Dive into our GPCR coverage for this week! We’ve curated 10 GPCR papers, seven industry news, and two GPCR job ads! This week's highlight: Dr. GPCR University February 8 - 29: Join Dr. GPCR University's live course with Dr. Terry Kenakin. , and more The multifaceted functions of β-arrestins and their therapeutic potential in neurodegenerative GPCR Ecosystem

We’ve curated 18 GPCR papers, 8 industry news, and 2 GPCR job offers! Congratulations to Domain Therapeutics for appointing Michael Gottlieb as Chairman and Dr. states Reviews, GPCRs, and more G Protein-coupled Receptors (GPCRs) as Potential Therapeutics for Psychiatric modulate engagement of CCR5 by chemokines by removing key electrostatic interactions Industry News Domain Therapeutics GPCR Ecosystem

We’ve curated 23 GPCR papers, four industry news, and 3 GPCR job posts! This week's highlight: Drs. GPCR Ecosystem Members! GPCR Access to Dr. Morgan Healthcare Conference Andrew Hopkins appointed CBE by HM King Charles III Voyager Therapeutics GPCR Ecosystem

Check out our curated GPCR coverage for this week, which includes 14 GPCR papers, four industry news, one GPCR Event, and two GPCR job ads! GPCR University Our first Dr. GPCR at the Endocrine Metabolic GPCRs Summit on April 22-23, 2024, in Birmingham, UK. Dr. GPCR Ecosystem

November 2022 "Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of physiologies A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain and the dipping of the cleaved The structures also reveal the uncharted structural information of GPCR/G12 coupling. Taken together, our study lays the groundwork for understanding aGPCR activation and G-protein-coupling Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter HERE

GPCR podcast with Dr. Nicole (Nicki) Perry-Hauser is now available What a fun chat! GPCR Ecosystem paid membership to enjoy everything Dr. GPCR has! ➡️https://bit.ly/3TCJVQQ #gpcr #drgpcr

Hi GPCR lovers! GPCR University live Zoom sessions hosted by Dr. Terry Kenakin. , and more Structure, function and drug discovery of GPCR signaling Illuminating the understudied GPCR-ome Muscarinic Agonist Candidates in Phase 1 Clinical Studies AbbVie to acquire neuroscience drugmaker Cerevel Therapeutics GPCR Ecosystem

Thus, identifying novel molecular targets for developing HF therapeutics remains a key research focus G protein-coupled receptors (GPCRs) are critical myocardial signal transducers which regulate cardiac therapeutics currently used in HF target these receptors. A recent focus on GPCR intracellular-regulating proteins such as GPCR kinases (GRKs) has uncovered GRK2 Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Symposia 2023. Adhesion GPCRs CryoEM structures of adhesion in GPCR CD97: Filling in some of the gaps GPCR Activation identification of potential agonists of FFAR4 for type 2 diabetes mellitus therapy Industry News OMass Therapeutics (ANDA) Litigation PostEra Announces a Research Collaboration with Amgen to Discover Small Molecule Therapeutics GPCR Ecosystem

2022 Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal GPCR leverage multiple sophisticated technologies that drive creation of new drug discovery programs in key therapeutic the Sosei Heptares compound library for its industry-leading biology platform to identify potential GPCR targets and advance the development of new gastrointestinal therapeutics Tokyo, Japan, Cambridge, UK drug discovery programs in the area of gastrointestinal diseases. " Read more at the source #DrGPCR #GPCR

Hello GPCR people! We have great news! Take a few minutes, and dive into our GPCR coverage! We welcome GPCR paper suggestions! Adhesion GPCRs The Posttraumatic Increase in the Adhesion of GPCR EMR2/ ADGRE2 to Circulating Neutrophils Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation GPCR Activation and Signaling GPCR Ecosystem

network located on intracellular loop 2 that is subject to RNA editing, which differentially affects GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

