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This week's highlight includes congrats to: David A Cooper, David Minh, et al., for their research on

Kenakin attributes this to limited cooperativity: the allosteric ligand can only shift receptor affinity Mechanistically: The allosteric ligand imposes a finite change in affinity (cooperativity constraint) Cooperativity Tracks Species Movement Allosteric models quantify ligand effects through cooperativity Kenakin highlights a multi-parameter framework in which different cooperativity factors govern interactions implications: Ligand effects are defined by relational parameters, not absolute affinities Multiple cooperativity

and chemistry pulled him into the world of GLP-1R, pancreatic β-cells, and the biological questions David The call from David — the glowing islet — created a pivot the team couldn’t ignore. He learned tissue complexity from David; David picked up the quirks of acetonitrile. David Hodson

David Hodson needed molecules that were only one synthetic step beyond what JB was already making. When David later shared early data — including a moment where he realized he could image an entire islet David brought deep experience in islet biology, calcium imaging, and tissue physiology. David picked up unexpected chemistry insights — including a well-loved lesson involving acetonitrile David Hodson

Watch Episode #177 The Experiment That Was Never Meant to Succeed When David Hodson’s lab teamed up with David Hodson

In his collaboration with David Hodson, every major leap—from early ligand design to GPCR visualization David Hodson

Nguyen ,  Ziaurrehman Tanoli ,  Saad Hassan , Umut Onur Özcan ,   Jimmy Caroli ,   Albert J Kooistra ,   David Taracena Herrera , Søren N Andreassen ,   Jimmy Caroli ,   Albert J Kooistra , Gáspár Pándy-Szekeres ,   David

studies showing binding-function dissociation and residual signal effects ✅ Tools to model binding with cooperativity Kenakin shows how even small cooperativity values (like α = 0.1) cap the shift in signal . Each face of the cube is governed by a cooperativity constant : α:  Modulator’s effect on radioligand protein coupling (efficacy) γ:  G protein’s effect on radioligand binding (efficacy of A) β:  Dual cooperativity—how

David Gloriam and Dr. Albert Kooistra.

David Gloriam , Dr.

David Hodson

David Hodson walks through how his team uses fluorescence tools and chemically engineered ligands to

However, Trinquet’s team, in collaboration with Professor David Parker from Durham University, cracked

It’s the product of layered collaborations—with Durham University chemist David Parker on the probe chemistry

Maria Majellaro, Johannes Broichhagen, and David Hodson discuss GLP-1 receptor probes, fluorescence-based

David Parker spent years designing rare-earth europium probes.

David Hodson

But it also presents some issues, such as synthesizing the as the presence of the copper catalyst, which Thanks to the unique linker structure we obtain, which can be divided into three differentiated parts

spatial, temporal and ligand bias of G protein-coupled receptors Antonios Drakopoulos, Peter Gmeiner, Davide

Burger , Arthur Christopoulos , David M.

Allosterics offer a broader range of effects—additive, synergistic, or even inhibitory—depending on cooperativity   👉 Explore Trailers & Join Today Why Terry’s Corner The reality is dynamic—ligands compete, cooperate

Lukas Grätz, David Gloriam, and Gunnar Schulte’s research on Unveiling pathway selectivity in Frizzleds

reveals unexpected differences in downstream pathway activation Chiara D Mancinelli, Joshua Levitz, David

The heterologous facilitation was modelled based on the known cooperative interaction between the G protein The results suggest that the cooperative interaction between G βγ subunits and GIRK channels determines

David Gloriam and his team present GproteinDb in 2024 Are you looking to hire?

José Labandeira-García , Rafael Franco Endomembrane GPCR signaling: 15 years on, the quest continues Davide

Working closely with Professor David Parker of Durham University, Trinquet’s group cracked the scaffold

This Week’s Highlights: G protein-coupled receptor (GPCR) pharmacogenomics Miles D Thompson , David

The observed differences in the binding affinity and cooperativity arise from the functional groups that

Constituent structural motifs cooperatively transform ligand selectivity into specific functions, thus