📰 GPCR Weekly News, June 5 to 11, 2023

Hi there GPCR enthusiasts! Join us this week for a deep dive into the world of GPCRs. This week's GPCR papers feature publications from Drs. Ines Liebscher, Ross Cheloha and Silvio Gutkind.

Before we dive into this week’s news, we’d like to draw your attention to some of our events and resources:

• Please mark your calendars for July 21st for our next Dr. GPCR Symposium on Structural and Molecular Insights on GPCR Activation. Our website is updated as we confirm speakers so please check back often. We also seek speakers and poster presenters for the next symposium and beyond! Showcase your work by emailing us at Hello@DrGPCR.com.
  

• Stay updated with Dr. GPCR News by subscribing to our monthly newsletter.
  

• Our founder Dr. Yamina A. Berchiche is at the Molecular Pharmacology GRC, if you are also on-site, please stop by and say hi.

And now let’s dive into the weekly Classified GPCR News at a glance for June 5th to June 11th, 2023.

Adhesion GPCRs

• Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6.

• Hexahydroquinoline Derivatives are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1/GPR56.

GPCR Activation and Signaling

• Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome

• Antagonistic interactions between odorants alter human odor perception.

• Autocrine Proteinase-Activated Receptor (PAR) signaling in PC3 prostate cancer cells.

• Statin-induced increase in actin polymerization modulates GPCR dynamics and compartmentalization.

• Class B1 GPCR activation by an intracellular agonist.

• The G protein-coupled receptor neuropeptide receptor-15 modulates larval development via the transforming growth factor-β DAF-7 protein in Caenorhabditis elegans.

GPCR Binders, Drugs, and more

• Adenosine A2A Receptor (A2AAR) Ligand Screening Using the 19F-NMR Probe FPPA.

GPCRs in Cardiology, Endocrinology, and Taste

• Discovery of paralogous GnRH and corazonin signaling systems in an invertebrate chordate.

GPCRs in Neuroscience

• Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans.

Methods & Updates in GPCR Research

• A Peptidisc-based Survey of the Plasma Membrane Proteome of a Mammalian Cell.

Reviews, GPCRs, and more

• Diversification processes of teleost intron-less opsin genes.

• Regulation of the length of neuronal primary cilia and its potential effects on signalling.

Structural and Molecular Insights into GPCR Function

• Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.

• Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314.

GPCRs in Immunology and Oncology

• The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure

Industry News

• X4 Pharmaceuticals Expected to Join Russell 3000® Index.

• Novartis bolsters innovative medicines strategy and renal pipeline with agreement to acquire Chinook Therapeutics for USD 3.2bn upfront (USD 40 / share).

• EyeBio Announces First Patients Dosed in Phase 1b/2 Trial of Restoret™ in Neovascular Age Related Macular Degeneration and Diabetic Macular Edema.

• Confo Therapeutics Enters Into Research Collaboration For GPCR-Targeting Antibody Discovery With AbCellera.

GPCR Events, Meetings, and Webinars

• GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023)

• Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

• GPCR Retreat (November 2 - 4, 2023)

• NEW Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024)

GPCR Jobs

• NEW Scientist I / Scientist II DOE (Native Mass Spectrometry)

• Senior Vice President of Global Medical Affairs

• Postdoctoral Position on Gliovascular Unit of Glioblastoma

• Associate Director / Director, Clinical Operations

• Postdoctoral Research Associate

• Lab Manager

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