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- How sensitive can a GPCR really be | Dr. GPCR Ecosystem
Home → Flash News → How sensitive can a GPCR really be How sensitive can a GPCR really be? How disease can hijack signaling organization — and what that means for drug discovery.
- Lighting up a native pancreatic islet isn’t just a technical win it’s a shift in what GPCR imaging can reveal | Dr. GPCR Ecosystem
A breakthrough in GPCR imaging reveals a full native pancreatic islet and advances how GLP-1R can be Lighting up a native pancreatic islet isn’t just a technical win it’s a shift in what GPCR imaging can Lighting up a native pancreatic islet isn’t just a technical win — it’s a shift in what GPCR imaging can
- What can an updated profile do for you? 🔎 Personalized content, better networking, and collaboration opportunities. Fill in the blanks—update now! ✳️Visit https://bit.ly/4fY4UHV today #gpcr #drgpcr | Dr. GPCR Ecosystem
Home → Flash News → What can an updated profile do for you? GPCR Profiles What can an updated profile do for you?
- Ready to stand out in the GPCR world? Take advantage of a platform where you can network within your field! 🌍 Showcase your expertise by keeping your profile up-to-date on Dr. GPCR. | Dr. GPCR Ecosystem
Take advantage of a platform where you can network within your field! Take advantage of a platform where you can network within your field!
- Did you know allosteric modulators can change the GPCR G protein subtype selectivity? Have a look at this study to dive deep into its molecular mechanism. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. | Dr. GPCR Ecosystem
Home → Flash News → Did you know allosteric modulators can change the GPCR G protein subtype selectivity Published on December 12, 2024 Category GPCR Weekly News Did you know allosteric modulators can change
- What do you want to learn today? If you’re an Ecosystem Member, you can learn something new every day! 🚀 Take one of our courses On-Demand and expand your knowledge of GPCRs. ✳️Discover your next learning experience at https://www.ecosystem.drgpcr.com/gpcr-courses #gpcr #drgpcr | Dr. GPCR Ecosystem
If you’re an Ecosystem Member, you can learn something new every day! If you’re an Ecosystem Member, you can learn something new every day!
- From aspiring doctor to GPCR scientist! 🔬In this episode, Ian Chronis shares his journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor signaling. Can you guess what’s his favorite GPCR? ✅ Hear his response: Ep 164 with Dr. Ian Chronis #SciencePodcast #GPCR #PhDLife #DrGPCR | Dr. GPCR Ecosystem
Can you guess what’s his favorite GPCR? ✅ Hear his response: Ep 164 with Dr. Can you guess what’s his favorite GPCR? ✅ Hear his response: Ep 164 with Dr.
- Do you know we can discover allosteric modulators that bind to the intracellular allosteric binding site to better fine-tune the GPCRs’ activity? Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors CCR6 and CXCR1. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! | Dr. GPCR Ecosystem
Home → Flash News → Do you know we can discover allosteric modulators that bind to the intracellular Published on October 29, 2024 Category GPCR Weekly News Do you know we can discover allosteric modulators
- Did you know registrations are already open for all our 2025 Dr.GPCR University Courses? Check out what you can learn this year from the master, Dr. Terry Kenakin 😉and save your spot soon! Remember Premium Members get a 25% discount 🙌 ✳️Click here and start your next learning experience https://www.ecosystem.drgpcr.com/gpcr-courses #gpcr #drgpcr | Dr. GPCR Ecosystem
Check out what you can learn this year from the master, Dr. Check out what you can learn this year from the master, Dr.
- Can we preserve opioid pain relief without the side effects? 🔬 On Ep.166 of the Dr.GPCR Podcast, Ben Clements shares how positive allosteric modulators (PAMs) at the mu-opioid receptor could revolutionize treatment —with a 10x boost in methadone efficacy. Tune in for a masterclass on translational pharmacology, curiosity-driven science, and meaningful mentorship. 🎧 Full episode: Ep 166 with Dr. Ben Clements #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology #DrugDiscovery | Dr. GPCR Ecosystem
Home → Flash News → Can we preserve opioid pain relief without the side effects? GPCR Podcast Can we preserve opioid pain relief without the side effects?
- Did you know that GPR20, a potential therapeutic target to treat gastrointestinal stromal tumours, performs high constitutive activity when coupling with Gi? Check out this paper to see how molecular dynamics simulation can be used to explore its constitutive activation mechanism. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/exploring-the-constitutive-activation-mechanism-of-the-class-a-orphan-gpr20 #gpcr #drgpcr | Dr. GPCR Ecosystem
Check out this paper to see how molecular dynamics simulation can be used to explore its constitutive Check out this paper to see how molecular dynamics simulation can be used to explore its constitutive
- Class B GPCR drugs are reshaping treatment for migraine, diabetes, and obesity- but did you know ligand bias plays a key role in their success? This new review explores how tweaking peptide drugs can boost efficacy, reduce side effects, and unlock next-gen therapies. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/reviews/where-are-we-now%3F-biased-signalling-of-class-b-g-protein-coupled-receptor-targeted-therapeutics #gpcr#drgpcr | Dr. GPCR Ecosystem
This new review explores how tweaking peptide drugs can boost efficacy, reduce side effects, and unlock This new review explores how tweaking peptide drugs can boost efficacy, reduce side effects, and unlock
- 🎧 Why Does GPCR Location Make All the Difference? GPCR location within the cell can change everything: function, pharmacology, and even drug response. In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren dives into: 🔬 How GPCR trafficking shapes signaling outcomes 🚀 Career insights from the lab to the broader biotech world This episode is packed with knowledge for scientists, drug hunters, and anyone fascinated by GPCRs! 🎙️ Listen now https://buff.ly/fYZ1tSq #DrGPCR #GPCR #DrugDiscovery #Pharma #Biotech #SciencePodcast ✅ Tune in today! | Dr. GPCR Ecosystem
GPCR location within the cell can change everything: function, pharmacology, and even drug response. GPCR location within the cell can change everything: function, pharmacology, and even drug response.
- Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr | Dr. GPCR Ecosystem
Home → Flash News → Did you know that cell types can affect the GPCR-mediated signalling cascade? #gpcr #drgpcr Published on January 14, 2025 Category GPCR Weekly News Did you know that cell types can
- Did you know that certain ergot derivatives can produce wash-resistant signalling through the 5-HT2B receptor persisting for many hours without losing potency or efficacy? By using signalling assays, radioligand binding assay, and microscopy, Gaidarov et al. suggested that this phenomenon results from persistently/irreversibly internalised signalling receptor complexes. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/mechanisms-of-constitutive-and-agonist-induced-5-ht2b-internalization%2C-persistent-endosomal-signaling-and-paradoxical-regulation-of-agonist-pharmacology #gpcr#drgpcr | Dr. GPCR Ecosystem
Home → Flash News → Did you know that certain ergot derivatives can produce wash-resistant signalling drgpcr Published on May 19, 2025 Category GPCR Weekly News Did you know that certain ergot derivatives can
- This is a Title 01 | Dr. GPCR Ecosystem
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- This is a Title 03 | Dr. GPCR Ecosystem
Here, you can make changes to your content, add new fields, create dynamic pages and more. You can create as many collections as you need. You can also collect and store information from your site visitors using input elements like custom forms Be sure to click Sync after making changes in a collection, so visitors can see your newest content on
- This is a Title 02 | Dr. GPCR Ecosystem
Here, you can make changes to your content, add new fields, create dynamic pages and more. You can create as many collections as you need. You can also collect and store information from your site visitors using input elements like custom forms Be sure to click Sync after making changes in a collection, so visitors can see your newest content on
- irreversible drugs post 2 | Dr. GPCR Ecosystem
That’s why a compound like phenoxybenzamine can knock down receptor populations after just a brief exposure And why slow-dissociating allosteric inhibitors can reshape signaling curves for hours — or even days When persistent binding meets structured tissues, this effect can amplify or collapse. High-affinity molecules can get trapped at the periphery of a tumor, never reaching the core.