Are you ready for some exciting news in the GPCR world? This week's highlights: Dr. GPCR Symposium of the year on GPCRs in Immunology and Oncology! GPCR Newsletter for more insights! Company in Immuno-Oncology, Domain Therapeutics, Presents Groundbreaking Advancements at ESMO 2023 Novo GPCR Ecosystem

that the affinity of Fzd for Dvl was not affected by Wnt ligands, in contrast to other members of the GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Newsletter to receive more insights! Adhesion GPCRs Piconewton Forces Mediate GAIN Domain Dissociation of the Latrophilin-3 Adhesion GPCR Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs GPCR Activation Tethered Ligands that Target the µ-Opioid Receptor Design and Synthesis of Novel GPR139 Agonists with Therapeutic GPCR Ecosystem

October 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised, therapeutic potential. Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Symposium about 'GPCRs as Therapeutic Modalities' rocked it! GPCR Newsletter! Dive into the Classified GPCR News from September 18th to 24th, 2023. recommended by NICE for acute migraines Addex mGlu2 NAM Cognition Program Receives €4 Million Grant Confo Therapeutics Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting GPCR Ecosystem

Our partner, Domain Therapeutics, will attend the SACHS 23rd annual biotech event in Europe. Dr. Christopher Langmead and colleagues' work on the 5-HT2C receptor as a therapeutic target for substance GPCR Symposium on ''GPCRs as Therapeutic Modalities' Share your project with a 1-minute abstract video Protein and Exendin-P5 Biased Agonist Molecular and structural insights into the 5-HT2C receptor as a therapeutic teams up with addiction treatment maker Indivior to make digital therapeutics for substance use disorders

We will be back next week with our regular weekly GPCR news digest. In the meantime, you can always check the  Classified GPCR News from the last weeks. GPCR Podcast. GPCR. Today is also the first session of our hands-on workshop with Dr. Sam Hoare. GPCR University content coming soon.

in the GPCR field. GPCR Symposium on 'GPCRs as Therapeutic Modalities'. neutrophil chemoattractant Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic Launches with $33 Million Seed Round to Fuel its Drug Discovery Engine and Pipeline of Small Molecule Therapeutics GPCR Ecosystem

October 2022 "Understanding the activation of G protein-coupled receptors (GPCRs) is of paramount importance Although many cardiovascular GPCRs have been extensively studied as model receptors for decades, new As a result, there is an ongoing need to develop novel approaches to monitor and to modulate GPCR activation nanobodies with tailored specificities may expand the impact of these tools for both basic science and therapeutic Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Symposia Mark your calendars! GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs Reviews, GPCRs, and more Butyrate as a promising therapeutic target in cancer: From pathogenesis to cadherin G protein-coupled receptors that bind cry toxins of Bacillus thuringiensis Industry News Domain Therapeutics GPCR Ecosystem

are small-lipidated peptides designed from the intracellular loops of G protein-coupled receptors (GPCRs ) that act in an allosteric manner to modulate the activity of GPCRs. activity in an orthosteric site-independent manner to compounds with therapeutic potential that have development for each receptor, as well as the structural, signaling, pathophysiologic consequences, and therapeutic Read more at the source #DrGPCR #GPCR #IndustryNews

Read more at the source #DrGPCR #GPCR #IndustryNews

Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Newsletter HERE

GPCR Symposium on 'GPCRs as Therapeutic Modalities'. Want to share your project in a casual way? GPCR Newsletter! npr-38 regulates avoidance and stress-induced sleep in Caenorhabditis elegans Towards the convergent therapeutic Provides Corporate Updates, and Reports Emerging Data from Chronic Neutropenia Clinical Program Structure Therapeutics GPCR Ecosystem

Xavier Leroy for his new role as CEO of GIO Therapeutics Dr. at the plasma membrane Industry News Launch of GIO Therapeutics, founded by Cumulus Oncology, to develop therapeutics targeting G protein-coupled receptors to treat cancer and inflammation AVROBIO and Tectonic Therapeutic Announce Merger Trevena Inc Elevates Barry Shin to Executive VP and CFO GPCR Events, Meetings GPCR Ecosystem

release of these hormones in the adrenals is tightly regulated by adrenal G protein-coupled receptors (GPCRs In this review, we discuss important aspects of adrenal GPCR signaling and regulation, as they pertain modulation of cardiac function in the context of chronic HF, by focusing on the 2 best studied adrenal GPCR the β-arrestins in the adrenals, 2 protein families that regulate the signaling and functioning of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews