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This week's highlight includes congrats to: David A Cooper, David Minh, et al., for their research on Minh and the team are looking for collaborators from academia and industry.

Nguyen ,  Ziaurrehman Tanoli ,  Saad Hassan , Umut Onur Özcan ,   Jimmy Caroli ,   Albert J Kooistra ,   David Taracena Herrera , Søren N Andreassen ,   Jimmy Caroli ,   Albert J Kooistra , Gáspár Pándy-Szekeres ,   David

David Gloriam and Dr. Albert Kooistra.

David Gloriam , Dr.

The Innovation Trap: Why Most Scientists Think Too Narrowly Eric doesn’t mince words: many junior scientists Mini Timeline 🎯 Early 2000s: Trinquet leads IP1 & Tag-lite development 🧪 Mid-2010s: Rare-earth scaffold It’s the product of layered collaborations—with Durham University chemist David Parker on the probe chemistry

However, Trinquet’s team, in collaboration with Professor David Parker from Durham University, cracked Mini Timeline: pHSense Development Early 2020s: Rare-earth probe synthesis begins Collaborative screening

David Parker spent years designing rare-earth europium probes. Mini Timeline: The Road to pHSense → Initial lanthanide probe design with Durham University (chemistry

reveals unexpected differences in downstream pathway activation Chiara D Mancinelli, Joshua Levitz, David It is an opportunity to connect with like-minded scientists and researchers and gain valuable insights

spatial, temporal and ligand bias of G protein-coupled receptors Antonios Drakopoulos, Peter Gmeiner, Davide

Lukas Grätz, David Gloriam, and Gunnar Schulte’s research on Unveiling pathway selectivity in Frizzleds

Burger , Arthur Christopoulos , David M.

David Gloriam and his team present GproteinDb in 2024 Are you looking to hire?

José Labandeira-García , Rafael Franco Endomembrane GPCR signaling: 15 years on, the quest continues Davide

This Week’s Highlights: G protein-coupled receptor (GPCR) pharmacogenomics Miles D Thompson , David

Working closely with Professor David Parker of Durham University, Trinquet’s group cracked the scaffold

GPCRs are divided into six classes based on amino acid sequence similarities, but only four of the classes

Gq, Gs, Gi, G12 and G13 engagements with GPR110 reveals details of G-protein engagement, including a dividing

This may be broadly divided into studies focused on obtaining detailed molecular information in the intracellular

Thanks to the unique linker structure we obtain, which can be divided into three differentiated parts

Physiology or Medicine was awarded jointly to Ragnar Arthur Granit, Haldan Keffer Hartline, and George David The Nobel Prize in Physiology or Medicine 2000 - Speed read: Mind reading - NobelPrize.org. https://

Methods: Rats were divided into sham, sham + Exendin-4 (10 μg/day, i.p), MI, and MI + Exendin-4.

Manchanda and colleagues [37] showed that for the glucagon-like-peptide-1 receptor (GLP-1R), mini-Gs These findings suggest that the use of mini-G proteins could have hindered the accurate quantification Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells. Mini-G proteins: Novel tools for studying GPCRs in their active conformation. GPCR Activation States Induced by Nanobodies and Mini-G Proteins Compared by NMR Spectroscopy.

drugs, breaking down the science into accessible, engaging insights for early learners and curious minds

Choosing not to overthink major career decisions, because as she puts it:  “A lot of friends of mine

You can have the most brilliant minds and cutting-edge assays, but if your science isn't continuously believe we don't have time to build better systems, but in reality, our most brilliant and expensive minds

GPCR Colleagues & Curiosity-Driven Minds, We’re starting with exciting Dr.

Designing Strategically with Irreversible Drug Binding in Mind When irreversible mechanisms are designed If you’re not designing with persistent enzyme interactions in mind, you’re building risk into your molecule

This mini-review discusses recent insights into the mechanisms of PTHR endosomal signaling and its physiological

Hello GPCR Minds,   This week, you'll learn all about Terry’s Pharmacology Corner, your new learning

Alejandra Tomas, et al. for their research on Engineered mini-G proteins block the internalization of agonism The roles of RGS proteins in cardiometabolic disease GPCR Binders, Drugs, and more Engineered mini-G