August 2022 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12 different G The structural basis for G protein subtype selectivity by these GPCRs remains elusive. We find that the macro-switch by the TM5-TM6 length is shared by class A GPCR-G protein structures.

Methods: To address this question, we studied mice that express a Gs-coupled designer G protein-coupled

Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in

Stephen Ferguson The History of the Great Lakes GPCR Retreat with Dr. Stephen Ferguson About Dr. Stephen Ferguson Dr. Stephen Ferguson is a Professor in the Department of Cellular and Molecular Medicine at the University Marc G. Stephen Ferguson on the web Carlton University Canada Research Chairs Twitter ResearchGate LinkedIn Dr

Stephen Ferguson About Dr. Stephen Ferguson Dr. Stephen Ferguson is a Professor in the Department of Cellular and Molecular Medicine at the University Marc G. receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking Stephen Ferguson on the web Carlton University Canada Research Chairs Twitter ResearchGate LinkedIn Dr

Stephen Ferguson About Dr. Stephen Ferguson Dr. Stephen Ferguson is a Professor in the Department of Cellular and Molecular Medicine at the University Marc G. receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking Stephen Ferguson on the web Carlton University Canada Research Chairs Twitter ResearchGate LinkedIn Dr