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Fiona Marshall on structure-based GPCR drug discovery, the GABA-B heterodimer, the acetate that rewrote design as a productive strategy across GPCR families. Scientific Themes of the Conversation Structure-based GPCR drug design and the thermostabilization breakthrough drug design 18:47 Which GPCR families pharma is chasing now — and why 21:23 Why animal model validation stabilization and structure-based drug design.

Jacobson, Matteo Pavan Structure-Based Design of Modulators of Purinergic GPCRs <p class="font_8">Watch Now</p> Terry Kenakin Designing with Time: GPCR Ligand Kinetics <p class="font_8">Watch Now</p> Terry for assay design strategies. Structure-Based Drug Design Innovation & Strategic Application Agonists, Antagonists & Core Mechanisms The Masterclass is designed for GPCR researchers, pharmacologists, and drug discovery scientists working

Explore GPCR signaling kinetics and temporal drug action mechanisms with Sam Hoare. . < Back How Signaling Kinetics Shapes GPCR Drug Action May 14, 2026 10 AM - 11:30 AM EST 🔒 Watch Recordings Designed for pharmacologists, drug discovery scientists, and translational researchers working on temporal aspects of GPCR therapeutics. editor at the NIH Assay Guidance Manual and regularly teaches advanced pharmacology and experimental design

Explore Martin Marro’s impact on GPCR drug discovery, assay innovation, and translational pharmacology , Bias, and Translational Drug Discovery This episode features Dr. How advanced assay design is essential for translating cell-based GPCR signals to therapeutic outcomes drug discovery. How integrating antibody-based modalities has expanded options for hard-to-drug GPCR targets.

GPCR unites researchers, industry, and partners to accelerate GPCR science and drug discovery—through GPCR Ecosystem We unite the GPCR community to advance drug discovery. We bring the GPCR community together to fuel GPCR drug discovery—one receptor at a time. Contact Us Our Mission Advance GPCR science and drug discovery by connecting people, data, and opportunities across the global GPCR ecosystem.

Five scientists audit what AI can and can't do for GPCR drug discovery — from orphan receptors and biased Drug Discovery? drug discovery, or is it mostly a rebranding of methods the field has used for decades? from known peptides Generative models, scoring functions, and the role of molecular dynamics in ligand design GPCR-targeting drugs represent roughly 0.9 trillion dollars in global sales across 75 countries.

Joseph Kim: Structural Biology and Drug Discovery at GPCRs Scientific Abstract G protein-coupled receptors (GPCRs) remain one of the most important classes of drug targets in modern pharmacology. molecular structures inform the design and development of new therapeutics. GPCR Drug Discovery Is Increasingly Structural Modern GPCR drug discovery increasingly integrates structural I would like to remain in drug discovery , ideally working on GPCRs if possible.

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors (GPCRs) that control virtually everything in the body as drug targets. GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the GPCR About John Azietaku John Teye Azietaku,PhD is a trained pharmacist, holding a Ph.D. in Drug Discovery virtual drug screening to identify agonists and antagonists targeting Class A GPCRs.

These webinars are designed for scientists who want deep, data-driven discussion rather than surface-level discovery If you work directly with receptor systems, ligand design, efficacy modeling, or signaling These webinars are designed for scientists with foundational knowledge in receptor pharmacology, signaling These webinars are designed to support ongoing scientific development in GPCR pharmacology and drug discovery These programs are designed for scientists seeking advanced, mechanism-focused training in GPCR biology

biology, and drug discovery. Sam Hoare | Pharmechanics How Signaling Kinetics Shapes GPCR Drug Action Translational Pharmacology & Jacobson, Matteo Pavan Structure-Based Design of Modulators of Purinergic GPCRs Terry Kenakin Assessing The Masterclass is designed for GPCR researchers, pharmacologists, and drug discovery scientists working Experts explain how they think about pharmacological data, experimental design, and discovery challenges—insight

Terry Kenakin on detecting, quantifying, and applying receptor signaling bias in GPCR drug discovery. Candidates Turning functional selectivity into a practical decision-making tool in GPCR drug discovery Organizers Eurofins DiscoverX Eurofins DiscoverX is a one-stop-shop for GPCR drug discovery and development GPCR is a membership-based nonprofit ecosystem dedicated to advancing GPCR-targeted drug discovery. Curated intelligence on GPCR drug discovery trends and developments Expert-led webinars and masterclasses

impact and drug development. < Back How to Build Breakthrough GPCR Programs June 4, 2026 10 AM - 11: discoveries worth pursuing to clinical endpoints, and navigating the pathway from academic research to drug co-founder and CEO of Keltic Pharma Therapeutics, he leads a biotechnology company developing a novel drug-discovery Centre at the University of Glasgow, a £130M collaborative initiative housing over 550 researchers designed His recent work on muscarinic acetylcholine receptor modulation and structure-guided design of M1 receptor

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors (GPCRs) that control virtually everything in the body as drug targets. GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the on GPCRs. biology and for the identification of drug targets and future drug development.