- Dr. GPCR Summit 2021 | Dr. GPCR Ecosystem
How can I sponsor the 2021 Summit? You can pre-record your talk. We recommend submitting pre-recorded talks. What does this mean? Pros: You can polish your recording to your satisfaction. Anyone can watch it from anywhere, even multiple times. Can I present a live talk or event? How?
- Pod-Be Our Guest | Dr. GPCR Ecosystem
Can I reschedule or cancel our meeting? Yes, you can reschedule or cancel our meeting through Calendly. Can I promote my work or projects during the podcast? Absolutely! Can I listen to the episode after it’s been recorded? Can I watch the video podcast after it’s been published?
- Dr. GPCR Affiliate Program | Earn by Empowering the GPCR Community
GPCR brand ambassador affiliate program Who can be a Dr. GPCR ambassador? Can I invite someone to participate? Yes! You can invite anyone to participate, and we welcome anyone if they are qualified. You can leave the program at any time by contacting us. Dr. You can take part in other affiliate programs as well as be part of ours.
- irreversible drugs post 1 | Dr. GPCR Ecosystem
Unlike reversible ligands, their impact can persist long after the compound is gone — creating durable In this week’s lesson, you’ll unpack: Why low offset rates can mimic covalent effects without forming Understanding irreversible interactions can mean the difference between a stalled program and a strategic
- Dr. Yamina Berchiche | Dr. GPCR Ecosystem
The explosion of biomedical data such as in genomics, structural biology, and pharmacology can provide ML/AI can be powerful for identifying abstract patterns within large data where traditional methods would This comes without the need for manual feature engineering as systems can learn through implicit rules How can we best leverage these exciting new techniques in areas such as protein structure prediction,
- ama session sept 18 post 3 | Dr. GPCR Ecosystem
pharmacologists navigating a fast-changing field: “Try to keep a finger on the pulse of as much as you can New ideas come up, and if we can encapsulate them and expose them, you can just hit a button, hear about
- ep 175 with jens carlsson clip 3 | Dr. GPCR Ecosystem
about structure, function, and discovery — but Jens Carlsson reminds us: the real test isn’t whether we can explain today’s data, it’s whether we can predict tomorrow’s results . With tools like AlphaFold , his lab can now model receptor–peptide complexes in seconds — an achievement
- Donate to Dr GPCR — Support the GPCR Community & University
Can I make a donation on behalf of a company? Can I become a monthly supporter? Absolutely. Monthly donations sustain long-term programs and can be changed at any time. Can I be recognized publicly? Together, we can accelerate GPCR discoveries and develop more effective drugs for everyone. 👉 Donate
- Dr. GPCR Summit 2022 | Dr. GPCR Ecosystem
You can join us for free when you become a Dr. GPCR Ecosystem site member, which is also free! You can participate: As an attendee by becoming a site member. You can verify it too by checking out the schedule on our website. before September 30th, 2022 You'll need a 1-minute video abstract in addition to the written version You can
- Weekly News October 16 | Dr. GPCR Ecosystem
Discover how enzyme inhibition can enhance drug discovery strategies. noncompetitive, mixed, uncompetitive), the messy truth of CYP450 allostery and DDIs, and why allosteric control can
- Explore / Organizations | Dr. GPCR Ecosystem
Discover how organizations in the GPCR field can leverage the Dr. GPCR Strategic Partner Request Your Quote How Organizations can benefit from Dr. GPCR Ecosystem? Post you job description and since this is a closed Ecosystem, you can (if you'd like) share the contact



