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We’re zeroing in on kinetic tools that reveal what steady-state data can’t—so you can vet leads faster

Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased

Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news

and Molecular Insights into GPCR Function A method for structure determination of GPCRs in various states

signaling regulates GPCR levels on the plasma membrane and suppresses the Saccharomyces cerevisiae mating

“The desire to take medicine is perhaps the greatest feature which distinguishes man from animals.”

for small molecule modulators of small protein GPCRs, but discovery is challenging and the attrition rate Available structural data across the GPCR superfamily is increasing at an exponential rate, alongside technology Hartley, O. et al. (2004) Proceedings of the National Academy of Sciences of the United States

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Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery.

Clinical Stage X4 Pharmaceuticals Announces Positive Phase 3 Results Showing Mavorixafor Reduced the Rate

Welcome back GPCR fans, The pace of GPCR innovation is accelerating at a rate that can be difficult to

Phosphorylation state of muopioid receptor determines the alternative recycling of receptor via Rab4

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Let's take a quick look at the weekly Classified GPCR News from June 26th to July 2nd, 2023.

GPCR Events You can begin organizing and marking a few dates in 2025 .

including multicellular organisms and human cells, to better mimic physiological conditions and disease states

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This week, Terry’s Corner takes you beyond curve shapes into the kinetic and mechanistic realities that

It is about designing clarity early enough that chaos never takes over.

Therefore, the in vivo state of the receptor and its existence as homo and herero-oligomeres at the cell

GPCR Events You can start planning and save some dates in 2025 .

When he moved to Uppsala in the late 1990s to study engineering, it was biotechnology—then on the rise—that

Stay informed and up to date with the latest GPCR research and industry news.

reality starts with hepatic metabolism , where enzymes such as cytochrome P450s  determine a molecule’s fate

Illuminating GPCR trafficking Cell swelling enhances ligand-driven β-adrenergic signaling Roles of the gate

The FA values were normalized by taking the average FA value of C = 0 points as 100% and the average Netherlands: Dordrecht, 2014; pp 55–74. https://doi.org/10.1007/978-94-007-7423-0_4 . (12)      Yung-Chi H.; Bates, M.; Zhuang, X.