Expert support, trusted CROs, and ready-to-use tools to accelerate GPCR drug discovery, reduce risk, GPCR Foundry: Accelerate GPCR Drug Discovery Move from idea to insight—faster, smarter, and with confidence Get Team Access GPCR University Expert-led courses spanning GPCR drug discovery — from receptor biology GPCR ecosystem. biotech innovators and showcase your expertise Training & Upskilling Specialized, insight-packed courses designed

<< Back to podcast list Strategic Partner(s) Empowering Drug Discovery for the GPCR Community with Dr GPCR Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Your One-Stop-Shop for GPCR Drug Discovery and Development Researchers developing GPCR-targeted therapeutics These industry-standard assays, designed for regulatory submissions, are backed by partnerships with , Eurofins DiscoverX provides you with a variety of drug discovery and development products with multiple research and drug discovery and development. GPCR services, the benefits from integration provide the most comprehensive GPCR research and drug discovery

Every session is designed to move your science forward. Topics Covered The biological basis of receptor signaling bias and ligand-dependent conformations How to design They're designed for scientists who want deep, data-driven discussion rather than surface-level overviews These sessions are designed for interaction — scientists asking direct questions and getting real answers GPCR pharmacology, signaling, structural biology, allosteric modulation, biased agonism, assay design

The most comprehensive knowledge system in GPCR science. Intelligence Hub Every resource the GPCR ecosystem has ever produced. GPCR community live this week to examine what standard models don't account for — what happens when GPCR Research Hub in Cambridge, Massachusetts to Expand Drug Discovery Capabilities and Accelerate Medicine News April 2, 2026 Binder2030: a quantitative membrane proteome binding dataset enabling AI-driven drug

GPCR signaling in disease. << Back to podcast list Strategic Partner(s) Hacking GPCRs: Tools, Tech & Drug Discovery with Tom Sakmar & Ilana Kotliar In this episode, host Dr. Ilana Kotliar , his former graduate student, to explore the development of powerful multiplex tools designed About Tom Sakmar Tom Sakmar is a physician-scientist and Rockefeller University professor dedicated to drug He and his artist/designer wife, Karina Åberg, have three teenage children.

GPCR: Advancing GPCR Drug Discovery Through Collaboration Discovery On Target 2024 GPCR targeted drug discovery Summit 2024 GPCR targeted drug discovery Summit 2023 The Dr. GPCR Podcast GPCR targeted drug discovery Summit 2022 Dr. GPCR: Where all GPCRs are created equal Dr. GPCR: Beyond the lab Dr. GPCR: From idea to Ecosystem Dr. GPCR: Beyond the lab

We'll also preview upcoming courses designed for both experienced researchers and newcomers. 🚀 Develop Terry Kenakin’s unique course, Development of GPCR Ligands as Therapeutic Drugs , and gain essential insights into: 🔹 Drug Development Basics – PK-PD insights, absorption, and drug properties 🔹 Clearance Distribution, renal/hepatic pathways, and elimination 🔹 Safety First – Identifying toxicity risks and drug-drug GPCR signaling and drug discovery Symposium & Workshop - Brazil NEW April 1 - 3, 2025 | 2nd Peptide-Based

Explore their innovative GPCR projects, collaborations, and contributions to cutting-edge drug discovery innovative fluorescent probes that de-risk the pre-clinical drug discovery phase. dramatically improve how scientists measure ligand-receptor interactions, visualize binding in live cells, and design GPCR Functional Assay Fluorescent GTPγS enables sensitive, non-radioactive GPCR activity assays for drug Custom Development Tailored fluorescent probes designed for unique research requirements.

How receptor residence time — not affinity — rescued a CRF drug discovery program, and why a career in Partner(s) Sam Hoare: Receptor Residence Time and GPCR Data Analysis For most of GPCR pharmacology's The Neurocrin team had to confront an explanation no assay had been designed to find — and then built underlying pharmacological theory, from operational models of agonism to allosteric binding equations, was designed affinity at pH 7.4 vanished entirely at the physiological vesicle pH of 5.5 — the pattern recurs: assays designed

Stay at the Forefront of GPCR Drug Discovery Gain insider methods from the pioneers shaping biased signaling , assay design, and pharmacology—skills you won't find in any textbook or paper. ⧖ 20+ Hours of Expert research Access exclusive training from the scientists shaping the future of GPCR drug discovery Dr. for assay design strategies. field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way.

and drug discovery innovation. << Back to podcast list Strategic Partner(s) From Curiosity to Breakthrough : Ajay Yekkirala on GPCR Innovation What if the key to safer, more effective drugs lies in asking the drug developer and entrepreneur. Ajay reveals how humility, curiosity, and collaboration fuel the future of drug discovery. GPCR Podcast? Leave a Review.

GPCR Ecosystem We unite the GPCR Community to advance drug discovery Where GPCR Experts Move Science Forward Join the global community accelerating GPCR drug discovery through trusted insights, expert tools We designed the Ecosystem to support your work —no matter where you are in your GPCR journey. behind-the-scenes tools and insight What Makes the Ecosystem Different Built for Drug Discovery Designed by scientists in the GPCR space to accelerate your research goals Collaborative by Design Connects researchers

GPCR pharmacology, receptor signaling, and drug discovery evolved inside one of the world’s largest pharmacology and drug discovery. Serendipity Depends on Experimental Design and System Choice . understanding receptor activation in patients, but requires realistic views of effect sizes and trial design research and drug discovery.

GPCR Ecosystem – the ultimate hub for GPCR professionals to connect, collaborate, and advance drug discovery Home: About The global hub for GPCR science Accelerating GPCR drug discovery, together Where academia For scientists University Your professional home in GPCR science. GPCR is a 501(c)(3) nonprofit empowering the GPCR field through shared knowledge, collaboration, and open access to tools that accelerate drug discovery. 🤝 Support the Mission

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors (GPCRs) that control virtually everything in the body as drug targets. GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the GPCR podcast. Dr. GPCR Podcast? Leave a Review.

Sykes, BSc Hons Pharmacology, MSc Molecular Biology and Biochemistry, PhD in Molecular Pharmacology & Drug David has over 20+ years of experience working in a drug discovery environment mainly in a specialist current interests include the development of HTS fluorescence-based kinetic binding assays specifically designed GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.