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This week's highlight includes congrats to: David A Cooper, David Minh, et al., for their research on Minh and the team are looking for collaborators from academia and industry.

Nguyen ,  Ziaurrehman Tanoli ,  Saad Hassan , Umut Onur Özcan ,   Jimmy Caroli ,   Albert J Kooistra ,   David Taracena Herrera , Søren N Andreassen ,   Jimmy Caroli ,   Albert J Kooistra , Gáspár Pándy-Szekeres ,   David

and chemistry pulled him into the world of GLP-1R, pancreatic β-cells, and the biological questions David The call from David — the glowing islet — created a pivot the team couldn’t ignore. He learned tissue complexity from David; David picked up the quirks of acetonitrile. David Hodson

David Hodson needed molecules that were only one synthetic step beyond what JB was already making. When David later shared early data — including a moment where he realized he could image an entire islet David brought deep experience in islet biology, calcium imaging, and tissue physiology. David picked up unexpected chemistry insights — including a well-loved lesson involving acetonitrile David Hodson

Watch Episode #177 The Experiment That Was Never Meant to Succeed When David Hodson’s lab teamed up with David Hodson

David Gloriam and Dr. Albert Kooistra.

David Gloriam , Dr.

The Innovation Trap: Why Most Scientists Think Too Narrowly Eric doesn’t mince words: many junior scientists Mini Timeline 🎯 Early 2000s: Trinquet leads IP1 & Tag-lite development 🧪 Mid-2010s: Rare-earth scaffold It’s the product of layered collaborations—with Durham University chemist David Parker on the probe chemistry

However, Trinquet’s team, in collaboration with Professor David Parker from Durham University, cracked Mini Timeline: pHSense Development Early 2020s: Rare-earth probe synthesis begins Collaborative screening

David Hodson

David Hodson walks through how his team uses fluorescence tools and chemically engineered ligands to

David Parker spent years designing rare-earth europium probes. Mini Timeline: The Road to pHSense → Initial lanthanide probe design with Durham University (chemistry

at the door, or the moment a team realizes the question in front of them is simply too big for one mind finally into islet biology — each step revealing a simple truth: Complex problems require multiple minds David Hodson

reveals unexpected differences in downstream pathway activation Chiara D Mancinelli, Joshua Levitz, David It is an opportunity to connect with like-minded scientists and researchers and gain valuable insights

spatial, temporal and ligand bias of G protein-coupled receptors Antonios Drakopoulos, Peter Gmeiner, Davide

Lukas Grätz, David Gloriam, and Gunnar Schulte’s research on Unveiling pathway selectivity in Frizzleds

Burger , Arthur Christopoulos , David M.

David Gloriam and his team present GproteinDb in 2024 Are you looking to hire?

José Labandeira-García , Rafael Franco Endomembrane GPCR signaling: 15 years on, the quest continues Davide

This Week’s Highlights: G protein-coupled receptor (GPCR) pharmacogenomics Miles D Thompson , David

Working closely with Professor David Parker of Durham University, Trinquet’s group cracked the scaffold

GPCRs are divided into six classes based on amino acid sequence similarities, but only four of the classes

Gq, Gs, Gi, G12 and G13 engagements with GPR110 reveals details of G-protein engagement, including a dividing

This may be broadly divided into studies focused on obtaining detailed molecular information in the intracellular

Thanks to the unique linker structure we obtain, which can be divided into three differentiated parts

Physiology or Medicine was awarded jointly to Ragnar Arthur Granit, Haldan Keffer Hartline, and George David The Nobel Prize in Physiology or Medicine 2000 - Speed read: Mind reading - NobelPrize.org. https://

former students now work in industry, where their ability to bridge the computational-experimental divide

Methods: Rats were divided into sham, sham + Exendin-4 (10 μg/day, i.p), MI, and MI + Exendin-4.

organization absolutely fascinated me — the idea that receptors could cluster and control specificity blew my mind Mini Timeline: Manual assay years — technical rigor as foundation Technology boom — scaling curiosity

Manchanda and colleagues [37] showed that for the glucagon-like-peptide-1 receptor (GLP-1R), mini-Gs These findings suggest that the use of mini-G proteins could have hindered the accurate quantification Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells. Mini-G proteins: Novel tools for studying GPCRs in their active conformation. GPCR Activation States Induced by Nanobodies and Mini-G Proteins Compared by NMR Spectroscopy.