understanding of signaling pathways activated by GnIH

Our results suggest that strategies to selectively target OGR1 expression may represent a novel therapeutic

Our NMR analyses demonstrated that while the C tail-mediated interaction alone induces partial activation

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🚀✨ This Week’s Highlights: Congrats to: Ya-Tzu Li , our notable contributor, for her superb undergrad This transition will enable us to invest in higher-quality content and resources, ensuring our community

Together, our findings reveal an important suppressive role of ADGRA1 in anxiety control and synaptic

Our PKC KO cell lines expand the repertoire of KO HEK293A cell lines available to research GPCR pharmacology

Our results suggest that GPR15/GPR15L have a pathogenic role in RA and their antagonizing could be a

Overall, our studies are expected to allocate new targets for cancer therapy.

Our previous work demonstrated that GPR3-mediated β-arrestin signaling modulates amyloid-β (Aβ) generation

Our earlier reports suggested that GPR3 enhances both neurite outgrowth and neuronal survival.

Overall, our work reveals insight into PI3Kγ regulation and identifies sites that may be exploited for

Surprisingly, our results also demonstrate that exposure to SFK inhibitors, including dasatinib or knockdown

Our site-directed mutagenesis results show that mutations of this interface impact the function of the

flavonoids can target brain GPCRs and provide neuroprotection via inhibition of monoamine oxidases (hMAOs), our

Enhancing our knowledge of these regulatory frameworks will provide critical insights into the contribution

Our results showed that the inhibition of cellular respiration hindered the internalization of F-Hst1

Overall, our data shows that, in TNBC, it is not universally true that kisspeptin/KISS1R stimulate migration

Taken together, our results indicate that the astrocytic Gi pathway plays an inhibitory role in neuroinflammation

A greater understanding of this function of GPCRs is likely to significantly augment our ability to further

However, our knowledge of how GPCRs regulate liver metabolism and fibrosis in the different cell types

Our findings provide novel mechanistic insight into how GPR183 signaling in the spinal cord produces

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This is complimentary with other applications, and essential in our understanding of signaling pathways

Dear GPCR Enthusiasts , Get ready for an exciting learning experience with our newly updated Principles

In addition, our analysis also shows that phosphatidylinositol-4-phosphate (PI4P), along with some ICD

Our findings identify the BET protein family, and Brd4 in particular, as novel regulators of basal and

This research not only deepens our understanding of a key biological process but also provides a valuable